Basic Information

Gene Symbol
ZEB2
Assembly
GCA_013141755.1
Location
CM023249.1:22139755-22141294[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.97 56 4.3 0.5 2 23 182 208 181 208 0.88
2 9 0.00011 0.0063 16.7 1.5 2 23 239 261 238 261 0.91
3 9 0.029 1.7 9.1 3.8 3 23 272 292 270 292 0.94
4 9 0.028 1.6 9.1 0.3 2 23 296 317 295 317 0.90
5 9 1.8e-05 0.001 19.2 0.5 1 23 324 346 324 346 0.98
6 9 4.3e-05 0.0025 18.0 2.4 2 23 356 378 355 378 0.97
7 9 0.018 1 9.8 2.6 1 23 385 408 385 408 0.97
8 9 1.4e-05 0.00081 19.5 0.3 1 23 413 436 413 436 0.90
9 9 0.00041 0.024 14.9 2.7 1 23 442 465 442 465 0.98

Sequence Information

Coding Sequence
ATGCGTGAAAAGTGTCGATTATGTCTCGGTACCATCAGTGCTCGGAAAGGATGTTCCATATCGGACGATAAAATCAGCCCCATCTTGtgtaaagtgttttattttccgCTTTCTCGAACCGAGCCCAACTTGCCCACAAAAGTATGTCCACGATGTGTGACAACGGTACGCGACTTCAGCGAGTTCAGCGAAGAGGTGCGTAACAATCAGGAGATCCTACTGCAAGCGTGTGTGAAAAGAGAGAACAACGATCCGGACGATGCAGACCATCAAGAAGATCCGTCCGAACCCGATAACGTCAGTGAGCATCACCCCTTAATAGAGGACGTTGAAGTAACGTTGGATGATGGGGAAGATTCACTGTCATCGGAAGATGTACAAGACACTGTAGCAAAGCTTAATTTGCCAGCGGAAaccgaaaagcaaaagcaCACCGAACGAACAGATGGTAGGGATGAAGCAACCGAGCCCAACCCCGGCCCGGATTCGGAGCAACGCGAACTGCATGAGAATGATCGTATAATACGGGAGTTTTTCACGATGCGCTGTGAGCTGTGCCCGGCCAAGACGGAGCAACAGTTCGATCGGTTCTTTGCGCTCCAGCTACACTACCGCAAGCAGCACCAGTGCCGCGGATTTTTACGCTGCTGTGGCAAACAGCTGTACCGACGGTTTCGCGTAATGGAACACATCGCCTCGCACCGTGGAACGATCCGTTGCGAGCTGTGCGATAGAACGTTTAAAAGCAAACGCTACCTGCTGCACCACGTGGCCGAGCAGCACGTTGACGCGCAGCAAAGCAAATCGTTCGGCTGTGAACACTGTGATAAGACGTTTCACACGAAACGGCAACGGGATGCGCATCGGATTGCGCACGAAATTACCGTATGTAAGCTGTGCGGGAAAACGGTCAACAGTCGGTACATTAAGAAACATATCGCACAGGTACACGACGCACCCACGCCTGCGTACATGTGCGATCTGTGTGGGAAGAACTTTTCCACCAGCATGGTGCTGGATCGGCACATCAAGCAGCATCGGGGCATCGAAACGGTTGAGCTGGTACAGTGCGTGCACTGTGGCAAGCGGCTACGGGGGAAGTACAATATGCAGAGGCACATGCAGCGTATGCATCTGGAAGTGGACCGGGTGCATCGGTGCGATGTGTGTGGACACGACAGCCCGAACAGTATTGCGCTCGAGCATCACAAGAAGCGGGTCCACTCGGGCGATCAGTTTGCGTGCGACCAGTGTGGGAAGCGGTTTAAGCGGAAAATCTATCTAACGGAGCACGTGGCAGCGCTGCACACCCGGATGCCGCTGTACAAGTGCGAGTTTTGTGAGGCCACGTTTAACTCGAAGGCTAACTACTACAGCCACCGGAAGTCGCGCCACACGGAAGAGTGGGAAACGTTGCgggaggagaaggaaaggaaggaagcgaaAGGGTTGGCGGACGGAGTGTAG
Protein Sequence
MREKCRLCLGTISARKGCSISDDKISPILCKVFYFPLSRTEPNLPTKVCPRCVTTVRDFSEFSEEVRNNQEILLQACVKRENNDPDDADHQEDPSEPDNVSEHHPLIEDVEVTLDDGEDSLSSEDVQDTVAKLNLPAETEKQKHTERTDGRDEATEPNPGPDSEQRELHENDRIIREFFTMRCELCPAKTEQQFDRFFALQLHYRKQHQCRGFLRCCGKQLYRRFRVMEHIASHRGTIRCELCDRTFKSKRYLLHHVAEQHVDAQQSKSFGCEHCDKTFHTKRQRDAHRIAHEITVCKLCGKTVNSRYIKKHIAQVHDAPTPAYMCDLCGKNFSTSMVLDRHIKQHRGIETVELVQCVHCGKRLRGKYNMQRHMQRMHLEVDRVHRCDVCGHDSPNSIALEHHKKRVHSGDQFACDQCGKRFKRKIYLTEHVAALHTRMPLYKCEFCEATFNSKANYYSHRKSRHTEEWETLREEKERKEAKGLADGV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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