Basic Information

Gene Symbol
-
Assembly
GCA_000390285.2
Location
NW:2352-7521[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 9.7 3e+02 1.9 0.1 1 17 238 254 238 255 0.81
2 13 0.0004 0.012 15.7 3.8 1 23 269 291 269 291 0.99
3 13 0.2 6 7.3 4.5 1 23 300 322 300 322 0.98
4 13 0.0015 0.045 13.9 2.8 1 23 331 353 331 353 0.99
5 13 0.0028 0.087 13.0 5.6 2 23 363 384 362 384 0.97
6 13 0.0037 0.11 12.7 3.2 1 23 393 415 393 415 0.99
7 13 0.00062 0.019 15.1 3.3 1 23 424 446 424 446 0.99
8 13 0.74 23 5.4 6.0 1 23 455 477 455 477 0.97
9 13 0.00033 0.01 16.0 1.4 1 23 486 508 486 508 0.98
10 13 0.0023 0.071 13.3 3.5 1 23 517 539 517 539 0.98
11 13 0.00072 0.022 14.9 5.1 1 23 548 570 548 570 0.99
12 13 0.0011 0.033 14.4 3.1 1 23 579 601 579 601 0.98
13 13 0.00013 0.0039 17.3 3.0 1 23 610 632 610 632 0.98

Sequence Information

Coding Sequence
ATGGATAAACAATCTTGCATTAAAATTGAAGAGATGAAAATAAAACTGGAAGAAGATGGGCAAGACACAGgggagaaatataaaaatggtGATACCCCATCTTACATTGAAACCGTGGGGACTGAAATAAAAGTGGAAAATGGTCAGTATGGGCGTGAGAACTATGAAAATGTTGGTATGCAGTTTGATATTAAATCTGAAGATATCGAAATAAAACTGGAAGGAGATGGTTCGGATGCACTggagataaataaatatgttgataaGCAGTGCTACATTAAGATTGAAGACATTGAAAAAGAGCTGGAGAACAGTCAAAATGTTCAggaaaaatgtaaaagttttgaaaatcaGCCGTATATTAAATCTGAAGAGATTGAAATAAAAGATGCTCGTAGAAGtcaTTCCCCTTCATACGACTTTGATGAtgaaacaattgaaaataaaaggcaccatatttcagaaaatacagGAGAAATAAAGAATGAACACATGATTAAATGTATGACTggatttaatgaaaatgttacgACATTGACGTCTGTTCACAATATTGAAATACACAAAAGTGAAAAGTTTAGATTTCAAAAGCTTGGGCCCTCATTAGATGAACAATTCTACCAATGTGataattgtaaatttgaaaCTAAACTTAAGGCAACTCTGGACAGCTATCGATTCCTACAGGATGACCCCTCCATAGtgcaaatgtacaagtgtgatgcCTGTGGTTATGAAACCAACTACGGGAGAAATTTGATTAGGTATCGCACAATAAATATAGACCTTTCAGAAGTGAGATTGTACAAGTGTGATACATGTAGTTATGAAACTCGACAAAAAGGTCATCTGAAAATGCATCAATTAACTCACAAAGATTCTtcagaaatccaaatgtacaagtgtaatacATGcagttatgaaactaaatacctTAAATGTTTAAGAATGCATCTGTTATTACACAAAGACCGTTCGGAAATCCAAATGTATAAATGTGATGTTTGCctttacgaaactaaatacaagggtCATCTTAAATCGCATCAGATAACGCACAAAGACCCTTCAGAAATCCAAATGTGGAAGTGTGAAGTGtgtaattttgaaactaaacatAAGAATCACTTGAAAAGACATCAGTTATCGCACAAAGACCCTTCGGAAATCCAGATGTACAGATGTGATATGTGCAATTATGAAAGTAAACATAAGATTGGTCTCAAAACGCATCGATTAACTCACAAGGACCCTTCAGAAAGTAAAACGTACAAGTGTGAGAAGTGTAGTTATACAACTGATTTTAAAAGCAGTTTAAATACGCATCAGTTAAAACACAAAGATTCGTGGGAAGTCCAGATGCACAAGTGTGATACATGTgcttatgaaactaaatataagagccatataaataaacataaattgtcACACAAAGACCCTtcagaaatccaaatgtacacCTGTGATACTTGTacttatgaaactaaatataaaagcGATCTAAACGTGCATCAGTTATCACATAAAGACCCTTCAGAAGTCAAGATGTTTAGGTGTGAAACGTGTAgttttgaaactaaaaataagAGTCGTTTGAAAAGGCACCAGTTATCGCACAAAGACCCatcagaaattaaaatgtacaagtgtgatacttgcagttacaaaactaaatataaggAACATCTGAAAGTTCATCAGTTAACACACAAAGATCCTTcggaaatccaaatgtacaaatgtgatacaTGCAGTtacaaaactaattttaaaagcaGTTTAAAAACACATCAGTTAATACACAAAGAGCCTTCAcaaatccaaatgtacaagtgtgatacttgtacttacaaaactaaatataaaagtgATCTAAATAAACACCAGTTAATACACAAAGACTGA
Protein Sequence
MDKQSCIKIEEMKIKLEEDGQDTGEKYKNGDTPSYIETVGTEIKVENGQYGRENYENVGMQFDIKSEDIEIKLEGDGSDALEINKYVDKQCYIKIEDIEKELENSQNVQEKCKSFENQPYIKSEEIEIKDARRSHSPSYDFDDETIENKRHHISENTGEIKNEHMIKCMTGFNENVTTLTSVHNIEIHKSEKFRFQKLGPSLDEQFYQCDNCKFETKLKATLDSYRFLQDDPSIVQMYKCDACGYETNYGRNLIRYRTINIDLSEVRLYKCDTCSYETRQKGHLKMHQLTHKDSSEIQMYKCNTCSYETKYLKCLRMHLLLHKDRSEIQMYKCDVCLYETKYKGHLKSHQITHKDPSEIQMWKCEVCNFETKHKNHLKRHQLSHKDPSEIQMYRCDMCNYESKHKIGLKTHRLTHKDPSESKTYKCEKCSYTTDFKSSLNTHQLKHKDSWEVQMHKCDTCAYETKYKSHINKHKLSHKDPSEIQMYTCDTCTYETKYKSDLNVHQLSHKDPSEVKMFRCETCSFETKNKSRLKRHQLSHKDPSEIKMYKCDTCSYKTKYKEHLKVHQLTHKDPSEIQMYKCDTCSYKTNFKSSLKTHQLIHKEPSQIQMYKCDTCTYKTKYKSDLNKHQLIHKD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-