Basic Information

Insect: Anopheles cruzii
Gene Symbol: ZFX
Assembly: GCA_943734635.1
Location: OX030879.1:20974843-20977302[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.00079 0.048 13.9 1.3 1 23 172 195 172 195 0.96

2 8 1.1 67 4.1 0.9 1 23 468 491 466 491 0.92

3 8 3.1e-07 1.9e-05 24.7 0.3 2 23 498 519 498 519 0.97

4 8 0.00011 0.0067 16.6 1.1 1 23 525 549 525 549 0.99

5 8 2.3e-06 0.00014 21.9 2.7 1 23 559 581 559 581 0.96

6 8 6.9e-06 0.00042 20.4 0.4 2 23 592 613 591 613 0.96

7 8 1.2e-07 7.2e-06 26.0 0.7 1 23 619 641 619 641 0.98

8 8 0.024 1.4 9.3 1.3 2 20 649 667 648 669 0.94

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.00079	0.048	13.9	1.3	1	23	172	195	172	195	0.96
2	8	1.1	67	4.1	0.9	1	23	468	491	466	491	0.92
3	8	3.1e-07	1.9e-05	24.7	0.3	2	23	498	519	498	519	0.97
4	8	0.00011	0.0067	16.6	1.1	1	23	525	549	525	549	0.99
5	8	2.3e-06	0.00014	21.9	2.7	1	23	559	581	559	581	0.96
6	8	6.9e-06	0.00042	20.4	0.4	2	23	592	613	591	613	0.96
7	8	1.2e-07	7.2e-06	26.0	0.7	1	23	619	641	619	641	0.98
8	8	0.024	1.4	9.3	1.3	2	20	649	667	648	669	0.94

