Basic Information

Gene Symbol
grau
Assembly
GCA_000349025.1
Location
KB663721.1:6551017-6552756[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.35 20 5.5 0.0 2 23 195 217 194 217 0.95
2 10 1.6 89 3.4 0.1 6 23 226 243 226 243 0.93
3 10 1.5e-05 0.00085 19.2 1.7 2 23 248 270 247 270 0.96
4 10 0.00045 0.025 14.6 1.3 1 23 278 300 278 300 0.96
5 10 0.00013 0.0072 16.3 1.2 2 23 304 326 303 326 0.94
6 10 2.7e-06 0.00015 21.6 0.5 1 23 332 354 332 354 0.96
7 10 3.6e-05 0.0021 18.0 1.4 2 23 364 386 363 386 0.95
8 10 0.005 0.28 11.3 0.3 1 23 393 416 393 416 0.96
9 10 2.4e-08 1.3e-06 28.0 0.7 1 23 421 443 421 443 0.98
10 10 0.0071 0.4 10.8 2.5 1 23 449 473 449 473 0.96

Sequence Information

Coding Sequence
ATGAGTGAGAAATGTCGCCTTTGTCTGGGAATTTTACCGAACGAACCAAGAGTTTCAATCAGGGACACAGCCTTCCACGTGgagttgaaaaatgtgttccattttGATATCGTGCCCGATCTGCAACTGCCGGAATACGTGTGCGGTGAATGCAGAGGAACGGTGGCATATATTGACTCATACTGCCAGCAGGTTCGGAACAACCAGGTGGAGCTGCTTGGTCAAGCGAAGGAAAGTATTCTGcaaccggtggaaaatgtcAAGGTGGAGTCACTATACGATGCTGACTATTTCGAAACGGAAGAATGCACTACAAAAAATGAGCCTAGATGTGTACAGGATATGCACGCCACTCAACTGAACAGTCCGATTGGTTTGAATGATGAAAAACCAATGAAACAAGCTTCAAGGAAAGTTACAAAGCACAAAACTGGACAGGAAAAAACCTGGCGACGGGATCGCAGAAATATTagagaaaaaatcatcacaaacagGGAAAATGCAAAGCAAGACAGTTCGAAAGGAGAGGTGCAAACAAAGCAGCTAGAAAACGATCAGCTGATAAAAGATTTCTTCACCCTGGAATGTGAGATTTGTTCTGCACcattggaaagttttgtgaTGCTGCTGGACCACTATCGGAGCGCACACGATACGCGGGGCTACGTACGCTGCTGTGGTAAGCAATTTTTTCGACGCTACATACTGGTGGACCATATCGCAGCTCACCGTGGCTCGACGCGGTGTGAAATTTGTCAGAAAACCTACAAAACCAAACGCTATCTGATGCTGCATATGGCCAAAAGCCACAGCAGCGAAGAGGAACGACCATTCAAATGTGCCAAGTGTCACATTTCGTATCCCAAGCAGTACTTGCTTCGAGCACACGAACTGCTACACGTCCAGCAGCAGTGCCACATTTGCCAGAAGATGCTCTCGAACAATCAGTCCCTTAAAGTACATATCGCCCAAATGCACAGTGATGATGGAAATCACATTTGTGACACGTGCGGGAAGGTGTTCCGCACCAAACCGGCCATGGAACGGCACATCAATGAGCATCAAGGGTTGGATGTGGTTGAGCGCCTGCAGTGCGAGTATTGCAAGAAGTGGTTCAGCGGCAAGTACAACCTGAACAAGCACATTCGCTTTCTGCACATGCAAGATGGGCAAGTGTTCCCGTGCGACGTCTGCCAGCATGTTAGCCCGAACAGTCGAGCGCTCGCGAACCACAAACAGCGGATACACGTGGAGGAAAGATTCGAATGTGAGTACTGCGGGAAGCGGTTCAAGCGAAGGCCTAACTTGCGCGAGCACATTGCAACGCATACGAACGTTCCGTTGTATTCGTGCGAAATCTGCGAGAACCGTACGTTCAATTCGAAGGCGAATTATTTTACTCatcggaaaaacaaacacccgcAAGAATGGGAAGCACGTGTGCGTCTGCGGGCGGAACAATTAATGAACAATACTCCAAACGATTAG
Protein Sequence
MSEKCRLCLGILPNEPRVSIRDTAFHVELKNVFHFDIVPDLQLPEYVCGECRGTVAYIDSYCQQVRNNQVELLGQAKESILQPVENVKVESLYDADYFETEECTTKNEPRCVQDMHATQLNSPIGLNDEKPMKQASRKVTKHKTGQEKTWRRDRRNIREKIITNRENAKQDSSKGEVQTKQLENDQLIKDFFTLECEICSAPLESFVMLLDHYRSAHDTRGYVRCCGKQFFRRYILVDHIAAHRGSTRCEICQKTYKTKRYLMLHMAKSHSSEEERPFKCAKCHISYPKQYLLRAHELLHVQQQCHICQKMLSNNQSLKVHIAQMHSDDGNHICDTCGKVFRTKPAMERHINEHQGLDVVERLQCEYCKKWFSGKYNLNKHIRFLHMQDGQVFPCDVCQHVSPNSRALANHKQRIHVEERFECEYCGKRFKRRPNLREHIATHTNVPLYSCEICENRTFNSKANYFTHRKNKHPQEWEARVRLRAEQLMNNTPND

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00101862;
90% Identity
-
80% Identity
-