Basic Information

Insect: Anopheles darlingi
Gene Symbol: THAP4
Assembly: GCA_000211455.3
Location: scaffold:48569-61343[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 3.7 2.2e+02 1.9 0.0 2 10 143 151 142 155 0.90

2 9 2.2 1.3e+02 2.6 0.9 3 17 456 470 456 474 0.88

3 9 0.00064 0.038 13.7 0.5 3 20 488 505 486 506 0.95

4 9 0.0013 0.077 12.7 0.0 1 23 548 570 548 570 0.96

5 9 0.0031 0.19 11.6 0.3 1 21 578 598 578 599 0.95

6 9 0.00015 0.0087 15.7 0.5 1 23 643 665 643 665 0.96

7 9 1e-05 0.00059 19.4 1.3 1 23 671 693 671 693 0.97

8 9 9.4e-07 5.6e-05 22.6 0.3 1 23 699 722 699 722 0.96

9 9 0.54 32 4.5 0.1 1 16 728 743 728 745 0.82

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	3.7	2.2e+02	1.9	0.0	2	10	143	151	142	155	0.90
2	9	2.2	1.3e+02	2.6	0.9	3	17	456	470	456	474	0.88
3	9	0.00064	0.038	13.7	0.5	3	20	488	505	486	506	0.95
4	9	0.0013	0.077	12.7	0.0	1	23	548	570	548	570	0.96
5	9	0.0031	0.19	11.6	0.3	1	21	578	598	578	599	0.95
6	9	0.00015	0.0087	15.7	0.5	1	23	643	665	643	665	0.96
7	9	1e-05	0.00059	19.4	1.3	1	23	671	693	671	693	0.97
8	9	9.4e-07	5.6e-05	22.6	0.3	1	23	699	722	699	722	0.96
9	9	0.54	32	4.5	0.1	1	16	728	743	728	745	0.82

Sequence Information

Coding Sequence: ATGCCTGCGCACTGTGTAATTCAGGATTGTAATTTAAGGTACACGCACAGCGAAGAAGTTTCCTTCCACAAGTTTCCACTTCGGAATCGGGAGTTACTGAAACGGTGGATCGAATTCGCGAACCGCAACCAAAATTGGAGTCCCAGCAAATGGAGCTGCATCTGCAGTCGCCACTTTCTACCGTCCGACTTCCGGGACTGTGCTTTGCGAAGGAATCTTTCTTCCAGTGCCATCCCATCGATCCGGGCTCCTTTGAAGGAGCCTGCACCTTACGATATGAACCAGCAACAGCCGCAAGAGCTACCGCAGCGAGGTGATGAATACTATACTACGGAGGAGTTGGAAGGCCAATTCTACGGAGCAGCAGGCGAAGGCATGGAAACGGAAGAGATTCCAGAAGATGAAGACACTCCCTTGGCCGACATCAGCTGTCGAGTTTGTGGCGAGGTGTTTGGTGGAGCAGCGGAAAAGCTGCTCGCGGATCTGAGCGAATCGTTGATCGTGATAGGCAAATATCTGCCCTTTGTAAATCTCACTTTGCCCAATTTACCCCGGAAAATCTGTGCCCACTGTTCGAAGGTGGTGCACGAGTTTGCCACTTTCTGCGAGAAGGTTCTGCAAGCTCAAACCGATTTGGAGCACCGATTCGCTTGGAATGATGCGACTATATCGGAACATCCGTCGCCAACGGTATCAAGAGGCCCATTGGAACTGGGAGGCACTAAAGTAATGAAAATCAAACAGGAACCTATCACCAATCTGTACATCAAAGAGGAGAAGACCGAAGTAGTGGCAAACAGTGCCAACCACCGACTGAAGGAAACGTTACAGCAGCCAGAGGCCCTCATCTACCACCAGCCTGTGCAAACCATTGCTACTAATAAGAATGGGATCATTTACTTCGGGAATGTGGCGACAGAGCACGGATCCCGGAGTGATACACCGCAGCAACAGCATGCGCCTTATCGGGAATCGACGAAAAATTGTGAAATACTCGAAATCGTAAACCTCTACCCACCGATCGTGGACATTACAAGTGCTACGATCAGGGAAGTGCAACCATGCGAGGTCGAACTCACCCCGGCGCTACAACCTTCGAGTGGGCCACAAACTGTATGTCGTCTGAAAGTGGAGAACACGACCGATCCTGAAGGGGAAATAGATGATTACTATCTGCCCGAGCCGATGTCTTTTATTCAAACGCTCGAGGAGCATAACTACACCAAGTTACCTATCCAAGCGGACGACAAGGATGAAATATTTAACAGTCTTAAAGCTACGGTAAACGAAAGCCAACAAGAATCGATCGCAGCTGGTGATTCGATCGAGAAGATTCATTCAGTACCAGAGGAAGCTAGTAGAGGTTGTGGCAGCTGTGGTGAACTTTTTACGCGACGTCGGCAATTACTTTGCCATCGAGTGTTGATGTGTCCGGAACGGCGCAGAACGTACCAGGTACACTGCCCCCTTTGCAAACGAAAATTTTCTTCCTGGTTCCGCTTGCGAGTGCATATGGTTTGCAGGTGTCCTAGAAGATTGGTAAAGCGTaaaaaaaaGTCGATCACCAAGCAATCCGATCCTGTCACTGCTAGAAATTTGGATTCCGAGCTTCAACCGGGAGATGAGGTCCTGATAACACGATATCCCTGCTCGTTATGCGATCGATCATATGGTGCTCCCTCGGCCATGCGCCGTCACCTTGCAGCGCACCGCCCCGAAGAACAGTGGAACCACAAATGTGGCGTTTGCTTTAAAGTTGTCGATAGATTGCTCGATTTAAAGAGACATCTGCGGATATCTTCCTGTGGTAATCCCATACTAGTCAATAGGACCGCCGAACAATCTGCCCCAGGAGTAGAAGTGTCTGATGAAAAACCGGTTACCCCAACCGTGGACATATCGTCCACAGCGATCGATCGCTTACTGTATGTTTGCCCAACTTGCAACAAACAGTTTCGATGGTATAGCAATCTTAAGACACACGAAGCAGTGCACACAGGCGTGAAGGCATTTATCTGCGAATCCTGTGGAAAACGTTTCAGTGGACAGGCGCATCTGCTGCAACACCGCTTGACACACTCCGAAGTACGGCGGTTCCAGTGCCAGCAGTGTCCCAAAGTATTTAAGCGCAGCGGTGGCCTAAACCAGCACGTGCGAGCTGTGCATTTGAAAATCCGACCATTCCGCTGTGCCACCTGTGGTTACCAGTTTGCACTCCGGGCTGATATGACGCGTTGTCGACACTCCAAGTTAAAGGAAGCGGACACTTGTTAG
Protein Sequence: MPAHCVIQDCNLRYTHSEEVSFHKFPLRNRELLKRWIEFANRNQNWSPSKWSCICSRHFLPSDFRDCALRRNLSSSAIPSIRAPLKEPAPYDMNQQQPQELPQRGDEYYTTEELEGQFYGAAGEGMETEEIPEDEDTPLADISCRVCGEVFGGAAEKLLADLSESLIVIGKYLPFVNLTLPNLPRKICAHCSKVVHEFATFCEKVLQAQTDLEHRFAWNDATISEHPSPTVSRGPLELGGTKVMKIKQEPITNLYIKEEKTEVVANSANHRLKETLQQPEALIYHQPVQTIATNKNGIIYFGNVATEHGSRSDTPQQQHAPYRESTKNCEILEIVNLYPPIVDITSATIREVQPCEVELTPALQPSSGPQTVCRLKVENTTDPEGEIDDYYLPEPMSFIQTLEEHNYTKLPIQADDKDEIFNSLKATVNESQQESIAAGDSIEKIHSVPEEASRGCGSCGELFTRRRQLLCHRVLMCPERRRTYQVHCPLCKRKFSSWFRLRVHMVCRCPRRLVKRKKKSITKQSDPVTARNLDSELQPGDEVLITRYPCSLCDRSYGAPSAMRRHLAAHRPEEQWNHKCGVCFKVVDRLLDLKRHLRISSCGNPILVNRTAEQSAPGVEVSDEKPVTPTVDISSTAIDRLLYVCPTCNKQFRWYSNLKTHEAVHTGVKAFICESCGKRFSGQAHLLQHRLTHSEVRRFQCQQCPKVFKRSGGLNQHVRAVHLKIRPFRCATCGYQFALRADMTRCRHSKLKEADTC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00098434; iTF_00092402; iTF_00092202;
90% Identity: iTF_00098434;
80% Identity: iTF_00098434;