Basic Information

Gene Symbol
L
Assembly
GCA_963971155.1
Location
OZ020118.1:3744848-3757038[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 1.4e-05 0.0007 20.8 1.7 1 23 210 232 210 232 0.98
2 17 1.1 56 5.3 5.7 1 23 238 260 238 260 0.98
3 17 6.3e-07 3e-05 25.0 3.1 1 23 266 288 266 288 0.99
4 17 5.2e-05 0.0025 19.0 0.2 1 23 294 316 294 316 0.98
5 17 1.3 61 5.2 0.2 9 23 383 398 375 398 0.87
6 17 0.0091 0.44 11.9 0.6 2 23 420 442 419 442 0.96
7 17 0.1 5 8.6 0.3 1 23 537 559 537 559 0.95
8 17 6.8e-05 0.0033 18.6 1.3 2 23 568 589 567 589 0.96
9 17 0.0088 0.43 12.0 0.6 1 23 597 621 597 621 0.88
10 17 0.063 3.1 9.3 0.8 1 23 656 679 656 679 0.98
11 17 0.0058 0.28 12.5 2.1 1 23 711 733 711 734 0.96
12 17 0.0022 0.11 13.9 4.8 2 23 885 907 884 907 0.97
13 17 0.32 15 7.1 0.1 1 23 913 935 913 935 0.92
14 17 0.39 19 6.8 0.5 2 23 943 964 942 964 0.96
15 17 5.4 2.6e+02 3.2 0.1 2 23 1050 1071 1050 1071 0.93
16 17 0.004 0.19 13.1 0.0 1 23 1081 1104 1081 1104 0.96
17 17 0.074 3.6 9.1 0.5 1 23 1111 1133 1111 1133 0.95

Sequence Information

Coding Sequence
atggcattaaaaatgttatatcGTGGACCTAGTTCAAGATTGGAAACActtattgaaaaaattcagCAAACCAAGGAAATTGGTGGAGatTTATATTCAACTCATACTTCATCAAGTTATTCACCCTCAATGTCAGAAGGAGCAGCAACACCAAATTCTttaatacatcatcatcagcaTCTACATTCACATAATCATCAGAACCACCCACTAGACACGTCAGAAAATAATGAAGGCGATGGTAGTActaatacaaataataataatgatcGTCTTAGAAGACGTCGTCAACGTTGTGATAATGGAGGTGGAGAAGGTGAAGCAATACCATCAACAAATGGATGTAAAAAAGATGGtattaatgatgatgatgaagaagatgaaattgattttaatgatAAAAGGGTTGAAAAACATAATCGTAATCACGATGATGACAACATTGGTGGTGGTAGTGTTAATGGAAACGAAGAAATTTGcaatgatgataataatgatggtGTTAAAATACCAAAGAAAGTGCGAAAAATTGATAAAGATCTGATTAAATCAGAAAAGATGACAGGTGACAGTATTAAAACGGGAAATGGTGGCGGCGGTGGTAACACTACAAATTCCGATGGATCTTATCAATGTCAATTCTGTGATAAATCATTTCCACGTCTTGGCTATCTCAAGAAACATGAACAGaGTCATGCAGAACATCTTCCATTCAAATGTGAATATTGTGCTCGTCTATTTAAGCATAAACGTTCTAGAGATCGTCatacaaaattacatacaGGAGATCGTCGTTATCGATGCCCTCATTGTGAAGCAGCATTCTCAAGAAGTGACCATCTTAAGATTCATATGAAAACACACGATAATCAGAAACCATTTCAATGTACTGTGTGTAATAGAGGATATAACACAGCAGCAGCACTTACATCTCATATGCAAAATCATAAGAAACAAGCAGCCCTATTGGGAAGTGGTGGTGCTAGTAATGCACTAAATTACAGTCCTCGATCTACTGGTTCTGGTTCAAGTAATGGTAGTTTACATAAAAGACGTTATGCAACAGCTGACAATAGTCCAAATCGTATTGACTATCGAAAACATGGAAGAAGTTCTTTTCTAACATGCATTTATTGTACAAAAGCCGATTTTACATCTTTGGATCAACTTAATAATCATATTCAATCGATGCACGAAAATGTTGCAGTCAAGGAGGCTCTATTGAATCATCCAAATTCAAGCAATGTATTTCAATTATCATGCGAATATTGTACAATGAAATTTCCTAGTATACCAACGATGTTTCAACATATGAGAACGACACATATTGATCGTTTAACCAGTCCTAATTcttattttgaacattttaataGACTTGCTGCATCGGGAACATTTAGCCCACGTCTTGCAACCAATAGTAGTCGATTTGAggaaataaaaacaaaagctGAACAACCCAGTCCAAAACTGGAACGATCTTCAGTCGAACCTGAAAAGGCAGATGAAGAGCAAATTAGTCCTACAGATTTAAGTCAACCAAAACGAAAATCACAAACTCCTCCGCAAGCTCAAAACTCTGCAATAACTGTGGCCGAAAAACCAGGCGCATTTTTATGTAATCAATGTAATGCTGGTCTTCCTGATTTTGATACTTTCCGAGCACATTTGAAAACCCACATTACACAAGGAATAACGAATTTAGTTTGTCATCATTGTGGTTTATCATTTCGAGAACAAGCAGAATATGAACGTCATATAATTtcacattttcttttaactaGTTCAGAATATAACTGTGCTAGTAGTTGTAATAAAGTCTACACAAAAGCTGATGATTTACAAAAacatttatttgaaaatcatGTATTAACTGTGTACAAATGTTCACTTTGTTCAGACCTTTTTGATACTAAAGTGGCAATTCAGGTGCATTTTGCTTGTATTCATTCGACTGAAACCAAAATCTTTCGATGTTCAGCATGTATGGAATCATTCCGAGTagaaaaagattttatttCTCACATAAGGACTCGTCATTCGAATGCGAATGCAATTCAATGTATGTTTTGTCGTGCAGTTTGTTCATCAGAATTGGAAATGCATTTTCATTTAGCTGCTCACGCAAGACAGTTTCGATGTCCAGCATGTCCTGAAACATTTCATGTGGAGTTTCTTTTGGATCGCCACATGCAAACTCATCATTCACAACAAAAAGAAAGTGCTAATAGCTCATCGTATCACTATGGAAAATCTCCAAATAATAACAATGTATTAGATTACCATGCATTTGCAGCTGGAAAAAATCTTTTTCAAATGCCGactaataaattttataatccTTTGCAAATTGATATTAATTCAAACAAACAAACGGCTTTAATGTACGGTTTAGGTCAACGTTATTTCGATACGAATAAAACTCTAATGGATATGTACAATTATCATCAGGATAAAGTCAATTCAAATTATTTCATGGGAAATAATGTCTATGATAATCGAGCCAATAAAAgtcaaattgaaaataaaactaatGATAGAATTCAATCGAATGGTTTCAGTTGTGGAATATGTGAACGTAATGACTTTCGTACTGAAGCTGAAGTTCATTCCCATCGAAAAATTGTTCATAATCTAAAAACAGGAGTTAGTTTAAAATGTGCTTATTGTAGTGGAAATTTTAAATCAAGAAGTGAGCTAGAGCATCACATGAAAACTTGTCATAACTCTACGGGAAAACATAAATGTCTCATTTGTGATGAAATTTTTCCATCACCAGCAATTTTAGCTGAACATAAGTTACAACACTCAAAAGTTGGCCAATCTGGAAAATGTTCTCATTGTTCAGCAGTTTTAAATGATATTTCTGCTTTTAAGTCTCACCTGTCAGAACATAATGCTGAAGGACAAATACCAGTTCAATGTATTTGTTGTCGTCAAACTCTTAATTCTGATTTTGAAATTGGTCTTCATGCTAAGTTTCACACAAAATCATCAAATACTCCTGAAAGTGTTTGTGCCCTATGTTTGGAACCAATTCCATCAACATCTGAAACTAGAGTTTGTGAAAAATGTTGTCGaaaacataatttaaattcaaaatttaataatatgcGTTTTgataataatcataaaattcatattGAGAATCGTTGCAATTTATGTAAAATGATATTACCAAATGCACAAAGATTACAGGAACATCTTGTTGAGCATACATTTGTTGGCTGTGAAGAGCGTGGATATTCATGTTATATTTGTTCAGCTGTTTTTACAGTACCAGCTGGACTTTTAACTCATATGAATGAAAATCATGGTTTAAATTCAAGGCCATATGATTGTAATCAATGTACAgagaaatttttctttagaGCTGAATTAGATAATCATTTAGCAgaacatgaaaataataataataatagtactAATGCGAATAATCataatattcttttaaataataataatcacaacaataataataataataatagtattAGAGATGTCAATTCTGAGTTATTGATGAATAAtcacaataataaaaaacaaatggaaaatgataatcatcatcatcatcaaagCCGATTGATTCATCAGGATATAATGCATCATCCtgtagaaaataaattacttaTTCATCAAGATTCCATTTTAAATGAAGAACCTACAACAGAAATTAAAAAGGAGGTAACCGATGAAAATGATATAAGCTGTCGTTCTGGTAATGGAATTGGATGTGATGACGAAGAAGAATATATTGAAGTTGAAAAACTTGCTGAACCTTTAGCCAGTATTAATAACAATCgtaacaataataacaatgaagaaaataaaaatgataattga
Protein Sequence
MALKMLYRGPSSRLETLIEKIQQTKEIGGDLYSTHTSSSYSPSMSEGAATPNSLIHHHQHLHSHNHQNHPLDTSENNEGDGSTNTNNNNDRLRRRRQRCDNGGGEGEAIPSTNGCKKDGINDDDEEDEIDFNDKRVEKHNRNHDDDNIGGGSVNGNEEICNDDNNDGVKIPKKVRKIDKDLIKSEKMTGDSIKTGNGGGGGNTTNSDGSYQCQFCDKSFPRLGYLKKHEQSHAEHLPFKCEYCARLFKHKRSRDRHTKLHTGDRRYRCPHCEAAFSRSDHLKIHMKTHDNQKPFQCTVCNRGYNTAAALTSHMQNHKKQAALLGSGGASNALNYSPRSTGSGSSNGSLHKRRYATADNSPNRIDYRKHGRSSFLTCIYCTKADFTSLDQLNNHIQSMHENVAVKEALLNHPNSSNVFQLSCEYCTMKFPSIPTMFQHMRTTHIDRLTSPNSYFEHFNRLAASGTFSPRLATNSSRFEEIKTKAEQPSPKLERSSVEPEKADEEQISPTDLSQPKRKSQTPPQAQNSAITVAEKPGAFLCNQCNAGLPDFDTFRAHLKTHITQGITNLVCHHCGLSFREQAEYERHIISHFLLTSSEYNCASSCNKVYTKADDLQKHLFENHVLTVYKCSLCSDLFDTKVAIQVHFACIHSTETKIFRCSACMESFRVEKDFISHIRTRHSNANAIQCMFCRAVCSSELEMHFHLAAHARQFRCPACPETFHVEFLLDRHMQTHHSQQKESANSSSYHYGKSPNNNNVLDYHAFAAGKNLFQMPTNKFYNPLQIDINSNKQTALMYGLGQRYFDTNKTLMDMYNYHQDKVNSNYFMGNNVYDNRANKSQIENKTNDRIQSNGFSCGICERNDFRTEAEVHSHRKIVHNLKTGVSLKCAYCSGNFKSRSELEHHMKTCHNSTGKHKCLICDEIFPSPAILAEHKLQHSKVGQSGKCSHCSAVLNDISAFKSHLSEHNAEGQIPVQCICCRQTLNSDFEIGLHAKFHTKSSNTPESVCALCLEPIPSTSETRVCEKCCRKHNLNSKFNNMRFDNNHKIHIENRCNLCKMILPNAQRLQEHLVEHTFVGCEERGYSCYICSAVFTVPAGLLTHMNENHGLNSRPYDCNQCTEKFFFRAELDNHLAEHENNNNNSTNANNHNILLNNNNHNNNNNNNSIRDVNSELLMNNHNNKKQMENDNHHHHQSRLIHQDIMHHPVENKLLIHQDSILNEEPTTEIKKEVTDENDISCRSGNGIGCDDEEEYIEVEKLAEPLASINNNRNNNNNEENKNDN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-