Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 8.4e-06 0.0007 20.7 5.3 1 23 133 155 133 155 0.98

2 6 1.8e-06 0.00015 22.8 0.1 3 23 188 210 187 210 0.95

3 6 9.9e-09 8.3e-07 29.9 1.2 1 23 216 238 216 238 0.98

4 6 2.1e-05 0.0017 19.5 0.2 1 23 244 265 244 265 0.97

5 6 0.00091 0.076 14.3 0.4 5 23 276 294 272 294 0.91

6 6 0.4 33 6.0 5.1 1 23 306 329 306 329 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	8.4e-06	0.0007	20.7	5.3	1	23	133	155	133	155	0.98
2	6	1.8e-06	0.00015	22.8	0.1	3	23	188	210	187	210	0.95
3	6	9.9e-09	8.3e-07	29.9	1.2	1	23	216	238	216	238	0.98
4	6	2.1e-05	0.0017	19.5	0.2	1	23	244	265	244	265	0.97
5	6	0.00091	0.076	14.3	0.4	5	23	276	294	272	294	0.91
6	6	0.4	33	6.0	5.1	1	23	306	329	306	329	0.95

Coding Sequence: ATGGATAAGTTCAGTGACGAGACGATGTGCAGAATATGTTTTAAGAAACAAGATACAGTGTTCTCATTGTTTCGTAAACGAAAAGGCATTTCTCCTTGCGagaaattgaataaaattggGGTAAAAGCTGGTTTGAATGATACAGGACCTTCTTGCATCTGTTGTGACTGTCTTACAGAGTTAGAGACTACAGTTCACTTTTTAGAAAAATGTGAGAAGTCGAACCAAATTCTTGTTGAACACTTTGAGAACAGACAAGTAGATGGAATCCAGGATGAGTGTGAGGATAACGTTGGACAAGTGTTGAAGAATAGTGAGGAGTTGGGGGTGGAGGAGGCTCGCTGTGAGGAGTGCGGGTCGAGCAGACGCTGCCGGCACTGGACACCGCCCGCCACGCACACCTGCCCCAAATGCCAGAAAGTATTCAACAGGAAGTTCAATTTTAAATTACATCTGATGCGCCACAGCCGCGAGCGCTCGTGGTCGTGCGCTAGATGTGGCGCGAGCGCGGTGTCGCGCTGGCTGGCGGCGCGCCACTGCGCCCCTCGCCCGCGCCGCCCCTGTCCCGTGCCTGGATGTGGGAAGACCTACACTACTAATACTAACCTTAGTGTGCATCTGAGGGTACATAAcgGTGAGAGACCATTTGAGTGTAATGATTGTGGAAAGAAGTTTTCTAGCAAGAATACTCTACAGAACCACATCAGGATACACACAGGTGCGTTACCCTACATCTGTCCTATATGCGGCAAGCAGTTCCGCACGAACAAGCTGTCAGCTCATATGGCCACGCACACGGACGCGCGCTACGGCTGCCTGAAGCAGGGCTGCAGCAAGCGCTTCGCGTCGCGCGCAGCGCTGCAGCGccacgcgcgcgcgcacgcgGCGCCCGGCCCGCCGCGCGTGCCCGCCGCGCACGCCTGCGCGCTGTGCGCCGCGCGGTACCACCACAAGCAGTCCCTGAACAAGCACGTGAGGAAGCAACACGCTCAGCTCCCTGTACCGGCACCAGAGGTGGAAACCAACGACATCACCAAAGATATTGAATGTGATCTAGAATAG
Protein Sequence: MDKFSDETMCRICFKKQDTVFSLFRKRKGISPCEKLNKIGVKAGLNDTGPSCICCDCLTELETTVHFLEKCEKSNQILVEHFENRQVDGIQDECEDNVGQVLKNSEELGVEEARCEECGSSRRCRHWTPPATHTCPKCQKVFNRKFNFKLHLMRHSRERSWSCARCGASAVSRWLAARHCAPRPRRPCPVPGCGKTYTTNTNLSVHLRVHNGERPFECNDCGKKFSSKNTLQNHIRIHTGALPYICPICGKQFRTNKLSAHMATHTDARYGCLKQGCSKRFASRAALQRHARAHAAPGPPRVPAAHACALCAARYHHKQSLNKHVRKQHAQLPVPAPEVETNDITKDIECDLE

Sequence clustering based on sequence similarity using MMseqs2