Basic Information

Insect: Anopheles stephensi
Gene Symbol: -
Assembly: GCA_013141755.1
Location: CM023249.1:72533491-72576337[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 22 2.7e-06 0.00016 21.7 4.9 1 23 213 235 213 235 0.98

2 22 1.3e-08 7.6e-07 29.0 3.3 1 23 241 263 241 263 0.98

3 22 1.7e-06 9.9e-05 22.4 5.6 1 23 269 291 269 291 0.98

4 22 7.1e-06 0.00041 20.4 5.9 1 23 297 319 297 319 0.98

5 22 1.4e-06 7.9e-05 22.7 5.2 1 23 325 347 325 347 0.98

6 22 1.9e-05 0.0011 19.1 5.9 1 23 353 375 353 375 0.98

7 22 4.5e-06 0.00026 21.0 2.7 1 23 381 403 381 403 0.99

8 22 3.3e-06 0.00019 21.5 2.3 1 23 409 431 409 431 0.97

9 22 9.5e-07 5.4e-05 23.2 5.0 1 23 437 459 437 459 0.98

10 22 1.1e-06 6.4e-05 23.0 3.7 1 23 465 487 465 487 0.98

11 22 4.8e-07 2.8e-05 24.1 5.9 1 23 493 515 493 515 0.98

12 22 2e-06 0.00011 22.2 6.6 1 23 521 543 521 543 0.98

13 22 1.2e-06 6.7e-05 22.9 5.4 1 23 549 571 549 571 0.98

14 22 1.7e-06 0.0001 22.4 5.7 1 23 577 599 577 599 0.98

15 22 3.6e-05 0.0021 18.2 6.7 1 23 605 627 605 627 0.98

16 22 1e-07 6e-06 26.2 4.6 1 23 633 655 633 655 0.98

17 22 3.2e-07 1.8e-05 24.7 5.5 1 23 661 683 661 683 0.98

18 22 4.2e-07 2.4e-05 24.3 7.7 1 23 689 711 689 711 0.98

19 22 2.8e-05 0.0016 18.6 8.0 1 23 717 740 717 740 0.95

20 22 2.3e-05 0.0014 18.8 0.6 1 23 746 768 746 768 0.98

21 22 0.0025 0.14 12.4 3.8 1 23 778 800 778 800 0.99

22 22 0.00092 0.053 13.8 4.3 1 23 806 829 806 829 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	22	2.7e-06	0.00016	21.7	4.9	1	23	213	235	213	235	0.98
2	22	1.3e-08	7.6e-07	29.0	3.3	1	23	241	263	241	263	0.98
3	22	1.7e-06	9.9e-05	22.4	5.6	1	23	269	291	269	291	0.98
4	22	7.1e-06	0.00041	20.4	5.9	1	23	297	319	297	319	0.98
5	22	1.4e-06	7.9e-05	22.7	5.2	1	23	325	347	325	347	0.98
6	22	1.9e-05	0.0011	19.1	5.9	1	23	353	375	353	375	0.98
7	22	4.5e-06	0.00026	21.0	2.7	1	23	381	403	381	403	0.99
8	22	3.3e-06	0.00019	21.5	2.3	1	23	409	431	409	431	0.97
9	22	9.5e-07	5.4e-05	23.2	5.0	1	23	437	459	437	459	0.98
10	22	1.1e-06	6.4e-05	23.0	3.7	1	23	465	487	465	487	0.98
11	22	4.8e-07	2.8e-05	24.1	5.9	1	23	493	515	493	515	0.98
12	22	2e-06	0.00011	22.2	6.6	1	23	521	543	521	543	0.98
13	22	1.2e-06	6.7e-05	22.9	5.4	1	23	549	571	549	571	0.98
14	22	1.7e-06	0.0001	22.4	5.7	1	23	577	599	577	599	0.98
15	22	3.6e-05	0.0021	18.2	6.7	1	23	605	627	605	627	0.98
16	22	1e-07	6e-06	26.2	4.6	1	23	633	655	633	655	0.98
17	22	3.2e-07	1.8e-05	24.7	5.5	1	23	661	683	661	683	0.98
18	22	4.2e-07	2.4e-05	24.3	7.7	1	23	689	711	689	711	0.98
19	22	2.8e-05	0.0016	18.6	8.0	1	23	717	740	717	740	0.95
20	22	2.3e-05	0.0014	18.8	0.6	1	23	746	768	746	768	0.98
21	22	0.0025	0.14	12.4	3.8	1	23	778	800	778	800	0.99
22	22	0.00092	0.053	13.8	4.3	1	23	806	829	806	829	0.96

