Basic Information

Insect: Anopheles dirus
Gene Symbol: zfh1
Assembly: GCA_000349145.1
Location: KB672824.1:647460-665280[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.084 4.7 7.3 0.6 2 23 53 74 52 75 0.94

2 9 0.00047 0.026 14.4 1.2 1 23 244 266 244 266 0.95

3 9 9.4e-05 0.0053 16.6 1.5 2 23 273 294 273 294 0.97

4 9 2.6e-06 0.00015 21.5 5.8 1 23 303 325 303 325 0.99

5 9 1.4e-05 0.00078 19.2 0.8 1 21 331 351 331 352 0.95

6 9 0.96 54 4.0 0.1 2 21 694 713 693 714 0.91

7 9 1.8e-05 0.001 18.9 4.0 1 23 1145 1167 1145 1167 0.95

8 9 9.2e-05 0.0051 16.7 7.8 1 23 1173 1195 1173 1195 0.98

9 9 0.05 2.8 8.1 7.0 1 21 1201 1221 1201 1222 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.084	4.7	7.3	0.6	2	23	53	74	52	75	0.94
2	9	0.00047	0.026	14.4	1.2	1	23	244	266	244	266	0.95
3	9	9.4e-05	0.0053	16.6	1.5	2	23	273	294	273	294	0.97
4	9	2.6e-06	0.00015	21.5	5.8	1	23	303	325	303	325	0.99
5	9	1.4e-05	0.00078	19.2	0.8	1	21	331	351	331	352	0.95
6	9	0.96	54	4.0	0.1	2	21	694	713	693	714	0.91
7	9	1.8e-05	0.001	18.9	4.0	1	23	1145	1167	1145	1167	0.95
8	9	9.2e-05	0.0051	16.7	7.8	1	23	1173	1195	1173	1195	0.98
9	9	0.05	2.8	8.1	7.0	1	21	1201	1221	1201	1222	0.96

