Basic Information

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 1e-51 5.4e-48 162.0 0.0 3 93 50 140 48 153 0.96

2 3 9.5e-18 4.9e-14 52.2 0.4 94 129 241 276 237 276 0.97

3 3 1.5e-18 7.6e-15 54.9 0.5 89 129 274 314 274 314 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	1e-51	5.4e-48	162.0	0.0	3	93	50	140	48	153	0.96
2	3	9.5e-18	4.9e-14	52.2	0.4	94	129	241	276	237	276	0.97
3	3	1.5e-18	7.6e-15	54.9	0.5	89	129	274	314	274	314	0.96

Coding Sequence: ATGTGTAGCACGCAGCGTGCGCGGGTGTCGAGGATGCACCTGACGGGCACCAGCAGTGGAGCCGTGTCGCCGGACACGAGCTCCACGCTGCTCCACGAGACCTATACGAAGATGACTTCGGACATTCTCGCTGAGCGGACGTTGGGAGAATTCTTATCGGAACATCCCGGCGAGCTGGTCCGAACGGGCAGCCCGCATTTCGTGTGCACAGTTTTACCACCTCACTGGCGATCGAACAAGACGCTACCGGTCGCTTTTAAGGTGGTAGCGTTAGGAGATGTCGGCGACGGTACAATGGTCACCGTCCGAGCAGGCAACGACGAGAACTGTTGTGCAGAGCTTAGAAACAGTTCAGCTGTGATGAAGAATCAGGTGGCGAAATTCAATGACTTGAGATTCGTCGGACGCAGCGGTCGCGGCCTTGTCAACCATAACGCGGCCGCAGCGACCGCCGACCCGGCGTGGTGGCTCGCTGGTCTACCAGGCCGGTTAGCCGCGATGGAAAACTACCATTTCATTTACGACCGCCCCTTGGTTTTCAGGTCAATTAGCGCTCAGGGCATTAGCAGGTTGTTCCGTCCGACATCGCTCAGTAATCACTGCGACTGCGACATGCCGAGGAGTGTATTTGACACCTGTCAAATTGGATTGCATCCAGCTATTAAGGGAATGTCGTCGTCAGCGCTGAGGCAGCGCGACGATAGCATAGGCTGGATATGTAAATCCTTTACGTTAACGATAACAGTCTCAACGACACCACCACAAGTGACGACCTACAACAAAGCTATCAAAGTTACCGTCGACGGACCAAGAGAACCCAGATCAAAAACCAGTAAATCCTTTACGTTAACGATAACGGTCTCAACGACACCACCACAAGTGACGACCTACAACAAAGCTATCAAAGTTACCGTCGACGGACCAAGAGAACCCAGATCAAAAACCAGTTAG
Protein Sequence: MCSTQRARVSRMHLTGTSSGAVSPDTSSTLLHETYTKMTSDILAERTLGEFLSEHPGELVRTGSPHFVCTVLPPHWRSNKTLPVAFKVVALGDVGDGTMVTVRAGNDENCCAELRNSSAVMKNQVAKFNDLRFVGRSGRGLVNHNAAAATADPAWWLAGLPGRLAAMENYHFIYDRPLVFRSISAQGISRLFRPTSLSNHCDCDMPRSVFDTCQIGLHPAIKGMSSSALRQRDDSIGWICKSFTLTITVSTTPPQVTTYNKAIKVTVDGPREPRSKTSKSFTLTITVSTTPPQVTTYNKAIKVTVDGPREPRSKTS

Sequence clustering based on sequence similarity using MMseqs2