Basic Information

Insect: Anopheles coluzzii
Gene Symbol: zfh2
Assembly: GCA_016097175.1
Location: CM027926.1:899367-914382[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 13 0.77 41 4.6 1.4 2 23 139 161 138 161 0.94

2 13 0.00013 0.0069 16.5 1.4 2 23 362 384 361 384 0.96

3 13 3.3e-05 0.0017 18.3 0.7 1 23 416 440 416 440 0.92

4 13 2.4 1.2e+02 3.1 1.1 2 23 632 654 631 655 0.93

5 13 0.055 2.9 8.2 0.3 2 23 891 913 890 913 0.92

6 13 6.4 3.4e+02 1.7 0.0 2 23 1019 1041 1018 1041 0.93

7 13 0.37 20 5.6 0.3 2 19 1109 1126 1108 1129 0.95

8 13 6.2 3.2e+02 1.8 0.6 4 23 1147 1167 1143 1167 0.86

9 13 0.0043 0.23 11.7 4.9 1 23 1180 1202 1180 1202 0.96

10 13 0.03 1.6 9.0 5.3 2 23 1209 1231 1208 1231 0.93

11 13 0.2 10 6.5 0.6 1 22 1320 1341 1320 1344 0.89

12 13 0.0012 0.061 13.5 0.1 1 23 1425 1449 1425 1449 0.93

13 13 7.7e-05 0.0041 17.2 2.8 1 23 2139 2161 2139 2161 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	13	0.77	41	4.6	1.4	2	23	139	161	138	161	0.94
2	13	0.00013	0.0069	16.5	1.4	2	23	362	384	361	384	0.96
3	13	3.3e-05	0.0017	18.3	0.7	1	23	416	440	416	440	0.92
4	13	2.4	1.2e+02	3.1	1.1	2	23	632	654	631	655	0.93
5	13	0.055	2.9	8.2	0.3	2	23	891	913	890	913	0.92
6	13	6.4	3.4e+02	1.7	0.0	2	23	1019	1041	1018	1041	0.93
7	13	0.37	20	5.6	0.3	2	19	1109	1126	1108	1129	0.95
8	13	6.2	3.2e+02	1.8	0.6	4	23	1147	1167	1143	1167	0.86
9	13	0.0043	0.23	11.7	4.9	1	23	1180	1202	1180	1202	0.96
10	13	0.03	1.6	9.0	5.3	2	23	1209	1231	1208	1231	0.93
11	13	0.2	10	6.5	0.6	1	22	1320	1341	1320	1344	0.89
12	13	0.0012	0.061	13.5	0.1	1	23	1425	1449	1425	1449	0.93
13	13	7.7e-05	0.0041	17.2	2.8	1	23	2139	2161	2139	2161	0.98

