Basic Information

Insect: Anopheles darlingi
Gene Symbol: -
Assembly: GCA_000211455.3
Location: scaffold:69717-82344[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 11 3.7e-05 0.0022 17.6 0.7 1 23 145 167 145 167 0.99

2 11 8.6e-05 0.0051 16.5 2.3 1 23 173 196 173 196 0.96

3 11 1.5e-06 9e-05 22.0 0.4 1 23 202 224 202 224 0.99

4 11 1.1e-06 6.4e-05 22.4 0.1 1 23 230 252 230 252 0.98

5 11 0.02 1.2 9.0 2.4 1 23 258 280 258 280 0.98

6 11 6.6e-06 0.00039 20.0 3.1 1 20 286 305 286 309 0.95

7 11 0.021 1.2 9.0 5.5 1 23 315 335 315 335 0.97

8 11 8e-06 0.00048 19.7 0.1 3 23 343 363 342 363 0.98

9 11 1.1e-05 0.00067 19.2 1.1 1 23 369 391 369 391 0.99

10 11 2.7e-06 0.00016 21.2 0.6 1 23 397 420 397 420 0.97

11 11 0.3 18 5.3 0.8 1 20 426 445 426 446 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	11	3.7e-05	0.0022	17.6	0.7	1	23	145	167	145	167	0.99
2	11	8.6e-05	0.0051	16.5	2.3	1	23	173	196	173	196	0.96
3	11	1.5e-06	9e-05	22.0	0.4	1	23	202	224	202	224	0.99
4	11	1.1e-06	6.4e-05	22.4	0.1	1	23	230	252	230	252	0.98
5	11	0.02	1.2	9.0	2.4	1	23	258	280	258	280	0.98
6	11	6.6e-06	0.00039	20.0	3.1	1	20	286	305	286	309	0.95
7	11	0.021	1.2	9.0	5.5	1	23	315	335	315	335	0.97
8	11	8e-06	0.00048	19.7	0.1	3	23	343	363	342	363	0.98
9	11	1.1e-05	0.00067	19.2	1.1	1	23	369	391	369	391	0.99
10	11	2.7e-06	0.00016	21.2	0.6	1	23	397	420	397	420	0.97
11	11	0.3	18	5.3	0.8	1	20	426	445	426	446	0.92

Sequence Information

Coding Sequence: ATGAAGAAGTCGACGCGCCAAACACGTATGTCCCGATACGTAGGGAAGCATTCGCCCAAGATTGCCTCCTCTGAAGAGAACCTTCACCacaacaacaacaacaacaCTTCTGATAGCAAGGTCGATAGTGCAGATAGCAGTCACCGGAAAGTGTTGTTTGCTGACGCTGGTTCGGCGGAAGAGGGTTCGTCTTCAGCCGAGCTATCGATCGGCGAGTTACCGTCGTACATTGTGGAGAAGTCGTCGGGCTCCTACGAAGCATCCTCGTCATCGGGCGGTGATGGAGAGGAGGTGGAAGATGATAAAACGGCAATCAAGCAACAGTTGGCAAGTAGTGAGGGTATTAGCGACCTGGATGACAGTAAAGGTCTCACTACCGGCGGCGGCAGCGGTCAGGCGAAACGTGGCCGAAAGCGAAAGGATCGCAAGCAGTACCGGTGTGAGGTGTGCCAGAAGGATTTCATGGGCACGAATGATCTGCGGAAGCATCTTCGAATTcacaacgatgagcgaccgtacccgtgtccacactgcagtaaccgctttcggcaggcgggctgcctgaagaatcatatcgcttcccagcacggcaccgatgagcagtacacgtgcgatttgtgtggcaaatcgttcccgatcaaagagcggctgcgacttcacatgcgcattcacactggcgaaaagccgtacagctgtccgatgtgcCCAAAAACGTTTGCGCGTGGCGGTCAGCTAACACAACACTTGGCGACGCACAATGGGGTGAAGAGGCACAAATGCAGCCAATGCGCAGCGGCTTTCTCCTGTGCGGCCAACCTGAAGATGCATCTCAAAAGCCACATGGAAATTCGGGACTACACGTGCCATATTTGTGGTAGGGGGTTCTATCGGCCAGATGCCCTAAAGAAGCACCTGCTTTGCTACCATGCCAACTTGAAGGCGTTCCACTGCAACATTTGCAACAAGATGTTCAAAGGACATCTGCCGCAGCACATGCGAACGCACCAGAAGGTACGACCGCACGGGTGCGCCGTTTGCGGATCCGTATTTTCCCAGCGTTCACAGCTGATCGTTCATCAGCGGATTCATAGTGGCGAACGACCCTATCGTTGTCAGGTATGCTggcaggcgttcgctcactcgagcgtattgaagctgcacattcgtaagcacacgggagagaaaccgttcgagtgtccgctctgtccttcgagcttttcgcagctaccacacctgaagaagcacatGCTCTCTATCCATCAGCAGGACAAATCTTATCTCTGTCAGAAGTGTAAGGATTTCTTTAAAACCAAAATGGATTACCAACTACACGTTGCTGCCTGCTATAATGATCCGGAAGCAGTGAAGAACCTGGACAATCTCATGGATCCGATGTATCGCCCAACGGAGAATAATGGCGTAGATCCACCGATGACGATTTCGCGGATGCGTTTTCTAGTGGCAATCCTACTGAAAAAGATCTCCACCGATGACCGTTTGAAAGAGCTGGGCTTTGACAAACGGTTGATCGATAACGTTCTGATTGATTCGTTGAAGTGCGCTGGTCGGAAAGTGGTAGATGATAAATCGTATGATGCGCTAAAGCGCCTCAAGTTGAACGTGCAAGAACTGTTGGAATGGACAGTGCCACCGAACTACATGGAAGAGTTCCGCACTGCAAACCGCAGCACCGAAGAGTTGCTAGAGGATCTGACCAATTGA
Protein Sequence: MKKSTRQTRMSRYVGKHSPKIASSEENLHHNNNNNTSDSKVDSADSSHRKVLFADAGSAEEGSSSAELSIGELPSYIVEKSSGSYEASSSSGGDGEEVEDDKTAIKQQLASSEGISDLDDSKGLTTGGGSGQAKRGRKRKDRKQYRCEVCQKDFMGTNDLRKHLRIHNDERPYPCPHCSNRFRQAGCLKNHIASQHGTDEQYTCDLCGKSFPIKERLRLHMRIHTGEKPYSCPMCPKTFARGGQLTQHLATHNGVKRHKCSQCAAAFSCAANLKMHLKSHMEIRDYTCHICGRGFYRPDALKKHLLCYHANLKAFHCNICNKMFKGHLPQHMRTHQKVRPHGCAVCGSVFSQRSQLIVHQRIHSGERPYRCQVCWQAFAHSSVLKLHIRKHTGEKPFECPLCPSSFSQLPHLKKHMLSIHQQDKSYLCQKCKDFFKTKMDYQLHVAACYNDPEAVKNLDNLMDPMYRPTENNGVDPPMTISRMRFLVAILLKKISTDDRLKELGFDKRLIDNVLIDSLKCAGRKVVDDKSYDALKRLKLNVQELLEWTVPPNYMEEFRTANRSTEELLEDLTN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00100454;
90% Identity: iTF_00092947; iTF_00092308;
80% Identity: -