Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.059 2.8 8.3 0.5 2 23 59 79 58 79 0.82

2 6 0.0074 0.35 11.1 5.8 1 23 86 108 86 108 0.95

3 6 0.0064 0.3 11.3 1.3 1 23 114 136 114 136 0.98

4 6 1.8e-07 8.6e-06 25.7 0.7 1 23 142 164 142 164 0.99

5 6 6.8e-06 0.00032 20.7 1.5 2 23 171 193 170 193 0.97

6 6 5.7e-05 0.0027 17.8 0.8 3 23 201 222 199 222 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.059	2.8	8.3	0.5	2	23	59	79	58	79	0.82
2	6	0.0074	0.35	11.1	5.8	1	23	86	108	86	108	0.95
3	6	0.0064	0.3	11.3	1.3	1	23	114	136	114	136	0.98
4	6	1.8e-07	8.6e-06	25.7	0.7	1	23	142	164	142	164	0.99
5	6	6.8e-06	0.00032	20.7	1.5	2	23	171	193	170	193	0.97
6	6	5.7e-05	0.0027	17.8	0.8	3	23	201	222	199	222	0.95

Coding Sequence: ATGAAAATGCATGGAACGGAAGATGAAAAAGCAGAAAGGACACGCCCCTGTATGATATGTAATAAGCTTATAAGTATCAGCTACTACAGTGATCATTTGAAAAGGGTTCACAAAGTCGGACCATACGGAGAGAAGTTGGAAGGGGAATTTGACCGCAGGAAACAAAACCATGTACAATGCCCAGTGTGTGACAAGAAGGTCAGAGAGAATAAATACTATAATCATTTATCACAGCATGGCAAACCTCCAAAGAAATATGTATGCGAACACTGCGCTAAGGAGTTTATTCACCGATCAGCGTTCAATACTCATTGTTTGACTCACGGGGGAGAAATGAAGTACAATTGTCAGTTCTGTCCATATAAAGCCCAGCATCTAGGATTACTTAAAGTTCATGTGCGCACTCACACTGGCGATTATAATTACAAATGTACTATATGTCCCGCACGATTTATTACCAAAAGTAATCTAAACCAGCATGTCCAAAGACACAACGGGCCGGGAAACATTAAATGTTATGAATGTGATAAAAGATTTTACCGTCAACGTAACATGGAAGAACATTACAAAACTATACATTTAGGTATTAAGGATGTTATTTGCAACATTTGTGGAAAAGGTTTCAGCCATCGTGATCGTATGCTGAGCCATCAATTGAAAGTTCATAAACGGGAAAGACTGTTGCCAAGAGTACCGACATATTTGAAAATTGCTAATGAAGGAAAAGTGATATACAAAAATTTTGATAACTCTTGA
Protein Sequence: MKMHGTEDEKAERTRPCMICNKLISISYYSDHLKRVHKVGPYGEKLEGEFDRRKQNHVQCPVCDKKVRENKYYNHLSQHGKPPKKYVCEHCAKEFIHRSAFNTHCLTHGGEMKYNCQFCPYKAQHLGLLKVHVRTHTGDYNYKCTICPARFITKSNLNQHVQRHNGPGNIKCYECDKRFYRQRNMEEHYKTIHLGIKDVICNICGKGFSHRDRMLSHQLKVHKRERLLPRVPTYLKIANEGKVIYKNFDNS

Sequence clustering based on sequence similarity using MMseqs2