Adar008448.1
Basic Information
- Insect
- Anopheles darlingi
- Gene Symbol
- Gzf1
- Assembly
- GCA_000211455.3
- Location
- scaffold:199215-202381[-]
Transcription Factor Domain
- TF Family
- zf-C2H2
- Domain
- zf-C2H2 domain
- PFAM
- PF00096
- TF Group
- Zinc-Coordinating Group
- Description
- The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 17 2.1 1.2e+02 2.7 1.2 2 23 244 266 244 266 0.89 2 17 0.001 0.061 13.1 0.2 2 21 276 295 275 296 0.95 3 17 0.052 3.1 7.7 3.1 2 21 304 323 303 324 0.92 4 17 0.92 54 3.8 0.9 2 20 437 455 437 459 0.89 5 17 0.35 21 5.1 0.1 2 23 470 491 470 491 0.94 6 17 0.00034 0.02 14.6 0.3 1 21 497 517 497 522 0.95 7 17 0.35 21 5.1 0.4 2 23 600 622 600 622 0.93 8 17 0.15 8.7 6.3 0.5 1 20 637 656 637 658 0.94 9 17 0.00091 0.054 13.2 0.7 3 21 669 687 667 692 0.94 10 17 0.46 27 4.7 2.1 2 23 764 788 763 788 0.87 11 17 0.89 53 3.8 2.4 1 20 804 823 804 825 0.94 12 17 0.00012 0.007 16.0 1.2 1 23 832 855 832 855 0.97 13 17 3.6e-06 0.00021 20.8 0.7 1 23 862 884 862 884 0.97 14 17 0.00025 0.015 15.0 0.7 1 23 890 913 890 913 0.95 15 17 6.4e-05 0.0038 16.9 0.6 1 23 919 941 919 941 0.98 16 17 0.00035 0.021 14.5 5.0 1 23 947 970 947 970 0.93 17 17 0.0003 0.018 14.7 0.7 1 23 976 998 976 998 0.98
Sequence Information
- Coding Sequence
- ATGAAACGAACCTCGAAACGACTTGAGAAGATCAACGCAGATCAGAAAAAGAAACCGAAACCCGATGGCGCCGTTTGCTGCTGTTTTTGTTTGCAACAGTATCGTACCACGGGGCTCAACAAACTGGACGCTGTTGTACCCGACGAACCGTCTTTGACCATCGGAAGAGTCGTCGAAAAGGTCGCCTCGGTTAAGATCAAAAGCAACAACGAGAGCATATGTGATCCGTGCTGGCACCAGATAAAGAGCGCCTACGAGATTCAACGCAGAATCCGTGTCTCGAATCGGTTGGTGGTGAAACAAGAAGAGCACGAAATCGAATCATCCGATGAGTCCGATACATCATCACCCATCGAACAGGTAGTAATAGAGGAGATTCTGGTGAAAGATGAGGCGGAATACGACGCGGAGTATCTAGATCACTGTGCCGTATCGAACGATCATAACTACGATGGGCATGGTCCGGATGAAGAAGACACCCTGATTTTAAGCGATACCTTCCTACATGAAGAACaggaagaggaatacgaggaggacgacgaggaggaggaggaTGATTTCCATCCGGAAATGACGCTACATATGAAAGCGGACGTCATTGTAGAGGACGAAAACAGACCGTACGAAACGACCGGCAACATGACGCGCCAGTTCAAATGCCCTTCCCAGGCACTTATTGTGAGTGATGAGAAGTTCGAGAACTACCGGCAAGTACGGGTGACCGGTAACCGGTGCTGTGGATGCAGCTTCGTAGCGGCGAACCGTCGCGAACTATTACGCCATTCGGAGCAGCTTCACGCATGCACCATCTCCGATGTAGGCGACTACTGTCCCATCTGTTTTTTCAAGTTTGCCAACGATAAGCAACTCGAGCGGCACATACGAGAGTTTGAATCCAGCACGATGCTCGTCTGTTTGCGCTGCAATTGTTTCTACAACAACCGGTCCCATCTGTACAAGCATTTGCTAATGTGTGGCGAAGAAGCGACACCCGAAGCAGCGGCCAACGATTCGACGGACGAAAGCGAAGACGAAGCGGAGAATGCGGGCGATGAGAATGAAGCGGACGAAAGCAATACTGGTGATGGTGACGCAAACGACACGATCGAGTACTACCTGCTAGAAGAAACGCCAACCCGTGGAAGTGATCTGCGGAGGATGTATCGATACCGGGCCAAAATTGCTGACCTGCTCACCGATATTAATCTATCGTATCCCGGAGGCCAGGAACAGCTCAACATCCAAGAGAGTCAAATACACCAGCGAGAAGTGTTTGATACGTTCGAGTATGTGTATCTGCGAGGAGAGCGATGCTGCGGTTGTACGTATACGGCCGTCTCGGCCGATCACCTAATGGAGCACGGTGTCTTAAACCATAATGCGGGTACTGGTGCAATCGACAACCGTACCTGTGGTTTGTGTAACGCCGGGTTCAACAGTGTGCTGGAGCTGTTGAAACATTATATTTTCCATGTCTGTAAACAACTGTTCTTCTGTACGATCTGCCAGGTGTCCTTCGTTTCCCTCGATGGCCTTCAGAACCATCAGCGCGATAGCGAAACCCACCACCAAATCGCCAAGTACCAGCAAGCCGGTTTAGCGGATCGCATCACGGATGAGCCAAACCTGTTCGTCGAGTTGGATCGACCGGGGGTGATGGACCGATTACAGAAGGTGCTTGCTCAGAGAATGATCTACCGTACCACTCCAATGCGAGGTTTACTCATCCCGGACGAGAAGTTTATTGTGGAAGAGGAAGAGTACAACACATACCGTAAGCTAAAAATGACCGGTGAGCGTTGCTGCGCTTGTGGACGGTTTTTTGAAACGATCGAGGAGATGCTTGAACACGCCCGGTTGGCACACTTTCGGCCGATCGTGAATGTGTCCTCCTTCTGGGACGGAGGTCACCAGTGCAACTACTGTCTGTCGCAATTCGAAAGCCAACGCGGACTCCGGATGCACTGGGCGTATCGGCGTAAGGGCAACATTACCCTTTATGGCTGCAAGTTGTGTGGCCTAGTGTTTTCCCGAATGTTTTGTCTTGCCCGCCATATGCAGCTAGCCCCGAATCATCTGTCGAAATTGATGCAGGAGGCATCTCAAGACAAGAATGCCGAGAAACAGCTCGTGAAACCGAAGCACCTGACACATGACAAAGCGTACGGGGATGCAGCACGTGGATCGAAGGAGCGGAAGGTGAAGCAAAAGGAAGATCCGCGCGTCGCCGAGGCGCTTGAGCTGCATCCCACGATTAAGTCGGGAAAAGTGGGACAACAGATCGGATATCACTGCTGCTTTGCCAAGTGTTCGCAAGCGTTCGAGGAAGAGCAAGAGCTGCTTCAGCACACCCGCGCCGAACACGAGGGCAAACGTAAAGAGTATGAAAGCGAGCGGACGTCTGTGAAGCACGTGTGTCCGGCATGCTGCAAATCCTACGACACGCAGACGAAGCTAAACTGGCATCGTTTCCAGCGCTTCATACCCCGTCAATACAATTGCAAACATTGCAATCTAAGGTTCACCAAGTGGCCGCTGTTGCAGATGCACGTTGCTACCGATCATCTCGGGAAGCCACCCAGCTTTGCGTGTACAAAATGCGACAAGGTGTTTGTCACCCGGTCGCGCCTGAAAGCTCATGAGAAGGTACACGAAGAGGTCAAACAGTTCGCATGCGACGAGTGTGGCGATAGGTTCCGGCACAAGGGATTGCTGGTGCGGCACAAGCGTGCCATACACACGGCCGAGCTGCGCTTCGAGTGCAAACTCTGCTCGAAGAAGTTTGCCGTGGTGGAAAAGCTGAAAGTGCACCAGCGGGTGCACACGGGACATCGCCCGTACCCATGTCAGCATTGCGATCGCAGCTTCAGTCACCATAGCGATCGCAAGCGGCATGAAATGGCGGCCCATACCGGGGTACGACCGTACCAGTGCACGATCTGTTCCGCTTCCTACATCCGGAACCGAGATCTTGTTTTGCACAAGCAAAAACACGTGTCAAGGGGGGAAACGGAAGCAACCAACAAACTCATGGAGCAATAA
- Protein Sequence
- MKRTSKRLEKINADQKKKPKPDGAVCCCFCLQQYRTTGLNKLDAVVPDEPSLTIGRVVEKVASVKIKSNNESICDPCWHQIKSAYEIQRRIRVSNRLVVKQEEHEIESSDESDTSSPIEQVVIEEILVKDEAEYDAEYLDHCAVSNDHNYDGHGPDEEDTLILSDTFLHEEQEEEYEEDDEEEEDDFHPEMTLHMKADVIVEDENRPYETTGNMTRQFKCPSQALIVSDEKFENYRQVRVTGNRCCGCSFVAANRRELLRHSEQLHACTISDVGDYCPICFFKFANDKQLERHIREFESSTMLVCLRCNCFYNNRSHLYKHLLMCGEEATPEAAANDSTDESEDEAENAGDENEADESNTGDGDANDTIEYYLLEETPTRGSDLRRMYRYRAKIADLLTDINLSYPGGQEQLNIQESQIHQREVFDTFEYVYLRGERCCGCTYTAVSADHLMEHGVLNHNAGTGAIDNRTCGLCNAGFNSVLELLKHYIFHVCKQLFFCTICQVSFVSLDGLQNHQRDSETHHQIAKYQQAGLADRITDEPNLFVELDRPGVMDRLQKVLAQRMIYRTTPMRGLLIPDEKFIVEEEEYNTYRKLKMTGERCCACGRFFETIEEMLEHARLAHFRPIVNVSSFWDGGHQCNYCLSQFESQRGLRMHWAYRRKGNITLYGCKLCGLVFSRMFCLARHMQLAPNHLSKLMQEASQDKNAEKQLVKPKHLTHDKAYGDAARGSKERKVKQKEDPRVAEALELHPTIKSGKVGQQIGYHCCFAKCSQAFEEEQELLQHTRAEHEGKRKEYESERTSVKHVCPACCKSYDTQTKLNWHRFQRFIPRQYNCKHCNLRFTKWPLLQMHVATDHLGKPPSFACTKCDKVFVTRSRLKAHEKVHEEVKQFACDECGDRFRHKGLLVRHKRAIHTAELRFECKLCSKKFAVVEKLKVHQRVHTGHRPYPCQHCDRSFSHHSDRKRHEMAAHTGVRPYQCTICSASYIRNRDLVLHKQKHVSRGETEATNKLMEQ
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -