Basic Information

Gene Symbol
-
Assembly
None
Location
GWHABGR00000003:5017762-5067706[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.00037 0.024 15.3 0.4 1 23 472 495 472 495 0.98
2 11 0.00076 0.05 14.3 0.2 1 23 516 538 516 538 0.95
3 11 2.8e-05 0.0018 18.8 4.4 1 23 544 566 544 566 0.97
4 11 0.00021 0.013 16.1 4.8 1 23 573 595 573 595 0.99
5 11 5.7e-06 0.00037 21.0 0.4 1 23 601 623 601 623 0.93
6 11 9.9e-05 0.0065 17.1 3.6 1 23 629 651 629 651 0.97
7 11 8.5e-05 0.0055 17.3 2.1 1 23 657 680 657 680 0.95
8 11 0.0089 0.58 10.9 9.6 1 23 686 709 686 709 0.96
9 11 4.8e-05 0.0031 18.1 0.4 2 23 716 737 715 737 0.97
10 11 1.2e-05 0.00077 20.0 1.5 1 23 743 765 743 765 0.96
11 11 0.037 2.4 9.0 0.1 1 23 771 795 771 795 0.92

Sequence Information

Coding Sequence
ATGACCAATTGTTTTCTTTGCAACATTCAAATGGGCGTATCTCCGAGGAATTCGATAAATCTGTTTGGAGAAAACAATATATTCCGATCAGGTGATAAACTGCACGAAGTAGTCAGTGATATAATAGAGAGACCTTTAAAAGTGAACGCAGTACACGCAAATGTTATCTGTAAGAAGTGCTACAGTACGTGCTCGGAATACGATGAGATGAAGACAAGTTTACAATCAATGAAATCAGAAATATTAAAACAATTCAAGGCATCGCTAAACGATCAGCATATCTCGTACGATACGTACGAATCGGATGTTAAAATGAAACTGACCGATAAATCCGATGCGGTCATTATAAAGAAGCTGTCAAAGAAGGTGGTGTTGCCAGCGTCGAAATTGCAACCGTTGCCGCCGGATTTTTTGTTGAGAGTCGACAGACTCACTGGGTTAAAATCTTGTAGTAATATCGAGAAGACGAAGTCAATAACGGTGACCACCGTTAACGCGTCAGTGACATCATCGAACGGTACGTCCGTACAGAATAAAACGGTCAAACCGACGTATTACCTATCGACGCTCGCCAACACGCTCGACGAGCGAACTGATACGAAATGCTCGAGTCAGGTGATGAAGAATTTTACCTTCGCCACTTTGACGAAGGATTTCGTTGATGATTCCGAAGCGGTCGATGAGATATGTGATAATGAAGCTGGTGGTGATGCTGTTCAAGACGTTGATGATGATGAAGAGGCTCTAAAGATCGATCAAGATTGCGCAATCTCCGTAGTGCCAGTGACGTCAGCGAGTGGGGATTTGGTGCTGGAAGTGCAGGGTATCCCGGCAAAATCTAAAGCGACAGCGAAAACAGATTACGTAGACGTGGAAATGGTACGAGCTCTGGATGCGAACGTGACGTCAGACGGGGCGGAGTCGCGGGACAAGTTTATATTCGGGAAATTAGAGATAATCAACGATGTCGATGAAGACGACGATAACGAACATACGATCGTATTTTACGACGGCAATGAACTATCGCTGATGGTGCCTGATGAGAATTCCCAACAGGATGAAGAGCATCTCGATAACGGAGACAGTCACGATTCGAATGACGAGTCGCAAATCGAATTACAAGTGTCCGGGGATGAGGAGACAGCGAACGCTATCATTGCGGCAGCACAGGAACAAGGTGGGGCATTCATAAAGGTGGAATCCGGGGAGATGTACAGAGTTCAATCGGTACAGAGCAAAACAGAAGACGAGGTGGAGGAACAGCAGCCGCTGCTGATGGTGGAACAGGAGGGGGAACGGTTCAAGTGCCTGTTGTGCGAGAACAGCATCAAAAACGGTAACAAGTCAGAGTCGTTCCTGTCGGACGCGGAAACTATGATGCAGCATCTCAAATCTGAACACGACGCGAGACTCTACATCTGTTCCATCTGCGGAATCCTACTCAGGAAACGTTCCGACTACACGAGACACGTCAGGACCGAGCACAAGGTGCGGGTGTCGGGGGGTCGCGCGGGGGTCGCGGCGGGGGGTCGCGGGGGGCGCGTGCACGCGTGCGGCGTGTGCGGGCGCACGTATAACTCGCGCACGCTGCTGGCGGAGCACGCGAACGTGCACGCGGGCGTGCGGCCGCACTCGTGCACGCGCTGCAGGAAGTCCTTCGCCTCCAAGTACACGCTGCAGGCGCATCTCAAGACACACTCGGAACGTCCGCGGCCGTTTAAATGCTCGCACTGTGAGAAATCGTTCCTGACGCAACAGAATCTGAATCAGCACGAGAAAACTCATTCCGGTGTCAAGGACTTCGTATGCAGCGTTTGCAACAAAGCGTTCAGCACACAGCACAACCTGGAGGTGCACGGCGTGGTGCACTCGCGCGCGCGCCCGCACCGCTGTCCCCACTGCCCCAAGGGGTTCGCGCGCGCCGCCGAGCTCAGGGACCACTGCCGGACGCACACGGGCGAGCGTCCGTTCGCGTGCGACATGTGCAGCGCCACCTTCACGCAGCGCTCGAACCTGCACTCGCATCGCCGCGCCACGCACTTCGGCGAGAAGCCGCACCACTGCACACACTGCAACAAGCGGTTCAAGCGACGCCGTTTATTGGATTACCACATAAAGTCATCGCACACGGGCGAGCGCCCTCTGGAGTGCGAAGTGTGCTCTGCTACGTTCGTGTACCCGGAGCATTACAAGAAGCACATCCGCATTCACAGCGGCGAGAGGCCTTACAACTGCGAGATCTGCGGCAAGTCGTTCACGTCGCGCGACAACCGGAACACGCACCGGTTCGTGCACAGCGACAAGAAGCCGTACGAGTGCCTCGCGTGCGGCGCCGGGTACATGCGCAAGAACCTGCTCTACGCACACATGAAGTCCAGCGGCCACTTGGCTGAGTCGATTGTGGTGAATCAACCGAGAGTCGCAAAGAACGTTAACGGACAAGTATTAAACGTACAAAATATAGATAGTAAAAATTTCGATACGATATTTCCAACCGTCAGTCAATTGGAATTCGATGGGAATAAATTACAAAGCGACGATAAAAGTGAAATAACTGACGGAGCGGCGAAATATTTCATTGCACATAAGAACTTCTACATAGACGGTGCAACATCACTGGACAGTGAAAAAACTCAAGACCACACACTCCTGGAAACCGAAGACATGGCACAGATGGTCACCAGCGACGGTAACGGTGATATGGTACGACTCATACAGATCAAACTGCCCGACGGTAATAATGGATGGATGGCACTCAATAACTAG
Protein Sequence
MTNCFLCNIQMGVSPRNSINLFGENNIFRSGDKLHEVVSDIIERPLKVNAVHANVICKKCYSTCSEYDEMKTSLQSMKSEILKQFKASLNDQHISYDTYESDVKMKLTDKSDAVIIKKLSKKVVLPASKLQPLPPDFLLRVDRLTGLKSCSNIEKTKSITVTTVNASVTSSNGTSVQNKTVKPTYYLSTLANTLDERTDTKCSSQVMKNFTFATLTKDFVDDSEAVDEICDNEAGGDAVQDVDDDEEALKIDQDCAISVVPVTSASGDLVLEVQGIPAKSKATAKTDYVDVEMVRALDANVTSDGAESRDKFIFGKLEIINDVDEDDDNEHTIVFYDGNELSLMVPDENSQQDEEHLDNGDSHDSNDESQIELQVSGDEETANAIIAAAQEQGGAFIKVESGEMYRVQSVQSKTEDEVEEQQPLLMVEQEGERFKCLLCENSIKNGNKSESFLSDAETMMQHLKSEHDARLYICSICGILLRKRSDYTRHVRTEHKVRVSGGRAGVAAGGRGGRVHACGVCGRTYNSRTLLAEHANVHAGVRPHSCTRCRKSFASKYTLQAHLKTHSERPRPFKCSHCEKSFLTQQNLNQHEKTHSGVKDFVCSVCNKAFSTQHNLEVHGVVHSRARPHRCPHCPKGFARAAELRDHCRTHTGERPFACDMCSATFTQRSNLHSHRRATHFGEKPHHCTHCNKRFKRRRLLDYHIKSSHTGERPLECEVCSATFVYPEHYKKHIRIHSGERPYNCEICGKSFTSRDNRNTHRFVHSDKKPYECLACGAGYMRKNLLYAHMKSSGHLAESIVVNQPRVAKNVNGQVLNVQNIDSKNFDTIFPTVSQLEFDGNKLQSDDKSEITDGAAKYFIAHKNFYIDGATSLDSEKTQDHTLLETEDMAQMVTSDGNGDMVRLIQIKLPDGNNGWMALNN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00112707;
90% Identity
-
80% Identity
-