Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 1.1e-07 1.5e-05 26.6 1.3 1 23 197 219 197 219 0.98

2 5 0.00039 0.054 15.3 0.0 2 23 229 250 228 250 0.97

3 5 1.6e-06 0.00023 22.8 0.4 1 23 254 276 254 276 0.97

4 5 7.4e-08 1e-05 27.1 0.0 1 23 282 306 282 306 0.97

5 5 3.8e-05 0.0053 18.5 3.8 1 22 312 333 312 333 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	1.1e-07	1.5e-05	26.6	1.3	1	23	197	219	197	219	0.98
2	5	0.00039	0.054	15.3	0.0	2	23	229	250	228	250	0.97
3	5	1.6e-06	0.00023	22.8	0.4	1	23	254	276	254	276	0.97
4	5	7.4e-08	1e-05	27.1	0.0	1	23	282	306	282	306	0.97
5	5	3.8e-05	0.0053	18.5	3.8	1	22	312	333	312	333	0.95

Coding Sequence: atgttttccaACATATATTACTTTCTTTCAGAACCACAACAACCACCTACTGAATATGCCGAGCTTGCCAGTACGCCGGTTGGCGAAAGGTCAGCAGCGGACACAGAAGCAGCGCATGAGCTACTTTCTCTCGCACAAGGACTCCCGCCGCTGCCGCCAGCTACCGTCGTCACTGTCCTCCATACACCCGAACCACCAATAGTTCCTGTATACACCTACACCATTCAACCAACTAACATTTACATTATCACCGAGGAACCTCCCGAACCTATCTATCATGCTGTGCAAACTCCAATTGTTGCTCCAATATCACAATTTGAGTATACAATTGAGCCTCAACTCAGTTATGTTGCCTATCAACCAATTCCGGAGCCTATGCCAGAACCAATACAAATACCGGTCCCTATAACTCAGTACGAAGAAAGTATTGCTATTTCTGAACCTATACTACTTGAAAAGTCTCCAACACCACCACCACAATCACCTCTACCATCACCACAACCTCGATCACCATCACCACCACCTTCAGAACTTGCTAAAGTAGCCGAAGAAAAAACACCATCGACTCCTaaggaaaaacaaataaaatatgacTGTAACGAGTGTGGTAAGCGTTACGCAACTTCTTCCAATTTGTCTCGACACAAACAGACACATCGTAGCCTCGACTCTGTGGCTGCTAAACGTTGTGAAGACTGTGGCAAAGCGTACGTCTCGATGCCGGCACTTGCCATGCATGTTCTTACTCATCGAATGGGCCACGTGTGTGGTGTTTGTGGTAAGCAGTTTTCAAGACCATGGTTACTTCGAGGGCATTTGCGTTCCCATACGGGAGAGAGGCCATACGATTGTCCAGCTTCTGGATGTGGAAAGGCGTTCGCCGATCGATCTAATCTCCGTGCCCATCTGCAAACTCATTCAGCTGATAAGAAATTTGAGTGCCATCGCTGTCACAAAACCTTTGCCCTTAAAAGCTATCTAACCAAACACCAAGAGACAACTTGTTTGCGCTCTGACAACGAGTAA
Protein Sequence: MFSNIYYFLSEPQQPPTEYAELASTPVGERSAADTEAAHELLSLAQGLPPLPPATVVTVLHTPEPPIVPVYTYTIQPTNIYIITEEPPEPIYHAVQTPIVAPISQFEYTIEPQLSYVAYQPIPEPMPEPIQIPVPITQYEESIAISEPILLEKSPTPPPQSPLPSPQPRSPSPPPSELAKVAEEKTPSTPKEKQIKYDCNECGKRYATSSNLSRHKQTHRSLDSVAAKRCEDCGKAYVSMPALAMHVLTHRMGHVCGVCGKQFSRPWLLRGHLRSHTGERPYDCPASGCGKAFADRSNLRAHLQTHSADKKFECHRCHKTFALKSYLTKHQETTCLRSDNE

Sequence clustering based on sequence similarity using MMseqs2