Basic Information

Insect: Anopheles sinensis
Gene Symbol: zfh2
Assembly: GCA_000441895.2
Location: KE525369.1:1460190-1478133[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 11 0.0001 0.0074 16.5 1.4 2 23 76 98 75 98 0.96

2 11 2.6e-05 0.0019 18.4 0.7 1 23 130 154 130 154 0.92

3 11 0.015 1.1 9.7 0.4 1 22 260 281 260 284 0.91

4 11 0.027 1.9 8.9 0.3 2 23 812 834 811 834 0.92

5 11 4.9 3.5e+02 1.8 0.6 4 23 913 933 909 933 0.86

6 11 0.012 0.83 10.0 4.7 1 23 946 968 946 968 0.96

7 11 0.012 0.85 10.0 3.4 2 23 975 997 974 997 0.93

8 11 0.00021 0.015 15.6 0.2 1 23 1093 1117 1093 1117 0.91

9 11 0.16 11 6.5 0.6 1 22 1188 1209 1188 1212 0.89

10 11 0.00092 0.066 13.5 0.1 1 23 1313 1337 1313 1337 0.93

11 11 6.1e-05 0.0043 17.2 2.8 1 23 2106 2128 2106 2128 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	11	0.0001	0.0074	16.5	1.4	2	23	76	98	75	98	0.96
2	11	2.6e-05	0.0019	18.4	0.7	1	23	130	154	130	154	0.92
3	11	0.015	1.1	9.7	0.4	1	22	260	281	260	284	0.91
4	11	0.027	1.9	8.9	0.3	2	23	812	834	811	834	0.92
5	11	4.9	3.5e+02	1.8	0.6	4	23	913	933	909	933	0.86
6	11	0.012	0.83	10.0	4.7	1	23	946	968	946	968	0.96
7	11	0.012	0.85	10.0	3.4	2	23	975	997	974	997	0.93
8	11	0.00021	0.015	15.6	0.2	1	23	1093	1117	1093	1117	0.91
9	11	0.16	11	6.5	0.6	1	22	1188	1209	1188	1212	0.89
10	11	0.00092	0.066	13.5	0.1	1	23	1313	1337	1313	1337	0.93
11	11	6.1e-05	0.0043	17.2	2.8	1	23	2106	2128	2106	2128	0.98

