Basic Information

Gene Symbol
-
Assembly
GCA_000390285.2
Location
NW:330480-333621[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.016 0.5 10.7 8.4 1 23 222 244 222 244 0.99
2 16 0.91 28 5.1 0.6 2 23 254 275 253 275 0.96
3 16 0.0024 0.072 13.3 0.4 2 23 285 306 284 306 0.96
4 16 0.7 22 5.5 5.2 3 23 317 337 317 337 0.98
5 16 0.023 0.7 10.2 4.0 1 23 346 368 346 368 0.99
6 16 0.00074 0.023 14.9 4.2 1 23 377 399 377 399 0.98
7 16 0.0032 0.098 12.9 3.4 1 23 408 430 408 430 0.97
8 16 0.013 0.41 10.9 2.5 2 23 440 461 439 461 0.97
9 16 0.0033 0.1 12.8 1.6 1 23 470 492 470 492 0.99
10 16 4.1e-05 0.0012 18.8 2.1 1 23 501 523 501 523 0.99
11 16 0.00018 0.0054 16.8 2.2 1 23 532 554 532 554 0.99
12 16 0.038 1.2 9.5 4.8 2 23 564 585 563 585 0.97
13 16 0.0056 0.17 12.1 1.4 1 23 594 616 594 616 0.98
14 16 8.3e-05 0.0025 17.9 1.8 1 23 621 643 621 643 0.99
15 16 0.0018 0.054 13.7 1.2 2 23 679 700 678 700 0.96
16 16 0.0022 0.066 13.4 2.7 1 23 709 731 709 731 0.99

