Basic Information

Insect: Anopheles coustani
Gene Symbol: zfh1
Assembly: GCA_943734705.2
Location: OX030902.1:2325988-2339897[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.065 5.1 7.9 0.2 2 23 51 73 50 73 0.96

2 9 0.0009 0.071 13.7 3.0 1 23 263 285 263 285 0.96

3 9 2.6e-05 0.0021 18.5 0.6 3 23 293 313 291 313 0.96

4 9 3.4e-06 0.00027 21.3 5.8 1 23 322 344 322 344 0.99

5 9 9e-05 0.0071 16.8 1.2 1 21 350 370 350 371 0.94

6 9 0.0098 0.77 10.4 0.6 3 21 848 866 847 867 0.93

7 9 2.3e-05 0.0018 18.7 4.0 1 23 1320 1342 1320 1342 0.95

8 9 8.3e-05 0.0066 17.0 7.8 1 23 1348 1370 1348 1370 0.98

9 9 0.064 5 7.9 7.0 1 21 1376 1396 1376 1397 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.065	5.1	7.9	0.2	2	23	51	73	50	73	0.96
2	9	0.0009	0.071	13.7	3.0	1	23	263	285	263	285	0.96
3	9	2.6e-05	0.0021	18.5	0.6	3	23	293	313	291	313	0.96
4	9	3.4e-06	0.00027	21.3	5.8	1	23	322	344	322	344	0.99
5	9	9e-05	0.0071	16.8	1.2	1	21	350	370	350	371	0.94
6	9	0.0098	0.77	10.4	0.6	3	21	848	866	847	867	0.93
7	9	2.3e-05	0.0018	18.7	4.0	1	23	1320	1342	1320	1342	0.95
8	9	8.3e-05	0.0066	17.0	7.8	1	23	1348	1370	1348	1370	0.98
9	9	0.064	5	7.9	7.0	1	21	1376	1396	1376	1397	0.96

