Basic Information

Insect: Anopheles stephensi
Gene Symbol: zfh1
Assembly: GCA_013141755.1
Location: CM023250.1:402747-416781[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.6 35 4.9 0.3 2 23 53 75 52 75 0.94

2 9 6.4e-05 0.0037 17.4 1.9 1 23 248 270 248 270 0.95

3 9 0.00012 0.0071 16.5 1.5 2 23 277 298 277 298 0.97

4 9 1.6e-05 0.00094 19.3 7.1 1 23 307 329 307 329 0.99

5 9 1.8e-05 0.0011 19.1 0.8 1 21 335 355 335 356 0.95

6 9 0.88 51 4.4 0.1 2 21 768 787 767 788 0.91

7 9 2.4e-05 0.0014 18.8 4.0 1 23 1235 1257 1235 1257 0.95

8 9 0.00012 0.0069 16.6 7.8 1 23 1263 1285 1263 1285 0.98

9 9 0.065 3.8 8.0 7.0 1 21 1291 1311 1291 1312 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.6	35	4.9	0.3	2	23	53	75	52	75	0.94
2	9	6.4e-05	0.0037	17.4	1.9	1	23	248	270	248	270	0.95
3	9	0.00012	0.0071	16.5	1.5	2	23	277	298	277	298	0.97
4	9	1.6e-05	0.00094	19.3	7.1	1	23	307	329	307	329	0.99
5	9	1.8e-05	0.0011	19.1	0.8	1	21	335	355	335	356	0.95
6	9	0.88	51	4.4	0.1	2	21	768	787	767	788	0.91
7	9	2.4e-05	0.0014	18.8	4.0	1	23	1235	1257	1235	1257	0.95
8	9	0.00012	0.0069	16.6	7.8	1	23	1263	1285	1263	1285	0.98
9	9	0.065	3.8	8.0	7.0	1	21	1291	1311	1291	1312	0.96

