Basic Information

Gene Symbol
L
Assembly
None
Location
AY:178467-220753[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 1.4e-06 6.5e-05 22.9 1.7 1 23 87 109 87 109 0.99
2 16 1.4 64 4.0 4.8 1 23 115 137 115 137 0.97
3 16 7.9e-06 0.00037 20.5 4.1 1 23 143 165 143 165 0.99
4 16 2.5e-05 0.0012 19.0 0.1 1 23 171 193 171 193 0.98
5 16 0.00062 0.029 14.5 0.0 2 23 209 231 208 231 0.95
6 16 0.91 43 4.6 0.2 9 23 262 277 258 277 0.96
7 16 0.57 27 5.2 0.0 3 23 330 350 329 350 0.97
8 16 9.1e-05 0.0043 17.2 1.0 1 23 393 416 393 416 0.94
9 16 0.092 4.3 7.7 0.0 1 23 421 444 421 444 0.92
10 16 0.0016 0.077 13.2 0.4 1 23 502 526 502 527 0.95
11 16 0.00019 0.0088 16.2 0.1 2 23 588 609 587 609 0.96
12 16 0.054 2.6 8.4 0.0 1 23 617 639 617 639 0.97
13 16 2 94 3.5 3.1 2 23 647 668 646 669 0.94
14 16 0.28 13 6.2 0.1 3 23 745 765 744 765 0.96
15 16 0.0033 0.15 12.3 0.1 1 20 773 792 773 795 0.95
16 16 0.13 6.3 7.2 1.3 1 23 802 824 802 824 0.94

