Basic Information

Gene Symbol
-
Assembly
GCA_000441895.2
Location
KE525298.1:428300-430769[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.34 24 5.4 4.7 1 23 104 126 104 127 0.95
2 10 0.02 1.4 9.3 0.8 2 23 143 165 143 165 0.95
3 10 0.022 1.6 9.2 3.1 2 23 170 191 170 191 0.96
4 10 0.00019 0.013 15.7 5.2 1 23 206 228 206 228 0.98
5 10 5.8e-06 0.00041 20.4 1.3 1 23 234 257 234 257 0.97
6 10 4.5e-05 0.0032 17.6 1.0 1 23 263 286 263 286 0.95
7 10 1.8e-05 0.0013 18.9 0.4 2 23 301 323 300 323 0.95
8 10 4e-06 0.00028 21.0 3.8 1 23 330 352 330 352 0.98
9 10 8e-06 0.00057 20.0 0.3 1 23 358 380 358 380 0.99
10 10 0.0014 0.1 12.9 0.6 1 23 386 409 386 410 0.97

Sequence Information

Coding Sequence
ATGTACGCCGGTTCGTGCCTCGATTGGCACCTCGACCCCGCTGACGACGATGTTTGTCTACTGCCACTGATCACGGCCAACGATAGTAGCGTTATCGCAAAGGAGGTCACCTTTGAGAGTGAGTATTTGCCGCCCGCACTGGAGCTACCACTGGCGGACTTTGGTCTACTCGAGCAGGAGGAGCGTTTCCGGTCGCCGGTGGATGAAACGGAAGTACCACTAACTCCAAACCCTCCGTCGCAACCTCGATTGCGTAACAAATCGGAAGTAAAACTTCAGGATGCGAAGGATAAAGCACGGAAGGCGTTCTTTTCATGTGAAAATTGCACCCTTATTTTCCAATGCAAAACTCAGCTGGTCCGCCATCAGTTACTCCACCACGAAAAGGATGTGGTCGATTTAAAATGTGCCAATCGGCTACGTAACCGATGCAGGTTGTGCCGCGAACAGTTTGCAACAGTGAAACAATTAGCAACACACTTAACGATGCAACACCCACGATCCCCTGTATGCGACCTTTGCCTGACGACTTTTCACGACCGGGCGACCCTTGAGTGGCATCGAAAGCATCACCTCTACTCGGTGGGAGATTCCGACAACCGACCGGCTAACGGATATGTTTGTGATGTTTGCGAAAAACGCTGCGCCAGCTCAAGCCATCTGCACCTACATCGGAAGGTACACCTCGAGAAAAAACCGTACTCCTGTGTGTACTGTGATCGCACATTTACATCATCCGGCAACCGACAGAAGCACATCACACGTGTCCATACGCACGAACGCAGATACCAGTGCACCAAATGCAGCGAATCGTTCATCTATGCGCGTCAGTTGAAAATACATCGGGACATAAAACACACTTCCTTCATCGATGGGGATCGGAATTCCGGAAAATGGGTCACTTGCTCGACCTGCAACGAATCATTTCCCTCTCAAGTATCGCTTCGGAATCATCAAAACCAGGAGCACCGTAAGGAACAGCGTGCTTTCGTTTGCGGACACTGTGCTAAACGGTTCAAGCAGGCAACCCACCTGCGAAATCACATCCTAACACACACCGGCGTGCGGGCATATGAGTGTGAATTTTGCACCAAACGGTTTGCCATGGCTGGCGATCTGCGGGTTCACCGGCGCATTCACACCAAAGAGAAACCGTTTCGGTGCGAGCTCTGTCCGGCCGCGTTCATCATGGGGAAACAGTTGAATAAGCATCGTTCGACTGCACACCACCAGCAGATCGATAAATGA
Protein Sequence
MYAGSCLDWHLDPADDDVCLLPLITANDSSVIAKEVTFESEYLPPALELPLADFGLLEQEERFRSPVDETEVPLTPNPPSQPRLRNKSEVKLQDAKDKARKAFFSCENCTLIFQCKTQLVRHQLLHHEKDVVDLKCANRLRNRCRLCREQFATVKQLATHLTMQHPRSPVCDLCLTTFHDRATLEWHRKHHLYSVGDSDNRPANGYVCDVCEKRCASSSHLHLHRKVHLEKKPYSCVYCDRTFTSSGNRQKHITRVHTHERRYQCTKCSESFIYARQLKIHRDIKHTSFIDGDRNSGKWVTCSTCNESFPSQVSLRNHQNQEHRKEQRAFVCGHCAKRFKQATHLRNHILTHTGVRAYECEFCTKRFAMAGDLRVHRRIHTKEKPFRCELCPAAFIMGKQLNKHRSTAHHQQIDK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00109332;
90% Identity
-
80% Identity
-