Sequence Information

Coding Sequence: ATGGTGTCCTGCAGCGTTGCTGTGTCGACGTACTACAACGTGGAAGAAAGTATCATGCCATCTTCGACCAAGTTTTCCCTGCAATTTCCTTCCTTGCCATCCGGATTACCGAAGGACAGTGAAAACGATGCACTAGCGGACGGCGATTGCTGCGTTCAGTGCTCTCAGTGCCACCAGACGGTTCAGGGAATCGAGGCGCTGAAAGAACACATTCAGCTTAATCATAGCAGTGGTCCAGAAGGCCCGAGAGCAAAGTTCTCGAACGATACAGCCGAACcggacggcgacgacgacgaagaagacgacgacgatcagAACGACAACATCATGGCGGAGGAGGACGAACATCACGTCGATCCGGACGCAGCCTCACCACCACCTGCCGCTCCCCCAGAGCCACCGGTGACCAGCGCGGTGGGAAGCCGTGCCAGCGGTGATCTGATCGGTAGCCGTCTGCAAGCGAAGTGCGTCAGCTTgctccagctccagcagcaaaaacatcAAGCCTCGGTAAAGGCGCTAGACGACGAGCCGGAAGATGACGACGACCCAGAGGTACCGTCCGGTACGACTCCACGGGATCTACTTATGGCGGGTTTGACACCGCAAACCGTAGCGGACAACCTACCGTATGGTCCACGTTCCATGGTGATTAGCCCGGCCCAGGACGGCAGCAGTAATTCCAGCAGCGGACCCAGCTTACCAACCGGCGGCACAGTTAAGGACACTGATCTAGCGGTGTACGACTGTTCCCAGTGTCCGACCACATTCACTAGCCGGGATCAGCTGGAACGTCACGAGTTGCATCATCCACCATCGGCAGATGCGAGTTGCAAGGTGTGTCACAAACCGTTTGCCAACGTTTACCGACTCCAGCGCCACATGATCTCCCACGACGAATCGTTGCAACGGCGCAAGTTCAAATGCAACGAATGTGATAAAGCGTTCAAATTCAAGCACCATCTGAAGGAGCACAAACGTATCCATTCGGGCGAGAAACCGTTTGTCTGCCCCAACTGTGGCAAGCGCTTCTCGCACTCCGGCTCCTACTCGAGCCACATGACCTCGAAGAAGTGCATCAACATGGGCATTAGGCTCAaccacaacaataacaacaacaatagcagcagccacaacaacaacaatagcaCTAGCCTCAACAATAACAGTTCAAACAATAGTGGCAGCGGCAGTGACAGTAATCATCGATCACCACAGTATCCTTTCCATGCTGGTAACGGGTTGACAGGACTACCGAACGGACATGCCATTAGCACCGGAGGACTAGGCCGTTCGCCTATTAGCTTGCGACCACAGCACGGCGTAAGTGCGCTGCATCGCGATCTAGACATAGCTAGTCGGCTCGGGCTAGTCACCTCACCGTCTCCAACGTCGTCCTGCTCGTCGGCGACCAAGCACGAGCTGGACACGATCGGACAGCCGGGAGTAGACGCACTGCTGCTCACCAAGATACAGCAAGCGTCACTACTCGCGTACTCGTTCGCCATGCTCGATCCGAACATGTTGCGTCTGTTTGATTTCTCAGCCGCTGCCCAACACCAGCCGCAACAATCGTCGGCGAGTACCGAAACGCAGGAACCAATGGACGATGGTCAGCAGCGACCCGCTTCGCCGACCGGCGATGAAGACGTGCAGCAGCGACCTGAATCGGCAAAGCGACCAGCATCTTCGTCCATCGGTGTGGACGCCATCACAATGGCGCAAAACACTGCCGACGACACCCAGCAACCGAACCCGTCCGACACCGAGCGCATGGAGGTCGATGATGAGCAGGAGGAGAGCTGTGCTGTGGAGAAGGTAGAGGTGGTGATGGCATCCTGCCCAGACAGTGTACAACCTCATCTCACACCCTTTCACGATGAGGAAGACAAGCAGCGAGCTAGCACCACTTCTAGCAGTATCCATACCAGTGAACAGGTCGAGGCATCGCAACAGCCACCGAATGCGAATGACGACACCGAAAGCAAGCACGGTTTGCCAATACTtcccaagcaagaaccaccaGAGGAAGTGCCACAGGATTCCATACGTTCCAGCACGAGTGCAGAAACAACGCACCACGAATTGCGTGCATCAGCCGACCGCAGATTGAACAGTGACGGTGGCTATGACGCCCCAGGTGACAAACCTATCGTGAAAGACGAGCCGTCCGAGGAGGAGATCGGTATCGATCAGATTGAAATGGTCGAACTCAAGTTAACCGATCGTGACGACCGGCTGCACTTCTCCTCACCCTCTGTCACGTCCTCACACTCCCCATCGGTTTCCGGTTCTCCGCTGCACTGTCTTTACTGCAGCGAGGAGTTTGCTACCGAGCCCGAAATGTTGCAGCACGCACGAATGTTCTGCAAACGCTCGCTGCTGCTCAACCCGTTCGTGAACGCGTCGGGCCCACTGTCACAAACCACAGCGAACGGCACTACAATTGCCAGTAGTACCAGTGGTAACAGTAGTAGCAGTTGCAGCGAGGACGATACCGACTACGACACGGTCGCTCTCAAGGGTGGCTGTGGTGGAGGTGCGTACGGACTGCATGGTAGTGTAGCCGGTGGCACTCTCGGGATGGCAGGACCACACGGTGGTGCGGGAGGTGGTGGAAAGGTGCGAGTTCGTACTTCTATCTCCGAAGAGCAGCAGAATGAGTTGAAGAAGTACTACGCTCGCAATAGTAAACCCAGCCGCGACGAGTTCCAGGCAATTGCCCAACACGTCAAGATGGAAGCGCGTGTCGTACAGGTGTGGTTCCAGAACAATCGATCACGCGAGCGCAAAATGGGAGCGGGAGCTGTTCGTCAGTATCCCACTCAGTCAGGCCCAGCGGCTGGTCAAACGGTAGCAACGGTAGGAGCACCCATCTCACCGCTCCATGCCGATCGTGCACCATCGGTCGTAGTCACCGGTCAGGACACGGGCGATCAACCGCTCGATCTATCCGTCAAAAAGGGTCTACTGACGGTAGGCGAGGCTCTGCTTAGTGCAGCCACCAATTCGCAGGCTGCTGCATCAGCACTGGCTGCCGGCACGCTACCAGCGGTGCTGCTCCAAGCAGACACCATGTCCGCCCTGAACGAAGCGATGAACCTCAGCATCAAGACGTCCTGTTCGCCGACCGCCTACTTCTACCATGACATTCATCCGATCCATGGAGTGACGGCCGGACCACAGTCCCACGGAACCGGCGGCAACCCGCTCAAGCTTGGCCTGGGCACTGGTCTTCCACGGGACACACCCTCACCGCCccaggatgatcgggttcagcacacagcacaatcTGCGCCAGTACCGCCGCACACACCGCACACGTTCGGCAAATATCCGCCAATACACGGACTGCACCATccaagccaccaccaccatcattcaGCCAACCAGGCCAACATGGACCAGTTGCTCCGGCAGTTCTCACCGAAACTGTCGGCTGCTGCAGCCGCCACCGGCGGTGTTATGCTGGGACGGGCGAGCCTGAGTCCTGGTGCGCGCGACATGCTACCGGACGACAGTGCGTCCAAGTACTATGCCGCCTTTCCGGACAAGAAGCATCTGCTGCAATCGATGCTGAACGTGCCGAAAAGATTGACCGGAGCTTACGGGCTCGGTGGAGGTAATGGAGGGGCCGGAGTTGCCGGTGGTAAGGATGCCGGAGGTTCACTTGCACAGCCAGCTCCGGACGCCGAGGGCCAGTACGTCTGTGATCAGTGCGACAAGACGTTCAGCAAGCACAGCTCCTTGCAACGCCACAAATACGAACATTCAGGTCAACGTCCTTACAAGTGCATGGAATGTCCGAAGGCGTTCAAGCACAAGCATCACCTAACCGAGCACAAGCGTCTGCACAGTGGCGAGAAACCGTTCCAGTGCTGCAAATGTCTGAAGCGCTTCTCGCATTCCGGCTCATACAGCCAGCACATGAACCATCGCTACTCCTACTGCAAACCGTACAGGGAGGGCAAATAA
Protein Sequence: MVSCSVAVSTYYNVEESIMPSSTKFSLQFPSLPSGLPKDSENDALADGDCCVQCSQCHQTVQGIEALKEHIQLNHSSGPEGPRAKFSNDTAEPDGDDDEEDDDDQNDNIMAEEDEHHVDPDAASPPPAAPPEPPVTSAVGSRASGDLIGSRLQAKCVSLLQLQQQKHQASVKALDDEPEDDDDPEVPSGTTPRDLLMAGLTPQTVADNLPYGPRSMVISPAQDGSSNSSSGPSLPTGGTVKDTDLAVYDCSQCPTTFTSRDQLERHELHHPPSADASCKVCHKPFANVYRLQRHMISHDESLQRRKFKCNECDKAFKFKHHLKEHKRIHSGEKPFVCPNCGKRFSHSGSYSSHMTSKKCINMGIRLNHNNNNNNSSSHNNNNSTSLNNNSSNNSGSGSDSNHRSPQYPFHAGNGLTGLPNGHAISTGGLGRSPISLRPQHGVSALHRDLDIASRLGLVTSPSPTSSCSSATKHELDTIGQPGVDALLLTKIQQASLLAYSFAMLDPNMLRLFDFSAAAQHQPQQSSASTETQEPMDDGQQRPASPTGDEDVQQRPESAKRPASSSIGVDAITMAQNTADDTQQPNPSDTERMEVDDEQEESCAVEKVEVVMASCPDSVQPHLTPFHDEEDKQRASTTSSSIHTSEQVEASQQPPNANDDTESKHGLPILPKQEPPEEVPQDSIRSSTSAETTHHELRASADRRLNSDGGYDAPGDKPIVKDEPSEEEIGIDQIEMVELKLTDRDDRLHFSSPSVTSSHSPSVSGSPLHCLYCSEEFATEPEMLQHARMFCKRSLLLNPFVNASGPLSQTTANGTTIASSTSGNSSSSCSEDDTDYDTVALKGGCGGGAYGLHGSVAGGTLGMAGPHGGAGGGGKVRVRTSISEEQQNELKKYYARNSKPSRDEFQAIAQHVKMEARVVQVWFQNNRSRERKMGAGAVRQYPTQSGPAAGQTVATVGAPISPLHADRAPSVVVTGQDTGDQPLDLSVKKGLLTVGEALLSAATNSQAAASALAAGTLPAVLLQADTMSALNEAMNLSIKTSCSPTAYFYHDIHPIHGVTAGPQSHGTGGNPLKLGLGTGLPRDTPSPPQDDRVQHTAQSAPVPPHTPHTFGKYPPIHGLHHPSHHHHHSANQANMDQLLRQFSPKLSAAAAATGGVMLGRASLSPGARDMLPDDSASKYYAAFPDKKHLLQSMLNVPKRLTGAYGLGGGNGGAGVAGGKDAGGSLAQPAPDAEGQYVCDQCDKTFSKHSSLQRHKYEHSGQRPYKCMECPKAFKHKHHLTEHKRLHSGEKPFQCCKCLKRFSHSGSYSQHMNHRYSYCKPYREGK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00105349;
90% Identity: iTF_00108270;
80% Identity: iTF_00108270;