Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 3.1 1.6e+02 2.6 1.4 3 18 157 169 156 174 0.65

2 6 3.2e-06 0.00016 21.4 0.7 1 23 181 203 181 203 0.97

3 6 5.4e-05 0.0028 17.5 4.7 1 23 209 231 209 231 0.98

4 6 1.3e-05 0.00065 19.5 1.1 1 23 237 260 237 260 0.96

5 6 0.0051 0.26 11.3 1.7 1 23 265 287 265 287 0.92

6 6 1.7e-05 0.00087 19.1 4.4 1 23 293 316 293 316 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	3.1	1.6e+02	2.6	1.4	3	18	157	169	156	174	0.65
2	6	3.2e-06	0.00016	21.4	0.7	1	23	181	203	181	203	0.97
3	6	5.4e-05	0.0028	17.5	4.7	1	23	209	231	209	231	0.98
4	6	1.3e-05	0.00065	19.5	1.1	1	23	237	260	237	260	0.96
5	6	0.0051	0.26	11.3	1.7	1	23	265	287	265	287	0.92
6	6	1.7e-05	0.00087	19.1	4.4	1	23	293	316	293	316	0.97

Coding Sequence: ATGAATAACGACTGTGTGGATTTGcgattaaattttgaaaatgtgtgtCGCTTCTGTCTTTCCCTAGAAGATATTGTGCCTTTGTTCATTAACTCAACCATAAACGAAATCCTGATCGATGCTGTTGATGTGCTCCTGCCCAAGGTTGATGAGCACGATGGACTGCCCAACTGTGTTTGTGCCCGGTGCCATCAAAGGATGGCCGATTTTTCCAAATTTGAGGCAACTGCTCTGGAAGTCTACAACAAGCTGCAAAGCGTCATAGCTTACCTTGATGAAGAAGGGGATGATTGTAATGCCGGGCCTCAGCCGATGCACGAAGACGATGCTAATGACCAGCTAGAACCGCCCCCGAATGCAATTGAAGATGGTCCCGCTCAAGAGATGGAAAGTATCGCACTGGAAACCGAAattgcagcaacaaaaacacaccctGCATCAAAACCCACCCGTCGCCCAAAGAAAGCTTGTCCCGTGTGCGGCAAGCTAGTGTCGCAGATCAGCAAGCACATGTCGGTGCACAGCAGCGCAACGAAACGCTTCGCCTGCGAACAGTGCGACAAACGCTTTACGCTGTTGGCTAGCTTGCGGAAGCATCTGAAGATACACCGGAACATACGCAACTATCGGTGTGAGCACTGTGGGGACAGTTTCTGCGATCGGTCCTCGCTCAGGTATCACCTGGCCAAGCATCGGGGTGTGCCGGGGTTTGCGTGTGAATTCTGCGACCGGCAGTTTTACACCTCGTCCCAGTGGAAGCAACACCAACGCTTGGCCCACCGGGAGCGTACGTTTCGGTGTGATGTTTGCGGGCAGGCGTTTCTGCTAAAACACCATCTGATGGAACATGCGCAACTGCACACCGATGGACGTCCGCACGAATGCGACGTGTGCGGTAAAGCTTTCAAGCGGGAACGATACTTGCATGTTCATAAGCGACGCCGGCACACCATGAAAGAGAAAGGGGAGTGA
Protein Sequence: MNNDCVDLRLNFENVCRFCLSLEDIVPLFINSTINEILIDAVDVLLPKVDEHDGLPNCVCARCHQRMADFSKFEATALEVYNKLQSVIAYLDEEGDDCNAGPQPMHEDDANDQLEPPPNAIEDGPAQEMESIALETEIAATKTHPASKPTRRPKKACPVCGKLVSQISKHMSVHSSATKRFACEQCDKRFTLLASLRKHLKIHRNIRNYRCEHCGDSFCDRSSLRYHLAKHRGVPGFACEFCDRQFYTSSQWKQHQRLAHRERTFRCDVCGQAFLLKHHLMEHAQLHTDGRPHECDVCGKAFKRERYLHVHKRRRHTMKEKGE

Sequence clustering based on sequence similarity using MMseqs2