Amel010680.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Anopheles melas
Gene Symbol
ZNF219
Assembly
GCA_000473525.2
Location
AXCO02011438.1:6911-10143[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 2.7e-05 0.0015 18.7 0.2 1 23 138 160 138 160 0.98
2 11 2.4e-05 0.0013 18.9 0.7 1 23 166 188 166 188 0.99
3 11 0.0085 0.46 10.9 2.5 1 23 280 302 280 302 0.98
4 11 5.4e-06 0.00029 20.9 0.6 1 23 308 330 308 330 0.99
5 11 0.00013 0.007 16.6 0.0 1 23 421 443 421 443 0.95
6 11 0.00083 0.045 14.0 3.4 1 22 449 470 449 473 0.90
7 11 4.2e-07 2.3e-05 24.4 0.8 1 23 520 542 520 542 0.99
8 11 9.7e-05 0.0052 17.0 4.0 1 21 548 568 548 570 0.94
9 11 0.00017 0.0094 16.2 0.8 1 23 805 827 805 827 0.98
10 11 1.2e-06 6.2e-05 23.0 2.6 1 23 833 855 833 855 0.99
11 11 0.0019 0.1 12.9 1.0 2 23 862 884 861 884 0.96

Sequence Information

Coding Sequence
CAGCAGCACCAAGCGGACGCGAACCAGCAGTACGAGCATCGTGCCAAGCGGCCCCGCTTGATGGTGCGCAAGATCGAGGATTTGGTGGACGACCGGGGCAGCAGTGCGGCGCTGAAGGGCCGGTTTGGGGCGGTGTCGCGGCGCACCTCACACACCGGCACGAGCATTTCGAGTGACGATCGGCGCGACGACGACGATGACGATGAGGATGGCGACGATGAGGGGACGGGAGCGGACAGCAGCGATCAGCACCAGCGGTTCCTGCAGCGAAGGGAGGGTGGGTCGGTGGGCGGTGGGCGTAGCCTGCTGCCGAGGCTGAGCGGTGTGCATGGCCGGTTTTTGGCCGCGATGGAGGAGCAACATTCGAAGCGGCTGGCGGCGGCAGCGGCGGCGGTGGAAGAGAGCGGCAAGCATCGGTGTCCGGTGTGTGATCGAGGGTTTGCCCGCGAGCCGGAGCTGATGCTGCACGTGCGATCGCATCCTGATTTGCCCACCTTCAAGTGTCCGCTGTGCGAGCTGACCTTCATCGGGTCGGACTATCTGAAGAATCATCTGAAGAAGCACGTGATCGGCAACGGGGAAGATCCGGGCGCACCGGGGGCGATCGATTTGAAGGTAAATCCTGCCGCCGACACGAAACCGACCGGCCGGCAACCGCCCGCTGGCGATGGTGGCTCGTCCCAGACCACGCTCCTGCCCTCCACCGCCAAGCTGCCCAAACCGATCATCACGTCCAAGCCGCCCTCGACCGGCATCTCGCTGCTGAAACCGATCGAGGAGCGCAAACCGCCCGACCACCACCAGCAGGAGTACTGCGTGAAGACGCCCGATGGCAAGTTCATGTGCACGGTGTGCGAGCGGCTCTTCTCGCACCAGCAGACGGTGCGCATCCACTTCCGCATCCACACGAACGAGAAGCCGTACAAGTGCGCCTTCTGCGACGAGTCGTACATCCGGTCGGACTATCTCGAGCGCCATCTGAAGGTGCACTTTAAGGATGGGATGCTGCCGGCGGCCGCCATCGCGAGCATGGCGGCGGCGGCCGCTGCTGCCTCTGCATCGAGCGGGGGAAGTCGTTCGGCTGCCTCCACGCCGCCACCACCGGCACTGGCGACGGTGAAGGAGGATTTGGCGTACGCGGAGTCGAGTCCCTCCACACCGGTGGCTGCTGGTACGGGGGGCTCCACCGGCAAACCGCTGATCGGGCGGGCCGGGCTGGCGCCGGAAAACTACCACTTTACCGAGTCGAACGACGGGCAGTTTGTGTGCAAGATCTGCGACGCCGTGTTCAGCCAGGTGGCCTTACTGCGCAAGCACGCGCTAGCGCACACGGAGGAGAAACCGTTCCACTGCGACATCTGCGACCGGTCGTTCAACCGGGTCGACTACCTGAAGGAACACTTCAAATCGAAGCGCCACCTGCAGCTGGTGGCGGAGGCGGCGGCCGCCGGCGGGGGTGCTGACGGGCGCGAGGCGGGTGAGGTGATCGAACCGGCGTCCCGGTCGGTGCTCGGTGAGTTCCATCGGTCCGATTACGAGCGCACGAGCGACGGGCGGTACAAGTGCAACCAGTGCGACAAGACGTTCGTGACGGCCGTCACGCTGAAGATGCACATCCGGCTGCACACGGGCGAGAAGCCGTACAAGTGCGACAAGTGCGATAAGGCGTTCATCCGCTCGGACTATCTGAAGACGCACGAGAAGTGCCACCGGCAGGAATCGTTCCTCAGCATGCTGTCGCTGACGACGTCCAAGGAGCCGAGCACCGCGTCTGAGGCGGGCGACTCCGATGCGGACGGTGGTGGGGAGCTCGGTGAGCTGAGCAGCAATCGGTCGTTGATGGACGCGGCCGGTGGGACGATGAACGGTGCGGGCGGTCATGTTGGTGAGAATGGTAATGGTGTCGGAGGGCAGCTTAATGATGATACGGATGAGGAGGAAGGAGAAGAAGAGGCGGAAGAAGAGGAGGCAGATGAATCGGAAGAGAGCGAAGATGAGCAGGTTATTGAAGTGATGGTGAAGGAAGCGAGCTGCTCTGAAAGTGAAGAGGAGGACGAAGAGGAGGAAGATGATGGCGAGGATGAGGAAGAGGATGAAGAAGATGGGGAGGAAGGGCAGCATCCGCTGTACCAATCGACCACCGACAACAGTACAAACCGAATTGCGACCAACACGACGGCCGCCAGCATGGACCGAAAAGAAAGCAAGAGCGCTAGCAAGCGAAAAAATCGACCAAAGGACTCGCGCACCCCGAACCGCCCGTCCCTGCCGGCCACGAGCGGGTGCGACAGCAGCAACAATGGCTACGAAGACGACAGCGCATCGCAGGCGAGTGGGCCGGTCACGGCCGGCAGCCATGGTGGTGGTGCGTACGCCGGCTCGGAACTGCTGCCGAACGGGCAGAAGGGCAAGCACCGCTGTCCCATGTGCGACAAGCTGTTTGCGTGGCCCAAGTCGCTCAAGATCCATCTGCGCACGCACACGGGCGAGAAGCCGTACCGGTGCGACGTGTGCGGCAAGTGCTTCGGCCGCTCGGACAGCTTGCGCGGCCACAAGCGGACGCACGCCGACGACAAGCTAATACAGTGCCATCTGTGCGATGTGAGCTGCCCGAACGCGACCGAGCTGGTGCAGCATCAGTACACGGTGCACGGTTTGCAGCCGCTGGAGAGTTAG
Protein Sequence
QQHQADANQQYEHRAKRPRLMVRKIEDLVDDRGSSAALKGRFGAVSRRTSHTGTSISSDDRRDDDDDDEDGDDEGTGADSSDQHQRFLQRREGGSVGGGRSLLPRLSGVHGRFLAAMEEQHSKRLAAAAAAVEESGKHRCPVCDRGFAREPELMLHVRSHPDLPTFKCPLCELTFIGSDYLKNHLKKHVIGNGEDPGAPGAIDLKVNPAADTKPTGRQPPAGDGGSSQTTLLPSTAKLPKPIITSKPPSTGISLLKPIEERKPPDHHQQEYCVKTPDGKFMCTVCERLFSHQQTVRIHFRIHTNEKPYKCAFCDESYIRSDYLERHLKVHFKDGMLPAAAIASMAAAAAAASASSGGSRSAASTPPPPALATVKEDLAYAESSPSTPVAAGTGGSTGKPLIGRAGLAPENYHFTESNDGQFVCKICDAVFSQVALLRKHALAHTEEKPFHCDICDRSFNRVDYLKEHFKSKRHLQLVAEAAAAGGGADGREAGEVIEPASRSVLGEFHRSDYERTSDGRYKCNQCDKTFVTAVTLKMHIRLHTGEKPYKCDKCDKAFIRSDYLKTHEKCHRQESFLSMLSLTTSKEPSTASEAGDSDADGGGELGELSSNRSLMDAAGGTMNGAGGHVGENGNGVGGQLNDDTDEEEGEEEAEEEEADESEESEDEQVIEVMVKEASCSESEEEDEEEEDDGEDEEEDEEDGEEGQHPLYQSTTDNSTNRIATNTTAASMDRKESKSASKRKNRPKDSRTPNRPSLPATSGCDSSNNGYEDDSASQASGPVTAGSHGGGAYAGSELLPNGQKGKHRCPMCDKLFAWPKSLKIHLRTHTGEKPYRCDVCGKCFGRSDSLRGHKRTHADDKLIQCHLCDVSCPNATELVQHQYTVHGLQPLES

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
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90% Identity
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80% Identity
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