Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00037 0.042 14.8 0.1 1 21 41 61 41 62 0.94

2 6 0.12 14 6.8 6.0 1 23 120 143 120 143 0.96

3 6 0.004 0.45 11.5 0.5 1 20 166 185 166 187 0.89

4 6 7.4e-05 0.0084 17.0 1.2 1 21 195 215 195 216 0.95

5 6 2.7e-05 0.003 18.4 0.6 1 19 280 298 280 301 0.93

6 6 4.6e-06 0.00052 20.8 5.8 1 23 309 332 309 332 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00037	0.042	14.8	0.1	1	21	41	61	41	62	0.94
2	6	0.12	14	6.8	6.0	1	23	120	143	120	143	0.96
3	6	0.004	0.45	11.5	0.5	1	20	166	185	166	187	0.89
4	6	7.4e-05	0.0084	17.0	1.2	1	21	195	215	195	216	0.95
5	6	2.7e-05	0.003	18.4	0.6	1	19	280	298	280	301	0.93
6	6	4.6e-06	0.00052	20.8	5.8	1	23	309	332	309	332	0.98

Coding Sequence: atgcaatcagGAATCGAGATTCTACTGTGCCTTTTGCACCTATCGAATGTAGTGGAACGGTCTACGAAAAAATATGATTATTATCGCAGAGGCAACTCGGATCCTTCCTCGTTCGCGAAGTACAACTGCGAGTCCTGCGGCAAGATTTACAGGATTTGGGGTTCGTTGAAGAACCATCGGAATATGGATTGCAAGAAGGAACCTAGCTTTGCTTGCTCCTTCTGCAGTTATAGATCTCtgaaTCATTACTCAAGTTATGCTACGTTGGATGCTACATTGACTAAAGAAAAATCTGCACCTGCATATGAATCGCTTGTAGTCGAGGCGTATTGGTCCAATAGTCATGCGAGCCCAAAATATGCGTGCAGCAAGTGTTACTACAGGACCAAAAGGATGTACAACATGCACAGACACTACGAACGCAAACACATAAAAAACAGCAGAAGAAAACATTATTATCCCAGAGGCAACTCGGGTCCTTCCTCGTTCGCGAAGTACAACTGCGAATCCTGCGGCAAGATTTACAGGAGTTGGGGTTCGTTGAGGTTCCATCGGCATATGGAGTGCAGGAAGGAACCTACTTTCGCTTGCACCATCTGCAATTATAGATCTCATAGGAAAAGCAACCTGCTTAGACACATGCAGGATAGTGGAACCGACCTAAAGCTATTTCTTCTCCCGTTTACAGGTACGGCGAAGGAGAATAGGAGCATGATCGATCTATCAGAGGACGAATTCATGGATCTACCAATGCAGACGCAGGAGAAAACAGTGATGCCGTTCGCCGAGCTGAAGATACCGAAAGCTTGGAACTACGTCAACAAACCGCACGGCCGATTCGCCTGCGCTAGATGTGGCCGTTCTTACAGGAGGAAGGACTCGCTGCAACGCCACGAACATTGGGAATGCGGCAAGGAGCCGCAGTTTAAGTGCCCGTATTGCCCGCAACGTTGCAAGCGCAAAGCACACTGGCAGCGTCACATACGTCGCCAACATCAAGATAAAATAGATGTGGAGAAGTACCTGAATTCCAACATGCCGAAATTAGAGTTGGACTGA
Protein Sequence: MQSGIEILLCLLHLSNVVERSTKKYDYYRRGNSDPSSFAKYNCESCGKIYRIWGSLKNHRNMDCKKEPSFACSFCSYRSLNHYSSYATLDATLTKEKSAPAYESLVVEAYWSNSHASPKYACSKCYYRTKRMYNMHRHYERKHIKNSRRKHYYPRGNSGPSSFAKYNCESCGKIYRSWGSLRFHRHMECRKEPTFACTICNYRSHRKSNLLRHMQDSGTDLKLFLLPFTGTAKENRSMIDLSEDEFMDLPMQTQEKTVMPFAELKIPKAWNYVNKPHGRFACARCGRSYRRKDSLQRHEHWECGKEPQFKCPYCPQRCKRKAHWQRHIRRQHQDKIDVEKYLNSNMPKLELD

Sequence clustering based on sequence similarity using MMseqs2