Basic Information

Gene Symbol
-
Assembly
GCA_035772565.1
Location
JAQQSE010000171.1:286922-293139[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 0.0027 0.22 12.8 3.6 1 23 365 387 365 387 0.98
2 4 1.9e-05 0.0015 19.5 2.9 2 23 393 414 392 414 0.97
3 4 0.11 8.4 7.8 7.6 1 23 420 442 420 442 0.99
4 4 0.00073 0.058 14.6 1.0 1 23 449 472 449 472 0.95

Sequence Information

Coding Sequence
ATGTTTAGACTCTGCATCAATGCACATATGTTGGGAATGAGGCAGAATTTTCAGTTTCCAACAAGCCGAGCGCTCCGTCGCAAATGGCTCGATGCTATACAGATAACTGGAAAATTGACCGTCGATTCTGTAGTCTGTAGCGAGCACTTCCCGAAAACTGACTATGAGGTTGTCAGAGGGAAAGTCAGGTTGAAGAGGAAGGTGGTGCCAAGCATCTTTCAGAGGGATGAGgTGAAAAAACTTAACGgtgataataatgatattgATACAGAAACAGACAAAGCTCAGGATATGAAATGTTCAGGAAATACATCAGCGGCAGATAAAGACACTCCATCACACACGGAAATTCCCGCAATGAGGGTAGATAGAGAATTAGAAAAATCACAACACCCTAACTCTAGATTAGATAGCGAATCTAACATAGATAAGTCCACAAATGATATTAGTATGAATAAATCAGAAAAATGTTTGAACATAAATAATGAGGGTAGATCGAAAAACACACATACAAGATCGAGTCAGACAAATTATTTTGGTTGTGAAAGTATTGTAAAAGAATGCATCCAAACAGACATGACGTTAGATCCAGATCCTAGACAGGATATAGAGGAGATGATAACGAATTATCACATAAAGAACAAGCCGAATAAGCTGATGAGTCCACCGTGCCACGTGCCAGAACCTGTAGAGGTTGTCCAAGAGCCCAGGGTGGTGGAAACTGAACCGGTGTTTATAGAAGTCGCTGTCGGGAAAGATGGGAGAACATCAGAGGTGAACACTGGCAACAGAGACTGTCTTATGGTGCTGGAGAGCGTCCAAGTGGATATAGATCCATCGACCCTGATGTTGCCAGAGAGAGAAGAGGAatcagatgatgatgatgtagtgGAGGTCACCaaGAGGGAGGACCCAATAAGTCTACTAACATCAAGCGATGAGGACGAAGTCATCATCGAGGAGCCACAGATCGATACCGTTGAAGTCTCAGATGAAGACGAGGACGATATACCACTGGGGAGGCTCGCAAAGTTGAGGCCGGATGATGATAAATACCCAGACATTGCTAAGATAATGTGGGGCCTCTATGAATACTACTGCCTAAAATGCAAGTTTAACACGACGAACCGTTcagattacaacaaacacttgAAAGTCCACGGTATGGTGCTTCAAATGTGTCAGATATGCGGTTACACGACATCGAGCAAGAGCCAATTCACGAGGCACAAACGGAAACACCAAGACGAGAAACGATTCAAGTGTCACCTGTGCAGTTTCAAGTCGAGGCACCGGATGAGTCTCATTTACCATCTGAAGACCCACGATGGAGACAAGAAGCGATTCGCCTGCGGCGTGTGTAAATACGAGACGAGGAGACGGGCAGACCTGAAGAGGCACCAGTTCAGGTTACATGGGTTGGATAAAGATTTGGACAGTTATTGTGAAGTTTTATTTGTGTGGTTGAAAGTGATGTGGTGGTATCGCCAGACCTTTGTTCCTGTAATGTACCTGATGGCGAGTATAGTAATGCAATATAAGAACAACTGTGAACTACGACATCTCTACAATCTTGTTGTTCACCACTCGTATATATATCTGGTACCTTGTCTACAAATCAGATCATATATTATGTCTGATCCTGAGGCGTGA
Protein Sequence
MFRLCINAHMLGMRQNFQFPTSRALRRKWLDAIQITGKLTVDSVVCSEHFPKTDYEVVRGKVRLKRKVVPSIFQRDEVKKLNGDNNDIDTETDKAQDMKCSGNTSAADKDTPSHTEIPAMRVDRELEKSQHPNSRLDSESNIDKSTNDISMNKSEKCLNINNEGRSKNTHTRSSQTNYFGCESIVKECIQTDMTLDPDPRQDIEEMITNYHIKNKPNKLMSPPCHVPEPVEVVQEPRVVETEPVFIEVAVGKDGRTSEVNTGNRDCLMVLESVQVDIDPSTLMLPEREEESDDDDVVEVTKREDPISLLTSSDEDEVIIEEPQIDTVEVSDEDEDDIPLGRLAKLRPDDDKYPDIAKIMWGLYEYYCLKCKFNTTNRSDYNKHLKVHGMVLQMCQICGYTTSSKSQFTRHKRKHQDEKRFKCHLCSFKSRHRMSLIYHLKTHDGDKKRFACGVCKYETRRRADLKRHQFRLHGLDKDLDSYCEVLFVWLKVMWWYRQTFVPVMYLMASIVMQYKNNCELRHLYNLVVHHSYIYLVPCLQIRSYIMSDPEA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00114157;
90% Identity
iTF_00112572;
80% Identity
iTF_00112572;