Basic Information

Gene Symbol
-
Assembly
GCF_000005575.2
Location
NT:14464902-14474016[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 1 53 4.1 3.4 1 23 253 276 253 276 0.92
2 11 4 2e+02 2.2 4.1 1 23 282 305 282 305 0.94
3 11 1.1e-05 0.00057 19.7 1.6 1 23 328 350 328 350 0.98
4 11 0.00012 0.0061 16.5 0.5 1 23 357 379 357 379 0.98
5 11 0.0013 0.066 13.2 0.1 1 23 394 417 394 417 0.97
6 11 0.0031 0.16 12.0 0.2 1 23 437 459 437 459 0.96
7 11 3.4e-05 0.0018 18.2 0.2 1 23 569 592 569 592 0.96
8 11 0.00025 0.013 15.4 7.1 1 23 707 730 707 730 0.98
9 11 0.00097 0.049 13.6 1.4 3 23 738 758 736 758 0.97
10 11 0.25 13 6.0 0.8 1 23 773 795 773 795 0.97
11 11 1e-05 0.00053 19.8 0.1 2 23 812 834 811 834 0.95

Sequence Information

Coding Sequence
ATGGAGgaaccgccgccgccgccgccaccacccgCACCACCGTCGCCACACGGGACGAAAAGTGAACCGATGACAGTGGCCGCACCGAACGAAGCCACACAACGGTTGGCCGTTGCCGTCGGTGGCAGGATGGTAGTGGTGTGCCGGATCTGTCTCTCCACCCGTCCGCGCATGATATCCATCCACAGCCCGGTGCCGGAGTACGACCAGAAGACGCTGTACGCCATGCTGCTGTCCGTGTGCTTGCCGCTGAACCAGCGCGAAACGGTGCAGGGCTTGCCGGAGCAGATCTGCCGCAACTGCCAGTGGAAGCTGCTGTCGGCGTACGATCTGTACGAGACGACGCTGGCCAGCGACGAGCAGCTGCGCGCCGAAACGTCCCGGAAACCACCGACCGGGAAGGTGACACTGGCCGGTGAGGTGTTGCAGCCGGCGGAAGCACCGCCAGCGGACGGCGGTTTGATCCGTGTGAAGGAAGAAACGCCCGACGACGGGTACGAGGAGCACGGGTACGGACCGGGCGGTAGGGCCGAAGAGGAGGACGCCCCGGGCGCGGTGTACGACACGAGCGGGGAGATGAGCATGCTCAGCATTCAACCCGACGTAAGCCTGCTGACGGAGGAGGGTGGCCGTGAGCcgggcgaggaggaggagggagacGACGCCAACTTGCTTGAGGAGTCGAAAGCCGACCTGCCCGATCCGATGGAAGCGTTCGTGGACGAGCACTACCAGCAGGACGAGGACAGTGGTAACCACGTGTGCGGGCTGTGCAAGCAGGACTTTGCGTACAAGAGCCAGTGCCGGATGCACATCGCGCAAAAGCACAACCCGGCCAAACCGTTCAAGTGCGACGTGTGCTACTGCACGCTTACCAGCCATCTGCGCCTGGTGCGGCACAAGATCGTGACGCACGGCGCCGGCCAGATCAAGCGGGAGGACGTGATCGAGGCGCAGAACGACAGCACCGGCGAGATGACGTACACGTGCCCGATCTGCCGGAAGGTGTTCAACTCGTCCGTGCGCTTCAAGCGCCACCGGAACGTGCACGTGGTGCACAATCGGCCGTTCAAGTGTGAGGTGTGCCTGTACCGGTTCGCCACCAAGCCGCAGCTGACGCAGCACGCCAAGGTGCACGACGAGAAGAGCGTGTCGCCGGGCAGCTCGGAGGTGGGCGAGTACCCGTGCGACCGCTGCGAGGAGGTGTTCGTGGCGAAGCGCGCCCTCACGATGCACCTGAAGAAGGCGCACCAGGTGTACCGGGTGCCGGGCGGGGCGCGGCCGGACGAGCAGCGCGAACGCAGCGAGTACGTGTGCATCATCTGCAAGGCGACGTTTGCGCGCGAAACCGTCCTCAACACGCACATGAAGATGCACGAGCTGCTGGCGgcggagaaggagaaggagcggCGGCTCGATCTCGAGCGGCTGGTCAAGcaggagctgcagcagcagatgcagcAGAGCGTGCCACCACTGCCGCCCCTCTCGCCGGAGCAAACCGATCCGCCGTCCTGCGTGCTCGATCCGGTGGCGCTCGGGCTGGTGCCGGTGGCAAAGGCGCAAGGCGGAGCGGCATCCGGCACggacaataacaacagcagcacgagcatcaacaacaacagtccACCCGGCGGCTCCGGTGGTCCGAGCGGGCTGAAGCGGAAACTGTCCCTGCCGCCGGCACCGCCGAGCGACATGGCGTACGTGTGTCCGGTGTGCGACACCGAGTTCGATGAGCGGGAAGCGCTGAAGAAGCACCAGAAGGAGCAGCACACCCGGCTGCAGGTTGGCATCGTGTCGTCGAGGATGGGTGAGTCCGGCACGCCGACCGGTGGGGGGGGACATTCGCAGCCGAAGATGATGCCACGGTTGACCGCCCTGCCCGGGATGAAAATGCGCCTACTGGATGGGAAGCGGATAATGGACAAAAAGCGACGCCTACTGCCCGACCCAGCCGATGATGACGTTGAGCTAATAGAGCACGACGATTCGCTAGACAACGACGGCCACAGCACTGGCGGCCTAATACCGATAGATGATAGCCCGCGGGGCCTTGAACGGCGGCAGACCGCATCCGGTGCTACCGCGTCATCGCCCACTGAAGAACCGTCCCAGTTCCAGTGCGACCTCTGCCATAAAAAGTTCCCCTACAACTGCTACCTAACGATGCACATGCGTAAAAATCACGACAAATCTAAACCGTACGGCTGCAAGGTGTGCCATTACCGTTTCGGGTACCGCGGTACGCTGCTGCGCCACCAGCTGATCCACTCGTCCCAGCGCGTCCAGCCCGGCAGCCACGGTTCAATCATCTTCAAGTGCCGCATCTGTTCGGCCAAATTTCTCGAGCTAAGGCAGCTGAATATGCATCTGAAAGGGCACCGGAAGGTGCCGGAAGAGCCAGAGCCCAACCAGCAGGTGCAGCTGATTCGCTGCAACGAGTGTCCGCAAATCTTTAGCAACCCGAACCAGCTCGCCCGGCACATGGTGAAGGAGCATCAGCAGGAGCAGCAAGAGAGCGAGGACGACGAGCTATACAATTCCGACCGATTAtttcagcaccagcagcaagcCGACCTGGCCATGTATCCGTCCTCTTCGTCGTTAAGAGGTGACGGTGGTGGTCGTACCACCACGAACGATCTCAAGCATAATTCCGAACAGTCGAAAGACGGCCACGGTGCTGCACTCATAAACGACGATGTATCGATTATCAAGCTGGAGCCAAACTTTGATTAA
Protein Sequence
MEEPPPPPPPPAPPSPHGTKSEPMTVAAPNEATQRLAVAVGGRMVVVCRICLSTRPRMISIHSPVPEYDQKTLYAMLLSVCLPLNQRETVQGLPEQICRNCQWKLLSAYDLYETTLASDEQLRAETSRKPPTGKVTLAGEVLQPAEAPPADGGLIRVKEETPDDGYEEHGYGPGGRAEEEDAPGAVYDTSGEMSMLSIQPDVSLLTEEGGREPGEEEEGDDANLLEESKADLPDPMEAFVDEHYQQDEDSGNHVCGLCKQDFAYKSQCRMHIAQKHNPAKPFKCDVCYCTLTSHLRLVRHKIVTHGAGQIKREDVIEAQNDSTGEMTYTCPICRKVFNSSVRFKRHRNVHVVHNRPFKCEVCLYRFATKPQLTQHAKVHDEKSVSPGSSEVGEYPCDRCEEVFVAKRALTMHLKKAHQVYRVPGGARPDEQRERSEYVCIICKATFARETVLNTHMKMHELLAAEKEKERRLDLERLVKQELQQQMQQSVPPLPPLSPEQTDPPSCVLDPVALGLVPVAKAQGGAASGTDNNNSSTSINNNSPPGGSGGPSGLKRKLSLPPAPPSDMAYVCPVCDTEFDEREALKKHQKEQHTRLQVGIVSSRMGESGTPTGGGGHSQPKMMPRLTALPGMKMRLLDGKRIMDKKRRLLPDPADDDVELIEHDDSLDNDGHSTGGLIPIDDSPRGLERRQTASGATASSPTEEPSQFQCDLCHKKFPYNCYLTMHMRKNHDKSKPYGCKVCHYRFGYRGTLLRHQLIHSSQRVQPGSHGSIIFKCRICSAKFLELRQLNMHLKGHRKVPEEPEPNQQVQLIRCNECPQIFSNPNQLARHMVKEHQQEQQESEDDELYNSDRLFQHQQQADLAMYPSSSSLRGDGGGRTTTNDLKHNSEQSKDGHGAALINDDVSIIKLEPNFD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2