Basic Information

Gene Symbol
Znf296
Assembly
GCA_947579855.1
Location
OX388286.1:5931082-5936316[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 4e-06 0.0002 21.8 0.7 1 23 167 189 167 189 0.98
2 15 0.0001 0.0051 17.3 2.0 2 23 194 215 193 215 0.96
3 15 6.5e-06 0.00032 21.1 3.2 1 23 221 243 221 243 0.97
4 15 0.00025 0.013 16.1 1.1 1 23 248 272 248 272 0.95
5 15 2.8e-06 0.00014 22.2 2.5 1 23 278 300 278 300 0.98
6 15 5.4e-07 2.7e-05 24.5 0.7 1 23 306 328 306 328 0.97
7 15 3.3e-06 0.00016 22.0 1.7 1 23 334 356 334 356 0.98
8 15 0.0024 0.12 13.0 0.2 1 23 362 384 362 384 0.95
9 15 2.3e-05 0.0011 19.4 1.5 1 23 390 412 390 412 0.96
10 15 6.3e-05 0.0032 18.0 2.6 2 23 433 454 433 454 0.97
11 15 0.0001 0.0051 17.3 0.8 1 23 460 482 460 482 0.98
12 15 1.8e-05 0.00089 19.7 0.2 2 23 489 510 489 510 0.97
13 15 1.2e-06 6e-05 23.4 1.0 1 23 515 538 515 538 0.97
14 15 0.00029 0.015 15.9 0.5 1 23 544 566 544 566 0.97
15 15 0.001 0.052 14.1 0.5 1 21 572 592 572 593 0.96

Sequence Information

Coding Sequence
ATGTCCGGCTCGGACGCCGAGGCGGTGTGCCGCGTGTGTCTGGGCGGCGGGCGGATGGACGCCGTCGATAACGAGCTGCTGCTGCGCTTGTACGAGAAGCTGACCAGCGCTAAGCTTCACGCAGGAGATGGCAGGCCGAGTGTGCTGTGCTACATTTGTTCCTCGCAGCTGCAGAGATGTCACAGGTTCTCCGACATGGCGCACACATCTGAGAAGCTTCTCAAAGATATCTTGCAGAATAATCAAAAGGTAACGCATTTAACCGTGGGTTCCCTTAAGACAGGAGCGAGACCGAGCTTGTCTGTGACCACGCTTGAGAGCGTCTCGTACGACGGATACTCGTCAGACAGCACCACCATGTTCCACGTGTCCGTGAAGCAGGAGGCCCAGTCCGAAGACTGCACCAAGACCGAGAGGAGCTCCTTCAGCGACGACTGCGACCCGCCCGCCATCAAGAAGGAGAAGGTCTTCGTGAACACCAACAACACGGAACTGTACTATAACTGCGAGGAGTGCCAGATCAAGTTCACGACGAAGCGGCAACTCCTCGCCCACCTGCGGATCCACAACTACGACACCTACTGCAAGAAGTGCAACAAGCTGTTCTCCAACACCAGCAGCCTGAAGGGCCACATGAGCATCCACACCGGCGAGCGGCCCTTCGCCTGCCACATCTGCAGCCGCACCTTCCGCAAGAAGCCCTATCTCACCAGCCACATCCGGATGCACAAGGAGAAGCCGTTCTTCTGCACGTTCGACGGCTGCACCGCCGCGTTCCCGCACCCGGACCACCTCGCCAAACACATGCAGATCCATACGCGGGAGAATCCATTCGTGTGCCACCGCTGCAGCAAGACGTTCGCGTACAAGAGCGCGCTGACGCGCCACGCGCGGATCCACACGGGCGTGAAGCCGTTCGCGTGCGAGCACTGCGACATGACGTTCGCGGTCCAGAGCGGCCTCACCAAACACATGCGGATCCACACCGGGGTCAAGCCGTACGCGTGCGGCAAGTGCGACGCCGCCTTCAACCACGCGGGCAACCTCAAGCGGCACATGCACACGCACGAGCAGGAGAAGCCGCATGCGTGCGACGCATGCGAGAAGCGGTTCCCCAGTCTCGAGGCGCTGCAGGAGCACTCGAGGATCCACACGGGGGAGAAGCCGCACGCGTGCACCGAATGCGAGATGAGGTTCGCGTTCAGCAGCACCCTGGCCAAGCACATGCAGACGCACGAGGAGAAGCCGACGCCGCGGGAGCCCCCGAGCCAGGCGGCCAGGCCGCGCGTGCGGCCTAGCTGCCAGGTGTGCAAGAAGCAGCTGACGTCGAACTCGCACCTGATCATCCACATGCGCTCGCACACGGGCGAGCGGCCGTACCCGTGCTCGGAGTGCAGCCAGACGTTCCGCACCAAGACGATCCTGAAGGGGCACATGCGGGTGCACACGGGCGAGAAGGTGGCGTCCTGCGAGATCTGCGGCATGGCCTTCACGCAGACGGGCAGCCTCGGCAAGCACATGCGCCTGCACACCGGCGAGCTCTACGCCTGCCACCTCTGCGGGAAGGGCTACAAGCAGAGCGGCCAGCTCACCGCGCACATCCGCAACTTCCACGAGGGCATCAAGCGGTTTTCGTGCGACATCTGCGCCGCCAGGTTCACGGCGCGCGGGCACCTGCGCAACCACATGAACGCGCACGCCGGCATCAAGCCCTACTCCTGCCTCAAGTGCGGGAACCGCTTCGCCACCAGGACCGTGCTCCGGCGGCACATCAAGAACTCCTGCAAATGA
Protein Sequence
MSGSDAEAVCRVCLGGGRMDAVDNELLLRLYEKLTSAKLHAGDGRPSVLCYICSSQLQRCHRFSDMAHTSEKLLKDILQNNQKVTHLTVGSLKTGARPSLSVTTLESVSYDGYSSDSTTMFHVSVKQEAQSEDCTKTERSSFSDDCDPPAIKKEKVFVNTNNTELYYNCEECQIKFTTKRQLLAHLRIHNYDTYCKKCNKLFSNTSSLKGHMSIHTGERPFACHICSRTFRKKPYLTSHIRMHKEKPFFCTFDGCTAAFPHPDHLAKHMQIHTRENPFVCHRCSKTFAYKSALTRHARIHTGVKPFACEHCDMTFAVQSGLTKHMRIHTGVKPYACGKCDAAFNHAGNLKRHMHTHEQEKPHACDACEKRFPSLEALQEHSRIHTGEKPHACTECEMRFAFSSTLAKHMQTHEEKPTPREPPSQAARPRVRPSCQVCKKQLTSNSHLIIHMRSHTGERPYPCSECSQTFRTKTILKGHMRVHTGEKVASCEICGMAFTQTGSLGKHMRLHTGELYACHLCGKGYKQSGQLTAHIRNFHEGIKRFSCDICAARFTARGHLRNHMNAHAGIKPYSCLKCGNRFATRTVLRRHIKNSCK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01336120;
90% Identity
-
80% Identity
-