Basic Information

Gene Symbol
Clamp
Assembly
GCA_905404175.1
Location
FR989953.1:7404169-7412081[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 7 2.2e-05 0.0022 18.7 0.7 1 23 122 144 122 144 0.99
2 7 2.2e-05 0.0022 18.7 2.2 1 23 323 345 323 345 0.97
3 7 1.6e-05 0.0016 19.2 0.1 1 23 351 373 351 373 0.98
4 7 1.7e-06 0.00017 22.2 3.0 1 23 379 401 379 401 0.99
5 7 1.4e-06 0.00013 22.5 0.4 1 23 407 429 407 429 0.98
6 7 3.4e-06 0.00034 21.3 0.7 1 23 435 457 435 457 0.98
7 7 6.4e-05 0.0062 17.3 0.2 1 23 463 485 463 485 0.96

Sequence Information

Coding Sequence
ATGTTCACAACCAATACAGTTCAGGCCGGAACTGTACCGACTTTACAGTATCAAGAGCACACTCAAAAATCTCAAGGAAAAAATATAGAAAATGCTCAACAGAAAGCTGGTCAGCAGACTCAACAAACTCAGCAGGAATTTCCCACGTTTTGTTATACAACCAATGTTAACATGATTGGTAAAATTAATACTGGTACAACAACTGGAGCAGGAGCAGTGACAGGCGGAGTTAATATAGCTCAGTTAACTACCAGTGATGATAAAACTTGTTACATAGCGCAGCCTTTCTCTTACAACTATGCATTAGTGAACCAAATGCAAATAGCCCCCAATGGAATTCAAAACACCATCTCCAATATAAGTTTTAAATGTGATGTGTGTGGTCTGATGTTTGGACATCTAACACTTCTGAATGCCCATAAAAGAATACATGCTCAAGATACAGACAATAACATAACAGTTGTGGCAACTGGAGTAAGTAATGCAAATGATGTAGCAATGCCTCCACATATACAAATACTCTCATCAGACCCCAGTGAACAAACGCAACATGTGCAAATACAGGATACAAAACCTATTTTATTAGATAAAATACAAAAGTGCATCACATGTGGCAATGTGATTCCTAATAATCCAAAAAGAAAAGGACCAAAACTGATAAGATGTGAAAATTGTATTGCACTGGTCAATGTTGAGCACAGGCAAAATCAAATGAACACGACACAAATATTTGTGACAGAGGAGAATGTTAAGTTTGAAGTGGGCGGTGTCAGCGGAGTTCAGCCGTCCGCGGACCCGCTCGCCAACACTCAGAGCAATCAGCAACAGCAGCAGCAGAAACATTTGCCCGGCCATCATCCTGTGAAAAAAAGAAACTTGGCTTCAGTGACAAAGTGTCAGAACTGTAACGGATCAGGCATCATATTTGTAGGCGGCAACAAAAATAAAAGTAATCAAGAAAAGTCATATCATTGTAATATATGTGGGGGATCATTTTCAAGATACTCCTCACTATGGTCTCATAAGAAGCTACATTCAGGGGAAAAGAATTTTAAATGTGGTATTTGTGGGATTGCATTTGCTAAAGCTGTTTACCTTAAAAATCATTCTCGAATACATACTGGGGAGAAACCTTATAGGTGTAATACATGCGGTATGCAGTTTTCTCAATCACCACATTTGAAAAACCATGAAAGGACGCATTCTGGGGAGAAACCATATGTTTGTGAGGTTTGCGACAAAGGCTTCGCGAGACACGCGACTCTATGGAATCATCGACGCATACACACCGGCGAGAAACCTTACAAATGTGAAACTTGCGGGTCAGCGTTCAGTCAAGCGGCTCACCTCAAGAACCATGCGAAGGTGCACTCCGGTGAGAAACCATTCAAGTGCGACATTTGTACCGCAGCGTTCGCAGACCGTTTTGCGCTCAAGAGGCACAGGGGGATCCATGACAAATATGGTCAAACTGCGCCTTTACCATCGAAAATACACCAGAACCAGATAGAACAGCAGCAAGCAACACTACAGACAATAACCACCAATCAACAGCAACAAACCAGCGCACAACCCGCAGTTGAAGGAGAACATTGTCCAGAACAGGCTCTATGA
Protein Sequence
MFTTNTVQAGTVPTLQYQEHTQKSQGKNIENAQQKAGQQTQQTQQEFPTFCYTTNVNMIGKINTGTTTGAGAVTGGVNIAQLTTSDDKTCYIAQPFSYNYALVNQMQIAPNGIQNTISNISFKCDVCGLMFGHLTLLNAHKRIHAQDTDNNITVVATGVSNANDVAMPPHIQILSSDPSEQTQHVQIQDTKPILLDKIQKCITCGNVIPNNPKRKGPKLIRCENCIALVNVEHRQNQMNTTQIFVTEENVKFEVGGVSGVQPSADPLANTQSNQQQQQQKHLPGHHPVKKRNLASVTKCQNCNGSGIIFVGGNKNKSNQEKSYHCNICGGSFSRYSSLWSHKKLHSGEKNFKCGICGIAFAKAVYLKNHSRIHTGEKPYRCNTCGMQFSQSPHLKNHERTHSGEKPYVCEVCDKGFARHATLWNHRRIHTGEKPYKCETCGSAFSQAAHLKNHAKVHSGEKPFKCDICTAAFADRFALKRHRGIHDKYGQTAPLPSKIHQNQIEQQQATLQTITTNQQQQTSAQPAVEGEHCPEQAL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01417101;
90% Identity
iTF_00771277; iTF_00430868;
80% Identity
-