Sequence Information

Coding Sequence: ATGCCGCTGTCCATTACTGCCGATGTTGCCAGAAACCCCCCGAGCCGAAAGGGTGCGCGCAAGGTATCGGCTCAGCAGATTCCTTCCCTGCCATCCGGTTTGCCGAATGACAGCGACAACGAGGCGCTAGCGGCCGCGGATTGCTGCGTCCAGTGCCCACAGTGCCACCAGACGGTCCAGGGAATCGAGGCGCTCAAGCAGCACATCCAGGTGAACCACAGCGGCAGTTCGGCGGAGGGGGACAACAGCGGCAGCCTTGGTCTGCGGTTGAAGGCCCCGGCAGCAGAAGCGAGCGAGCcggacgacgacaacgacgactacgacgacgacgacgacgatgacggcgCTGAGGAGCCCGCCAAACGGCGGACGGATCCGGATGCCAGCGGCCACGCTCCGTCGCCCTCGGTAGTGTCCGGCCTGGAACCATTCCCAGTGGGCAACAACCGGGCGAGCGGCGATCTCATCGGCAGTCGCCTGCAGGCCAAGTGCGTCAGCCTtctgcagcagcaggagcacaAGGACCGGCAACGGAAGCAGCACGAGCAGGCCGCGGACggcgaggacgaggaggacatCGAGGTCGAGCACCGAAGCACGCCGCTGGACTTCCTCATGGCCTCCGTACAGTCGCAGGCGACTGCGCTGCACCAACAGGAGGAGCCACCGTATAGACGCAGCGCGCTCGTCGTCAGCCCGGCCCAAAGTGGCAACAGCAACGCGAGCAGCGCCGGAAGTCTTGCCGCAGGCGGCTCCCCACAGGACGCCGATGGCCACGGCCCGATGTACCACTGTTCGCAGTGTCAGGCCACGTTCACCAACCGGGATCAGTACGAGAGGCATGAGCAACTTCACACACCCTCGGCGCTCGTGAACTGCAAGGTGTGCAACAAAACGTTCGCCAACGTGTACCGTCTCCAGCGCCACATGATCTCGCACGACGAGTCGACGCTGCTACGCAAGTTCAAATGCAACGACTGTGATAaagcatttaaatttaaacaccaCCTTAAGGAGCACGTGCGCATCCACTCGGGCGAGAAGCCGTTCGCGTGCAACAACTGCGGCAAGCGCTTTTCCCATTCCGGTTCCTACTCGAGCCACATGACCTCGAAGAAGTGCATCAACACGGGCATCAAGCTGCACCACAACCcgctcaacaacaacaacaacaacaataacaacagcagcagccataacaacaacaataacaacaacggcagcagcaacggGCTGAACTCCAGCCACACGCTGCTGCAGCTCCGgtacagcaacaacaacaacaacaacaacagcaacaacaacaacaataaccacAACGGTGGGCTAGGGCTGCACGCCAACGGCAAGCAGTCGTCGTCGGCGGCTCGGATCGCTTCCTCGCTGCAGGCCGACATGGACTGGATGGGGGCGGTGGGGTCCGGCAAGGGTGTACTGGCCATGTCGCCATCGCCCACGTCGTCCTGCTCGTCGGCAACGAAGCACGAGCTGGACATCAGTGCCGTCGCGCAcgcagccgccgccgtcgcTGTAGCGGCGAGTGGGGCCGGCAGCGGCCTGCAGCCGGGTGATGCGTTGCTGCCCATCATCGGCAAGTACCCGCCGAACTACACGGCGATGAACTTCCTGGCGGCCACCATGAGCCCGTTCTACTCGATGCTGAACAACCCGCTGCACCTACGCCTGCTGGAGCTGTCGGCGGCtgcacaacagcagcagcaacagcagcagcagcaacagcagcagcagcagcagcagcaacaccatcaAGCGGAAGCGGGTGTCAGTGACGGGACGGAGATATTCATGCCGCACCGGCAATCGTTTGGGCGAAGCGACGAGGACGAGAGCGATGAGCACTCGTCGACTCGCCGTCGTTCCAACTCGATCGAGCGGCAGATGGACGCGCTGTCTGCATCCGGCTCGAATGTCGACGTTGGCGAAACCGCTCGCCACAGCCCCGTGGCATCCAGTTCCGATTCGAGCGACCGGATGGAGGTTGACGACGAGGCGGCTAACGAAGGCGGCTCTTTTCGCGGCAGCGGCGATGATAAAATGGTGGCGGCTCAGACCGAACGGGACGATGAACAAGGCTTCCAACACGATGGCACCAACAAGTGTGAAACGGTCGCCGACACAAGCGACGAAACACGCGACCACCCGCTGGCTCTAGAGCCGCCGAAGGATGCTGGTGAGTTGGCGGGCAACGTTGTCTCGCCACTGGGGGCAACGGTACCACTCCTGCCACTCCCGAGCAAGCGCGAACCGATCGACGACGAAATGAATGGCAAGGCGTCGGTACAATCGGAACAACCGGATCAGCCGCCGCAGCAAGGAGGTGGGGCGAGCGAGCCGGTGACGATAAAAGGCGAGCCCGAGGACGACAGGGAAGACAACGCCGATGGAGAGATGGAGCTCGAGCCGTTGGCTCGCGGCTCGCCAGGTTCTAGTACACCGGTTGGTTCACCGTCCCTTTCCTCCTCGGCGTCGGCTACGTCACTCTCGTTAGCCTCCTCGCTGGTGGCGGCCGCCCAACCGCACTGTCTCTACTGCAACGAGCACTTCGCCAACCAGGCGGAGCTGCTCCAACACACACAGATCTTGTGCAAGCGGTCGCTTCTGCACAATCAGTTCGTGGCGGCTGCCGCGGCGGCTGCCAGCAGTCCCCAGTCTGCGCTGCCGCAGACCGCAGGCGGCAATACCacagccagcagcagcaacagtagcaGTAGCGGCAGCGAAGACGACACCGACTACGAGACCAAGGGTGGCGGCTTGAACGGTCccggcggcggctgcggcaTCTTCAACGGCCCGCACGGTCCAGCTGGGCTGGGTATGGGCCCCGGTGGCATGGGAGCAGCTGGTGGAACCGGCAGTGGCGGGAAGGTACGTGTGCGGACGGCCATTTCTGAGGAGCAGCAGAACGAGCTCAAGAAGTACTATGCGCGTAACAGCAAGCCGAGCCGCGATGAGTTTCAGTCGATCGCACAGCACGTCAAGATGGAGGCGAGAGTGGTGCAGGTATGGTTTCAGAACAACAGATCGCGCGAGCGCAAGATGGGCTCCCTTGGTGGAGGCGGCCGCCAGTACCCGAATGGTGGTGGtagcggcggcggtggcagcTCAGGTGCACCAGCCTCGCCGCTGCACGCTGATCGGGCACCGTCGGTGGTGGCCGGCCAGGAAACGGCAGCCGACCAGCCGCTCGACCTGTCCGTGAAAAAGGAGCTGTTCATGACGGCGGCTGAGGTGACCGCAGCGGCGGCTGAAGCACTGTTGACGGCTGCTGGCAATACGAGCGCCAATGCAACGGGCGGTTCGCTGCCTGCCGGGCTGCTGCAGGTGGCAGCCGGCCAAGCTGACACCATGTCCGCGCTCAACGAGGCCATCAACCTCACCATCCGTACACCCTGCTCTCCCAACGCCTTCTACTACAACGACATCCATCCTATCCACGGCGTACCGGCGACGCAGGGGCACGCCGGTCACGGCGGCCATCCTCTGCAAGACGGATTCGGCGGCGGTAGCGTTGGTACTCGCGATACTCCCTCACCTCAAGAGGCACGTGGTCAATATCACCACTACCATCCCCAGCCGCACACGCTCGTCCAGTACGGCCAGGGCCCTTACTCGGGCATGCTGCACTCGCACCATCCGGTCGGCCTGGAGCATCTCTTCCGACGCCAAATCTCACCCGAGCTCTCTGGTGTTGCCAGTGGTGGTGCCAGCTTGGCCAGTCTCAGTCCAGGAACCCGCGAACTGGTGCAGGATGCGGCCGGCACCGGTCCCTACGACGGTAAATACTACAATCCGTTCGACAAACAGCTCCTCCAGTCGATGCTGAACGTCCCGAAGCGAATGGGGGGACCGTACGGTGCAGGCGGCATAGGAAgcggcgcctccatcgggaaGGACGCCAACACTCAGCAGCAACCGCCGGACGCAGAGGGCCAGTACGTCTGTGATCAGTGCGACAAGACGTTCAGCAAGCACAGTTCTCTACAGCGGCACAAGTATGAACATTCAGGACAACGACCCTACAAATGCATGGACTGTCCGAAGGCGTTCAAGCACAAGCACCACCTGACCGAGCACAAGCGACTACACAGTGGCGAAAAGCCGTTCCAGTGCTGCAAGTGTCTGAAGCGCTTCTCGCACTCTGGCTCCTACAGTCAGCACATGAACCATCGCTACTCGTACTGCAAGCCATACAGGGAGGGCAAATAA
Protein Sequence: MPLSITADVARNPPSRKGARKVSAQQIPSLPSGLPNDSDNEALAAADCCVQCPQCHQTVQGIEALKQHIQVNHSGSSAEGDNSGSLGLRLKAPAAEASEPDDDNDDYDDDDDDDGAEEPAKRRTDPDASGHAPSPSVVSGLEPFPVGNNRASGDLIGSRLQAKCVSLLQQQEHKDRQRKQHEQAADGEDEEDIEVEHRSTPLDFLMASVQSQATALHQQEEPPYRRSALVVSPAQSGNSNASSAGSLAAGGSPQDADGHGPMYHCSQCQATFTNRDQYERHEQLHTPSALVNCKVCNKTFANVYRLQRHMISHDESTLLRKFKCNDCDKAFKFKHHLKEHVRIHSGEKPFACNNCGKRFSHSGSYSSHMTSKKCINTGIKLHHNPLNNNNNNNNNSSSHNNNNNNNGSSNGLNSSHTLLQLRYSNNNNNNNSNNNNNNHNGGLGLHANGKQSSSAARIASSLQADMDWMGAVGSGKGVLAMSPSPTSSCSSATKHELDISAVAHAAAAVAVAASGAGSGLQPGDALLPIIGKYPPNYTAMNFLAATMSPFYSMLNNPLHLRLLELSAAAQQQQQQQQQQQQQQQQQQHHQAEAGVSDGTEIFMPHRQSFGRSDEDESDEHSSTRRRSNSIERQMDALSASGSNVDVGETARHSPVASSSDSSDRMEVDDEAANEGGSFRGSGDDKMVAAQTERDDEQGFQHDGTNKCETVADTSDETRDHPLALEPPKDAGELAGNVVSPLGATVPLLPLPSKREPIDDEMNGKASVQSEQPDQPPQQGGGASEPVTIKGEPEDDREDNADGEMELEPLARGSPGSSTPVGSPSLSSSASATSLSLASSLVAAAQPHCLYCNEHFANQAELLQHTQILCKRSLLHNQFVAAAAAAASSPQSALPQTAGGNTTASSSNSSSSGSEDDTDYETKGGGLNGPGGGCGIFNGPHGPAGLGMGPGGMGAAGGTGSGGKVRVRTAISEEQQNELKKYYARNSKPSRDEFQSIAQHVKMEARVVQVWFQNNRSRERKMGSLGGGGRQYPNGGGSGGGGSSGAPASPLHADRAPSVVAGQETAADQPLDLSVKKELFMTAAEVTAAAAEALLTAAGNTSANATGGSLPAGLLQVAAGQADTMSALNEAINLTIRTPCSPNAFYYNDIHPIHGVPATQGHAGHGGHPLQDGFGGGSVGTRDTPSPQEARGQYHHYHPQPHTLVQYGQGPYSGMLHSHHPVGLEHLFRRQISPELSGVASGGASLASLSPGTRELVQDAAGTGPYDGKYYNPFDKQLLQSMLNVPKRMGGPYGAGGIGSGASIGKDANTQQQPPDAEGQYVCDQCDKTFSKHSSLQRHKYEHSGQRPYKCMDCPKAFKHKHHLTEHKRLHSGEKPFQCCKCLKRFSHSGSYSQHMNHRYSYCKPYREGK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00109027;
90% Identity: iTF_00109027;
80% Identity: iTF_00096272;