Basic Information

Gene Symbol
-
Assembly
GCA_905404175.1
Location
FR989978.1:5961917-5980687[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 3 2.9e+02 2.6 2.1 2 19 749 766 749 771 0.82
2 12 0.17 16 6.5 0.4 2 23 780 801 779 801 0.97
3 12 2.6 2.5e+02 2.8 0.1 1 11 805 815 805 818 0.86
4 12 6.5e-05 0.0064 17.3 0.9 1 20 833 852 833 854 0.93
5 12 0.0024 0.24 12.3 1.3 2 22 861 881 861 881 0.93
6 12 0.0017 0.17 12.8 0.1 2 23 900 921 899 921 0.94
7 12 4.1e-05 0.004 17.9 0.2 1 23 926 948 926 948 0.98
8 12 0.0045 0.44 11.5 5.8 1 21 957 977 957 982 0.94
9 12 0.009 0.87 10.5 1.7 1 23 990 1013 990 1013 0.87
10 12 0.012 1.2 10.1 0.4 1 23 1019 1042 1019 1042 0.95
11 12 0.022 2.1 9.3 0.4 3 19 1056 1072 1054 1073 0.89
12 12 0.0043 0.41 11.5 0.8 1 23 1086 1109 1086 1109 0.98

Sequence Information

Coding Sequence
ATGCCGGTCACCAGATCGCAAAAGGACGCACCATTGAGACATACGGACGACGAAAGTGAAGAAAGCTCTACCCAAGCGACAAGCGGTGACTTCACATCGGAACAAACATCATCGGGAGCTACCAGCACTACGACATCGGGAGAAACTCGAACTACTGTCACCACCGCGACCACTGCCAACCAGGAACCAGGAAGAAACGCAATGAACCTGGTACCAGCGGGTTCAACCCGGCATGCGAGGTCGACACGAACAACGGATACTTCAGCGCGCAGACGCGAGTTAGAAGCAAGGGAGGAATTGGCTCGCCTGGAGTTCGAACAGGCTCAGGCAGCAGCTCGTCTAGCCCGCGTCAGATTAGAGATGGCGCAGTACGAGGACACTGACTCCGTTGAAGAAGAGAATCCGGAAGAAAGAAATTCTCATGTAAGAAACTGGATTGAATCTTCGGTATTAGAAGAAAAGATTCAAGATGTTGAACCGGAAGTCAAGCAGACTTGTCATGTGGAAAAGGAATCATCGAAGATAGAAGTGCGAGTGCTGGCGGACGCGTTGAAGGAAGCATTTTCAGCAAAGTCAACCCCCGCGCCGCAGCCGAATGGGACTACGAGAAGACCTCTCAGACAAGCCACCCACAGTATCAGCGCCGACGAGGAGAGGAAGAAGACCTGCCCGCAGTGCGACGGAGATCACTCTTTGACAGAATGTCAGTCGTTCCTGAAAGCTTCAACGCAAGAGCGATGGAATACAGTAAAGAAAAGTCACGTCTGTTTCAAGTGCCTGCAAGGACGCCATCGAAAAGAATCATGCCGAAAACCACCATGCAAGCATTGTAAAAGATGGCACCACCCACTGCTTCACGTCACACCTCAACCCAACTCAACTCATGCTGCAATGGAGGTGGACAAGGAGACCACGTGTGAGAAGACTAACGAAGTTGCGATTGTGAACATTGCGCATACGGCACGCGCTCTGTTGAAAATGATTCGAGTGGAAGTCTACGGACCAAAGGGCTCCAAGAAGATAATAGCACTCATGGATGAAGGGTCGACAGTCACCTTATTGGATTCATCGATCGCAGATCACATCGGAACCACCGGAGTCACACAAGAACTGGTCATCGAAACAGTAGGGGGTAACCATATCAAGAAAGAAGATTCTATGATGCTGAACCTCACCGTGAAGGGCATACATCAGACGAAGAGGAAGAATCTTCAGAACGTCCGCACGATAGACAACCTTCGGCTGACCCCACAGTACCTGGATAAAAGGAGACTTGAAGACTGCCGTCACTTACGAAAACTCTCGGAAGTCTTATACTACGAAGCAGAGCCGCCCCAATTACTCATCGGTCAAGACAATTGGGACTTCATCATCTCTTTGGAAACAAGAAGAGGCAAGCCAGGACAACCAGTGGCATCAAGAACCAAGCTCGGTTGGGTGCTACATGGAACCGACTCCAACGTCACGAGACCAGTACACTTCATAAACACCTGTCTACATACAAGCGTCATCGAAGATCAGATTCATCAGATGCGTCTCACTACACAGAAGAAATATTTCAAACCCATCGGTGAAGAGATATTGCTACGAGCGGAAAGACTGCTGATACTAAGAAGTCAACACGAGAGCTTCAGCAAAGAAATACAGAGTTTGCAGAAAGGAAACAGCTTAGAAAGAAGCAGCAAACTAAAGAAGCTCGACGTGAAGCTAGAAGACGGAATACTGAGACTACGTGGAGGCGTGCTGAGACGACCGGCGACCAGGATCGTGCTGCTGGTGCCTGCAGAGTCACCGAGTCAAAAGGATGGTGCTTCGCACGAGGGGGAGAATTCTCCCAGTTTCCCAGTATCCAAGTTTCCCAAAGTACCTAGTTTCCCTCATTTTCCTAACCCCATACCAACCTCCTTTCCGACGTGTACTCACCGCTCTCTTACTATCGTCCAGCCGAGTGTGCCGTCCTGGCACAGTATAAAGGATGAGTCTTACAATTTTGAAGTCGCTTTTGATTATAATCAGTCTTCAGATGACGATACGCTTCTGGCTGACTTGAAAAGAGAAGACGAAGATAAGAAGAGTAAAAAAGAGGAGAAGAAGAAAAAGGATAAGGCTCCAAAAGCCAAACTTCCTCAAAAACTAAAGAATTTGCCCAAAGAAATAGTCGAATTGTACACTATGGATGAGTCAGAGATGTGGTCGACTCGCGCAAGCGACGTTGCCAATGAGGAGTTTGTCAAATTCAAACGCAAATGTATGGACTGCGTGCGGTGTTTCACCACGGAGAAACTGATGGGCTACCATTTTGACGGGAAGCATACACCGAGAGATAGTAGCTACGTACAGTGCGATGTCTGCAAGGGATTCTATATGAACAGAGACAACATGTTGGTGCATAGAAACCAACATCTGAGCGCTTACAAATGTCGTATATGTGGTCTCGTGACTACTTTAAAGATGATAATGTCGAATCACGAATGTGCGAAACGGACTGAAAACGGCCACACTTGCTCCATATGTGAGAAGGTGTTCAGTACCAAATCAAAGCTAGTGTACCACAGGAGTGTGTGCAACGAGGAGCGGCCGCAGTGCGACTGCTGCGGCAAAGTGTTCGCGAACAAGATCACACTCAAGTCGCATCTCAAGACCATGTCAGGAGTACCCTCAAATAAGAGCAAAAAACCAAGTACAAATATGTATATACCCTGCAAGGGGTGCGACAAGGTATTCTACTCCGGGAAGAGTTACAGAGCGCACGTCGTAATTCACGACGGATTAAGCTACCCCTGTCCAGTATGCGGCAAGCTGTTCCAGTGGAAGCGGAACCTCGCTCGGCACATGCGGAACCACCGCGAGCGGCAGTCCGGCACCACGCACCAGTGCCGCGACTGCGCCAAGACGTTCTCCAGCCGCGACTGCTACAACAACCACATGAAGCTCAGCAAGAAGCACGTGCACGAAAGCGCTCTTACCCACGCTTGTCAGTACTGCGACAAGCGGTTTGCCACGAAGTGGTGTATGGTGGATCATGTAGACTGGGACCACTTGAAACGCATCAAGTACAGGTGTAGGGTCTGCTATAAGCCATTCAAGACAGCTAAAATAATGGTGGCCCATATGAATAATATACACGAGGGGAAGAATAAGAAGGAGCCGGAAGGTGAACATCTCTGTGAAATATGTGGGAAGTCTTATAAGACAGTCAAGCGGTTGAAAGGCCACGTGTGGGCAATGCACACCAAGCGCTCAGACGCCAAGAGCTTCAAGTGTTCCCTCTGTCCGGCCACCTTCACCTGGCAGACGTCCATTTACAAGCATATGCGGATGATGCATGAAAATAAGCGCAACAAGCAACCCCGAAGCTTACCAGCGAAGAAGCAAGAGACCTACCCAGATGTCGAACTCGCCAACCGCATACAATACTACCAACAAAATATGACGGCTACCATGGGACAAATACAACCTATCAATATTGTACAAAATATCTAG
Protein Sequence
MPVTRSQKDAPLRHTDDESEESSTQATSGDFTSEQTSSGATSTTTSGETRTTVTTATTANQEPGRNAMNLVPAGSTRHARSTRTTDTSARRRELEAREELARLEFEQAQAAARLARVRLEMAQYEDTDSVEEENPEERNSHVRNWIESSVLEEKIQDVEPEVKQTCHVEKESSKIEVRVLADALKEAFSAKSTPAPQPNGTTRRPLRQATHSISADEERKKTCPQCDGDHSLTECQSFLKASTQERWNTVKKSHVCFKCLQGRHRKESCRKPPCKHCKRWHHPLLHVTPQPNSTHAAMEVDKETTCEKTNEVAIVNIAHTARALLKMIRVEVYGPKGSKKIIALMDEGSTVTLLDSSIADHIGTTGVTQELVIETVGGNHIKKEDSMMLNLTVKGIHQTKRKNLQNVRTIDNLRLTPQYLDKRRLEDCRHLRKLSEVLYYEAEPPQLLIGQDNWDFIISLETRRGKPGQPVASRTKLGWVLHGTDSNVTRPVHFINTCLHTSVIEDQIHQMRLTTQKKYFKPIGEEILLRAERLLILRSQHESFSKEIQSLQKGNSLERSSKLKKLDVKLEDGILRLRGGVLRRPATRIVLLVPAESPSQKDGASHEGENSPSFPVSKFPKVPSFPHFPNPIPTSFPTCTHRSLTIVQPSVPSWHSIKDESYNFEVAFDYNQSSDDDTLLADLKREDEDKKSKKEEKKKKDKAPKAKLPQKLKNLPKEIVELYTMDESEMWSTRASDVANEEFVKFKRKCMDCVRCFTTEKLMGYHFDGKHTPRDSSYVQCDVCKGFYMNRDNMLVHRNQHLSAYKCRICGLVTTLKMIMSNHECAKRTENGHTCSICEKVFSTKSKLVYHRSVCNEERPQCDCCGKVFANKITLKSHLKTMSGVPSNKSKKPSTNMYIPCKGCDKVFYSGKSYRAHVVIHDGLSYPCPVCGKLFQWKRNLARHMRNHRERQSGTTHQCRDCAKTFSSRDCYNNHMKLSKKHVHESALTHACQYCDKRFATKWCMVDHVDWDHLKRIKYRCRVCYKPFKTAKIMVAHMNNIHEGKNKKEPEGEHLCEICGKSYKTVKRLKGHVWAMHTKRSDAKSFKCSLCPATFTWQTSIYKHMRMMHENKRNKQPRSLPAKKQETYPDVELANRIQYYQQNMTATMGQIQPINIVQNI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-