Acru012926.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Anopheles cruzii
Gene Symbol
ush
Assembly
GCA_943734635.1
Location
OX030880.1:86537615-86544647[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.0045 0.28 11.6 0.0 1 20 263 282 263 284 0.93
2 9 0.00038 0.023 15.0 0.7 1 23 347 369 347 369 0.98
3 9 0.023 1.4 9.3 1.4 2 21 443 462 443 463 0.92
4 9 0.063 3.8 8.0 3.3 2 21 878 897 877 898 0.94
5 9 0.0029 0.18 12.2 0.0 3 21 958 976 956 977 0.91
6 9 0.0023 0.14 12.5 0.1 1 23 1031 1053 1031 1053 0.99
7 9 0.015 0.93 9.9 1.4 1 23 1059 1081 1059 1081 0.99
8 9 0.014 0.87 10.0 2.3 1 23 1152 1175 1152 1175 0.95
9 9 0.06 3.6 8.0 0.3 2 20 1345 1363 1344 1365 0.92

Sequence Information

Coding Sequence
ATGTTCACTCACGATATCTGTTCGAACTTGCGCCGCCGCCGCCGCCGGCGACCGCGGTGTCCAGGAGACGATGAGGATGCCGGTGACGagcagcaacagcagcagcagccaccgggtacaacggaagaaaacggagcaccagcgtcccaggatgcaacagtcagccatagcgacagcagcaccaccaccagcagcagcaacagcagcacactgatgaacaacaatagtcggagcagcagcagaagtagcgccagcggGTGTCTCGGGATGAACGGAACGGACGCGGGGGCCCCGGAAGAGGGCCCGATACGACCCACGGCGACGCCTTCCCCGATGGCGGCGGATGCCTCCGAGGACGGTGCGGCGCAGCGATCGCCCTCGCTGCGTGAAATCAAACTCGAGCCAAACGTTCCGTCGGACACGGAACCACCACGGCCACCGTCGGAAGCGCCGGTGGATCCGGTGGTGCGCTGTGACAGTAAATTGTCCCACTCGGGGGGTGGGTCACCGGCGACGACGTCACCGATTCCGATGCTCCGGCTCAACGTGGCCCTCGCCTCCGATCCGGCCGCCAATCCGGACGCGAAGGATCTCAAGAAAATTGGCGAAGCGGACGCGGTTGCGGCGGAGTTTGCGCAGCAACAGCTCGCCGCCCTCAACATGGCCATCGGGGGGCCGCCGCCGCCACCACCACCGATGCGCAAACCCGCACTCAAGGGACCGGAGGGGCTCGTTGGTCCCCTGGCCCTACCCGCCGTCGTCGAACTTCCACCCCGGTTGCCGATGTTTGTGTGCGGACCGTGTGGCATCCGGTTTTCGTCCGCGTCGACGCTGGAAGCGCACCAGACGTACTATTGTTCGCACCGGAAAGAAACAGAAGATGGCGGTGGTGGTGCTGGCGGAGGAACTGGGTCGACCGCTGGAACCGGAGGGTCAGCTTCCGGTGGGTCGATCGGTGGTAGTGGCACCAAGAACGCTCACCCGGGCGGTGACGGCTCGGGGGAACCTCCGGCGAAGGCGGCCAAGACGGGCAAGCAGTACGCCTGCTCCCAGTGCTCCTACAGCGCGGACAAGAAAGTGTCCCTGAACCGCCACATGCGCATGcaccagtcctctccgacgccgtcctccgtcaacggcgatgacaccggtcgtcaacagcagcatcagcagcaccaccaccagcagcagcagcaacagctgcagctcatccaagctcaagccgtggccgcggccgcagcggtgctccatcagcagcaacagcagcagcaactgcagccccagccggttggccaggcgcaagcgccgccACCGCAGGTCGATCGGTACTGCTCCGATTGTGATATCCGATTCTCCAGCACCAAAACATATCGCGCCCACAAGCAGCACTACTGCAGCTCGCGTCACCGGGAAGGGCAGCAGTCCAACAACTCGACCCCGAAACCCGGCTCGACGCAGAAGTCGGGCTCCCAAAGTCCACCGGAAGTGCCGAAGACGCCACCGGTGGCCGCCGCACAGCAACCGTTCCTGGCGCTGCCCACCAACCCGATCATTGTGATACCTTACTCGCTGATTCGCGGCGCCAGCGTCATCCCGGGATTGCTACCATCACTAGCCCCGGGAGTCGCCAATCCGGAGTCGGCTTGTTTCATCTTCCAAAACGGAACCCTGCAACCGATCGCGATGTCGCTGGCGTCGCAGGTTGCCCACCAAGCCGCGACCTCGGCGGGGGGCCACGCCGAGGTGGGACCGGGACCCCAGCGGCCCCCCTCGCAGCAGCATCCATCGCGCGGAACGACGCCGAGCGTCTCGAACGAAAACAGTTCCCACAGCACGCAGGGCGCCGGACCCACTCCGGGCGGTGCCCCGTCATCGACCGGTGAGGTGCTGAAGGCACTCAACAAGCGCGAGAATTCGGCCAACAAGGAAGCTACCTTGACGTCTACGACCACTCCGTTGGATCTGTCCGTGCGACGGTTTTCGCCGGGCGCCATCGGAGCGCTCCGCGAGCGCTCGCTCTCCCTATCGTCGGCCGTCTCCGGTGACCAGCGGATGGACTACGACAGTCTGATGGAGGGCAAGGAGAACCTGTCGGTCAGCGGGGACTCGCTCACGCCGGAGCAGATTGTCTGTGCTCCGTCGCTGCCCGGGAGTCCACCGTTGACGCCCTCCCCGAAACGGCGCTCCAATAGTCCACGTGCCACGGGCCCCGGACCGATGGCTTCGAATGCGGCGCTGGCAGCGGCCGCTGCCGCTGTCGCCGGTCACCACGCCGGTCTGGGACCGGCGGCCACCCTATCCCTGTCGCCAATGACACTCCAGCAGCAACTGATGCGACCGCTCCTCCCCGCGGACATAGCCCTGCGTCTGTCAGCCGATCCGTCAGTTTGCAGTCTCAACCTATCGATCCTGGCCGCCCCCGGGGGGGCAACGCCACACCCGTTGTTGACCCCGAAGCAGAGTGTCGAGCTGGCGCTCCGACTATCGACCCCGGTGGGTGACGGCAAGCACCCACCGCAGCAGATATCACCTCTGCTGAACAGTATCTCTCCGACGGCGGCCGCTTCCGGCGGAGCGTCCGTTCTGCCGTCGGGGGCCGCGCCCCAAATCTTCGTCAAACAGGGTGACTCCAAGTGCAAGGAGTGCAACATCGTGTTCTGCAAGTACGAGAACTATCTGGCCCACAAGAAGCACTACTGTTCCGCCCGGAACCAGGACGACGGTGGCGGCGGCGGCGGCGAAGGGGCCAAGGTTAGCCCACCGATCTCGCCACAGACCGGCACGAGTCCGTCGGCCGGTGCACCGTTGTCGACGGTGGGCGGTGGACCGCGGCCACCGGTCGGGACCGGGGTCGCCTACCAGCAGCTGATCTGTGCCGCGTGCGGCATCAAGTTCACCTCGCTGGACAATCTAACCGCCCACCAGATGTACTACTGTCCGAAGCGGATCGACGTCGGCGGTCCGGTGAATGTCACTCCGACCAGTCAGCTCGTTGCGGTCAGTCAGCCGCAACCGCACAAGGAACGGTGCTCAAAGTGTAAGAGCATCCACGAACCGGGCCAACCGTGCACGGTCGCGGGGCACGGTGCCTACAAGTGTCCCATCTGTGAGGTCATCAGCCCAAACTCGACCGAAGCCCGGCGGCACATGGACACGCACGGCGGCGTGAAGGCGTTCCGCTGTACGATCTGCCGGTACAAGGGCAACACCCTACGTGGCATGCGTACCCACATCCGGATGCACTTCGACAAGAAGACGAGCGAGTTTAACGAGGAGAACTACATCACCTGCATCCTGGAAGAGGACGGCATCGAGATACCGCCGGCCGGGGCCCAGAATGCGGCTGCCGTGGCCGCCGCAGCGGCCGCCCTCGCTTCGGCGACCCACAAGTTCCTCGCCCAGGACGGCTCGGGCCCACCGGACGTGGCCGGATCACCCGTAGCCAGCGTCCGCCATCACTGCGAGCTGTGTCCGTTTACGACGAGCGATCGGGTCAATATGATCAAGCATATCAAGCAAGTGCACGGCGGAGGCCGTTCGGTTCCGTTCGGGTTGGACTCGGCCGAACTCTACAACGGGATCGCTGCTGGCGCCGTAGTAGAACTGGCTGTGAGGCCACCGATCGCCAGTACACCGGGACCGGGCAGCAGTAGCACCAGCAGCAGTCTGATCAAAACGGAACCGATCGACGATCGGTCTCCGTCACCGTCGGGCGGTGACCAAGACACAACCACCGACATCAATGTGGACGTCTGCCTGGAGGAGACAGCCCCGGTGGTGGCCACCACCGTCAAAACGGAGGCCATCGATCCGCACATGCCCTCGCTCAACTCACCGCTCGCCGGGTCACCGTCGCCACCTTCCTCTTTGAATCTGAAACCGAAATCTCAAACGCCGACGAAGACGACGGCCGGTGACGCAATCTCGTCCTCGCTCGTCCGGCGCTCCGACACGCCGACCCGAGCGAAAACACCGTCCCCGCCGGTGCCGCCGACGCCGCTGACACTGGAGCACCTACCACCGGGGCCAAAGTACTGCGATACGTGTGACATAACCTTCAACTACGCCAAAACGTACATTGCGCACAAGAACTTCTACTGCAAGGCGGTCCCGCTTGCCGGTGGCAGTGCCCCGACGGCGACCGGACAACCTGCTGCCGGTACTGGTCGACGTAGCGCATCCGTTTCACCAAATGGTGGGGCCACGAGCCCCGCGGTAACGGTCGCGGTCAACCGGGCGACGGAAACTTCCGTCTAA
Protein Sequence
MFTHDICSNLRRRRRRRPRCPGDDEDAGDEQQQQQQPPGTTEENGAPASQDATVSHSDSSTTTSSSNSSTLMNNNSRSSSRSSASGCLGMNGTDAGAPEEGPIRPTATPSPMAADASEDGAAQRSPSLREIKLEPNVPSDTEPPRPPSEAPVDPVVRCDSKLSHSGGGSPATTSPIPMLRLNVALASDPAANPDAKDLKKIGEADAVAAEFAQQQLAALNMAIGGPPPPPPPMRKPALKGPEGLVGPLALPAVVELPPRLPMFVCGPCGIRFSSASTLEAHQTYYCSHRKETEDGGGGAGGGTGSTAGTGGSASGGSIGGSGTKNAHPGGDGSGEPPAKAAKTGKQYACSQCSYSADKKVSLNRHMRMHQSSPTPSSVNGDDTGRQQQHQQHHHQQQQQQLQLIQAQAVAAAAAVLHQQQQQQQLQPQPVGQAQAPPPQVDRYCSDCDIRFSSTKTYRAHKQHYCSSRHREGQQSNNSTPKPGSTQKSGSQSPPEVPKTPPVAAAQQPFLALPTNPIIVIPYSLIRGASVIPGLLPSLAPGVANPESACFIFQNGTLQPIAMSLASQVAHQAATSAGGHAEVGPGPQRPPSQQHPSRGTTPSVSNENSSHSTQGAGPTPGGAPSSTGEVLKALNKRENSANKEATLTSTTTPLDLSVRRFSPGAIGALRERSLSLSSAVSGDQRMDYDSLMEGKENLSVSGDSLTPEQIVCAPSLPGSPPLTPSPKRRSNSPRATGPGPMASNAALAAAAAAVAGHHAGLGPAATLSLSPMTLQQQLMRPLLPADIALRLSADPSVCSLNLSILAAPGGATPHPLLTPKQSVELALRLSTPVGDGKHPPQQISPLLNSISPTAAASGGASVLPSGAAPQIFVKQGDSKCKECNIVFCKYENYLAHKKHYCSARNQDDGGGGGGEGAKVSPPISPQTGTSPSAGAPLSTVGGGPRPPVGTGVAYQQLICAACGIKFTSLDNLTAHQMYYCPKRIDVGGPVNVTPTSQLVAVSQPQPHKERCSKCKSIHEPGQPCTVAGHGAYKCPICEVISPNSTEARRHMDTHGGVKAFRCTICRYKGNTLRGMRTHIRMHFDKKTSEFNEENYITCILEEDGIEIPPAGAQNAAAVAAAAAALASATHKFLAQDGSGPPDVAGSPVASVRHHCELCPFTTSDRVNMIKHIKQVHGGGRSVPFGLDSAELYNGIAAGAVVELAVRPPIASTPGPGSSSTSSSLIKTEPIDDRSPSPSGGDQDTTTDINVDVCLEETAPVVATTVKTEAIDPHMPSLNSPLAGSPSPPSSLNLKPKSQTPTKTTAGDAISSSLVRRSDTPTRAKTPSPPVPPTPLTLEHLPPGPKYCDTCDITFNYAKTYIAHKNFYCKAVPLAGGSAPTATGQPAAGTGRRSASVSPNGGATSPAVTVAVNRATETSV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00094729;
90% Identity
-
80% Identity
-