Sequence Information

Coding Sequence: ATGAACGCTGCCGGTGACTTCCACCTGAAGAAGTACAGCCCGGTCGATCTGTACAAGCAGCTGCTGGCGAACAACTTCCGGCCGGATGCCATGGACATGGGCGACGTCGAGATGAAGAACGACCATCAGATCAGCGTGAAGAAGCTGGAACCCGAACCATCGACTGCGTTCCGGAACAGCAACTTCAGCCCGAACATCTCGACGCGCAACTCGTGCAAGACGCTCAAGTGTCCGCAGTGCAACTGGCACTACAAGTACCAGGAGACGCTCGAGATTCACATGCGCGAGAAGCATCCGGACGGCGAGACGGCTTGCAGCTACTGCCTGGCCGGGCAGGCCCATCCACGGTTGGCCCGAGGTGAGTCGTACACGTGCGGCTACAAGCCGTACCGGTGCGACATCTGCAACTACTCGACCACGACCAAGGGCAATCTGTCGATCCACATGCAGAGCGACAAGCACCTGAACAACATGCAGGACCTGAACGGCATGATGAACAAGGGCAGCCAGAGCTTCCTCAACCTGGCGACGCTGCAGGCGAACGAGAAGGTGGTGAACAGCTCGCGCAGCCAGTACATGGCGGCGGCGGCGGCCGCAGCGGCCAGCGGTCCGCTCTCGTCCATGTCGGCTAAGCTGGGTGGCGCGGGGAACGGTGGAGCGGGTGGTGTTGGTGGCGCCGGGGGTCAGTCGAAGGACGGTGTGATGCAGGGTGCCGGTGGTAACGGTGGTGGCGGCGTCGGATACGAGAGTGCGGTCGGCGGGCGTCCGAAGTCCTTCTTCAAGTGTGACATCTGCAACTACGATACGAACATCGCGCGCAACCTGCGCATTCACATGACGAGCGAAAAACATATCAGCAACCTGAACTCGTTCCAGTCCAGCTTCAACCAGCTGAAGAGCCTGCAGAGTCTGTCGCAGTCGGACAACCTCGACTATCTGAGTGCGATCAATCTCAACACGCTGAAGGAGGACTCGCCGATGACGCGCGTCGACGAGTATACGGCGGCGGCGGCCGCAGTAGCAGCGGCAACGGCGGCCTCCTCAGGTGGCGGAACCGGCGGCAACAACTGCCTGAAGCCGCTGTCGATGCCCTCGTCACCGTTCGCCGGCACGCCGCTCGAGACGGTGACGCCCGACTCGCTGTTCCTGAACCAACCGTCGCCGTTCAGCGGCGCGGGCAGCGAAGCCGGCGGCACCGAGCGGGACTATCACCAGCACCAGCAGTACCAGCTGGACGAGGACAAGAACCCGCTGCACTTCGAGCCCCCGATCCGGCTGTCGCTCGATCCGTCCACCTACTACAGCTGCCTGGTGTGCGCCGACTTCGAGACGAACAACCTCGAGGAGCTGAAGCGGCACGTCATCAAGGACCGGTCAAGCAGCGCCCTGGACACGATCCTGCTCGCCGGCGGCGGCCAGGAGTGTCTGCTGTGCGGGCAGCGGGTGCACGACCACGAGCGCCACCTCAAGTCCGAGCAGCACCTGAAGCGGCTCGATCTGCTGGTGCACCTGCTCGAGGGGCGCGACAAGTCGGCGGCCAAGCTGCGCCAGGTCGTCGCGCCCGAGCTGTTCAAGAAGCTGCAGCTGATCTTCCCATTGGCAGAGGAATCGAAATTTGCCTACGATGAGATGCCTAGCGTCAGCGAAATTTCCCGATCTCCGCTAATGCTGCTGCTCGAGCCGAAGACCGAGCTGATCGAGCGCGACTTTCCCGGCACCAACGGTATCGACACCGATCCCACATCTTCCTCGTGCCCCGACAACGTGCAGCTCAAGTGCAACTGCTGCAACTTCTACACGACCTCGCTGGAGAAGATCGGCATCCACAGCCTGTCGGAGAAGCACATCTTCCGGCGGATCTGCTTCGACTACCTGCTGCTCATCGCGAGCGAACGGTCCGGCGCCGGTCCGGTGAAAGGCGAAGGCAAGTGCGAACCACTAACCTACTACTACCCGCGGCCACCTAACCACAACCATCCGCAACCCAACACTATCAACGCGTCCACCACTGCCTCACGAGTCTTGCTGATGCAAATGATGCTACTTGCAGATGGAGGAGGAGGAGGAGGAGGAGGAGGAGGAAAGCACCAGTCCGTGTCCGCGTCGTCGTCGTCGTGTTCGTCCTCGCCGAACCGCGCCGCTGGCGTCAACCAGCTGATGCTGACCTGCGTGCCGTGCGGCTTCAAAACCGACCACATCTACTACATGATACACCATCTGAAGAAGAGCTGCAAAGTGGAGCAGAACATCAACCTGCTCGGGCTGCGTAACATTTTCAAGCTGACGGCCAAAGGCCTGGACGCCCAAGATGCAATGGATACGGCGGACAACGGGCTGTGCAGCATACTGCAGGAGAAGAAGATGTGGAACGGGGAGAACGCGGCCGGCAACAACAAGCAGCCGGCGGCGGCGGGCTGCAAGGACCGCTGCCTGGTGTGCAGCGTGTGCAACAAGTTCTCGTCGAAGAAGGCGAACGTGATGCAGCACCTGCTGGCGAGCCACAACCTGGTCGGCAACGAGCTGCTGGGCGGTGCGAGTGAGCTAGCGCCCAATGTGCCATCGCTGCAGAAGAAACCGTTCGACTACTTGCGCACGCTGACCGAGGCGCGGTGCGCCCAGAACCTGCGCCTCATCGAGAAGGCGTCGTTCGACTCGATGGTCGACCTGAAGATCCACTGCAACGAGAGCAACCACTTCAAGCGGAGCGCCGACTCGGACGATCTCGCCTGCTTCCTGCACGACTGCAAGGACGCGTTCGACAACCTCGCCGACCTGAACCAGCACTTCAAGGCGAGCCATCTCAACTTTCTGATCTCCGAGCATCACACCTACAAGTACCGCTGCCGCCAGTGCCCGTTCGCGTTCAAGACGCACGAGAAGCTGAGCCGGCACCTGTTCTACCACTCGCTGCGCGAGTCGACCAAGTGCTTCTACTGTGATCATCACTTCAAGAACATCAACTCGCTGACGGCGCACATCGCCGAGAAGCACCCGCAGGAGGCGCTCCAGTCGAAACCGTCCCCGCCCGGTATCGCCTCGCCCGACACCTCGATCCTGTTCTTCAAGGACCTCAAGCGCAAGATGCTCCACAGTCAGCAGCAGCAGCAACAGCAGCAACGGAACGGGTTGAGTCCCCGGTCGGATCGGTCGGGTGGGAGGGAGGCGCGGGACAGCGTGGACGAGGATCGGCTGAGTGAGAAGTCGGTCAGCTCGAAGAGCAGCAGCTTCTACTACGACAAGAGCCTCGATGGGAGCGGCACACTGGACGGGGGTCGGTACGCGTGCGGCGACTGTCAGTTTTCATTCACGGATGCGGCCGCCCTCGAGCGCCACCTGGCCACCGCCTGCCATATGCCCCGGGACGACAAGGCATCACCCGACGGGTCGCTGCTCGGGTCGTTGCCAGCGCTCGGCAAGCAACAATCAACCACCAGCGGTCACCAGCAGCAGCAGCAGTCGCACTCGGGTTCGGGCTTGCAAACCCAGCAGCTGCCCGCGTCCGGCTCCGCGTCCATCTTCTACGACATCAAGTCGGAGAAGTTCACCAACCCGAACCGCCCGTTCAAGTGCACCATCTGCATGGAGAGCTTCACGCAGAAGAACATCCTGCTGGTGCACTACAACAGCGTGTCGCATCTGAACAAGCTGAAGAAGCTGAAGGCGGAGAAGGGTTTCGCGCAGATGTTCACCGGTTCGCTGCTGGGGGCCGGCGACAGCGACGCTGGCAGCCTGGAGCGCGGTAAGAACTCACCTTCGCCGTCGAGTCTCGTGCGGGAGGTGGGTGCGTCGGCGTCGATCGGTGGATCGTTCAGCGACAAGGCGGCCACGCCCTTCTCGATGCCAATGTTCGCCGTCGACGGGTGTCTGGGGTCTGGGGCGAGCGGCGGCGAGAAGCGCAAGGACATCAGCGACGAGAAGGAGTCGGCCCGCAAGAAGTTCAAGTGTGACATCTGCAACGTCGCGTACACGCAGGGTAGCACGCTGGACATTCATATGCGCAGTGTGTTGCATCAGACGCGCGCCTGTCGGCTGCAGGAGCGAGGTCTCTTCTCCGGACAGCAGTCGAGCAATGCGTCCACCGCGTCCCAGCAGCAGCAGCAACCGTCCCCACAGGGCGCCGCCGCTGATGGGCCAAAGAAGAAGGGAGGCAGCGAGTTCCCGCTTATCCATCCGATTCCCGAGATACCGGCCGGAGTTGGTGGCGGAGACAAGCCGGAGATCTGTGTGTGCGAGTGCTGCTACCAGATGTTCCCCGGTAAGCTGATGCTCGAGGCGCACCTCGACCTCAACCCGGAGTGTTTGGCGCACAAGAAGAAGCTGCTGGATGCGGCGGCGGCAGCTGCGGCCGTTCAGGACAGTGCCGCTGCGGCCGCCTCCTTCAACGATGGTGCAGCTGCGGCAGCGGCAGCAGCGGCGGCAGCCGCCTACCAACACCAGGCGCTCATGAACGACCTCGTGAAGGTGAATGCCCTGTCTGGGTTCGATGCGCTGAACGCGTCCGATGCGCTGCTCGGTGCGAAGAGTCCGCTCATGCCGGCCCTCGATCCCACCGCCAACCTGATGGATCCGAACTTCCTGAAGAACGCGTCGCTGCTGCAGTTCGCCGCCTCCGATCCGAACGCCAAGCTCAACCCGAACGCACTGAACGTGCTCAACTTCATGCACTTCCACCATCTGATGTCGCTGAGCTACCTCAACCTGGCGCCGCAGCTCAACTTTGGTGGTGTGCCGGCAGGCAAGGTGGATGGATCCGGCGGTGGTAAGCCGGACGGTTCGCCAGGCGTTGGCCTTTCCGATGGAGGCGTCGGTGGGTTAGGCGCGAACAGCGTTGGAGTGGGCGGTGGCAAAGCGGGCAAGCATGGTCCACCGGTGGGCGTTTGTGCGCCGGTCAACCTGAACGGCAAGCCGCTCGACCTCAACAACCTGCTGCCACACGGCCTGGACCCGAAGATGGCACCGCAGCCGCCGCAGGGTGGCCAACAGCCGTGCACGCAGAAGCGGGCCCGCACGCGCATCACCGACGAACAGCTGCGCATCCTCCGGTCGCACTTCGACATCAACAACTCGCCGAGCGAGGAAAGCATTCAGGAGATGTCGATCAAGGCGAACCTGCCGCAGAAGGTGGTGAAGCACTGGTTCCGCAACACGCTGTTCAAGGAGCGCCAGCGCAACAAGGACAGCCCGTACAACTTCAGCATCCCACCGTCGACCAAGCTGAACGTGGAGGAGTACGAGCGCACCGGCGAAACCAAGGTGACCGACCTCGAGACGTCGTTCAAGTCGGTCGAGACGTCGCAGGACAACTCCTGCTCGCAGAACTCGAGCGACATGAGCAAGGCGCTGAACGAGGCGATGAAGCAGAACATCTCCAAGTCGCTGCTCGAGTCGCTCAGCAAGCACCAGCAGTCGGCGGCCGGCCACCCGGACCTGGTCGGTGCCGCCTTCCAGCTCAACAAGAGCCTCTTCCCGGAGAGCTTCGTCGGCGCGGACTTTAGCAGCCACGACGCCGTCAGCTCCGTGTCGGACTACTTTCAGCGTGCGGCGGCCGATGCGGTGGCACTCGGGGCGGCCGTCGGTGCAGTCACGATGCCTGGTGCCGGCGGAGGAGCCGGTGGTGTCCTGAGCAGCGTCGGTATCGGTGGACCTGCTCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNAAGAAGAAAAAGATCAAGTCCGAATCGTCGAACGACAGTCCAACGCCGGCGGACCTGCAGCTCGACTCCTCCAACTCTAGCCCGATGCCGATGCGACCTCCGAGCGCCATCTCGCTGAAGAAGCACATGTCCACACCGCCGACCGCTGGCAGTACACCCGGAAGCGGTGGCGCTGCCGGTGGAGGCACTGGTGGTGCTGGTGGTGGTGGCGCCGGTGGCGGTGGAACGCTGCTCGAAGAGATGAAGATACCGAGCCCGATCGACAGTCCCGTCATCTCGTCGCCGAACTCGATGGGGCTGCACACGATGCCACCGCAAACGCAGCCAATCACCTGCTCGAACGGCAAGCGGGCGAACCGGACGCGCTTCACCGACTACCAGATCAAGGTGCTGCAGGAGTTCTTCGAGAACAACTCCTACCCAAAGGACAGCGATCTGGAGTACTTGAGCAAGCTGCTGATGCTTTCACCCCGCGTGATAGTGGTGTGGTTCCAGAATGCTCGCCAGAAGCAGCGCAAGATCTACGAGAACCAGCCGAACCCGACGTTCGAGACGGACGAGAAGAAGGCAATCAACATCAACTACACCTGCAAGAAGTGCAACCTCGTGTTCCAGCGCTACTACGAGCTGATCCGCCACCAGAAGAACCACTGCTTCAAGGAGGAGAGCAACAAGCGGTCGGCGAAGGCGCAGCTGGCCGCGGCCCAGATCGCCCACTCGTTCACCAGCGGCAGCGAGGACTCGGACTCCAGCCTGGACGTCAGCCGGCGCGAGTTCCAGCCGCGCGAGAACGACTGCCCCTTCTAG