Sequence Information

Coding Sequence: ATGAAAACACTCAAAGTGTCTCGGGTCCACTGGGAAACAGCCATTTTaaGGTCGTCACACCTCACCAACCTGTCTGGCCCTGCTGCTACACATAGTAGCAGGGGCAGCACAGGCCATCTTCCTCCTCCCCCGGGGTCGCACCTTCAGCAACTCCATGGGTCTGGAGTCCTTACGGATCATACAAAATTACAGTATTTGGGCAACATGCAGgTGCATCCCGCACACAGCGGTAGCGGAGGACATCATCCGCCACCGCCGCCCACCCAGGGACCGCCTCAGTCCGCCCATCCGCCACCACCGCAACCGATACCGATCGTGAAGCCGGAGTTTAAGGTGCCGCCGATACCGGCCCacctgatggatgtgcgcggaccggatgggtcgctggtCAAGATCAACATGCCGGAGCATCACGATCCGAGCAAACCGCCGAACAACGTCGAAATGCTGAAGGTGAACATCGAGGATCTCAGCCAGTTTCTGTCGTACCATGAGGTGTTCGGCAAGCTGCCCTCCGACATGCTGACGGGCCCGTCCGCCAGCTTAGTGCCATCGTCCTCTACCAACACCGCTACGACCAGTGCGCATAGCAATGGTAAATTAAATCACATCCGTCAGCATACGGGCGAATCTCCGTTCAAGTGTAGCTACTGTGCGAAAAGCTTCACCCGTAAGGAACACCTGACTAACCACGTTCGCCAGCATACCGGTGAATCGCCTTACCGATGTCCGTACTGCGGTAAAACGTTCACCCGAAAGGAACATCTTACGAACCATGTCAGGTTGCACACCGGCGAGACTCCTTTTCAATGTTCTTATTGTCAGAAAAAGTTCACTAGGAAAGAACATTTAACGAACCACGTCAGGTTGCACACCGGCGAGACACCTTTTCAGTGTTCTTATTGCCAGAAGAAGTTCACTCGCAAAGAACATTTAACGTACCACGTCAGGTTGCACACCGGCGAGACTCCTTTTCAATGTTCTTACTGTCAGAAAAAGTTCACTAGGAAAGAACACTTAACGAACCACGTCAGATGGCACACGGGAGAGACTCCGTACCATTGCACGTACTGCGAGAAAAAGTTCGCCCGCAAAGAGCACCTTACTAATCACGTCAGATTGCACACAGGAGAGACCCCTTATCAATGCACATATTGTGAAAAGAAATTCAGTAGAAGAGAGCGTTTAACGATTCACACAAGaatCCATACCGGAGAGACTCCGTACGCATGCACAtattgtgataaaaaatttagcCGCAAAGAACGATTAACGTATCACATAAGATTACATACCGGAGAAACTCCCTATCAGTGCACGTATTGTGAGAAGAAATTCACTCGCAAAGAACACCTTACAAATCACGTCAGaTTACACACCGGAGAAACTCCCTATCCGTGTACGTACTGTGAAAAGAAGTTCACACGTAAAGAGCATCTTACCAATCACGTCAGATTGCACACCGGAGAGACCCCTTATCAGTGCACCTATTGTGACAAGAAATTCACTCGCAAAGAGCATTTGACTAATCATACAAGATTGCATACCGGAGAAACTCCGTACCAATGTACGTACTGCCAGAAGAAATTCACGCGAAAAGAGCATTTAACAAACCACACCAGATTGCATACGGGCGAAACACCTTACCAGTGTTCTTACTGTCAGAAGAAGTTCACCCGCAAAGAACATCTCACGAATCACGTCAGGCTGCACACCGGCGAGACTCCCTACACGTGTACCTACTGTCAGAAGAAGTTTACGCGTAAAGAGCATTTGACGAATCACGTCAGATTACACACCGGTGAGACTCCGTATCATTGCACCTATTGCGAGAAGAAGTTCATGCGAAAAGAACACCTTACGAATCATATCAGATTGCACACCGGAGAAACTCCCTATCAGTGCACGTATTGCGGGAAGAAATTCACCCGAAAAGAGCATTTAACAAATCATGTCAGATTGCATACCGGAGAGTCTCCCTATCGGTGTTCGTACTGTAACAAGTCATTCACCAGAAAAGAGCACCTCAAGAATCACGTCAGATTGCACACGGGTGATTCACCGCACAAATGTGAGTACTGCAACAAAACGTTCACGCGGAAGGAGCATCTCAACAATCACATGCGCCAGCACAGCGGAGACAATCCACACTGCTGCAATGTGTGCAACAAAACCTTCACCCGGAAGGAGCATTTGATCAACCACATGAGCCGTTCGCACACGGGCGAGCGACCGTTCCAGTGTGACGAGTGTGGCAAATCGTTCCCGCTGAAGGGCAACCTGCTGTTCCACCAGCGCAGCCACACCAAGGGCCAGCCGATGGATCGGCCGTTCCGGTGCGACATGTGCCCGAAGGATTTCATCTGCAAGGGCCACCTGGTGTCGCACCAGCGGTCGCACACGGGCGAGAAGAACCATCACTGCCCGCAGTGCAGCAAATCGTACGTCGAGCGGGGCAACATGCTGCGGCACATGAAGAAAACGCACCCGGACGCGGTCATACCGGTGCTGCCCAAGTTGCCACACATCAAGGTGGAACCGAAGTCTACCGTATCTCAGCCCGCGTCCGTGGTGACGTCGCCGGCTCAGGCCACGTCAACAATAACGTCGATTATCTCCAACAATACTCACCCATcgcagcatcaccatcacatTCAACCGAAAATGGAACAGAAATCTCAGATACATCATCTTCCGCTTCCTCATCAGCATCCAGCTCACCAGCTGCACCACCACATCTCGGCGGGCCCCCCGCCCCCACCGCCCTCGATGCATCTGCCACCATCAAATCCGCAGTTGGCAGCGCTCGCCCTCCATCATCaggtccagcagcagcatcagcagcagcagcaacaacagcagcagcaacagcagccgcaATCTTCGCCTTCAACGGTACGAACCCAGCCATCCCCTCGTACATCACATCAGCCGCCGCCGcatccacagcagcagcaaccgcagcagcagccgccgccggAAAGCCACCAGCAACAGGGACCGGGCCCAGCTGGACCCCTTCCACCTCAGCACCATACGGTCCCGGTTACTATTATAACCCATGCTGGAAGCATTAATCCCGGCAACATGCCGGTGGTGGATGCggtcggtggcggtggcggcggtggcccACCGAACGGTCGGGTCGGTGCAATCCAGATGCATCATCTGGCGGcggcccagcagcagcaggcggccGAAGAGCATTCGGTGGTTTATTGA
Protein Sequence: MKTLKVSRVHWETAILRSSHLTNLSGPAATHSSRGSTGHLPPPPGSHLQQLHGSGVLTDHTKLQYLGNMQVHPAHSGSGGHHPPPPPTQGPPQSAHPPPPQPIPIVKPEFKVPPIPAHLMDVRGPDGSLVKINMPEHHDPSKPPNNVEMLKVNIEDLSQFLSYHEVFGKLPSDMLTGPSASLVPSSSTNTATTSAHSNGKLNHIRQHTGESPFKCSYCAKSFTRKEHLTNHVRQHTGESPYRCPYCGKTFTRKEHLTNHVRLHTGETPFQCSYCQKKFTRKEHLTNHVRLHTGETPFQCSYCQKKFTRKEHLTYHVRLHTGETPFQCSYCQKKFTRKEHLTNHVRWHTGETPYHCTYCEKKFARKEHLTNHVRLHTGETPYQCTYCEKKFSRRERLTIHTRIHTGETPYACTYCDKKFSRKERLTYHIRLHTGETPYQCTYCEKKFTRKEHLTNHVRLHTGETPYPCTYCEKKFTRKEHLTNHVRLHTGETPYQCTYCDKKFTRKEHLTNHTRLHTGETPYQCTYCQKKFTRKEHLTNHTRLHTGETPYQCSYCQKKFTRKEHLTNHVRLHTGETPYTCTYCQKKFTRKEHLTNHVRLHTGETPYHCTYCEKKFMRKEHLTNHIRLHTGETPYQCTYCGKKFTRKEHLTNHVRLHTGESPYRCSYCNKSFTRKEHLKNHVRLHTGDSPHKCEYCNKTFTRKEHLNNHMRQHSGDNPHCCNVCNKTFTRKEHLINHMSRSHTGERPFQCDECGKSFPLKGNLLFHQRSHTKGQPMDRPFRCDMCPKDFICKGHLVSHQRSHTGEKNHHCPQCSKSYVERGNMLRHMKKTHPDAVIPVLPKLPHIKVEPKSTVSQPASVVTSPAQATSTITSIISNNTHPSQHHHHIQPKMEQKSQIHHLPLPHQHPAHQLHHHISAGPPPPPPSMHLPPSNPQLAALALHHQVQQQHQQQQQQQQQQQQPQSSPSTVRTQPSPRTSHQPPPHPQQQQPQQQPPPESHQQQGPGPAGPLPPQHHTVPVTIITHAGSINPGNMPVVDAVGGGGGGGPPNGRVGAIQMHHLAAAQQQQAAEEHSVVY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00093593;
90% Identity: iTF_00099797;
80% Identity: iTF_00108527;