Sequence Information

Coding Sequence
ATGGACACCGAGGACAGCATTTATCCTTATGTTAATTCTGAAACTGAGGCTCCCGTCGATTTAAGAGACATTTATCTAAAGTCAAGAGATAAAGAACATTTGAAGGATGTATTGGAAGACGAAAAGATTTGTCGTTTGTGTATGCAAGTAGTCACCTGTGGATTTACGCCAGTAAAAGAAGTGGATGCCGATACACTCCTTCAATATATTCCTGAAGTGAACTTGACTTCCATTACAGAACCCATTATATGCAAAGTATGTATCGATTCGTTGGACACCCACACGAGTTTCTTAAAAGGCTGTTTAGATTTGGAAGAggcaattaaaaatatgtctgATGACAAATCCGTACAAAGTCCACTCCATATTATCAAAGAAGAGATTGAAATAAAATCTGAAGATTATTTAGGTTCCCCCTCGGAAGATGAACTCCTTGAACGCTCAAGTGACTGCCGATCTGAAAATGCGGGGATCACAAATAATTCTAAGCGGAAGCGTAAAAGGAAGCGATGTTTGTCAAAGAACAACAACCGTCACTTGAAAAGCACGAATTCATCTGAAAAGCTAATACATAAATGTGATTTCTGTGATTATAGGACCGGTCGAGATAAACTTCTTACCTGTCACCTTCTACAACACAAAGACATCTCCGAAGAGCAGATGTTTAAATGTCATTCGTGCAATTTTAAAACTATGCGTAAACAATATCTTAAACGACATCAGCGAAGGCACAAAATTGTCCCGGAGGAGCAGATGTTGAAGTGTGACTCCTGCGATTATAAAACCGGTCAAAGGAAAATTCTTATCCGTCATGTTCTACGGCACAAAAACATCCCCGAAGAGCAGATGTTGAGATGCAATGTCTGTGATTACAAAACCGGTGACGGGTATCAACTCAAACGTCATCAATTAATACACATAGACGTCCCGGAAGAGGAGATGTTGGGATGCGATTTCTGTGATTACAAAACTGCTGATAAGCATTGCGTCAGACGCCATCAGATAAGACACAAAGACATCCCCGCAGAGCAAATGTATAGATGCGATTCTTGTGATTATAAGACCATTTATAGGCACGGCCTTAGAATCCATAAACGGAAACACACAGGCGTCCCCGAAGAGCAGATGTTCAGATGTGATATCTGTGATTACAAAACCGGTGATAAGTATTGCCTGAAGCGTCATCAATTAAAACACAAAGACATCCCTGCGGAAAAGATGTATAAATGCAATTCCTGTGATTATAAAACCATTTATAAGGAAAGCCTTAAACGACATCAGTTTCAACACAAAGACTTCCTCGGAGAGAAGATACTGAAATGTCATTTGTGCGATTATAAAGCCATTGATAAGAAAAGTTTTACAGTTCACCAGCTCAAACACAAAAACATTCCTGTAGAGCAGATGTACAAATGTCAATCGTGCGATTATAAAACCATTTTTGAGCCCTATCTTACAAAACATCAGCGAGTTCACAAAAACATTCCCGAAAATCGCAAATATAAATGTGATATGTGTGACTTTAAAACGGTCTATAAAGGCAATCTTAAAAAACATCAACTGACACATGAAAATGTTCCcaaagaacaaaaatataaatgtgaTATGTGTGATTTTAAAACGGCTTATAAATCCAGTCTTAAAGATCATCAGATGAAACACAAAGTCATCCCGGAAGAGCAGATGTTGAAATGTCATTCGTGCGATTACAAAACCGTTTATAAGAAGAATTTTACACTCCACCAGCTCAAACACAAAAACATTCCTGTAGAGCAGATGTACAAATGTCAATTGTGCGATTATAAAACCATTTTTGAGCCCTATCTTACAAAACATCAGATTAGACACAAAAAACGGAAATATAAATGTGATATGTGTGATTTTAAAACGGTCTATAAAGGCAATCTTAAAACACATCAACTGACACACAAAAATGTTCCCAAAgaacgaaaatataattttaaaacgacTTATAAATGCAGTCTTAAAGATCGTCAGCCGAGACACAAAGACATCCCCGAAAAGCAGATGTTGAAATGTTATTCGTGCAATTACAAAACCAGTCGAAAGGATCAGCTTGCACAACATCAATTAATACACAAAGTCATCTCAGAGGTGCAATTCTATAAATGCAATTCGTGCGATTATAAAACCGTTGATAAGTATCGTCTTACGCAACATCAACTCAGGCACAAAGACATCCTGTAG
Protein Sequence
MDTEDSIYPYVNSETEAPVDLRDIYLKSRDKEHLKDVLEDEKICRLCMQVVTCGFTPVKEVDADTLLQYIPEVNLTSITEPIICKVCIDSLDTHTSFLKGCLDLEEAIKNMSDDKSVQSPLHIIKEEIEIKSEDYLGSPSEDELLERSSDCRSENAGITNNSKRKRKRKRCLSKNNNRHLKSTNSSEKLIHKCDFCDYRTGRDKLLTCHLLQHKDISEEQMFKCHSCNFKTMRKQYLKRHQRRHKIVPEEQMLKCDSCDYKTGQRKILIRHVLRHKNIPEEQMLRCNVCDYKTGDGYQLKRHQLIHIDVPEEEMLGCDFCDYKTADKHCVRRHQIRHKDIPAEQMYRCDSCDYKTIYRHGLRIHKRKHTGVPEEQMFRCDICDYKTGDKYCLKRHQLKHKDIPAEKMYKCNSCDYKTIYKESLKRHQFQHKDFLGEKILKCHLCDYKAIDKKSFTVHQLKHKNIPVEQMYKCQSCDYKTIFEPYLTKHQRVHKNIPENRKYKCDMCDFKTVYKGNLKKHQLTHENVPKEQKYKCDMCDFKTAYKSSLKDHQMKHKVIPEEQMLKCHSCDYKTVYKKNFTLHQLKHKNIPVEQMYKCQLCDYKTIFEPYLTKHQIRHKKRKYKCDMCDFKTVYKGNLKTHQLTHKNVPKERKYNFKTTYKCSLKDRQPRHKDIPEKQMLKCYSCNYKTSRKDQLAQHQLIHKVISEVQFYKCNSCDYKTVDKYRLTQHQLRHKDIL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-