Basic Information

Insect: Aphidoletes aphidimyza
Gene Symbol: run
Assembly: GCA_030463065.1
Location: CM059996.1:33456077-33459187[+]

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 2.8e-61 9.2e-58 193.5 0.0 3 129 41 178 39 178 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	2.8e-61	9.2e-58	193.5	0.0	3	129	41	178	39	178	0.91

Sequence Information

Coding Sequence: atgcatttgccaACACATCAAACAACACAATCGTCACCATCGACAAACAGTTCGTCGTCACAGCCACAACAATCACAAACCGAATCAAACATGTTGAACGATATTTAtccaaatttattgcaaatgttgAAAGAGTGTCACGGTGATTTAGTGCAAACAGGCTCGCCAATGATTTTGTGCTCGACATTGCCAACGCATTGGCGCAGCAACAAAAGCTTACCGTGTGCATTTAAAGTGATTGCACTCGACTATGAAATTCCCGATGGCACGGAAGTTGTGATTTCGGCTGGCAACGATGAAAATTACAATCCAGAGCTACGAAATAACACGGCATTGATTAAAAACGGTGTTgcaaaattcaacgatttacGTTTTGTCGGACGCAGTGGACGCGGCAAATCATTTTCCGTGACAATCACAATTCGTGCATCGACCGTTGTATCACCGATCGGTCTCCCGATTCCAGATCAAATTGCCACCTATAACAAAGCGATCAAAGTCACAGTGGATGGACCACGTGAACCAAGAAGTAAGCAGAgcTTTGGATATGGTCATCCGAATGGTTTGCATCCATTCATGTTAAATCCAGGCTGGCTCGATGCAGCTTACATGAGCTACGCATTTCCGGAATACTTCCGTCAGCAACCACACAATCCGCAATTTGCAAAAGTATCGCCAACATTGTCCGGAGCAGTGCCAGCCACAGTATTGCCACCGACACTGGGTAGTGAATTTAATCCAATGCAACAAACAATGGCACCTACACAACCAACAATTCTATCAACACATTCAACAGCCACGATTATCCCCCCGCAACCTGGAACACCAGCACGATCAAGCACATACTTGCCATCGCCATTCCATCCATTCGCTCACCCAgaatttttgtgcaaaaatccATTCTTGCCATACGATTTGGCCGGATTACGTAGTGTTACAGTGAATGGACGTCCAATGCATCACATCCAGCACAACACAAGCCTAACATCCGAATCAAgtatcatttcaaatcaaacgcCCGAGCACACATCACGTTTATCGCCAACATCATCACGGCCATCTTCATCGAGTCCGCCATCGTCTGCACACAGTGATGCCATCAAAATGAAcatatcgattgaaatgaaatccgAATCAGAAGATTCCGAGGATGAACAAATCGATGTGGTGAAATCCGCTTTTGTGCCGATCTTGCGACCAAATCCGGCGCTTCAATCGATTGTCGGTGCAGCCGATTCAACAGTCAATGATCAAATGGATGTATCAGCGACAGCACGGGTGCGTTGCGAATTGAAGGCACCATCATCCCGAAAACCGTTGCATGAAACCGCACCAACTGGACCACGGTCACCtgaaaccaaaattaaatcaCCGATTAGCGCACAAAAAACAGTTTGGAGACCAtattaa
Protein Sequence: MHLPTHQTTQSSPSTNSSSSQPQQSQTESNMLNDIYPNLLQMLKECHGDLVQTGSPMILCSTLPTHWRSNKSLPCAFKVIALDYEIPDGTEVVISAGNDENYNPELRNNTALIKNGVAKFNDLRFVGRSGRGKSFSVTITIRASTVVSPIGLPIPDQIATYNKAIKVTVDGPREPRSKQSFGYGHPNGLHPFMLNPGWLDAAYMSYAFPEYFRQQPHNPQFAKVSPTLSGAVPATVLPPTLGSEFNPMQQTMAPTQPTILSTHSTATIIPPQPGTPARSSTYLPSPFHPFAHPEFLCKNPFLPYDLAGLRSVTVNGRPMHHIQHNTSLTSESSIISNQTPEHTSRLSPTSSRPSSSSPPSSAHSDAIKMNISIEMKSESEDSEDEQIDVVKSAFVPILRPNPALQSIVGAADSTVNDQMDVSATARVRCELKAPSSRKPLHETAPTGPRSPETKIKSPISAQKTVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00133006;
90% Identity: iTF_00133006;
80% Identity: -