Sequence Information

Coding Sequence: ATGACTACTCGCAAACAGACAAAATTCTCCACCAAAATTCAGTTCTACCTGAAGCACAGAGAGTCGCGGATACTGAAGCTATGCAACGACACGATCGGCCCGGTGCCAAACGATTCCCTCAGCAAAGCGATCTTCAGACTGTTGTCCAAACCGGTAGACAATAAAGGCATTATACAACTTTTTGTCGACAAGGAGAGCGGCGTCACCGCCGGCGGCGACACGTTCGCGCCCGCCGCCGACGAGGACGACGCGCCGGCAGTGGTCGGTGGTGCCGGTGCGGCGCAGGAGCAGGAGCAGGCACAGAACCTCATCACCCGGTCGCCGCCGGCCGCACGGTCCCCGTCGGCCGGTCCGGCTGCTGCCGCCAGCGTGGTACCGCTGGCGGGCTCGACCAGCAGCCACAAGGCGATCCTGATGTGCTTCAGCTGCAAGCTCAGCTTCGGCACCTGCCGGTCCTTTATAGCGCATGCCAAAATCGAGCACAGTCTCACACTGAACGACTACGAGCGGATGCTGCTGGAGAAGAACTACAGCAGTGCCATCATACAGACGAACGCGGAGAAGCACGAAGGCGAGAAGAAGGGTGGCGTGGCCAGTGCGGCTGCGGCCGCCGTCAGTGGGAAACTGCTGACCGACTTCCTGAACCAGCAGAAGATGCTCTCGTCCGTGGGGGAGAATCTGTACGGCAAGCAGAACAAGTTCCTCGAGCTGATCAGCTCGGCGGCTGACATGAAGCTGAATCCGCTGGCGGCGGCTGCGGTGGCGGCCGTAGCCTCCAACAAGGGCGCGCCCGGACCGGCGGAGCTCGGGGCAGGAGGCGGCGTCGGTGGTGTTGGAGGTGGTGCCGGTGGTGGTGGTGGTGGTGGTGCCGGTGGTGACTTCCATCTGAAGAAGTACAGCCCGGTCGATCTGTACAAGCAGCTGATCGCGAACAACTTCCGCCCGGAGGCGATGGACGTCGGGGAGGAGCTGAAGAGCGAACATCAGATCAGCGTGAAGAAGCTGGAACCGGAACCGTCGACGGCGTTCCGGAACAGCAACTTCAGCCCGAACATCTCGACGCGCAACTCGTGCAAGACGCTCAAGTGTCCGCAGTGCAACTGGCACTACAAGTACCAGGAAACGCTCGAGATACACATGCGCGAGAAGCACCCGGACGGCGAGACGGCCTGCAGCTACTGTCTGGCCGGGCAGGCCCATCCGCGGCTGGCGCGCGGTGAATCGTACACCTGCGGGTACAAACCGTACCGCTGTGACATCTGCAACTACTCCACCACGACCAAGGGCAACCTGTCGATCCACATGCAGAGCGACAAGCATCTGAACAACATGCAGGACCTGAACGGCATGATGAACAAGAGCAACCAGAGCTTCCTGAACCTCGCGACGCTGCAGGCGAACGAGAAGGTGGTGAACAGCTCGCGCAACCAGTACATGGCGGCGGCTGCAGTAGCGGCGGCCAGTTCACCGCTCTCTTCACTGTCGGGCAAGCTCGGCGGAGGCGGTGGTGGTGGTGGTGGTGGTGGCGTTGGAGGTGTTAGTGGTGGCAGTGGAGGTGTTGGTGGCGGCCCAGGCAGTGCCCAATCGAAGGAGAGCGGCCCGGTCGGGTACGAGACGGGCGGGCGACCAAAGTCCTTCTTCAATGGGGCAAGCGAACCGGGCACAGACCGGGACTACCACCAGCACCACCATCATCACCACCAGCACCAGCTGGACGAGGACAAGAACCCGCTGCACTTCGATCCGCCGGTCCGGCTGTCGCTCGACCCCGCCACCTACTACAGCTGTCTGGTGTGTGCCGACTTCGAGACGAACAGCCTGGAGGAGCTGAAAAAGCACGTGCTGAAGGACCGGAGCAGCAGTGCGATGGACACGATCCTAATCGCTGGCCAGGAGTGTCTGCTGTGCGGGCAGAAGGCCCACGACCGGGTGGAGATGGAGCGGCACCTGAAGGCGGACCACCATCTGCGCCGGCTCGAGCTGATGATCCATCTGCTGGAGGGGCGGGACAAGGCGGCCACCAAGCTGCGCCAGTTCGTTGGCCAGGAGCTGTACAAGAAGCTGCAGCTGATCTTCCCATTGGCGGAGGAACCGAAATTTGCGTACGATGAGATGCCAAGCCTGATCGAGCGGGACTACGGGACCGGCGCGAACGGTATCGATGGTGAGCAATCATCTTCACCGTCGTGCCCGGACAACGTGCAGCTCAAGTGTAACTGCTGCAACTTCTACACCACCTCGCTGGAGAAGATCGGCATCCACAGCCTGTCGGAGAAGCACATCTTCCGGCGGATCTGTTTCGACTATCTGCTGCTCATCTCTAGCGAAAAGTCCAGCCTGGCGACGACCGTAAAGAGCGAAGATGGAACAAAGCAGCAGTCCTCGCCGAAAGCTAGCCAGCTGATGCTGACCTGCGTGCCGTGCTGCTTCAAGACCGACCACATCTACTACATGATACACCATCTGAAGAAGAGCTGCAAGGTGGAGCAGAACATCAACCTGCTCGGGTTGCGAAACATCTTCAAGCTGACGGCCAAAGGCTTGGACGCCCAAGATGCAATGGATACGGGCGACAACGGGCTGTGCAGCATACTGCAGGAGAAGAAGATGTGGAACGGCGAGAACGCCAGCAACCGCCAGACGGCCGGCGGCTGCAAGGACCGCTGCCTCGTGTGCAGCGTGTGCAACAAGTTCTCCTCGAAGAAGGTGAACGTGATGCAGCACCTGCTGGCGAACCACAACGCCGGCAACGAGCTGCTGGGCGGGGCCGAGCTCTCCCCGGCCGTGCCGTCGCTGTCGCGCAAACCGTTCGACTATCTGCGCACGCTGGCGGAGGCCCGCTGCGCCCAAAATCTGCGGCTCATCGAGAAGGTCACCTTCATGAGCGACTCGTTCGCGCTGAAGGAAAACTGCAACGACCTGAAGCACGGCAACCTGGCGGAGATGCTGGAGCAGTACGCGGCCCGGCAGGATGCGGGCGACGGCTTTACTGCCGCCCGTTCGCCGCCGCTCGAGAAGCAGCAGCAGCAGCAGCAGCAACACTCGCCGACCCTGTCCTGTCCGCTGTGTGCGGAGGCGTTCCTCGACCAAGCGACGGTCGAGACGCACGTGCTGCGCGTCCACAACATCAAGATGGACGGGCTGAACCGGCTGCTGAAGCTGGTCGATACCTCGCAATTTTTGAAAACGACCAACGGCAAACAGCAGCCGCCGCCGCCCGGCAGCAACAGCAGCAGCCCAGTGGACAAGCCAGGGTCGCCCCATTCGCCGCAGCAGGGCGGCAAGGAGGGTTCGGTGTCGCCCGGGGGTGGCACACCGAGCATCCGCTGCTCCTACTGCAAGGCACCGTTCGACACGATGGTCGACCTGAAGATACACTGCAACGAGAGCAGCCACTTCCGGCGCAGCGCCGACTCGGACGATCTCGCCTGCTTCCTGCACGACTGCAAGGACGCGTTCGACAACCTGGCCGACCTGAACCAGCACTTCAAGGCGAGCCATCTGAACTTCCTCATCTCGGAGCACCACACGTACCGGTACCGGTGCAAGCAGTGCCCGTTCGCGTTCAAGACGCACGAGAAGCTGAGCCGGCACCTGTTCTACCACTCGCTGCGGGAGTCGACCAAGTGCTTCTACTGCGACCACCACTTCAAGAACATCCACTCGCTGACGGCGCACATCGCGGAGAAGCACCCGCAGGAGGCGCTGCAGTCGGGCAAACCGTCGCCGCCGGGCATCGCCTCGCCCGACGCGTCCATCCTGTTCTTCAAGGATCTCAAGCGCAAGATGCTCAACAGCCAGCAGCAGCAGCAGCGGAACGGGTTGAGTCCGCGGTCGGATCGGTCGGGTGGGCGGGATGCGCGGGACAGCGTGGATGAGGATCGGCTGAGCGAGAAGTCGATGAGCTCGCTGTTCTACGACATCAAGTCGGAGAAGTTCACCAACCCGAACCGGCCGTTCAAGTGCACGATCTGCATGGAAAGCTTCACGCAGAAGAACATCCTGCTGGTGCACTACAACAGCGTCTCCCACCTGAACAAGCTGAAGAAGCTGAAGGCGGAGAAGGGCTTCGCGCAGATGTTTACCGGCTCGCTGCTCAGTGCGGACATTGGCGCGGGAGAGAGCTGTCCCGATCGGGGCAAGAACTCGCCCTCCCCGACCGTGCCGTTCGGCGAGAAGGCGGCCACACCCTTCACGATGCCCGCCTTCGCCGAGGGATGCGGCGAAAAGCGCAAGGAGGTGGGCGACGAGAAGGAGTCGGCGCGCAAGAAGTTCAAGTGCGACATCTGCAACGTGGCGTACACGCAGGGCAGCACGCTGGACATCCACATGCGCAGCGTGCTGCACCAGACGCGGGCCTGCCGTATGCAGGAGCGGAGTCTCTTCGCCGTGCAGCCGGCAGGGACGCCGCAGCAGCAGCAACCTTCGCCCCAGGGCGGCGACAGCAAGAAGAAGAGCGAGTTCCCACTGATCCATCCCATCCCGGAAAGCCACGACCAGTCGCCGAACATGCTGGACGAAGTTTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGCACTCGGCCCACTGTTCTGCGGGGTGCCCGTCGGTGGCCCCGACAAGCCGGAAATTTGCGTGTGCGAATGCTGCTACCAGGTGTTCCCGGGTAAGCTGATGCTCGAGACGCACCTCGAGCTGAGCCCGGAGTGTCTGGCGCACCGCAAGAAGCTGCTCGAGGCAGCCGCCGGTCTGCCGAGCGATCCGGCCGGCCCGCTGGGCTTCCCGGGCGACGGTGTAGGCTTCCCGCACCACCACCAGGCGCTGAGCGAGCTGGCCAAGGTCAACCAGGGCGGCGGTGGGTTCGATCTGGGAGCGCCGGGCGACGCAGCCGCCCTGCTGGGCGCCAAGGGGCTCGTGCCGGCGATGGATCCAGCCGCTACGGCCGCGGCAGCAGCAGCCGCCGCCAACCTGATGGATCCGAGCTTCCTCAAGAACGCATCGCTGCTCCAGTTTGCCGCCTCCGATCCAGCCAACAAGCTCAATCCGAACGCACTGAACGTGCTGAACTTTATGCACTTCCACCATCTGATGTCGCTGAGCTATCTGAATCTGGCGCCGCAGCTAAGCTTCGGCGGCGTGCCGCCGAAGGTCGACCCGACCAAGCCGGACGGTTCGCCCGGCGGTGGCGGTGATCCCGTGGGCGGCAAGGGTGGCAAGACACCGTCGGGCGGCTCCGTCGTACTGCCGCCGAAGCGGGCCCGCACCCGCATCACGGACGAGCAGCTGCGCATCCTGCGCTCCCACTTCGACATCAACAACTCGCCGAGCGAGGAAAGCATCCAGGAGATGTCGCTGAAGGCGAACCTGCCGCAGAAGGTGGTGAAGCACTGGTTCCGCAACACGCTGTTCAAGGAGCGGCAGCGCAACAAGGACAGCCCGTACAACTTCAGCATCCCACCGTCGACGAAGCTGAACGTGGAGGAGTACGAGCGGACGGGCGAGGCGAAGGTGACCGACCTGGAGACGGCATCGTTCAAGGCGTCCGATGTGGGCGGGTCGCTGTCGCAGGACAACTCCTGCTCGCAGGGCTCGACCGACATGAGCAAAGCGTTGAACGAGGCGATGAAGCAGAACCTGTCCAAGTCGCTGCTCGAGTCGCTCAGCAAGCACCAGTCGGCGACGGGGCAGGATTTGGTCGGGGCAGCCGCTGCCTTCCACCTGAACAAGAGCCTCTTTCCGGACAGCTTCGGTGCAGGTGTTGTGGGTGGCGGCGTCGGCGTAGGAGGTGGTGGTGGCGGTGGTGGTGTCGTCGGTGGGCCGGACTTTTCCGGCCCCGACACGGTGGGCGTAGTGTCGGACTACTTCCAGCGGGCGGCCGCCGACGCCCTGGCTGGGGGCCCCCTCGGGAGTCCTCTCCCGACGCCGGCCGACCTGCAGCTCGACTCGTCCAACTCTAGCCCGATGCCGATGCGGCCGCCGAGCGCGATCTCGCTCAAGAAGCACATGGCCACGCCGCCGTCGCTCGTCGGCGTCGGGGACGAGATGAAGATACCGAGCCCGATCGAGAGCCCGGTCATCTCGCCGCCCGGCTCGATGGGGCTGCACGCGCTGCCCCCGCAGACGCAGCCGATCACCTGCTCGAACGGCAAGCGGGCCAACCGGACGCGCTTCACCGACTACCAGATCAAGGTGCTGCAGGAGTTCTTCGAGAACAACTCCTACCCGAAGGACAGCGACCTGGAGTACTTGAGCAAGCTGCTGATGCTGTCGCCCCGCGTCATCGTCGTCTGGTTCCAGAACGCTCGCCAGAAGCAGCGCAAAATCTACGAAAACCAGCCGAACCCGACGTTCGAGTCGGACGAGAAGAAGGCGATCAACATCAACTACACGTGCAAGAAGTGCAACCTGGTGTTCCAGCGGTACTACGAGCTGATCCGGCACCAGAAGAACCACTGCTTCAAGGAGGAGAGCAACAAGCGGTCGGCCAAGGCGCAGCTGGCCGCCGCCCAGATCGCCCACTCCTTCACCAGCGGCAGCGAGGACTCGGACTCGAGCCTGGACGTCAGCCGGCGCGAGTTTCAGCCGCGCGAGAACGACTGCCCTTTCTAG