Sequence Information

Coding Sequence: ATGGTGTCCTGCAGCGTTGCTGTGTCGACGTACTACAACGCGGAAGGAAGTATCATGCCATCTTCGACCAAGTTTTCCCTACAGTTTCCTTCCCTGCCATCTGGTCTACCAAAGGACAGTGAAAACGATGCACTAGCGGACGCCGCCTGCTGCGTTCAGTGCCCTCAGTGCCACCAGACGGTTCAAGGAGTCGAGGCGCTGAAAGAACACATCCAGCTCCATCACAGTGGCAGCTCGGACGGGCTGCGGCTCAAATTCGCGACCGAGCCGACCgagctggacgacgacgacgacgacgacgacgacatggcggaggaggacgagCATCACATAGACCCGGACGCGGCCTCGCCGCTGCCGGCCGCGCCGCTCGAGTCGCTGGCGGCGGCCTGCGGGGGCCGGGCGAGCGGTGACCTGCTCGGCAGCCGGCTCCAGGCGAAGTGCGTCagcctgctgcagctgcagcagcagaagcaccgGGCGGCGAAGGACgtcgacgacgccgacgacggcgacgacgacgacgacgagggcgAGGAGGTCGAGGTGGACGTGACGCAGCGGGCGACACCGCGCGgtctgctgctggccggccTGCCGCAGCCGGACCTGCCGTACGGCGGGCCGCGGTCGATGATGGTCAGCCCGTCGCaggacggcagcagcaactcgAGCGGCGGCCCGAGCCTGCCCACCGGGGGCCTCGTCAAGGACGGCGACCTGGCCGTGTACGACTGCGCCCAGTGCCCGAACACGTTCACCAGCCGGGATCAGCTGGAGCGGCACGAGCTGCACCACGCACCGTCAGCGGACGCGAGCTGCAAGGTGTGCCACAAGCCGTTCGCCAACGTCTACCGGCTCCAGCGCCACATGATCTCCCACGACGAATCGTTGCAGCGCCGCAAGTTCAAATGCAACGACTGTGATAAAGCGTTCAAATTCAAGCACCATCTGAAGGAGCACGTGCGGATCCACTCCGGCGAGAAGCCGTTCGTCTGCCCGAACTGCGGCAAGCGCTTCTCGCACTCCGGCTCCTACTCGAGCCACATGACCTCGAAGAAGTGCATCAACATGGGCATCAAgctcaaccaccaccacaacaacaacaacaacaacaacaacaaccagaaccacaacaacaacaacaacaacagtagcagccagaacaacaacagctccaACACGAGTGGCAGCGGCAGTGACAGCAATCACCCGTCGCTGCAGTACCCGTTCCACGGTAGCAACGGCATGGGCGGTGTTGCGAACGGCAacggtgtgttggtgggccGGTCGCCGATCGGGTTCCGGCCGCAGATGCACCGCGAGCTGGACGTGGCCGGTCGGCTCGGGTTGGTGACGTCACCGTCTCCAACGTCTTCCTGCTCCTCTGCGACGAAGCACGAGCTGGACGGGGCGACCGGACCGGGTGGAGTCGACGCGCTCCTGCTCAGCAAACTGCAGCACGCCTCCTGGATCTACTCGCTGGCACTGCTGGAGCCGAACATGTTTCGCCTGATGGAGCTGTCAGCGGCggcccagcaacagcagcagcagcagcagcaacagccaccaACACTGTCCCAGGCGAGCGCCACAGCCGGAGGAGAAGCGGAGCGACCCCCGTCAGCCAAGCGTCCCGCGTCGTCCACCGACGTCGGCGTCGAGCCGCCCGAAGCCGACCCACACCAACCGTCCGCCGGGTGTCTGGAGCGCATGGACatcgacgaggaggagcaCGAGGGCTACGCCGAGCAGAAGGTGGAGGTCGTGATGGCCACCGAGGACAGTAGTGGCGCGTCGGGCGCCAGCGACCTTCCGGTGCCCGATGTCGCAGGCGCGAGCCTCGAGCCAGCGGCACCGAACGTGGAGCTGACCCAGCCGGTCCAGACCAAGCAGGAACCGCCGGAGGACGACAGTCGCCCGCCCAGCCTGCCGGCGGACGTGCCGGTGAAGGACGAACCGCCGGAGGAGCCGGGCCCGATCGAGATGGCCGAGCTGAAGCTGAGCGACGCGGCCGACGACCGGGGGCCCCGGTGTGCGTCCCTGTCGCCGTCGGTGTCGGGGTCGCAGGCGCCCCTCCACTGTCTCTACTGCAGCGAGGAGTTCGCGTCCGAGCCGGAGATGCTGCAGCACGCCCGGATGTTCTGCAAGCGGTCGCTGCTGCTCAACCCGTTCGTTGGGACGCCGACCGGGCCCACCCTAGCGCCCaccgccggcagcaacagtggcagcaacagcggcagcaacagtggcagcaacagctgcaacagcagctgcagcgagGATGACGCCGACTACGACCCGCTCAAGACGTTGCACGCCGGTGgggctggtggcggcggcgctgcgggcggtgttggtggcggtgttggtggtggtggcaacgCGGCCGGTCTGCACGGCGGAGCCGGCGGTGGCGGGAAGGTGCGCGTCCGCACCTCCATCTCCGAGGAGCAGCAGAACGAGCTGAAGCAGTACTACGCGCGCAACAGCAAACCGAGCCGGGACGAGTTCCAGGCGATCGCGCACCACGTCAAGATGGAGGCGCGCGTCGTGCAGGTCTGGTTCCAGAACAATCGGTCGCGCGAGCGCAAGATGGGTGGCGTGCTGCGCCAGTACCCGGCCGGTGCGACCGGCCAgacgccgtcgtcgccgctgCACGCCGACCGCGCGCCGTCCGTCGTGACCGGCGACACCGGCGACCAGCCGCTCGATCTGTCCGTCAAGAAGGGCCTGCTGACGGAGGCGCTGCTGACGGCGGCAACCAACACACAGGCGGCCGCCACCGCAATGGCCGCCGGTGCGCTCCCGGCGGTGCTCCTGCAGGCCGACACCATGTCCGCGCTGAACGAAGCGATGAACCTGAGCGTGAAGACGTCGCCGACGGCGTTCTTCTACCACGACATCCACCCGATCCACGGGGTGACGCCGACCGGGCCGCAGCCACCACACCAGCTCAGTCTGGCGGCAGGCACGCGCGACACACCCTCACCACAAGACGTCCGGAGTcagccgcaccagcaccagcagcaccagcagcaatcgacacaaccaccagcgccaccgcaCACGTTCGGCAAGTACACACCGgttcaccaacaccaccatcacccggcCAACCTCACCGGCATGGATCACCTGTTCCGGCAGTTCTCGCCGGAGCTGtcagcggcggccgcagcggccgccgccgccgccgccgctgccgtcggCCGGGCCAGTCTCAGTCCGGGCGCGCGCGACCTGCTACCCGGGGACGCCGGCGACACCAGCTACTACGGCACCTTCCCGGacaagcagctgctgcagtcgATGCTGAACGTGCCGAAGCGGAGTGGTGGCGCGTACGGTGCAactaccgccgccgccgctgccgccgccgtcggtaAAGACCCGTCCGGTCAGCTGGCGACGCCGGACGCCGAGGGCCAGTACGTCTGTGATCAGTGCGACAAAACGTTCAGCAAACACAGCTCCCTCCAGCGGCACAAGTACGAACACTCCGGTCAACGACCGTACAAATGTATGGAGTGCCCAAAGGCGTTCAAGCACAAGCATCACCTCACCGAGCACAAGCGGCTGCACAGCGGCGAGAAGCCGTTCCAGTGCTGCAAGTGTCTGAAGCGCTTCTCGCACTCCGGCTCGTACAGCCAGCACATGAACCATCGCTACTCGTACTGCAAGCCTTACAGGGAGGGCAAATAA
Protein Sequence: MVSCSVAVSTYYNAEGSIMPSSTKFSLQFPSLPSGLPKDSENDALADAACCVQCPQCHQTVQGVEALKEHIQLHHSGSSDGLRLKFATEPTELDDDDDDDDDMAEEDEHHIDPDAASPLPAAPLESLAAACGGRASGDLLGSRLQAKCVSLLQLQQQKHRAAKDVDDADDGDDDDDEGEEVEVDVTQRATPRGLLLAGLPQPDLPYGGPRSMMVSPSQDGSSNSSGGPSLPTGGLVKDGDLAVYDCAQCPNTFTSRDQLERHELHHAPSADASCKVCHKPFANVYRLQRHMISHDESLQRRKFKCNDCDKAFKFKHHLKEHVRIHSGEKPFVCPNCGKRFSHSGSYSSHMTSKKCINMGIKLNHHHNNNNNNNNNQNHNNNNNNSSSQNNNSSNTSGSGSDSNHPSLQYPFHGSNGMGGVANGNGVLVGRSPIGFRPQMHRELDVAGRLGLVTSPSPTSSCSSATKHELDGATGPGGVDALLLSKLQHASWIYSLALLEPNMFRLMELSAAAQQQQQQQQQQPPTLSQASATAGGEAERPPSAKRPASSTDVGVEPPEADPHQPSAGCLERMDIDEEEHEGYAEQKVEVVMATEDSSGASGASDLPVPDVAGASLEPAAPNVELTQPVQTKQEPPEDDSRPPSLPADVPVKDEPPEEPGPIEMAELKLSDAADDRGPRCASLSPSVSGSQAPLHCLYCSEEFASEPEMLQHARMFCKRSLLLNPFVGTPTGPTLAPTAGSNSGSNSGSNSGSNSCNSSCSEDDADYDPLKTLHAGGAGGGGAAGGVGGGVGGGGNAAGLHGGAGGGGKVRVRTSISEEQQNELKQYYARNSKPSRDEFQAIAHHVKMEARVVQVWFQNNRSRERKMGGVLRQYPAGATGQTPSSPLHADRAPSVVTGDTGDQPLDLSVKKGLLTEALLTAATNTQAAATAMAAGALPAVLLQADTMSALNEAMNLSVKTSPTAFFYHDIHPIHGVTPTGPQPPHQLSLAAGTRDTPSPQDVRSQPHQHQQHQQQSTQPPAPPHTFGKYTPVHQHHHHPANLTGMDHLFRQFSPELSAAAAAAAAAAAAAVGRASLSPGARDLLPGDAGDTSYYGTFPDKQLLQSMLNVPKRSGGAYGATTAAAAAAAVGKDPSGQLATPDAEGQYVCDQCDKTFSKHSSLQRHKYEHSGQRPYKCMECPKAFKHKHHLTEHKRLHSGEKPFQCCKCLKRFSHSGSYSQHMNHRYSYCKPYREGK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00098906;
90% Identity: iTF_00098906;
80% Identity: iTF_00098906;