Basic Information

Gene Symbol
zfh1
Assembly
GCA_030463065.1
Location
CM059999.1:12066318-12068095[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.00033 0.018 15.6 0.3 1 21 191 211 191 212 0.94
2 9 5e-06 0.00028 21.3 1.0 1 23 220 243 220 243 0.97
3 9 1e-06 5.7e-05 23.5 1.9 1 23 263 285 263 285 0.99
4 9 6.3e-08 3.5e-06 27.3 0.8 1 23 291 313 291 313 0.95
5 9 0.00036 0.02 15.5 0.6 1 23 319 341 319 341 0.99
6 9 3.5e-07 2e-05 24.9 0.9 1 23 347 369 347 369 0.98
7 9 0.00023 0.013 16.1 0.6 1 23 375 397 375 397 0.98
8 9 2.2e-05 0.0012 19.3 2.4 1 23 403 425 403 425 0.99
9 9 0.00016 0.0087 16.6 3.3 1 23 431 453 431 454 0.96

Sequence Information

Coding Sequence
ATGgccattcaaatggaaaaaatttgTCGAACGTGTATGGCAGAATCGAGGACGTTAATATCAATTTGGTCATCAGATGGGACTTCATCAAATAGTACAAGCTCAATATCTGAGCTTCCGTCGTTAGCACAAATGTTGAATGCATTAGCTACATATTCTGTTTCTCTGAATGATGAGCTGCCAGACAAAATGTGCTTAAATTGTATTAGTGAAATGAATCAggcattttctttcaaacaaaaatgtgaacggTCTGAAAAAACATTACGATCATATTTGGAACAAGCCAAAGCTGCTGTTGAAATGTGTATTCCTTCGAATGAAACTCATGTGATAAAAAGTCAAATGGTTGCTATTTGCAAATGCACGGACTATACAGAAGATGCTGGAATAAGATTAAAACACGAACATTCAGTTGATGAACTACAAACAATAGAATATTCAACAgttgaagaaattgattttgctAAAGACGAAGACAAGACTGAACCATCATTGATGACACTTAAAACTAACAAAAACGCCACAGAAGAATCGGTTGAAGTATTCATTGCAGAAAATACCTTTAAGTTTATTTGTAGCTATTGCAAAGCATCTTTTTCTAGTCGTCGATCTCTTAATTTACATGTAAATGGTCGAAAGTGCACGCAATTGTCATATGAATGTGACATTTGtcagaaaatatttattaaaaagcGCTACCTTATAAGGCACTTGCAACGGATGCATCGAATGATGAAAGACGCTGACTGTGCTGAAGAGCCGAAATGGAACAATAAGAGAAAATACAAATGCCACCTATGCCCAAAAGGATTTACTTTGAATTCATCTTTGAAGGATCATTTGCGAATTCATACTGGCGAGCGACCATTTCTATGCCCAACGTGTGGGAAAGGTTTTACACAAAACTCAAATTTGAGACAACATTTGATGCGCCACAATAAAACTaaaccattcaaatgtgtTAAGTGCTCTGCAAATTTCGTTAGCAAAGGAGAATTGGTGTCACATAATCGAACTCATTCTGGTGATCATCCATTCACTTGTGAAATCTGTAATACTGGATTTACAACGTCTAGCTCTCTAGTAAAGCATCGTCGAATCCATAGTGGAGAAAGACCGTATGCATGCGACCTATGTCCATTACGTTTCACAGCATTAAGTACGATGAAAAATCACCGTAGGACGCATACAGGCGAAAAGCCATATCAATGTGGAGTTTGTGGTAAATCTTTTAACCAAAGGACCGATTGCATTTCTCATCTTCGTACTCATTCAGAAGATGTACGTTATCAATGCAAGCAATGCACATCAACATTTGCACAATCTGCATCTCTGAAATTACATGTAAAAAAACATCATTCTGAATCAATGGACGAACTCATTCTCTAA
Protein Sequence
MAIQMEKICRTCMAESRTLISIWSSDGTSSNSTSSISELPSLAQMLNALATYSVSLNDELPDKMCLNCISEMNQAFSFKQKCERSEKTLRSYLEQAKAAVEMCIPSNETHVIKSQMVAICKCTDYTEDAGIRLKHEHSVDELQTIEYSTVEEIDFAKDEDKTEPSLMTLKTNKNATEESVEVFIAENTFKFICSYCKASFSSRRSLNLHVNGRKCTQLSYECDICQKIFIKKRYLIRHLQRMHRMMKDADCAEEPKWNNKRKYKCHLCPKGFTLNSSLKDHLRIHTGERPFLCPTCGKGFTQNSNLRQHLMRHNKTKPFKCVKCSANFVSKGELVSHNRTHSGDHPFTCEICNTGFTTSSSLVKHRRIHSGERPYACDLCPLRFTALSTMKNHRRTHTGEKPYQCGVCGKSFNQRTDCISHLRTHSEDVRYQCKQCTSTFAQSASLKLHVKKHHSESMDELIL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
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90% Identity
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80% Identity
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