Sequence Information

Coding Sequence
ATGATCATGCTATTCAAGGGTAATAGTAGTAGATTGGAGCATTTAATAGAGAAAATTCAGGCTAACAAAGAAAATCACGACGTCATATCCGAAGATATAAAAGAGGCACTGGGCAGCGTGGGGAGCACGGCGGGTAGCTCTTGGCCGTCGACGACGCCGGAGCACTCGCCATCACCTGCTTCTACTCCGACCTCGGCTGACGCTGCTGAAGGAGATACTGAACCACCCTTTACAATCGGCGCTACTGAGCACACACCTTATCAGTGCCAGTTCTGCGACAAAGCCTTCCCTAGGCTCTCATATCTCAAGAAACATGAACAGACGCACTCGGACCAGATGCCATTCCGCTGCGAGTTCTGTGCGCGACTGTTCAAGCACAAGAGATCCCGCGACAGGCACGTCAAACTGCACACCGGCGATCGCAAATACCGCTGTGCACATTGCGAATCAGCGTTCTCTAGAAGCGATCACTTGAAGATACACATGAAAACTCACGACAATCAAAAGCCATTTCAGTGCACGGTGTGCAACCGTGGTTACAATACTGCTGCAGCTCTGACCTCTCACATGCAAGGCCATAAGCGTGACCGCGAGGGACGTGAAACCGAACGGCGACGACCTCTGCGCTGTTTGCGGTGCGGTGATGCCTTCCGACGTCCTGATCTATTGCAGGCACATATGGCGAGTGCACATGGTGTGGACACAGCAGCGCTCACTCCACCGAGTCGAGTGGCTTCACAGCCACCTCCTACCCTTCTGGCCTGCATCTACTGTACTCGTGACACCTTTACTAGTATGGAACAGTTACAACTTCATGTGAGGACCGCTCATTCGGCTCTTTTAAATGGTGAATCACCGATGCAAGTAATAGAACAACCGGCACCAACAGATCTGAGCAGACGAGGATCGGAGGATGTATCTGCAGTTAAACGGCCACGATCAGGGTCTGGAACACCACAGACTGCACTGTCGCCTAGCACATTGTTGTGTAATCAATGTGATGCAGCACTGCCTGATTTTGAAGCTTTTAGAGCTCACGTCAAAGCACATTTAGAAGAAGGAAATGAGTTTAGTAGGTCGAGTCCGGCCCCATGTGTGAATTGTGGTTCTACATTCGCCGATGCTGCCGCTTCTGAACGTTATCTTACATCTCATTATTTAGCTGTATCTTGCGAATATACGTGTCATAGTTGTGCGCGGAATTTCTCTTCTCCGGATGATTTGCAGAAACATCTTTTGGATCTGCATGCACATCATCTTTACCGGTGCGCTTTATGCAAAGAAATTTTCGATTCAAAAGTTGCAATACAGGTGCATTTCGCAGTAGCCCATAGTGGTGAAAATAAAGTATGGATGTGTCGATCATGTGGTGGAGGAGCTGGAGCGCTGCGCTCGGAGGCAGAGGGTGCGGCTCATGTGCGTTCTCGGCATGCGGCAGGGATCGCGCGTTGTACATGCGGGGCACTGATAGCGGGGCCACGACACGCTCGCCCCACCCGTCCCTACAGATGTCCTGTACCGACTTGTACGGATGCATTTACCGTGCAGTATCTCTTAGAGAGACATATGCAGGCACATCACACTTTGCCTCACCAGGTATTAAATGGAGAGATCAATAGAGGAAAAAGGGGAGAAAATAATAACAGTGGTGAAGTAATTGATGGCGCCTGCTCACCTTGTACAACGTTGCCGGAAAACGCAACTGGTATTGGAGCGGGCACGAGTGATGAGAGGCGTCGAAAGAATGGCGCTGTAGCGTTACAATGTGCATATTGTGGTGAACGGACACGCAGCCGAGCCGAGCTTGAAGCGCATACTAGAGCACATTCTGGTGCGGCCGCAGCGCGACACAAGTGTCTCATTTGTGATGAGGTGCTACCTTCCGCCGCTGTTCTTGCAGAACACAAGCTCACTCATTGTAAGGTTGTGGCAGGAGACACGTGCTCACGCTGCCGTGCTCATCTTACGTCTGAGGAGATGTTTTTAAATCACATGGCGAGACACCACCCAGCGCTGCCCGCTCCTTGCGTGGTTTGCAGACAGACATTGGCTTCAGAGGCAGAAGCACGACTCCATGCGCGTTTCCATCTTCGTCCAAACGAGGATGAACAGAGGTGTGCGATATGTCTGCGAGCTCTACCGGAAAATGAAGCCGGTGAAGGTGCTCGTGCGTGTTCCACTTGCTACGCCCGTCATGCTGCCCCTCGACCTCAACCTCCGACGGATAACGATTGCAAGCTATGTAGAAGAGTTCTGGGTTCCCCCACTCGACTCCAAGCGCATCTAATCGAACATACCTTTGCTGGAATAGGCGCATTTACGTGTTACTTATGTTCGGCAGTATTCACAAGTGCAGCTGGCCTACAGCGACATCTACCAGAACATGCGACTGCACCGAGACCTTACGACTGTGGCAGATGCGGCCATAAATTTTTCTTTAGAGCGGAACTAGATAATCACGCTTTTGTTCATTTAGAAGAGGCGGAAATAGCACAGAGGGCGTTTTACGAAGCCTATGCACGAGGGGCGGCCTCTGCGTGGGCTGCGCTAGCACCTACCGATCCGTCACCGACTATGTCGTCAGCACCACCTCCACCCGAAATGAAGCGCGAGTCTGAAATTAAGGAGGAACGCAACGACGAGTACATTGAGGTATCATCTCCTCCGCCCCCCGCACCACCTCCCTCTGGACCGACTCCGCCGCCAGTAGTAAAACAGGAGAAGCCTGACGAAGACTAA
Protein Sequence
MIMLFKGNSSRLEHLIEKIQANKENHDVISEDIKEALGSVGSTAGSSWPSTTPEHSPSPASTPTSADAAEGDTEPPFTIGATEHTPYQCQFCDKAFPRLSYLKKHEQTHSDQMPFRCEFCARLFKHKRSRDRHVKLHTGDRKYRCAHCESAFSRSDHLKIHMKTHDNQKPFQCTVCNRGYNTAAALTSHMQGHKRDREGRETERRRPLRCLRCGDAFRRPDLLQAHMASAHGVDTAALTPPSRVASQPPPTLLACIYCTRDTFTSMEQLQLHVRTAHSALLNGESPMQVIEQPAPTDLSRRGSEDVSAVKRPRSGSGTPQTALSPSTLLCNQCDAALPDFEAFRAHVKAHLEEGNEFSRSSPAPCVNCGSTFADAAASERYLTSHYLAVSCEYTCHSCARNFSSPDDLQKHLLDLHAHHLYRCALCKEIFDSKVAIQVHFAVAHSGENKVWMCRSCGGGAGALRSEAEGAAHVRSRHAAGIARCTCGALIAGPRHARPTRPYRCPVPTCTDAFTVQYLLERHMQAHHTLPHQVLNGEINRGKRGENNNSGEVIDGACSPCTTLPENATGIGAGTSDERRRKNGAVALQCAYCGERTRSRAELEAHTRAHSGAAAARHKCLICDEVLPSAAVLAEHKLTHCKVVAGDTCSRCRAHLTSEEMFLNHMARHHPALPAPCVVCRQTLASEAEARLHARFHLRPNEDEQRCAICLRALPENEAGEGARACSTCYARHAAPRPQPPTDNDCKLCRRVLGSPTRLQAHLIEHTFAGIGAFTCYLCSAVFTSAAGLQRHLPEHATAPRPYDCGRCGHKFFFRAELDNHAFVHLEEAEIAQRAFYEAYARGAASAWAALAPTDPSPTMSSAPPPPEMKRESEIKEERNDEYIEVSSPPPPAPPPSGPTPPPVVKQEKPDED

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00112844;
90% Identity
iTF_00113541;
80% Identity
-