Amel008686.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Anopheles melas
Gene Symbol
ZNF219
Assembly
GCA_000473525.2
Location
AXCO02002956.1:19247-22834[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 4e-05 0.0022 18.2 0.6 1 23 128 150 128 150 0.99
2 11 0.00011 0.0058 16.8 2.8 1 23 156 179 156 179 0.96
3 11 2.4e-06 0.00013 22.0 0.4 1 23 185 207 185 207 0.99
4 11 6.9e-06 0.00037 20.6 0.2 1 23 213 235 213 235 0.98
5 11 0.0094 0.51 10.7 3.0 1 23 241 263 241 263 0.98
6 11 1e-05 0.00056 20.0 3.1 1 20 269 288 269 292 0.95
7 11 0.046 2.5 8.6 5.4 1 23 298 318 298 318 0.97
8 11 1.3e-05 0.00069 19.7 0.1 3 23 326 346 325 346 0.98
9 11 1.8e-05 0.00096 19.3 1.1 1 23 352 374 352 374 0.99
10 11 1.2e-05 0.00063 19.9 1.0 1 23 380 403 380 403 0.97
11 11 0.018 0.96 9.9 1.2 1 20 409 428 409 429 0.92

Sequence Information

Coding Sequence
ATGAAGAAATCAACGCGACAAACTCGAATGTCCCGATACGTGGGGAAGCATTCGCCTAAAATCGCATCTCCAGAAGAAAGCAACAATAATATCAACAACAGCAAGAACCCGATCGAAACCGTCCCGAAGGTAATCAGCGGTGATGAAATGATGAGCAATCTCCCTTCGTACATTGTGGAAAAACCGATTGGATACGACGAATCATCCGCGGATGATGAGGAGGATGACAAGTCGATAGTGAAGAAACTAGTAAATGCGTCTGTTGATGCCGGCGAGGGACGAGACGGTGCAGAGTCCGGTAGTGGCACTGATGCGTCCGTATCGTCGACCGGTGGGTCTTCGTCATCGAAACGCGGCCGAAAACGTCGTGAACGGAAGCTGTATCAATGCGAGGTGTGTCAAAAGGACTTCATGGGCACCAACGATTTGCGCAAACATTTGCGAATACATAACGACGAACGGCCGTACCCGTGTCCACACTGCAAGAACCGCTTCCGGCAGGCGGGATGTCTGAAAAATCACATCGCCTCGCAACACGGCACGGACGAGCAGTATACTTGCGACCTGTGCGGCAAATCATTCCCGATCAAGGAGCGTCTACGGTTGCACATGCGTATCCACACCGGCGAAAAACCATACAGCTGCTCGCTATGCCCAAAAACTTTCGCACGTGGTGGTCAATTGACCCAACATCTTGCTACACACAACGGTGTGAAGAAGCACAAATGTGACCAGTGCACGGCAGCTTTCTCCTGTGCGGCTAATCTGAAGATGCATCTTAAAAGCCACATGGATATTCGTGACTATACGTGCCATATCTGTGGCCGCGGATTCTATAGGCCAGATGCTTTGAAAAAACATCTGCTTTGCTATCATGCCAACCTGAAGGCATTTCACTGCAGCATTTGCAATAAAATGTTTAAGGGCCATTTACCACAGCACATGCGAACGCATCTAAAGGTTCGTCCTCACGGTTGTGCTGTATGCGGTTCGGTGTTCTCTCAACGATCGCAGTTGATCGTTCACCAGCGAATTCATAGCGGTGAACGTCCCTATCGTTGCCAGGTTTGCTGGCAGGCGTTTGCACACTCAAGTGTGCTGAAGCTGCACATCCGTAAACACACTGGCGAAAAACCGTTTGAATGTCCGCTTTGTTCATCAAGCTTTTCGCAGCTACCACATTTAAAGAAGCATATGCTGTCTATACATCAGCAGGACAAATCGTACCTATGTCAAAAGTGCAAAGAATTTTTCAAAACCAAGATGGATTACCAATTACACGTTACGGCGTGTTACAAGGATCCGGCAGCTGTGAAGAATCTCGACAATATGATGGACCCAATGTATCGACCGACCGAAAACAATGGCGTTGATCCACCAATGACTATTTCTAGAATGCGTTTTCTAGTGGCCATTTTGTTGAAGAAAATTTCTAATGAGGATCGGTTGAAGGAGCTGGGCTTCGATAAGCGATTGATTGACAATGTTCTAATTGATTCCTTAAAATGTGCTGGCCGAAAGGTTTGCGATGACAAATCGTATGATCCTTTGGAACGTTTGAAGCTAAACGTGCAGGAGCTTCTCGAATGGACAGTACCGCCCAATTACATGGAAGAGTTTCGTGGTGCCAATCGTAGTACGGAGGAGTTGCTTGAGGAACTAACAAACTAA
Protein Sequence
MKKSTRQTRMSRYVGKHSPKIASPEESNNNINNSKNPIETVPKVISGDEMMSNLPSYIVEKPIGYDESSADDEEDDKSIVKKLVNASVDAGEGRDGAESGSGTDASVSSTGGSSSSKRGRKRRERKLYQCEVCQKDFMGTNDLRKHLRIHNDERPYPCPHCKNRFRQAGCLKNHIASQHGTDEQYTCDLCGKSFPIKERLRLHMRIHTGEKPYSCSLCPKTFARGGQLTQHLATHNGVKKHKCDQCTAAFSCAANLKMHLKSHMDIRDYTCHICGRGFYRPDALKKHLLCYHANLKAFHCSICNKMFKGHLPQHMRTHLKVRPHGCAVCGSVFSQRSQLIVHQRIHSGERPYRCQVCWQAFAHSSVLKLHIRKHTGEKPFECPLCSSSFSQLPHLKKHMLSIHQQDKSYLCQKCKEFFKTKMDYQLHVTACYKDPAAVKNLDNMMDPMYRPTENNGVDPPMTISRMRFLVAILLKKISNEDRLKELGFDKRLIDNVLIDSLKCAGRKVCDDKSYDPLERLKLNVQELLEWTVPPNYMEEFRGANRSTEELLEELTN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00100454;
90% Identity
iTF_00105288;
80% Identity
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