Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 3 2e+02 3.0 0.2 2 12 142 152 141 162 0.80

2 6 3.8e-05 0.0025 18.4 1.5 1 23 169 191 169 191 0.98

3 6 2.2e-05 0.0014 19.2 0.6 1 23 197 219 197 219 0.99

4 6 0.0016 0.1 13.3 2.5 1 23 225 247 225 247 0.97

5 6 0.00012 0.0078 16.8 2.3 2 23 253 275 252 275 0.97

6 6 0.00011 0.007 17.0 0.3 1 23 281 304 281 304 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	3	2e+02	3.0	0.2	2	12	142	152	141	162	0.80
2	6	3.8e-05	0.0025	18.4	1.5	1	23	169	191	169	191	0.98
3	6	2.2e-05	0.0014	19.2	0.6	1	23	197	219	197	219	0.99
4	6	0.0016	0.1	13.3	2.5	1	23	225	247	225	247	0.97
5	6	0.00012	0.0078	16.8	2.3	2	23	253	275	252	275	0.97
6	6	0.00011	0.007	17.0	0.3	1	23	281	304	281	304	0.95

Coding Sequence: ATGTGTAACTCCGACGAAGTGAATAAATGTAGAATTTGTTTGAAAACTGGCAAGATACCAATATACGGTGAAAATTGCAAATCGGATATATCTTTCGAAGTACGAACGTTTGGAGATATCGACCTTTTCGAAAACGACGATTATCCAAAATACATATGCAGTGAATGCTTGAAATTACTACACTGTGCAATACTTTTTCGGAATACTGCTAAACGGTCTGACAGTATTCTTAAAGGGATAAGAAAACCGAAAACCGAGCTAAATTCCTGTGAAAAAGTTATCATACCCAACACATCTATTATTCCCTCGAATCCCTCTTCGTCATCTGAAGTGATACAGAATCATTTTAAAGAAGTCAGAGTAGCTGCATCATCAGATAGACCAAATAAAGTATGTCGTAGTAGATTGACAATAAACAGAGTACAGTGTAGTGTATGTCATAAGATCATCATTAGACGTCATGCTAGGGATCATTATGCCTTACACGATCCTAGTTTATCTAAATATATATGTGATATCTGTGGAAAGGCATTTCGTCAACGTAGTGGATGTGTAAATCATAGACAAACACATAGCACGGAATTCAAATTTAAATGCAATATCTGTCCTTACAAAGCGAACACTTCGTCATTATTGAAACTCCATGCGAGAACACATACAGGTGATTACCGTTACATGTGCACTAAATGCCCCGCCCGATTTCTCACTAAAAGCAACTTTAATAAACATTCCTTAAAACACAAGGAACCTCAATTGAAATGTGATTATTGCAAAAAACAATTCCATTCAAAAACACCATTAGAAAGTCATATTCAGACTGTTCATTTCGGATTAAAAAGTCATGTTTGTAATATATGTGGCGAGGCTTATGGAAACAGAAAATCACTTGTGAACCATCAAGTTAAAGTTCATGAAAGGAAAAAAGGTTCAACAGGCAGGTTACCAGCTTATTTAAAAGCCCAGATGCAAGAGCAAAAAGAAAATGAAATAATAAATGACCAGTAA
Protein Sequence: MCNSDEVNKCRICLKTGKIPIYGENCKSDISFEVRTFGDIDLFENDDYPKYICSECLKLLHCAILFRNTAKRSDSILKGIRKPKTELNSCEKVIIPNTSIIPSNPSSSSEVIQNHFKEVRVAASSDRPNKVCRSRLTINRVQCSVCHKIIIRRHARDHYALHDPSLSKYICDICGKAFRQRSGCVNHRQTHSTEFKFKCNICPYKANTSSLLKLHARTHTGDYRYMCTKCPARFLTKSNFNKHSLKHKEPQLKCDYCKKQFHSKTPLESHIQTVHFGLKSHVCNICGEAYGNRKSLVNHQVKVHERKKGSTGRLPAYLKAQMQEQKENEIINDQ

Sequence clustering based on sequence similarity using MMseqs2