Basic Information

Gene Symbol
-
Assembly
GCA_947507525.1
Location
OX382227.1:19787794-19798103[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 7 0.25 17 6.5 0.2 2 21 1722 1741 1721 1742 0.88
2 7 0.00012 0.0084 16.9 0.7 2 23 1855 1876 1854 1876 0.95
3 7 0.0011 0.078 13.8 4.8 1 23 1896 1918 1896 1918 0.98
4 7 0.0056 0.4 11.6 4.2 1 23 1958 1980 1958 1980 0.98
5 7 0.00097 0.069 14.0 4.9 1 23 2004 2026 2004 2026 0.96
6 7 0.015 1.1 10.3 0.5 1 20 2050 2069 2050 2071 0.93
7 7 0.48 34 5.5 0.5 5 23 2426 2445 2423 2445 0.90

Sequence Information

Coding Sequence
ATGGATAGGTTGAGCCACTTGCGGGGAGAAGCGGGGGGCTCGCGGGACTCCACGCTCGACACCACGTCCCCGCCGAGTGAGTCCTTCATGACAGCCAACGAGAGCTCCTCCAAGTACTTTTCTCTGTCAGAAGTTGACTCTGTTGATTCAACATTCGACATTTCTTCTATAAAAGATGTGTCGCTGGCTAGTACCACCACTGACTCCGAAGGGACCATGACAAACGCTGATGAACTGATATCGAACCTGTCACCAATTGGAAAGAAGAGTGATATGCTAGATAGCTACAAAATTGGTAAACAGATAGAGGCAGCAAACATATTATCAGGCGGTGTTGACATATTTGATGATAATGACAATTCTTATGATGGTGATGAGCTGGTGATTGATGACAATGTTGATGATGATAAGTCAAATTCGGAACTGAAGCAGCCAGAAGAAATGGAGTTTAAGTCTGATGAGAATATGATAGAGTCTACGTTGATAAATGAGGAGACAGATATAGCTAGTAAAGACACAGAAGTGGTGCTACAGATTGATGGTAAAAACGTAGATGCTATAGATATTGGTAATGGATTGTACTTGTATAGGAAGGAAGGTCAGGAGGAGCTGGCCGCTGTTCAGATAATTGATGATGATCAGCAGCAGACCAGCTTCAAGTTCTTGAAAGTGCGTGAAAATGCGGAGGGTAATTTAGAAGTTTATGAAGAAATAGAGATAGAAGTACCTAAAGAAGTGCCTGCAAAAGAAGGGAAGATGGCTGATAAGAAAATATCATCACATGTGCCTATAAAGGATATCAATAAAGTCATAAGTGAGTCTGCTTGCAACAAAGTTGCTGAAAGAAAAATTAAAGCACCAAGAAAAGAACCAATTTTAACAACTAAGATTACTGAAGTTGAACTCGAAGTAAATAAAGAAACATCGCCTGATGGAAAATCTGAATTCAACAAAAATGGAAAAATGATCAAGTTCAGTGAATCTCGGAAGTCTCCAGTTATAGGCAGTTTCACACCCATGACATACCACTCTACACCTAATAAAGAGCGCATACCATTGACTAAAACAATGGTTGAGCAACAGCTGCATCCTAACCGGCATTCAGATAATGTCAAGAAAACAATAGAAGTACATACTGATAGTTGTAAGCAAAGAACACCTGAAACACCAACTAAAAATAAATATGGTGAAGACAATAAAACTAATGACATAGACAGTCCTGAGAAAGAGATGGTGATTGATGAATCACTTGAAAAAGTTTCTGTGGCAGCTGAAGAAACTGTGAAGGAAACCATTGAAGAAAATAATATTCATAATGATAAACCTAAACCGTTGGAACCAAGTAATGATGAAGTGTTGAAAGAAAAACCTATCCCCAACGACACTTCAGTTCCAATTGAGCAAGAGAATATCATTGATTCCACTGAAAAAGATGTTACTATAGTAAAAGCAATATTTAACAAGAATCTACAAAGTGAAATTGAAAATGAAAAGAAAAAAATAGAAATGAGTGGGAATATAGTAGATATTGATGAAGATATGGAAGAAGATCTTGTAATTGTAGAAACAGTTGCTGAAACTGTAGAAACAGCTGCCGAAACTGTAGAAACAGCTGTCGAAACTGTAGTGAATAAAGATGAGGCAATAACTGAAGATCTCGTTAAAACTGATAGTGATAAACTGGAAAAGGTGAATGATGATATTCAAAAAACTCAAGCCGAAGTTAAGATTTCTGAGCCTATTCAAGTAATTAATAAAGATGTTGAATTTGATGCAACTGATAAGAGTGATAAGGCAGTAGTTAAAGACAATACTCAATGTGATAAACAAGATGAGACCAAAGTTGAAGAAATTATTTACGATATAACAGACCAAGAAAATGATGATATTATTATTATTGATGATAGTGAATTAGATGAAACCAAAATTGAAGAACCAACTTCAGCAGCTGATAAAGGTGATTTAAAGGTTGAAAATATTAAAAGCCATGATCAAGAAAGCGAGAAAATTGAATCAAATGTTGCAACAAAGAATAAAGAAGATGAATCAAAAATTAAAGAAAGTGTTCAAGAAAATAATAAAAAAGTTGCTGAAAATGTTCAAGCTGATACAACTTCCGCAGTAATTCTTGATACGCACAAAGAACAAATTAAAAAAGTTGAAATGCCTAAGGGAGATCCCCAAGGTGACATTGTTAAAAACAATCAGTCAAAAATACCTATAGCGAAACCAGACACTAAGAAAGAAATAACAAAACCTACTAGCAACGAAATCTCAATAACGATAAAACCTACAACAGCTGTTGATGTCAAAGAAGGAAAAGTTGAATTAAAACCTGAACCTTCTAAAGAAACAGGTTCAGCTTTAAAAGAGGTTGTTAAAGATATCGTACTGGATACGAAATCATCACAACCAATCATTACGCCAGAAGAATCCCAAAAACCAGTAAAAACTGAAAAACCACAAGTTATACCAAAAGTCGTACCTGAAGTACTAGTGCCTGCCAATAAGACACCACTTCATATTTCTCCCTTCACTATTACTAAAACAGAAACGGCAGTACTCAAAAGAAAAAATAATGTGTTTGAAAAATCTCCTAAAAAGGAATCTAAAAAGCCTATTCCAATTGCTGAATCTCAATCTAATGTAGTGCCTATGGAGGTTGACAGTACCACCAATGTGAAAGCGGAAGCTTCTGGAAAATCTCCAGTCAGCAGTAGCAAAGTGCCCAGCAGTGAAGTTAAGGAACAAAAACCTGTTACCCAAGAACCATTACCTGGAACCTCCTTTGAAGTAAAACCACAAGGGACAACCTTCGAACCTAAAGCAAGTACTTCTGGCGAAGTGAATGTTAAAGTAAGTCAAGTGCCAAAAGAAGAACAGCCTAGTTGCTCAGGCACACAGGATGTCAGTAGTACGTCAACAGACAGTCTTCCGAATAATGATAGGAATGAGGGCGAAGATGATTCCGAAGAACCTAAACCGGGTGGAAGTAAAAAGGCAGTGCCTTTTGGAAAATGGACAGCTACTAACAGAAAAGAGTTCTTAGATAAAATAAAGAATAGAAACACGACCCCGGCCCCGCCTGCCGTGCCTTCTACCAGTACCAATCAACTCAAAAGTTCCAATGATCTCAATAGAAGAGATGTTCTACAAAAAATTGACAGTCAACGGCAACAGTCAAGCAGTGCAGCAGCAGCTTTAGCGAAGACTCAAGAAGGCAACAAAGTTGTTAAAAACGAAACTGCGTTTGTGAGCAAAGCCAACCAACATAAAGATAATAATACTCAAGAAAGCAAGAGTCCTTTAAATGTGGAGACAGGTAAAGAAACTTCGGAAGCTGAGGCTGAAACAGCTGCCATCAAACAAGATGTAACAAATGATATTCAAAACGAAGATGTATCAGAAGTGGCGTCTGTAACCAGTCTAAAGAAAGAAGCTAAAGTAACGGAAGTCAATTACCAAGATTTGATTGATAAAACGATTGAAGATATGATACAAAGAACAGTAGGAACTTCAAAAGCGGGTCAAGATGAACCCAACCAGTCGTTGGCAAAAGATGCGAATGCTCCTCCAACTGGTAAATTCCCAGCAAACTACCAACCAACTGATCAAGCCACACTCGACGAAATAGAAATGAAGATGAACGAATTACACGGTATTCCTTTCATCGAAAGACCTCCACATGAATTACCTGTGGTTCCTTTAGCTGAACCTAAACTCAAAACCATTTCTAAAGTTGAAAAGGAGAAACCATCAATTCCTATCAAAACTACTAAAATACCAAATCTCCTACCGTTTCCAAATAAAACTCAACAAAAGATTATCAAGGAAAGTGTAATAGAGGTTGATTCTGAAGATGAAATGATAGAGCATGAGCCTATTACAGGAGACATTGATATAAATAAGAAAACTGTAGCAGCTAAGTTACCACCTAAGGAGAAGGTACTATCGAATGCTAACACAGATAAATCTAATACTGATACTGCTAAAAAAGAACCTATTATAACAGAAAAAGATTTTGACAAATTCGCGAGACGAAATTCCATAACTTATGAGAATTGTCTCACTATGAACTTCGATAGCAAAGATCCGCACAATGTCATTCAGACGGTTGTGGAGAAAGATCCATATCCAAAGACATACTCTAGGAATGACATTGCACGTGTTGATAAACCCAAGATGCCGTATAAATATCAGAATGCGCGCCAACCTATACCGGCTAAAGTGCAAACTGCAAACAAATTGGGCGCTACTGAAGATTCATCTACCAGAAATCAATCTAAGTTACAAAAAGCTTATCAATCGGCTTTGTCAGCCAAACGCCAGAAGGAATGTCCTATAACTATAATCGAAGATAAACCAGTAAAAGTGGTCTTTATGGACAATATGGAGTATGTTCCCAGTTCATTAAATATCCAGGGTCAACAACTTTCACCTGCTAAGAAACTAAGCACCGAACCAGACAGCTTCACTCTGAGCACTCTTGATTCTCTAGAATCTGACGTGCTGGATACTACTGATGACGCTAAATCACAAGAAGAAGTTAAAACAAAAACTAAGCATCAGAGAAAACAAGTTCTAACTCCTGTTGACGAACCGGAACTAGAACTCATAGAACCAAAAGATTTAGGCCTTGAAGTGTCACCCAAAAAGAAAAGAAAAACCGATGACGATAGAATGGATAAAAATGTTAAATATCCCATCCGGAAGAAATATTATCTTCTTGGCTCAAACACAGCAGCGGAGGATAAATATACGCACTCAACAGAAATAATTAAAAATCCACTCAAAGAGACCGTCAATCGTAACGACAATGGCGTAGCTCACAAGAATGCTGTCTCAGCTATAGACAGTTTAGTGAAAGCCGCTGAGTTACTTGAACACCAATCAGAAAACAGGAACATTATTGATTCTCCAACTCCTGGTAGTCAGCAAAGTACTCCTGTTAAGAGAGGAAGAGGTCGTCCGAGAAAGTATCCTCTTCCTGAAGAAGGAGTTGAAAAGAAAGTGCCAAGCCCACAAAAGAAGCCACGGTTAATAGATGCCAAAGTCCCAAAACGTGATACCGTAATGACTACTGATGATGAAGATGATGATGTAGACAGCGATGGTCAATTGATCAAAGAAAATTGGACCATGGGAAAAATTAATGAGAACATAGTATGTCCGATTTGTAACAAATTATTCAGAACAGAGAATGTTGTGTTTAAACACGTGAAACATTGCACCGGCCCTTCGCCAAGTCGATCTGGTTCGGACAAGAGAAGCCCCAGAAGAATGAGGCCATCGCAAGAATCAGATTCTAAGTCTCAAGGAAGTAAATCTGATGATATGGACCTTGACGATGACAAGCCACTTGTCGTCAGGAAAGAGACTCCTAAGAAGCGTAAATCCAAAGATTCAATTTCTAAATCGGATGATAGAGACGATATTATCGTCATAGAAGATACACCGCCAGTCAAGGAAAGGGCTGAAAAGAAAGAAAAGGAGGTTGATGAAAGAAAAATTCACGAATCTAGAAAACCAAGAGCCAAAATATTCCCAAAAACTAATGATCTGGTTTGCGAGTTCTGCGGCAAAACATTCAGGCAGTTATCCTATTTGGTCAGCCATAAACTACAGCATAAGACAGAGGAGCCAAAGAAAATAGAAAAGGAGGCTCCTGTCGCAAACAAATCTGTATACAGCTGCGAGGTTTGCAAGAAAGAGTTCAGGAAGCTTCATCATCTGGTTCAGCATCGCAATATCCATGACCATCCTAGTTCAGCACCCGCGAGGTCGCTACGAAAGAGTTCTTCAGAGCAGTCTGACACAAAGGTTGAAAAAGAACCGAGTACTTCTAAACTAAGCGAAGACCCAAGCACTGGTTTCCGCTGCGAACCATGCGACAAGTCATTCAGAAAACTGCACCATTTAGTGGAACACAGGGAAACTCACGACGGTATAAACAGACAGAAGACTACGCCAACTGTGGTACCGAACAACGTTGAGAAGCCCGTGACTTTGCACCAGTGTGAAGTTTGTAAGAAGACGTTCAAGAAACTGAGTCACTTGATTGAACACAAGGAGCAACATGTTGAGACCAGCTCTGAAAAGTCTGATGACAAGAGTGTCAAGAGTTCCTTATCAACCAGAGACATAATACACGAGTGTTCACTTTGTTACATGGTGTTCCCGAACGAGCACTCGCTGAACAAACACACCATCATATGTCAACGAAAGAAACGGCAGTCCAAGCAAGCTAAAGCGGCTAAAGAGTCTGAGGCAACGGCTGAATCAGTTGAAGACGCGAGTCAGAGTCCAAAGATTGAAGAAAAACTAGACGACGTTGATTCTCCTAAACTAGTTATTATTGAAGATATAATAGAAGACGAGCACGAAATGGAGGTTGTTGAAACAATAGAATTGTCTAAGGAAATACCTAAAGCAGCTGAAGAAAAACCTGTAGAAGTTGTAAAAGAGGTAGAAAAAGAAGTAGAGCCGGCTCCACAGAAAATAGAAATTAAACCCGTCGAACCACCAGTTATTCCTGCAAAGAGAGAATTCTCTGAAACGGAAGTAGTCAAAACAGAAGTTAAGCCGGAAGTCCCAGAGAAAATAAAGAAAGTTGAAATTAAGGAAGCTATTAAAGTCCATGAAACACCTAAAAAGAAAACATCCATCAAAGAGAAATCTACCGGTAGTGCAAGCAAACGTGTTAAAACTACAGCTCCTGTTGCTGTTCCCGAAGAAACTAAACCAGCGGTAGAATCGAGCGACGATGACGAAGTCAGGTACATGCTCAATCCGAACTTCAAAGTGGAGGAACCAGCCGAGGAGAAAGTGTTTATGAAAGTGAGAGCGAACAAGCGCAGCTCCCTCCAAATAGAACGGCCGAACTCCAAAGACCTAGTTAAGAGAAGAACGTCATTACAGCACCCACCCAAAATACCACGCCTGAAGCCGAAAGCCGTCGAACCCAACCCGGTAGCTGTAAAACACGTCACTAAAGCACCTAAACTAGAACCAGTGTCTGCGACGGACTCTGACGATAGCGAAACTGTTAAATACTCTTTCCCCAAAACCATTCCTGAAAAAACATCGAAACCCGCACGAGAGCGCACACCTAAAACTGTAGAAAGGAAAACTCAAAAGAAAACGTTAGCTGATAAGAGAAAGTCTCTGAGTGGGATAGCAAAGAGGAAATCTTTGGGGAAAACCGTCACTGCCAGGCACAAACCAACGCCCGTGAAGCAGATCAAGCGAAGAACGTTGGAGGCGGAGCACAGATGCGACTGCGGCCAGCTGTTCTCTAGCGCGGCGCTGCTGGCGCGCCACACGACGCTGGCGCACACGCCGCCGCGGGTGCGCGCGCGCCGCGACCTGGCGCCCGAGGGCCCGCCGCGCCAGCCCAGCGTCGCCGACGAGACCAAGCAAGCGCCGGCTTCGAGGAAATCCAGCGCACGAAGCGATAGCAGCGCCTCTACTAACACTAAACCGAACAAAAACGAAGCAAAACCTACGAGGAAGACGCTCGACAAAGAAACGAAAACTCCCGCCGGTACGAGGAAACCTAAACCTGAAAAGTCTGAGGCGAAATCCAGCGTCAAACCCAAGAGGACGCCGGCGCACCGAGGCGTGCCCGTGCCCGAGAAAATGAGGAAACTTATGCAAAAAAATAATAAATAA
Protein Sequence
MDRLSHLRGEAGGSRDSTLDTTSPPSESFMTANESSSKYFSLSEVDSVDSTFDISSIKDVSLASTTTDSEGTMTNADELISNLSPIGKKSDMLDSYKIGKQIEAANILSGGVDIFDDNDNSYDGDELVIDDNVDDDKSNSELKQPEEMEFKSDENMIESTLINEETDIASKDTEVVLQIDGKNVDAIDIGNGLYLYRKEGQEELAAVQIIDDDQQQTSFKFLKVRENAEGNLEVYEEIEIEVPKEVPAKEGKMADKKISSHVPIKDINKVISESACNKVAERKIKAPRKEPILTTKITEVELEVNKETSPDGKSEFNKNGKMIKFSESRKSPVIGSFTPMTYHSTPNKERIPLTKTMVEQQLHPNRHSDNVKKTIEVHTDSCKQRTPETPTKNKYGEDNKTNDIDSPEKEMVIDESLEKVSVAAEETVKETIEENNIHNDKPKPLEPSNDEVLKEKPIPNDTSVPIEQENIIDSTEKDVTIVKAIFNKNLQSEIENEKKKIEMSGNIVDIDEDMEEDLVIVETVAETVETAAETVETAVETVVNKDEAITEDLVKTDSDKLEKVNDDIQKTQAEVKISEPIQVINKDVEFDATDKSDKAVVKDNTQCDKQDETKVEEIIYDITDQENDDIIIIDDSELDETKIEEPTSAADKGDLKVENIKSHDQESEKIESNVATKNKEDESKIKESVQENNKKVAENVQADTTSAVILDTHKEQIKKVEMPKGDPQGDIVKNNQSKIPIAKPDTKKEITKPTSNEISITIKPTTAVDVKEGKVELKPEPSKETGSALKEVVKDIVLDTKSSQPIITPEESQKPVKTEKPQVIPKVVPEVLVPANKTPLHISPFTITKTETAVLKRKNNVFEKSPKKESKKPIPIAESQSNVVPMEVDSTTNVKAEASGKSPVSSSKVPSSEVKEQKPVTQEPLPGTSFEVKPQGTTFEPKASTSGEVNVKVSQVPKEEQPSCSGTQDVSSTSTDSLPNNDRNEGEDDSEEPKPGGSKKAVPFGKWTATNRKEFLDKIKNRNTTPAPPAVPSTSTNQLKSSNDLNRRDVLQKIDSQRQQSSSAAAALAKTQEGNKVVKNETAFVSKANQHKDNNTQESKSPLNVETGKETSEAEAETAAIKQDVTNDIQNEDVSEVASVTSLKKEAKVTEVNYQDLIDKTIEDMIQRTVGTSKAGQDEPNQSLAKDANAPPTGKFPANYQPTDQATLDEIEMKMNELHGIPFIERPPHELPVVPLAEPKLKTISKVEKEKPSIPIKTTKIPNLLPFPNKTQQKIIKESVIEVDSEDEMIEHEPITGDIDINKKTVAAKLPPKEKVLSNANTDKSNTDTAKKEPIITEKDFDKFARRNSITYENCLTMNFDSKDPHNVIQTVVEKDPYPKTYSRNDIARVDKPKMPYKYQNARQPIPAKVQTANKLGATEDSSTRNQSKLQKAYQSALSAKRQKECPITIIEDKPVKVVFMDNMEYVPSSLNIQGQQLSPAKKLSTEPDSFTLSTLDSLESDVLDTTDDAKSQEEVKTKTKHQRKQVLTPVDEPELELIEPKDLGLEVSPKKKRKTDDDRMDKNVKYPIRKKYYLLGSNTAAEDKYTHSTEIIKNPLKETVNRNDNGVAHKNAVSAIDSLVKAAELLEHQSENRNIIDSPTPGSQQSTPVKRGRGRPRKYPLPEEGVEKKVPSPQKKPRLIDAKVPKRDTVMTTDDEDDDVDSDGQLIKENWTMGKINENIVCPICNKLFRTENVVFKHVKHCTGPSPSRSGSDKRSPRRMRPSQESDSKSQGSKSDDMDLDDDKPLVVRKETPKKRKSKDSISKSDDRDDIIVIEDTPPVKERAEKKEKEVDERKIHESRKPRAKIFPKTNDLVCEFCGKTFRQLSYLVSHKLQHKTEEPKKIEKEAPVANKSVYSCEVCKKEFRKLHHLVQHRNIHDHPSSAPARSLRKSSSEQSDTKVEKEPSTSKLSEDPSTGFRCEPCDKSFRKLHHLVEHRETHDGINRQKTTPTVVPNNVEKPVTLHQCEVCKKTFKKLSHLIEHKEQHVETSSEKSDDKSVKSSLSTRDIIHECSLCYMVFPNEHSLNKHTIICQRKKRQSKQAKAAKESEATAESVEDASQSPKIEEKLDDVDSPKLVIIEDIIEDEHEMEVVETIELSKEIPKAAEEKPVEVVKEVEKEVEPAPQKIEIKPVEPPVIPAKREFSETEVVKTEVKPEVPEKIKKVEIKEAIKVHETPKKKTSIKEKSTGSASKRVKTTAPVAVPEETKPAVESSDDDEVRYMLNPNFKVEEPAEEKVFMKVRANKRSSLQIERPNSKDLVKRRTSLQHPPKIPRLKPKAVEPNPVAVKHVTKAPKLEPVSATDSDDSETVKYSFPKTIPEKTSKPARERTPKTVERKTQKKTLADKRKSLSGIAKRKSLGKTVTARHKPTPVKQIKRRTLEAEHRCDCGQLFSSAALLARHTTLAHTPPRVRARRDLAPEGPPRQPSVADETKQAPASRKSSARSDSSASTNTKPNKNEAKPTRKTLDKETKTPAGTRKPKPEKSEAKSSVKPKRTPAHRGVPVPEKMRKLMQKNNK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00037362;
90% Identity
iTF_00121935;
80% Identity
-