Basic Information

Insect: Anopheles bellator
Gene Symbol: sd
Assembly: GCA_943735745.2
Location: OX030929.1:1590226-1594828[+]

Transcription Factor Domain

TF Family: TEA
Domain: TEA domain
PFAM: PF01285
TF Group: Helix-turn-helix
Description: The TEA domain is a DNA-binding region of about 66 to 68 amino acids that has been named after the two proteins that originally defined the domain: TEF-1 and AbaA. The TEA domain is located toward the N terminus of eukaryotic transcription factors of the TEA/ATTS family. It shows a three-helix bundle with a homeodomain fold [3, 1]. Two α-helices are nearly anti-parallel and pack on either side of the third one, which is the DNA-recognition helix of the TEA domain. Phosphorylation of one or both of the two conserved serines found on the DNA-binding surface could interfere with DNA-binding activity, by introducing electrostatic repulsion and/or steric hindrance, and help regulate the transcription factor activity of the proteins [2, 1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 2.3e-31 1.6e-27 95.2 0.1 2 66 44 110 43 112 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	2.3e-31	1.6e-27	95.2	0.1	2	66	44	110	43	112	0.96

Sequence Information

Coding Sequence: ATGGGTCCAGGACCAACGGCCGGCTCGTTGGTCCCGGACGACACCAACGGCTCGGGCGTCGAAGGCGGCAAGCATTTGGACGTCGGCGACATGAGTGACGACGAACAGGACCTCTCGTCGGCTGACGCCGAAGGCGTATGGAGCCCGGACATCGAACAGAGCTTCCAGGAAGCGCTTGCCATCTACCCGCCGTGTGGCCGCCGGAAGATCATCCTCTCGGAGGAGGGAAAAATGTATGGTCGTAATGAACTGATAGCCCGCTACATTAAACTCCGTACTGGCAAAACGAGAACTCGGAAACAGGTCAGCTCACACATACAAGTATTAGCCAGACGGAAGCTGCGTGAGTTTCAGGCTAAAATGAAAGTGGATCACTCGATGGTGGGCGGTGTCAAGGATAAAATTTTCCCGGCACCTGACATCGCGATTCCTATGAGCAGTGCCCAGATCGTCACGATGACGGCGTCCAAAGGCGTTCGCCTTACCCCAGCCAATCCTTCTTACCACCACCTTCCGTACAACCAGCATCACCAAAACCATCAcctccatcaccaccaccaccagcccctACAGGGTACCGTTAGTCAATTCTGGCAGCCAGGGTTGCAGCCGAGCACATCCCAGGACGTGAAGCCATTCGCGCAACCCGGCTACCCGATAAAAACCGCGACCACGGTGTCAGAGAGCGCTCTACAGCCAGCGCATCCCTGGGAAGGACGGGCGATCGCGACGCACAAGTTCCGTCTGGTGGAGTACAGTGCATACCTGGAGCTGCGCGTGGAAGATAATTATCACAAGCACCTGTTTGTGCACATAGCCGATACGCCGGCCCACCCGCTGTTGGAGTCGGTCGAAGTGAAGGAGATTTACGATAAGTTCCCGCAGAAGTCAGGTGGTTTGAAGGAGCTCTACGAGAAAGGGCCAAGCAATGCATTCTTCCTCGTGAAGTTCTGGGCCGACCTGAACACCAACATCGCGAATGATGCTGGCGCGTTCTACGGTGTCAGTAGTCACTACGAAAGCAACGACAATATGGTGATCACCTGCTCGACGAAAGTTTGCTCGTTCGGCAAGCAAGTGGTGGAGAAGGTGGAAACGGAATATTCCCGTGTCGAGAACGGGCGTTACGTGTACCGCATCAGTCGGTCGCCCATGTGCGACTACATGATCAACTTCATCAACAAGCTCAAGCACCTTCCGGAGAAGTACATGATGAACAGTGTGCTCGAAAACTTCACCATCCTCCAGGTTATATCCAACAAGGATACGGAGGAAACACTGCTGTGTGTGGCATTCGTGTTCGAAGTGTCTACCTCGGAGCACGGTGCCCAGCACCACATCTACCGGCTGGTGAAGGAATAG
Protein Sequence: MGPGPTAGSLVPDDTNGSGVEGGKHLDVGDMSDDEQDLSSADAEGVWSPDIEQSFQEALAIYPPCGRRKIILSEEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKLREFQAKMKVDHSMVGGVKDKIFPAPDIAIPMSSAQIVTMTASKGVRLTPANPSYHHLPYNQHHQNHHLHHHHHQPLQGTVSQFWQPGLQPSTSQDVKPFAQPGYPIKTATTVSESALQPAHPWEGRAIATHKFRLVEYSAYLELRVEDNYHKHLFVHIADTPAHPLLESVEVKEIYDKFPQKSGGLKELYEKGPSNAFFLVKFWADLNTNIANDAGAFYGVSSHYESNDNMVITCSTKVCSFGKQVVEKVETEYSRVENGRYVYRISRSPMCDYMINFINKLKHLPEKYMMNSVLENFTILQVISNKDTEETLLCVAFVFEVSTSEHGAQHHIYRLVKE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00092124; iTF_00097022; iTF_01471396; iTF_00108344; iTF_00400533; iTF_00401672; iTF_00102328; iTF_00109093; iTF_00096337; iTF_00107647; iTF_00101641; iTF_00100266; iTF_00105104; iTF_00103634;
90% Identity: iTF_00097022;
80% Identity: -