Apic006310.1
Basic Information
- Insect
- Aphaenogaster picea
- Gene Symbol
- Runx1
- Assembly
- GCA_003063865.1
- Location
- NJRM01000103.1:454819-456918[+]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 1.9e-51 9.3e-48 161.5 0.0 4 100 90 186 87 204 0.91
Sequence Information
- Coding Sequence
- ATGACGAATCCTTCGCGAGATGCTCGACCCGAGGATCGGCCTCCCGGCCTAGACTATCCTGATCCTAGGTCAGTGCGTGGCAGTCATCAGGCGCATCAAGCAGTGAGCCAAATCGGCGGGCCGAGAATACGGAGGACTCGGGCCTCGTCCTCGAGGAGAAGAATGCACTTGGCCAACGAGGTTCCTCCTCAAGGTTCGACCGGCGGAAATCATCTCCCTGATTATGCCCTCACCGCCGATTTGCTCGCCGAGAGGACGTTGGATGGGCTTCTCGCCGAGCATCCTGGAGAACTTATTCGCACAGgTTGCCCACATGTGGTGTGCACGGTATTGCCGTCACATTGGAGGTCGAACAAGACCCTTCCGGTAGCCTTCAAGGTAGTAGCTCTTGGCGAGGTCGGAGACGGTACCCTCGTGACCGTTCGGGCCGGAAACGACGAGAATTGTTGCGCCGAGCTACGAAATTCTACTGCTCTAATGAAAAACCAAGTCGCCAAATTCAACGATCTTAGGTTCGTCGGTCGAAGTGGTAGAGGATACCGTTGGTCGCATTCCACGCTGGCCTCTTCCACTTCGAAAATAGAGAAATCCAAGATACTCGTTACAGAACAATGGAGACCCGGGAAACGGTTTCCAGAATTTTTTTAG
- Protein Sequence
- MTNPSRDARPEDRPPGLDYPDPRSVRGSHQAHQAVSQIGGPRIRRTRASSSRRRMHLANEVPPQGSTGGNHLPDYALTADLLAERTLDGLLAEHPGELIRTGCPHVVCTVLPSHWRSNKTLPVAFKVVALGEVGDGTLVTVRAGNDENCCAELRNSTALMKNQVAKFNDLRFVGRSGRGYRWSHSTLASSTSKIEKSKILVTEQWRPGKRFPEFF
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00393379; iTF_00867172; iTF_00279744; iTF_00109605; iTF_01269578; iTF_01270976; iTF_01390861; iTF_00264047; iTF_00881779; iTF_00882728; iTF_00182424; iTF_00127223; iTF_01354400; iTF_00979865; iTF_01407005; iTF_00064223; iTF_00460267;
- 90% Identity
- iTF_01354400;
- 80% Identity
- iTF_00127223;