Protein Sequence: MTTRKQTKFSTKIQFYLKHRESRILKLCNDTIGPVPNDSLSKAIFRLLSKPVDNKGIIQLFVDKESGVTAGGDTFAPAADEDDAPAVVGGAGAAQEQEQAQNLITRSPPAARSPSAGPAAAASVVPLAGSTSSHKAILMCFSCKLSFGTCRSFIAHAKIEHSLTLNDYERMLLEKNYSSAIIQTNAEKHEGEKKGGVASAAAAAVSGKLLTDFLNQQKMLSSVGENLYGKQNKFLELISSAADMKLNPLAAAAVAAVASNKGAPGPAELGAGGGVGGVGGGAGGGGGGGAGGDFHLKKYSPVDLYKQLIANNFRPEAMDVGEELKSEHQISVKKLEPEPSTAFRNSNFSPNISTRNSCKTLKCPQCNWHYKYQETLEIHMREKHPDGETACSYCLAGQAHPRLARGESYTCGYKPYRCDICNYSTTTKGNLSIHMQSDKHLNNMQDLNGMMNKSNQSFLNLATLQANEKVVNSSRNQYMAAAAVAAASSPLSSLSGKLGGGGGGGGGGGVGGVSGGSGGVGGGPGSAQSKESGPVGYETGGRPKSFFNGASEPGTDRDYHQHHHHHHQHQLDEDKNPLHFDPPVRLSLDPATYYSCLVCADFETNSLEELKKHVLKDRSSSAMDTILIAGQECLLCGQKAHDRVEMERHLKADHHLRRLELMIHLLEGRDKAATKLRQFVGQELYKKLQLIFPLAEEPKFAYDEMPSLIERDYGTGANGIDGEQSSSPSCPDNVQLKCNCCNFYTTSLEKIGIHSLSEKHIFRRICFDYLLLISSEKSSLATTVKSEDGTKQQSSPKASQLMLTCVPCCFKTDHIYYMIHHLKKSCKVEQNINLLGLRNIFKLTAKGLDAQDAMDTGDNGLCSILQEKKMWNGENASNRQTAGGCKDRCLVCSVCNKFSSKKVNVMQHLLANHNAGNELLGGAELSPAVPSLSRKPFDYLRTLAEARCAQNLRLIEKVTFMSDSFALKENCNDLKHGNLAEMLEQYAARQDAGDGFTAARSPPLEKQQQQQQQHSPTLSCPLCAEAFLDQATVETHVLRVHNIKMDGLNRLLKLVDTSQFLKTTNGKQQPPPPGSNSSSPVDKPGSPHSPQQGGKEGSVSPGGGTPSIRCSYCKAPFDTMVDLKIHCNESSHFRRSADSDDLACFLHDCKDAFDNLADLNQHFKASHLNFLISEHHTYRYRCKQCPFAFKTHEKLSRHLFYHSLRESTKCFYCDHHFKNIHSLTAHIAEKHPQEALQSGKPSPPGIASPDASILFFKDLKRKMLNSQQQQQRNGLSPRSDRSGGRDARDSVDEDRLSEKSMSSLFYDIKSEKFTNPNRPFKCTICMESFTQKNILLVHYNSVSHLNKLKKLKAEKGFAQMFTGSLLSADIGAGESCPDRGKNSPSPTVPFGEKAATPFTMPAFAEGCGEKRKEVGDEKESARKKFKCDICNVAYTQGSTLDIHMRSVLHQTRACRMQERSLFAVQPAGTPQQQQPSPQGGDSKKKSEFPLIHPIPESHDQSPNMLDEVXXXXXXXXXXXXXXXXXXXXXXXXXXXALGPLFCGVPVGGPDKPEICVCECCYQVFPGKLMLETHLELSPECLAHRKKLLEAAAGLPSDPAGPLGFPGDGVGFPHHHQALSELAKVNQGGGGFDLGAPGDAAALLGAKGLVPAMDPAATAAAAAAAANLMDPSFLKNASLLQFAASDPANKLNPNALNVLNFMHFHHLMSLSYLNLAPQLSFGGVPPKVDPTKPDGSPGGGGDPVGGKGGKTPSGGSVVLPPKRARTRITDEQLRILRSHFDINNSPSEESIQEMSLKANLPQKVVKHWFRNTLFKERQRNKDSPYNFSIPPSTKLNVEEYERTGEAKVTDLETASFKASDVGGSLSQDNSCSQGSTDMSKALNEAMKQNLSKSLLESLSKHQSATGQDLVGAAAAFHLNKSLFPDSFGAGVVGGGVGVGGGGGGGGVVGGPDFSGPDTVGVVSDYFQRAAADALAGGPLGSPLPTPADLQLDSSNSSPMPMRPPSAISLKKHMATPPSLVGVGDEMKIPSPIESPVISPPGSMGLHALPPQTQPITCSNGKRANRTRFTDYQIKVLQEFFENNSYPKDSDLEYLSKLLMLSPRVIVVWFQNARQKQRKIYENQPNPTFESDEKKAININYTCKKCNLVFQRYYELIRHQKNHCFKEESNKRSAKAQLAAAQIAHSFTSGSEDSDSSLDVSRREFQPRENDCPF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00095501;
90% Identity: iTF_00095501;
80% Identity: iTF_00095501;