Basic Information

Insect: Anopheles culicifacies
Gene Symbol: zfh2
Assembly: GCA_000473375.1
Location: AXCM01004918:3-8891[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 12 0.5 29 5.1 1.4 2 23 205 227 204 227 0.94

2 12 8.6e-05 0.005 16.9 1.4 2 23 445 467 444 467 0.96

3 12 2.2e-05 0.0013 18.8 0.7 1 23 499 523 499 523 0.92

4 12 0.013 0.73 10.1 0.4 1 22 623 644 623 647 0.91

5 12 0.045 2.6 8.4 1.4 2 23 844 866 843 867 0.93

6 12 0.036 2.1 8.7 0.3 2 23 1159 1181 1158 1181 0.92

7 12 4.2 2.4e+02 2.2 0.0 2 23 1283 1305 1282 1305 0.93

8 12 0.24 14 6.1 0.3 2 19 1368 1385 1367 1388 0.95

9 12 4 2.3e+02 2.2 0.6 4 23 1406 1426 1402 1426 0.86

10 12 0.0028 0.16 12.2 4.9 1 23 1439 1461 1439 1461 0.96

11 12 0.02 1.1 9.5 5.3 2 23 1468 1490 1467 1490 0.93

12 12 2.5e-05 0.0014 18.6 1.0 1 23 1584 1608 1584 1608 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	12	0.5	29	5.1	1.4	2	23	205	227	204	227	0.94
2	12	8.6e-05	0.005	16.9	1.4	2	23	445	467	444	467	0.96
3	12	2.2e-05	0.0013	18.8	0.7	1	23	499	523	499	523	0.92
4	12	0.013	0.73	10.1	0.4	1	22	623	644	623	647	0.91
5	12	0.045	2.6	8.4	1.4	2	23	844	866	843	867	0.93
6	12	0.036	2.1	8.7	0.3	2	23	1159	1181	1158	1181	0.92
7	12	4.2	2.4e+02	2.2	0.0	2	23	1283	1305	1282	1305	0.93
8	12	0.24	14	6.1	0.3	2	19	1368	1385	1367	1388	0.95
9	12	4	2.3e+02	2.2	0.6	4	23	1406	1426	1402	1426	0.86
10	12	0.0028	0.16	12.2	4.9	1	23	1439	1461	1439	1461	0.96
11	12	0.02	1.1	9.5	5.3	2	23	1468	1490	1467	1490	0.93
12	12	2.5e-05	0.0014	18.6	1.0	1	23	1584	1608	1584	1608	0.92