Protein Sequence: MNAAGDFHLKKYSPVDLYKQLLANNFRPDAMDMGDVEMKNDHQISVKKLEPEPSTAFRNSNFSPNISTRNSCKTLKCPQCNWHYKYQETLEIHMREKHPDGETACSYCLAGQAHPRLARGESYTCGYKPYRCDICNYSTTTKGNLSIHMQSDKHLNNMQDLNGMMNKGSQSFLNLATLQANEKVVNSSRSQYMAAAAAAAASGPLSSMSAKLGGAGNGGAGGVGGAGGQSKDGVMQGAGGNGGGGVGYESAVGGRPKSFFKCDICNYDTNIARNLRIHMTSEKHISNLNSFQSSFNQLKSLQSLSQSDNLDYLSAINLNTLKEDSPMTRVDEYTAAAAAVAAATAASSGGGTGGNNCLKPLSMPSSPFAGTPLETVTPDSLFLNQPSPFSGAGSEAGGTERDYHQHQQYQLDEDKNPLHFEPPIRLSLDPSTYYSCLVCADFETNNLEELKRHVIKDRSSSALDTILLAGGGQECLLCGQRVHDHERHLKSEQHLKRLDLLVHLLEGRDKSAAKLRQVVAPELFKKLQLIFPLAEESKFAYDEMPSVSEISRSPLMLLLEPKTELIERDFPGTNGIDTDPTSSSCPDNVQLKCNCCNFYTTSLEKIGIHSLSEKHIFRRICFDYLLLIASERSGAGPVKGEGKCEPLTYYYPRPPNHNHPQPNTINASTTASRVLLMQMMLLADGGGGGGGGGGKHQSVSASSSSCSSSPNRAAGVNQLMLTCVPCGFKTDHIYYMIHHLKKSCKVEQNINLLGLRNIFKLTAKGLDAQDAMDTADNGLCSILQEKKMWNGENAAGNNKQPAAAGCKDRCLVCSVCNKFSSKKANVMQHLLASHNLVGNELLGGASELAPNVPSLQKKPFDYLRTLTEARCAQNLRLIEKASFDSMVDLKIHCNESNHFKRSADSDDLACFLHDCKDAFDNLADLNQHFKASHLNFLISEHHTYKYRCRQCPFAFKTHEKLSRHLFYHSLRESTKCFYCDHHFKNINSLTAHIAEKHPQEALQSKPSPPGIASPDTSILFFKDLKRKMLHSQQQQQQQQRNGLSPRSDRSGGREARDSVDEDRLSEKSVSSKSSSFYYDKSLDGSGTLDGGRYACGDCQFSFTDAAALERHLATACHMPRDDKASPDGSLLGSLPALGKQQSTTSGHQQQQQSHSGSGLQTQQLPASGSASIFYDIKSEKFTNPNRPFKCTICMESFTQKNILLVHYNSVSHLNKLKKLKAEKGFAQMFTGSLLGAGDSDAGSLERGKNSPSPSSLVREVGASASIGGSFSDKAATPFSMPMFAVDGCLGSGASGGEKRKDISDEKESARKKFKCDICNVAYTQGSTLDIHMRSVLHQTRACRLQERGLFSGQQSSNASTASQQQQQPSPQGAAADGPKKKGGSEFPLIHPIPEIPAGVGGGDKPEICVCECCYQMFPGKLMLEAHLDLNPECLAHKKKLLDAAAAAAAVQDSAAAAASFNDGAAAAAAAAAAAAYQHQALMNDLVKVNALSGFDALNASDALLGAKSPLMPALDPTANLMDPNFLKNASLLQFAASDPNAKLNPNALNVLNFMHFHHLMSLSYLNLAPQLNFGGVPAGKVDGSGGGKPDGSPGVGLSDGGVGGLGANSVGVGGGKAGKHGPPVGVCAPVNLNGKPLDLNNLLPHGLDPKMAPQPPQGGQQPCTQKRARTRITDEQLRILRSHFDINNSPSEESIQEMSIKANLPQKVVKHWFRNTLFKERQRNKDSPYNFSIPPSTKLNVEEYERTGETKVTDLETSFKSVETSQDNSCSQNSSDMSKALNEAMKQNISKSLLESLSKHQQSAAGHPDLVGAAFQLNKSLFPESFVGADFSSHDAVSSVSDYFQRAAADAVALGAAVGAVTMPGAGGGAGGVLSSVGIGGPAXXXXXXXXXXXXXXXXXXXXXXXXXXXXKKKKIKSESSNDSPTPADLQLDSSNSSPMPMRPPSAISLKKHMSTPPTAGSTPGSGGAAGGGTGGAGGGGAGGGGTLLEEMKIPSPIDSPVISSPNSMGLHTMPPQTQPITCSNGKRANRTRFTDYQIKVLQEFFENNSYPKDSDLEYLSKLLMLSPRVIVVWFQNARQKQRKIYENQPNPTFETDEKKAININYTCKKCNLVFQRYYELIRHQKNHCFKEESNKRSAKAQLAAAQIAHSFTSGSEDSDSSLDVSRREFQPRENDCPF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00107525;
90% Identity: iTF_00107525;
80% Identity: iTF_00107525;