Sequence Information

Coding Sequence: ATGGATTACAAAAGGATAGTAACGCTCAAGAATCATCTCCCGCGGGAGCCGGAAAGCCACTGGAGCAAAAGACGATCGCAGTTGACCACCAGACGCACGTACAATCGGCAACCGAGTCGGGGGGGGCTACCGCAGGCAGTAAAAGAGTCATCCCCCAGCAGCGATAGTGGCATCGAGTCCGTGTTCGATGCTTCAGCCAACGCCAATACTACAAAGTGTTCCAAATTGGGCTTGGAAACGGCTGAGCAGCATGATGCGCGTGCAGAGCAACCGGCGTCCACCGGCCAAACACCTTCGACTGGTGGTGGCAGTGACGACGAGCGAACCGTTGTTGCAAGCGCGGAAGCGAATGTTGAAGGGCGAAGGTCGGATGATGGTATCGGTGCGAGCGGGCTGGACGAGACCACCACCGTGAAGCCATCGCGGTTGAGTCGCGTCGGGAGAAAACTATCGGCCAAGGCAAAGGAAGCAATGGCGGTCGCTGAAGCTCCTCCACAACTGATTTTTGGAGACTTTCAGTGTCGCAACTGTGACATGTCCTTTAAGACTGAGCTTTGGTACAAAAAGCACCTGCTGAACGTTCACCGGCACCCGGAGACGAGTCCTCCGAGTGGTGGAGACCTTGCACCGAACGTGGTTGCACGTTGTAATGAGAAGAACGTTCTGTCGGGAGAAGCAGAGCATATGACTGAAAACGCATCAACGCTTGCCCCGGATACTGCCCCTGAAACGGCGAATGGGTTGGATAAAAATGGCCATCACATTGAGCCGGACGCAACGACGAATGGGACGGAGGAGCAGGAAGATCTGGTCCCGCCAGTAGAAATAAATGGAACATCAAGTCGCGACGCGATGGCGGACACTGTGGTGCTGAATGAGATGGTGGGCCGTAAGCGCAAACTAACCGACTCCAGTGACGAAGGTACCGTAAAGAAGGGCCGTAAAGACATCAACGTGACACCACCACCGCCGTCGGTGAAGGAACCAACCGAACCGTTCACACCGGTGGTTAAGGCGAAAATATCGAACTTAAAGGTCGAATACCGTCCGTCTAGTGTCCGCAATCGGAATGCCGTGGTAGCGGCAGAGGCAAAGCAAGAACTGCAAGAGCAAACCGTGATCGATGAACAACAGCTTAACGTCGGCGTAACTTCCCAGCTGGTGCTTGATTTGCCGACGGAAACGAAAGCGGACGAAAAGgcgtcgatagtagctgcaccaccaccagcattagcaccggaagtagcaccagaagcagcaccagaagcaTTGGAGAGCAGCGTGGCGGAACCGCCAGTCGAGATGACCGAAGCCAAGGTGGAGCCAGAGGATCCGAATCGCCTAACGCCATTCGAGATGGCCAAGGTGACGATCATTGAAGCGGGGGTCGCGGGGTGCCACTTCAAGTGCATTATATGCGGTGGACAGTTCAGCGATATGCCCGCCATCAAGGCGCACCTCTCGAAGGTGCACGCGGCCATCAAGCGCCGTTCGTGCGAGTACTGTGGCCGTTCGTTCGTCCAGACGGGCGATCTGACGCGCCACATACGGATTCACACCGGGCACCGACCGTTCAAGTGTCCGTATGTCGAGTGTAGCTTCGCGTTCATTTCGTCCGGCGATCTGCACAAACACGTCCGGCGTCACAACGTGTCCGTGCCGGTCCCGAAGCCGCACGTGTGCGACTACTGCGGCAAAGAGTTCGAGCGGTCGTACGACTTGAAGCGCCACAAAACGATGCACCTGAAGACGGAGCCGGGCTTCAAGGGCATCTCGTGCGAGGTGTGCGGCAAGATGTTCGCCCGGAAGGATCAGTATCGGGCGCACACGTACCGCCACATCGGGTACCGCCCGTATCGGTGCGAGGTGTGCGGCAAAACGTTCACCGATCCGAGCAACTACTCCAAGCACGGCCGGCTCCACGAGATGGACGGCGTCGAGGTGGTGTGCTACTTCTGTTCGCGGAAGTTTAAAAACAAGAGCGCCATCTCGAAGCACATCTTCCACTGTCAGCAGCGGACGCAGGGCACACGCAAGACGAACCGCGGCGTCCCGCTGGCAGCCTCGTTTATTAAGGGCATGAAGAAGGAAGCGAAGATTGAGTCGGACTGCGGCGGGGAGGAAGAGAATGGATGGAACGACGACGATGATCAGCAGTCCCTCCTAGCAGCCTCGGTTACGGGCGGTGGTGGAGGCTCAGCGGTCCGAAAATCCAAGCGCGGCGGCGGCGGCAGCAAGGGGAAGAGCCGACGGCAACAACGGCGACGCGCGACGTTAGACGATGATAGTAGTGATGATTCGATGTACGATGCGAGCAGCTCCCGCCACACCACCAGCGATCAGGAGTCACCGGATGAAACCGTTCCGGTGAAGCGAAGTCGCCGAAGCAAACCGGCGGCTGACAACACCGCCACCGCCGTCGCCGCCATAAGTAGTGCTGCGGCGGACACTTCGTCGTAA
Protein Sequence: MDYKRIVTLKNHLPREPESHWSKRRSQLTTRRTYNRQPSRGGLPQAVKESSPSSDSGIESVFDASANANTTKCSKLGLETAEQHDARAEQPASTGQTPSTGGGSDDERTVVASAEANVEGRRSDDGIGASGLDETTTVKPSRLSRVGRKLSAKAKEAMAVAEAPPQLIFGDFQCRNCDMSFKTELWYKKHLLNVHRHPETSPPSGGDLAPNVVARCNEKNVLSGEAEHMTENASTLAPDTAPETANGLDKNGHHIEPDATTNGTEEQEDLVPPVEINGTSSRDAMADTVVLNEMVGRKRKLTDSSDEGTVKKGRKDINVTPPPPSVKEPTEPFTPVVKAKISNLKVEYRPSSVRNRNAVVAAEAKQELQEQTVIDEQQLNVGVTSQLVLDLPTETKADEKASIVAAPPPALAPEVAPEAAPEALESSVAEPPVEMTEAKVEPEDPNRLTPFEMAKVTIIEAGVAGCHFKCIICGGQFSDMPAIKAHLSKVHAAIKRRSCEYCGRSFVQTGDLTRHIRIHTGHRPFKCPYVECSFAFISSGDLHKHVRRHNVSVPVPKPHVCDYCGKEFERSYDLKRHKTMHLKTEPGFKGISCEVCGKMFARKDQYRAHTYRHIGYRPYRCEVCGKTFTDPSNYSKHGRLHEMDGVEVVCYFCSRKFKNKSAISKHIFHCQQRTQGTRKTNRGVPLAASFIKGMKKEAKIESDCGGEEENGWNDDDDQQSLLAASVTGGGGGSAVRKSKRGGGGSKGKSRRQQRRRATLDDDSSDDSMYDASSSRHTTSDQESPDETVPVKRSRRSKPAADNTATAVAAISSAAADTSS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -