Basic Information

Insect: Anopheles melas
Gene Symbol: TEAD1
Assembly: GCA_000473525.2
Location: AXCO02007519.1:324-4720[-]

Transcription Factor Domain

TF Family: TEA
Domain: TEA domain
PFAM: PF01285
TF Group: Helix-turn-helix
Description: The TEA domain is a DNA-binding region of about 66 to 68 amino acids that has been named after the two proteins that originally defined the domain: TEF-1 and AbaA. The TEA domain is located toward the N terminus of eukaryotic transcription factors of the TEA/ATTS family. It shows a three-helix bundle with a homeodomain fold [3, 1]. Two α-helices are nearly anti-parallel and pack on either side of the third one, which is the DNA-recognition helix of the TEA domain. Phosphorylation of one or both of the two conserved serines found on the DNA-binding surface could interfere with DNA-binding activity, by introducing electrostatic repulsion and/or steric hindrance, and help regulate the transcription factor activity of the proteins [2, 1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 8.9e-17 7e-13 48.5 0.9 37 66 9 38 3 40 0.94

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	8.9e-17	7e-13	48.5	0.9	37	66	9	38	3	40	0.94

Sequence Information

Coding Sequence: ATGAAGAATGTCTTTCGTGCTTGTCGCAATGAACTGATCGCTCGCTATATCAAACTACGCACCGGCAAGACGAGAACCCGGAAGCAGGTCAGCTCGCACATACAAGTATTAGCCAGACGGAAGCTGCGCGAGTTCCAGGCCAAGATGAAAGTGAATCACCCGCTGATGGGTGTGAAGGAGAAAGTCTTCCCGACCAACATGACCGGCATGAGCAGTGCCCAGATCGTGACGATGGCTGCAGCGAAAGGTCGCCTTCCCTTAGCCAATCCTTCTTACCACCACCACCACCACCACCACCACCAACAACAGCAACACCATCTTCCGTACCACCATCACCATCCTAGTGCTGCTGGTCAATTCTGGCAGCCGGGCCTGCAGCCGAGCACCTCCCAGGACGTGAAACCGTTCGCCCAGCCCGGCTACCCGATGAAGACGGCGACCGCCGTCTCGGAAGGCGCCTTACAGCCCGCCCACCCGTGGGAGGGGCGCGCGATCGCGACGCACAAGTTCCGGCTGGTCGAGTACAGCGCCTATCTGGAGCTGCGTGCCGAAGAAACGTATCACAAGCACCTGTTCGTGCACATAGCAGACACGCCCGCCAACCCGCTGCTGGAGTCGGTGGAGGTGAAGGAGATCTACGACAAGTTCCCGCAAAAGTCCGGCGGCCTCAAGGAGCTTTACGAGAAGGGTCCGAGCAATGCGTTCTTCCTGGTGAAGTTCTGGGCGGACCTGAACACGAACATCGCGAACGATGCGGGCGCGTTCTACGGCGTCAGCAGTCACTACGAGAGCAACGATAACATGGTGATCACCTGCTCGACCAAGGTGTGCTCGTTCGGCAAGCAGGTGGTGGAGAAGGTGGAAACGGAATACTCCCGCATCGAGAACGGTCGCTACGTGTACCGGATCAGCCGGTCGCCGATGTGCGACTACATGATCAACTTCATCAACAAGCTGAAGCACCTTCCCGAGAAGTACATGATGAACAGCGTGCTGGAGAACTTCACCATCCTGCAGGTTATATCCAACAAAGACACGGACGAGACGCTCCTGTGCGTGGCGTTCGTGTTCGAGGTCCACAATAACAGCAGCAGCGACGGCGGCAGCAGCGACCGTCCGGCCACCACCAACAGCACCAATCAAGACCCGGGCCACCTGCAGCAAACGGGGGCAGCAGAGGCCGCTGTACCACCGCCGGCACCACCACCGCCACCCCCGATCGTCGATCTGCCGAGCTGTTTGGTCGAGCAGCAGACGGCGGCTGCACTGCTGCCACAGTCAACCACGCCCCATCAACCGGCGACGAACCGCGAACCACCAGCACTGGGAGTGGTCCGAACCGAGCCGACGACCCCCACGGCCAGCCCGGAGGAGCTGGTCCGTTGCACCGGCGACCAGCAGCAGCAGCAGCGGCAACCCGTCAAGCAGGAGTATCTCGGGCTGGACCCGCCCGACTACGGCCAGCTGCTGGAGGTGGACGCGAAACGGGCCTCCCAGCAGCTGCTGCTGCTGCAGCACCGTCCCGCTCTACACCAGTTGCTGCGCGACTAG
Protein Sequence: MKNVFRACRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKLREFQAKMKVNHPLMGVKEKVFPTNMTGMSSAQIVTMAAAKGRLPLANPSYHHHHHHHHQQQQHHLPYHHHHPSAAGQFWQPGLQPSTSQDVKPFAQPGYPMKTATAVSEGALQPAHPWEGRAIATHKFRLVEYSAYLELRAEETYHKHLFVHIADTPANPLLESVEVKEIYDKFPQKSGGLKELYEKGPSNAFFLVKFWADLNTNIANDAGAFYGVSSHYESNDNMVITCSTKVCSFGKQVVEKVETEYSRIENGRYVYRISRSPMCDYMINFINKLKHLPEKYMMNSVLENFTILQVISNKDTDETLLCVAFVFEVHNNSSSDGGSSDRPATTNSTNQDPGHLQQTGAAEAAVPPPAPPPPPPIVDLPSCLVEQQTAAALLPQSTTPHQPATNREPPALGVVRTEPTTPTASPEELVRCTGDQQQQQRQPVKQEYLGLDPPDYGQLLEVDAKRASQQLLLLQHRPALHQLLRD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00095614;
90% Identity: iTF_00100925;
80% Identity: -