Amun032774.1
Basic Information
- Insect
- Anorthoa munda
- Gene Symbol
- Ets97D
- Assembly
- GCA_945859655.1
- Location
- CAMAOM010000773.1:190709-193828[+]
Transcription Factor Domain
- TF Family
- ETS
- Domain
- Ets domain
- PFAM
- PF00178
- TF Group
- Helix-turn-helix
- Description
- Transcription factors are protein molecules that bind to specific DNA sequences in the genome, resulting in the induction or inhibition of gene transcription [3]. The ets oncogene is such a factor, possessing a region of 85-90 amino acids known as the ETS (erythroblast transformation specific) domain [3, 5, 4]. This domain is rich in positively-charged and aromatic residues, and binds to purine-rich segments of DNA. The ETS domain has been identified in other transcription factors such as PU.1, human erg, human elf-1, human elk-1, GA binding protein, and a number of others [3, 5, 2]. It is generally localized at the C terminus of the protein, with the exception of ELF-1, ELK-1, ELK-3, ELK-4 and ERF where it is found at the N terminus. NMR-analysis of the structure of the Ets domains revealed that it contains three α-helices (1-3) and four-stranded β-sheets (1-4) arranged in the order α1-β1-β2-α2-α3-β3-β4 forming a winged helix-turn-helix (wHTH) topology [1]. The third α-helix is responsive to contact to the major groove of the DNA. Different members of the Ets family proteins display distinct DNA binding specificities. The Ets domains and the flanking amino acid sequences of the proteins influence the binding affinity, and the alteration of a single amino acid in the Ets domain can change its DNA binding specificities.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 18 4.5e-10 1.8e-06 29.3 0.2 50 77 1 28 1 32 0.96 2 18 1.2e-10 4.9e-07 31.1 0.4 49 77 38 66 29 70 0.91 3 18 1.2e-10 4.8e-07 31.1 0.3 49 77 76 104 67 108 0.91 4 18 1.2e-10 4.8e-07 31.1 0.3 49 77 114 142 105 146 0.91 5 18 1.2e-10 4.8e-07 31.1 0.3 49 77 152 180 143 184 0.91 6 18 1.2e-10 4.8e-07 31.1 0.3 49 77 190 218 181 222 0.91 7 18 1.2e-10 4.8e-07 31.1 0.3 49 77 228 256 219 260 0.91 8 18 1.2e-10 4.7e-07 31.2 0.3 49 77 266 294 257 298 0.91 9 18 1.2e-10 4.8e-07 31.1 0.3 49 77 304 332 295 336 0.91 10 18 1.2e-10 4.8e-07 31.1 0.3 49 77 342 370 333 374 0.91 11 18 1.2e-10 4.8e-07 31.1 0.3 49 77 380 408 371 412 0.91 12 18 1.2e-10 4.9e-07 31.1 0.4 49 77 418 446 409 450 0.91 13 18 1.2e-10 4.9e-07 31.1 0.4 49 77 456 484 447 488 0.91 14 18 1.3e-10 5.3e-07 31.0 0.4 49 77 494 522 486 526 0.92 15 18 1.2e-10 4.7e-07 31.2 0.3 49 77 532 560 523 564 0.91 16 18 1.2e-10 4.8e-07 31.1 0.3 49 77 570 598 561 602 0.91 17 18 1.2e-10 4.8e-07 31.1 0.3 49 77 608 636 599 640 0.91 18 18 1.6e-13 6.6e-10 40.3 1.1 49 81 646 678 637 678 0.94
Sequence Information
- Coding Sequence
- ATGAACTACGAGAAGCTGAGCCGCGCGCTGCGCTACTACTACGACGGAGACATGATCGCCAAGGTGTCCGGCAAGAGGTGCGTACTGTACTGTGTCACATGTGTACCGTACCGCATGAACTACGAGAAGCTGAGCCGCGCGCTGCGCTACTACTACGACGGAGACATGATCGCCAAGGTGTCCGGCAAGAGGTGCGTACTGTACTGTGTCACATGTGTACCGTACCGCATGAACTACGAGAAGCTGAGCCGCGCGCTGCGCTACTACTACGACGGAGACATGATCGCCAAGGTGTCCGGCAAGAGGTGCGTACTGTACTGTGTCACATGTGTACCGTACCGCATGAACTACGAGAAGCTGAGCCGCGCGCTGCGCTACTACTACGACGGAGACATGATCGCCAAGGTGTCCGGCAAGAGGTGCGTACTGTACTGTGTCACATGTGTACCGTACCGCATGAACTACGAGAAGCTGAGCCGCGCGCTGCGCTACTACTACGACGGAGACATGATCGCCAAGGTGTCCGGCAAGAGGTGCGTACTGTACTGTGTCACATGTGTACCGTACCGCATGAACTACGAGAAGCTGAGCCGCGCGCTGCGCTACTACTACGACGGAGACATGATCGCCAAGGTGTCCGGCAAGAGGTGCGTACTGTACTGTGTCACATGTGTACCGTACCGCATGAACTACGAGAAGCTGAGCCGCGCGCTGCGCTACTACTACGACGGAGACATGATCGCCAAGGTGTCCGGCAAGAGGTGCGTACTGTACTGTGTCACATGTGTACCGTACCGCATGAACTACGAGAAGCTGAGCCGCGCGCTGCGCTACTACTACGACGGAGACATGATCGCCAAGGTGTCCGGCAAGAGGTGCGTACTGTACTGTGTCACATGTGTACCGTACCGCATGAACTACGAGAAGCTGAGCCGCGCGCTGCGCTACTACTACGACGGAGACATGATCGCCAAGGTGTCCGGCAAGAGGTGCGTACTGTACTGTGTCACATGTGTACCGTACCGCATGAACTACGAGAAGCTGAGCCGCGCGCTGCGCTACTACTACGACGGAGACATGATCGCCAAGGTGTCCGGCAAGAGGTGCGTACTGTACTGTGTCACATGTGTACCGTACCGCATGAACTACGAGAAGCTGAGCCGCGCGCTGCGCTACTACTACGACGGAGACATGATCGCCAAGGTGTCCGGCAAGAGGTGCGTACTGTACTGTGTCACATGTGTACCGTACCGCATGAACTACGAGAAGCTGAGCCGCGCGCTGCGCTACTACTACGACGGAGACATGATCGCCAAGGTGTCCGGCAAGAGGTGCGTACTGTACTGTGTCACATGTGTACCGTACCGCATGAACTACGAGAAGCTGAGCCGCGCGCTGCGCTACTACTACGATGGAGACATGATCGCCAAGGTGTCCGGCAAGAGGTGCGTACTGTACTGTGTCACATGTGTACCGTACCGCATGAACTACGAGAAGCTGAGCCGCGCGCTGCGCTACTACTACGACGGAGACATGATCGCCAAGGTGTCCGGCAAGAGGTGCGTACTGTACTGTGTCACATGTGTACCGTACCGCATGAACTACGAGAAGCTGAGCCGCGCGCTGCGCTACTACTACGACGGAGACATGATCGCCAAGGTGTCCGGCAAGAGGTGCGTACTGTACTGTGTCACATGTGTACCGTACCGCATGAACTACGAGAAGCTGAGCCGCGCGCTGCGCTACTACTACGACGGAGACATGATCGCCAAGGTGTCCGGCAAGAGGTGCGTACTGTACTGTGTCACATGTGTACCGTACCGCATGAACTACGAGAAGCTGAGCCGCGCGCTGCGCTACTACTACGACGGAGACATGATCGCCAAGGTGTCCGGCAAGAGGTGCGTACTGTACTGTGTCACATGTGTACCGTACCGCATGAACTACGAGAAGCTGAGCCGCGCGCTGCGCTACTACTACGACGGAGACATGATCGCCAAGGTGTCCGGCAAGAGGTTCGTGTACAAGTTCGTGTGCGACCTGCGCCAGCTGCTGGGCTACGGCGCCGGCGAGCTGGCCGAGCTGGTCAAGGAGGTGCACGACGCGCGCCCCGCCATGGACAACAAGATGCTCTTCTGA
- Protein Sequence
- MNYEKLSRALRYYYDGDMIAKVSGKRCVLYCVTCVPYRMNYEKLSRALRYYYDGDMIAKVSGKRCVLYCVTCVPYRMNYEKLSRALRYYYDGDMIAKVSGKRCVLYCVTCVPYRMNYEKLSRALRYYYDGDMIAKVSGKRCVLYCVTCVPYRMNYEKLSRALRYYYDGDMIAKVSGKRCVLYCVTCVPYRMNYEKLSRALRYYYDGDMIAKVSGKRCVLYCVTCVPYRMNYEKLSRALRYYYDGDMIAKVSGKRCVLYCVTCVPYRMNYEKLSRALRYYYDGDMIAKVSGKRCVLYCVTCVPYRMNYEKLSRALRYYYDGDMIAKVSGKRCVLYCVTCVPYRMNYEKLSRALRYYYDGDMIAKVSGKRCVLYCVTCVPYRMNYEKLSRALRYYYDGDMIAKVSGKRCVLYCVTCVPYRMNYEKLSRALRYYYDGDMIAKVSGKRCVLYCVTCVPYRMNYEKLSRALRYYYDGDMIAKVSGKRCVLYCVTCVPYRMNYEKLSRALRYYYDGDMIAKVSGKRCVLYCVTCVPYRMNYEKLSRALRYYYDGDMIAKVSGKRCVLYCVTCVPYRMNYEKLSRALRYYYDGDMIAKVSGKRCVLYCVTCVPYRMNYEKLSRALRYYYDGDMIAKVSGKRCVLYCVTCVPYRMNYEKLSRALRYYYDGDMIAKVSGKRFVYKFVCDLRQLLGYGAGELAELVKEVHDARPAMDNKMLF
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -