Basic Information

Gene Symbol
ZFX
Assembly
GCA_951804975.1
Location
OX638116.1:16592372-16596828[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 1.3 6.7e+02 3.7 0.1 3 23 24 44 23 44 0.94
2 15 4.5 2.3e+03 2.0 3.7 1 23 907 930 907 930 0.81
3 15 0.0032 1.6 11.9 1.6 3 23 1014 1035 1012 1035 0.96
4 15 0.0039 2 11.7 0.7 2 23 1048 1069 1047 1069 0.97
5 15 1.6e-05 0.0082 19.2 3.1 2 23 1072 1093 1071 1093 0.97
6 15 0.0024 1.2 12.4 0.3 1 23 1099 1121 1099 1121 0.96
7 15 2.6e-05 0.013 18.5 4.5 2 23 1128 1149 1127 1150 0.95
8 15 0.12 59 7.0 3.7 5 23 1163 1181 1162 1181 0.97
9 15 2.4e-05 0.012 18.6 1.5 3 23 1188 1209 1187 1209 0.97
10 15 0.019 9.8 9.5 0.3 2 23 1225 1245 1224 1245 0.97
11 15 7.2e-05 0.036 17.1 0.7 1 20 1251 1270 1251 1273 0.92
12 15 0.00037 0.19 14.9 2.8 1 23 1281 1303 1281 1303 0.99
13 15 0.0025 1.3 12.3 3.2 1 23 1309 1331 1309 1331 0.97
14 15 4.5e-06 0.0023 20.9 3.9 1 23 1337 1359 1337 1359 0.99
15 15 0.0016 0.79 12.9 6.3 1 23 1365 1387 1365 1388 0.96

Sequence Information

Coding Sequence
ATGTGCAAACAAGATACCTCAGACACAATGGATACAACAAACAATGGAACATCAGGGAGTGCAGTGGCTTGTCCAGTATGTACCCTTTATTTGCGCGAGGGTATCAGTTTACAAAGACATTTGGACACTCATCCAAAGGAACAAGTCATTGAAGCTCTTATCAAAGCTAGTAGTAATTCGCAATTGCAACAGACTCAATTATTACCATCATCAACGCCTGCAGCATCTCCAGCTATACAATTACCACAAAATACACCTCAAGTTGCACAGAATACTCATCTATCAGCTCAATCTCCATATCCTATAGGACCTATTTTTGAGTGTCCACCGATTGGTACTGTGATGCCACCTCAGTTTGCTTCATTTAGTTATCAGCAGTTTGTAAATAATGGCACTATGATGATACCACAATACACAATGGCTCCACAAGTTAATCAGATGATGCAAATGCTATATAATCCATACAGTATGTACCAGCAGCAACAAATACCAACTGTTCAAATGATTTCACCAGTCACAACCATACCTAATACAGCTAGAGTCAAGCCAGTGGTGACTATGGCTGGTGAAACAAGTGGTAGAACTGCCATTGCTGTACCTGTAAATAATTCCGAGCCAAAACAAATTTTACCTGAAATTTTACCTGAATCGGAACAGGAGTCTGAACAAGTGTTACCAGATATTAATCTTCCAGTTTCTCCCCCATCATTGAACGAAGATACTTCTATGCAGCAAAATGAAAGTGAAGCTAGTACAATTCCAGTAGAAAATGAGGAAGAAGAACCCCATAGTTCAAATACTCTAATTCAGCATACAGTGCAGAATGAGTATGATAGCATTCCAAGATCATTGGCAATCACTTGTAATGTCGATGATACAACAGATGATAAAGTTGAGAGTGTATTACCGGATATTGATGATGGAGAATCATCGTGTGTTGTTAATACAGATGTACAATGTAAACCCCTTCATTATGAATCATCAGAAATTCAAGAATATGAACACAGATACAaagatgataatgataataaaattactatgCCTGAAATATCACCGATAgtaacagaaaatgaaaatgaagaagcaaCTAATGAAAAAGTTCCTTGCAGTGAAGAGATAAGTGAAAATGAAGGTACCTCAGCAGAAAAGCCTTTAGAAGATACGGTAAAGGAATCAGCTCAACCTGAAGTAGAACAATTAGAGCGTCTTTTAATCActatcatggaaaatgaatttaatgATACATCACAGAGAGAATCTACTTCTGAGGATGaccaaaaaaaaagtgaagataCAAAGGAAAGTCCTCCTCCtgagaaagaagaaagtgtAATTCATGAAACAACTAATAATTCCAGTGAACATGAAAGCAATTGTAAATCTGATATAGAACTAAAACTAAGTGAACATGAAAGCTCTTGTAAATCTGATATAGAACTAAAGCTTAGTCAAAATTCAGAAACTGATGTAAAgattattgaagaaaataagaGTTCTTGTCTTTCATACCATTATAAAAACAGTTTATCTGCACCTGCATCACCTGTTGTACAAAAGAGACCACGTAGAACCTATTCTGTTTGTTCAGAATTTGGTTCGAATGAAAATCTCAATTCTTATCCAATTGGCTTTGATGCAATTATATTACAAGATGAAGAAGATGAGGATGAAAAAAATGAAGCAGAGGATAATTTTGATGAGGCAGATATGGAAATAGAAGAAATACCTAGTCCACATACTCCTTTCACTAAATATGGTGAGAGTTCTGATCATGTTAGATCACATACTCCATTATCTGCAAGTAGTGGTATATCTGTTTTAAGGGTTAGGAAAGATCTCAGTAAACCATGCTCACCTGCTTCTGTACATTCATTTTGTCATATGGATGTTAATGGTATAAATCATGATGAAGAAAGTAATGCAGCAGTGGATGTAGCACCAGAAAAAGATCCTATTGATTGTTCTTCAACTGTACAGGATGTAAAGGTTGATCAATCAGAACTTCCTTTATGTgagaatgagaaaaaaattgaaggaaattCAGCATATCAGTCTGTAATCACTGAGCATATAAGTTCATTTACTACAATTCATTCACAACATTCTCAACAATCAACATCAATGGATGAATCATACAATACACCAAATAAAAGTAATAATCTTGTAAATTTGTCAGAATCTAGTGATGTTGCAAGTAGTTCTGATTCAAAAAGTTTTCATTCATCTAAATCAATTATACAAAAGCAATCGGTGGAACTTCTTAGTTTAAATGAAGATGCCCATGCAGGTCCAATGAATGTATTTGAATTTGATGGGCTTCAAATCTTAGTTCCTAGTACATTTATAAGTGATTCTTCACAAAAAGCTGTTAGTGCAACCAGTCAACAGTCTATGGCAAGTAGTGAAGGTGGAGTAGGTGCAGATGAAGAGGTTAAAAGCATTAACATGAGAGCTGATGAAACTATGCCACCCAGAGGTGAACTATCTGAACAGGAAAGCAACGGATGTACAGAACAATCTGCTTGGCAGTTATACACTGGTCAAGAATCATCGCGGATGTCCACCTCTTACGATTTAATGGCACGTGAAAGTTGGGAAGAATCTGAAGGATCAGACAATGAAATTGGAGGCCCACTATTAGATAGCAGATCTTTAGCCACACATTTTACATCAAGTTTATTTTTAGATCGAGATAGGAAAACTCCTACGAAAAGAACATTCAAATGTTATCATTGTCCGCAAGTATTTGAATGCCCGAAAGAACGTCGAGTACATAGTACCACCGCGCACAAAGAAGCTGGACCGAGTAGCAGTAGAGAATCTACTGATCAACCTGAAGTAAAGGATATTAAGTTATTGGATGGCCGTATGAATGTGTTTGAAGATATTTTTGTACCAGGTTTACATGTTCAACAAGTTTATCATCAACAACCGCTATTACATCAACTTCAACCTCCACAATCATCAGAATTAACAACAAAAGTAGAAACAGATCAAAAAATCGAAACTTTAGTAATACCGTCAAACATTGAAGTGATTTGCACACTTTGCAATCAACGATTTGGTAGTGAGAAGTCATTACAGCTTCATCATAGAAGAGTACATATTGCAGAAACAACAAAACGAATACGCGAGAGCACCAAGTGCCAGATATGCCATGAAGAATTTCCTTCACTTTTATTATTCAATGCCCATTTAAAAATACATCCATTAGAATGTAGCCAGTGTGGAaagtatttttatagaaaacaaaatttcaaattacacaTGAAACGACATTTAGGAATCAAACCATTTCCGTGTACCGTTTGCGATAAAGcatttttaacgaaacaaaaattGGAGGAACATACTAATGGTCATACCGGGAATGCACCTGTTAAGTGTAATCTTTGCAATGAAACATTTCGtagatattcaaatttaacaCAGCACAAAAATAGACatcatttaaatataaagaagaaattgaaagattaCATATGTCATTGTGGTGAGGTTTTTCatacaaagaaaaaattagCCTGGCATAAAGAAACACACGATGAAAAACCCAAAGCGTGTACATATTGCAATGAAAGATTCATTCACATGGCCAGCTTGACACGACACATGCGCCGAGCGCATAACAAAAGATTCGTTCCAGATGCTCAAAGAGAGAGCGAAAATGTTGAATGTCCCGTATGTAAGTGTATTTATTTGCGATCTTCCTTAGCAGTACATATGCGAGTTCATAATGGTGAAAGACCATATGAATGTCAAGTTTGCTCTAAAGCATTTAGTACTAAGTGGAACTTACAATTGCACAAATGGACTCACGCTGCCCGTAGCACCAAACCTTTCAAGTGTAATCAGTGTAGTGGCGCGTTTTACCGGCACAGTGATTATACTGCTCATATGAATTCTCATAGAAATGTGCGTCCTTACACTTGTAACTATTGTGGAGCGCAGTTCATACGAAAGTATAATTGTTTGAGGCATGTAAAAGAACATGAAGAGAACAAAGCATATACATGCGATGTATGCAACAAAACTTTTCATAGATCATATTACCTAAAAGAACACTTACGAGTACACTCAGGTGCCAGACCATATACATGTCATATTTGTGGAAAATCTAGCGGTACGAAATCCAATCATAACAAACATGTCAGAATTCATCATGCACGAGAACCTGTAACTACTGAAAATTAA
Protein Sequence
MCKQDTSDTMDTTNNGTSGSAVACPVCTLYLREGISLQRHLDTHPKEQVIEALIKASSNSQLQQTQLLPSSTPAASPAIQLPQNTPQVAQNTHLSAQSPYPIGPIFECPPIGTVMPPQFASFSYQQFVNNGTMMIPQYTMAPQVNQMMQMLYNPYSMYQQQQIPTVQMISPVTTIPNTARVKPVVTMAGETSGRTAIAVPVNNSEPKQILPEILPESEQESEQVLPDINLPVSPPSLNEDTSMQQNESEASTIPVENEEEEPHSSNTLIQHTVQNEYDSIPRSLAITCNVDDTTDDKVESVLPDIDDGESSCVVNTDVQCKPLHYESSEIQEYEHRYKDDNDNKITMPEISPIVTENENEEATNEKVPCSEEISENEGTSAEKPLEDTVKESAQPEVEQLERLLITIMENEFNDTSQRESTSEDDQKKSEDTKESPPPEKEESVIHETTNNSSEHESNCKSDIELKLSEHESSCKSDIELKLSQNSETDVKIIEENKSSCLSYHYKNSLSAPASPVVQKRPRRTYSVCSEFGSNENLNSYPIGFDAIILQDEEDEDEKNEAEDNFDEADMEIEEIPSPHTPFTKYGESSDHVRSHTPLSASSGISVLRVRKDLSKPCSPASVHSFCHMDVNGINHDEESNAAVDVAPEKDPIDCSSTVQDVKVDQSELPLCENEKKIEGNSAYQSVITEHISSFTTIHSQHSQQSTSMDESYNTPNKSNNLVNLSESSDVASSSDSKSFHSSKSIIQKQSVELLSLNEDAHAGPMNVFEFDGLQILVPSTFISDSSQKAVSATSQQSMASSEGGVGADEEVKSINMRADETMPPRGELSEQESNGCTEQSAWQLYTGQESSRMSTSYDLMARESWEESEGSDNEIGGPLLDSRSLATHFTSSLFLDRDRKTPTKRTFKCYHCPQVFECPKERRVHSTTAHKEAGPSSSRESTDQPEVKDIKLLDGRMNVFEDIFVPGLHVQQVYHQQPLLHQLQPPQSSELTTKVETDQKIETLVIPSNIEVICTLCNQRFGSEKSLQLHHRRVHIAETTKRIRESTKCQICHEEFPSLLLFNAHLKIHPLECSQCGKYFYRKQNFKLHMKRHLGIKPFPCTVCDKAFLTKQKLEEHTNGHTGNAPVKCNLCNETFRRYSNLTQHKNRHHLNIKKKLKDYICHCGEVFHTKKKLAWHKETHDEKPKACTYCNERFIHMASLTRHMRRAHNKRFVPDAQRESENVECPVCKCIYLRSSLAVHMRVHNGERPYECQVCSKAFSTKWNLQLHKWTHAARSTKPFKCNQCSGAFYRHSDYTAHMNSHRNVRPYTCNYCGAQFIRKYNCLRHVKEHEENKAYTCDVCNKTFHRSYYLKEHLRVHSGARPYTCHICGKSSGTKSNHNKHVRIHHAREPVTTEN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00962003;
90% Identity
iTF_00761136;
80% Identity
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