Sequence Information

Coding Sequence: ATGACAACTCGCAAACAGACAAAATTCTCCACCAAAATTCAGTTCTACCTGAAGCACAGGGAGTCGCGCATACTGAAGCTGTGCAACGACACCATCGGTCCAGTGCCGAACGATTCACTGAGCAAAGCGATCTTCAGACTGTTGTCCAAACCGGTAGACAATAAAGGCATTATACAACTTTTTGTCGACAAGGGTCAGCAAACTGCACAAACGAACGTCACGAGTAACAGCAGCAGCAGCAACAACACTGTGAAGACCGTACTGCCAGAGTATCAGAAGGACGTGGAACGGTTCCATGGACGCATCATCTGTAATGACAACACCTGCATCATCGACCCGGTCGCCTCTCCTAAGAACGACAGCAATTCGAATCCTCGCACACATTCCTTCCGAATTGTCTCGTTCAGCAAGGAGAGTGAACCGATCCGAGGTGGTGGTGGTGGTGACTCTTTCGCCACCACTGATGATGAGACGATGGGTGGTGTGTCGGGGGAGCAGGAGCAAGCGCAGAACCTCATCACGCGATCGTCACCGGCGTCACCGTCGGCGGTTACTGCCACCAACGTCGTCCCGATGGCGGGTGGCTCGACCAGTAACCATAAGGCTATCCTGATGTGCTTCAGCTGCAAGCTCAGCTTCGGTACCTGCCGATCCTTTATAGCGCATGCCAAAATTGAGCACAGTCTCACACTGAACGACTACGAGCGGATGCTGCTGGAGAAGAACTACAGCAAGAAGTACAGCAACGCGATGAACGAGAGTGCGGCTATtgcggctgctgccgccgccgccgcagctgctgccgctgccgccgctgccgGTGACGGTGACAAGAAGGTAACCGGCAACGGGGGCAATGGTGGTGGCGGTGTGGCCAGTGCGGCCGCCGCAGCCGTCAGTGGGAAGTTGTTGACCGATTTCCTAAACCAGCAAAAGATGCTCACAACCGTGGGCGAGAATCTGTACGGCAAGCAGAACAAGTTCTTCGAGTTGATCAGTTCGGCGGCAGATATGAAGCTGAACCCGCTGGCGGCGGCTGCGGTGGCGGCGGTAGCATCCAACAAGGGCCCCGGACCGGGTGGGCTAGCGGAGATGggtggagccggtggagctggtggtggtggtgACTTCCATCTGAAGAAGTATAGTCCGGTGGATCTGTACAAGCAGTTGATTGCGAACAACTTCCGGCCGGAAGCGATGGACGTCGGGGAGGAATTGAAGAACGAACATCAGATTAGCGTGAAGAAGCTGGAACCGGAACCCTCGACTGCATTCCGGAACAGCAACTTCAGCCCGAACATTTCGACACGCAATTCCTGCAAGACGCTCAAATGTCCGCAGTGCAACTGGCACTACAAGTACCAGGAAACGCTCGAGATACATATGCGCGAGAAGCACCCGGATGGTGAGACAGCCTGCAGCTACTGTCTGGCCGGGCAGGCTCATCCACGTTTGGCCCGGGGCGAATCGTACACCTGCGGCTACAAGCCGTATCGGTGCGATATTTGCAACTACTCCACCACGACCAAGGGCAACCTGTCGATTCACATGCAGAGTGACAAACATCTGAACAACATGCAGGACCTGAACGGCATGATGAATAAGAGCAATCAGAGCTTCCTTAACCTCGCGACTCTGCAAGCGAACGAGAAGGTGGTGAACAGTTCGCGCAATCAGTACATGGCAGCGGCCGCAGTTGCCGCCGCAACTTCCCCACTGTCCTCGATGTCAGGCAAGCTtggtggaggtggtggtggcggaggtggaggtggtggtggagttagtggtggtggtggtggtggtgTCCAATCCAAGGAGTCTGGACCGGTTGGGTATGAGACAGGCGGGCGGCCCAAATCCTTCTTCAAGTGTGACATCTGCAACTACGACACGAACATCGCGCGCAACCTGCGCATCCACATGACGAGCGAAAAACATATCAGCAACCTAAACTCGTTCCAGTCCAGCTACAATCAGCTGAAGAGCCTGCAGAGCCTACAGCAACAGTCCCAGCAGCAGTCGGACAATCTCGACTACCTGAGCGCGATCAATCTCAACACACTGAAGGAGGACTCGCCGATGGCACGGGTTGACGAGTATACGGCGGCGGCGGCGGCAGCTGCTGCAGTTGCGGCCGCTACTGCCAGTGCCGCAGGCAACAACAGCACTGGCAGTGGTGGTGGCGGCAGCAGCAGCAGCCTGAAACCGTTGTCGATGCCTTCGTCACCGTTCGGTGCACCGCACGAGACGGCCACGCCTGATTCGCTCTTCCTGAATCAGCCGTCACCGTTTAGTGGGGCGAGCGAACCGGGCAACGACCGGGACTACCATCACCACCATCAGCTGGACGAGGACAAGAACCCGCTGCACTTCGATCCACCGATACGGCTGTCGCTCGATCCCGCGACGTACTACAGCTGTCTGGTGTGTGCGGACTTTGAGACGAACAATCTGGAGGAGCTGAAGAAGCACGTGCTGAAGGATCGGACCAGCAGCGCGATGGATGCGATTTTGGTCGCCGGCCAGGAGTGTCTCCTCTGCGGGCAGAAGGCACACGACCGGTCGGAGCTGGAACGGCACCTGAAGGCGGAGCACCATCTGAGGCGGCTCGAGCTGATGATCCATCTGCTGGAGGGACGCGACAAAACCGCCACCAAGTTGCGCCAGTTCGTTGGGCAGGAGCTGTACAAGAAGCTGCAGCTCATCTTCCCGTTGGCGGAGGAACCGAAATTTCCGTACGATGAGATGCCAAGCGTCAGTGAAATTTCGCGTTCTCCGCTAATGTTGCTGCTCGAGCCGAAAACTGAGCTGATCGAGCGGGATTTCGCTACCGGTGCGAACGGTATCGATAGTGAACATGCAGCTTCCTCGTCCTGCCCGGACAATGTGCAGCTCAAGTGTAACTGCTGCAACTTCTACACCACCTCGCTGGAGAAGATCGGCATACACAGCCTGTCGGAGAAGCACATCTTCCGGCGCATCTGCTTCGACTATCTGCTGCTGATCTCGAGCGAAAAGTCCAGCCTGGCGAACGTGGGCGTGAAGAGTGAAGGCAAGTGTGAACTAGCCGAGCGGTTGCTGCTCGCTCATCAACATCAACCCGCGACCGATCACATCTCACGTGTCTTGTTGATGCAAATGATGCTACTTGCAGATGGAGCAAAGCACCAGCAGCAGCAATCCTCGCCGAAAGCTAATCAGCTCATGCTGACCTGTGTGCCCTGCTGCTTCAAGACGGATCACATATACTACATGATACATCATCTCAAGAAGAGCTGCAAGGTGGAGCAAAACATCAACCTGCTAGGATTGCGTAACATTTTCAAGCTAACCGCTAAAGGTTTAGACGCCCAAGATGCAATGGATACGGGCGACAATGGGCTGTGTAGCATACTGCAGGAGAAAAAGATGTGGAACGGTGAGAATGCCAGCAACCGTCAGGCGACCGGTGGTTGCAAGGATCGCTGCCTCGTGTGCAGCGTGTGCAACAAGTTCTCCTCGAAGAAGGTGAACGTCATGCAGCACCTGTTGGCAAATCATAACGCAGGCAACGAGCTGCTCGGCGGTGCGGAACTGTCACCGAACGTGCCATCGCTGGCGCGCAAACCATTCGACTATTTGCGCACGCTGACCGAGGCACGCTGTGCTCAGAATCTGCGCCAAATCGAGAAGGTCACCTTTATGAGTGATTCGTTCGCGCTAAAGGAGAACTGTAACGATCTGAAGCACGGCAATCTGGCAGAGATGCTGGAGCAGTACGCGGCACGCCAGGATGCGAACGAGAGCTTTACGGCGCGTTCGCCAACGCTGGAGAAGCAGCAGCAGCAATATGCGCCGACCCTGTCTTGTCCACTGTGCGCGGAAGCGTTCCTCGATCAGGCAACGGTGGAAACGCACGTGCTGCGTGTCCACAACATCAAGATGGACGGTTTGAATCGGCTGCTGAAGCTGGTCGATACCTCGCAATTTCTGAAAACGACCAATGGCAAACAGCAGCCAACGAGCAACAGTAGCAGCCCAGTGGAGAAGCCAGGGTCGCCCCATTCGCCGGCAGGCGGTGCCAAGGAGGGTTCGGTGTCGCCGGGCGTACCGAGCATCCGGTGCTCGTACTGCAAGGCACCGTTCGATACGATGGTCGACCTGAAGATACACTGCAACGAGAGTAGCCACTTCCGCCGCAGTGCAGACTCGGACGATCTCGCTTGCTTCCTGCACGACTGCAAGGACGCATTCGACAACCTGGCCGATCTGAACCAACACTTCAAGGCGAGCCATTTGAACTTTCTCATCTCGGAGCATCACACGTACCGGTATCGGTGCAAGCAGTGCCCGTTCGCGTTCAAAACACATGAGAAGCTGAGCCGCCACCTGTTCTACCATTCGTTGCGCGAATCTACCAAGTGCTTCTACTGTGACCATCACTTCAAGAACATTCACTCGCTGACCGCCCACATCGCGGAGAAACATCCGCAGGAGGCGCTCCAGTCTGGTAAACCATCGCCACCGGGCATTGCGTCACCCGACGCTTCCATTCTCTTCTTCAAGGATCTCAAACGCAAGATGCTCAACAATcagcagcagcagcagcaACGGAACGGATTGAGTCCACGTTCGGATCGATCCGGTGGTCGGGACGCACGTGACAGCGTCGATGAGGATCGGCTGAGCGAAAAGTCAGTTAGCTCGAAAAGCAGCAGCTTCTACTACGACAAAAGTCTCGACGGTAGCGGCACATCCGAGGGCCGTTACACCTGCACGGACTGCCAGTTTACGTTTACCGATTCCGGTGCGCTCGAGCGCCATCTTGCCACGGCCTGTCATATGCCGCGCGACGACAAGGCATCGCCCGACTCGTTGGCTGCCTCGCTGATGTCTTCCCTCGCCAAGCATCACCAG
Protein Sequence: MTTRKQTKFSTKIQFYLKHRESRILKLCNDTIGPVPNDSLSKAIFRLLSKPVDNKGIIQLFVDKGQQTAQTNVTSNSSSSNNTVKTVLPEYQKDVERFHGRIICNDNTCIIDPVASPKNDSNSNPRTHSFRIVSFSKESEPIRGGGGGDSFATTDDETMGGVSGEQEQAQNLITRSSPASPSAVTATNVVPMAGGSTSNHKAILMCFSCKLSFGTCRSFIAHAKIEHSLTLNDYERMLLEKNYSKKYSNAMNESAAIAAAAAAAAAAAAAAAAGDGDKKVTGNGGNGGGGVASAAAAAVSGKLLTDFLNQQKMLTTVGENLYGKQNKFFELISSAADMKLNPLAAAAVAAVASNKGPGPGGLAEMGGAGGAGGGGDFHLKKYSPVDLYKQLIANNFRPEAMDVGEELKNEHQISVKKLEPEPSTAFRNSNFSPNISTRNSCKTLKCPQCNWHYKYQETLEIHMREKHPDGETACSYCLAGQAHPRLARGESYTCGYKPYRCDICNYSTTTKGNLSIHMQSDKHLNNMQDLNGMMNKSNQSFLNLATLQANEKVVNSSRNQYMAAAAVAAATSPLSSMSGKLGGGGGGGGGGGGGVSGGGGGGVQSKESGPVGYETGGRPKSFFKCDICNYDTNIARNLRIHMTSEKHISNLNSFQSSYNQLKSLQSLQQQSQQQSDNLDYLSAINLNTLKEDSPMARVDEYTAAAAAAAAVAAATASAAGNNSTGSGGGGSSSSLKPLSMPSSPFGAPHETATPDSLFLNQPSPFSGASEPGNDRDYHHHHQLDEDKNPLHFDPPIRLSLDPATYYSCLVCADFETNNLEELKKHVLKDRTSSAMDAILVAGQECLLCGQKAHDRSELERHLKAEHHLRRLELMIHLLEGRDKTATKLRQFVGQELYKKLQLIFPLAEEPKFPYDEMPSVSEISRSPLMLLLEPKTELIERDFATGANGIDSEHAASSSCPDNVQLKCNCCNFYTTSLEKIGIHSLSEKHIFRRICFDYLLLISSEKSSLANVGVKSEGKCELAERLLLAHQHQPATDHISRVLLMQMMLLADGAKHQQQQSSPKANQLMLTCVPCCFKTDHIYYMIHHLKKSCKVEQNINLLGLRNIFKLTAKGLDAQDAMDTGDNGLCSILQEKKMWNGENASNRQATGGCKDRCLVCSVCNKFSSKKVNVMQHLLANHNAGNELLGGAELSPNVPSLARKPFDYLRTLTEARCAQNLRQIEKVTFMSDSFALKENCNDLKHGNLAEMLEQYAARQDANESFTARSPTLEKQQQQYAPTLSCPLCAEAFLDQATVETHVLRVHNIKMDGLNRLLKLVDTSQFLKTTNGKQQPTSNSSSPVEKPGSPHSPAGGAKEGSVSPGVPSIRCSYCKAPFDTMVDLKIHCNESSHFRRSADSDDLACFLHDCKDAFDNLADLNQHFKASHLNFLISEHHTYRYRCKQCPFAFKTHEKLSRHLFYHSLRESTKCFYCDHHFKNIHSLTAHIAEKHPQEALQSGKPSPPGIASPDASILFFKDLKRKMLNNQQQQQQRNGLSPRSDRSGGRDARDSVDEDRLSEKSVSSKSSSFYYDKSLDGSGTSEGRYTCTDCQFTFTDSGALERHLATACHMPRDDKASPDSLAASLMSSLAKHHQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -