Aara003404.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Anopheles arabiensis
Gene Symbol
topi
Assembly
GCA_016920715.1
Location
NC:57814966-57839863[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.00074 0.035 14.0 2.3 2 23 237 259 236 259 0.95
2 16 2.2 1e+02 3.1 1.4 2 23 295 317 295 317 0.92
3 16 0.00095 0.046 13.7 2.7 1 23 331 353 331 354 0.95
4 16 0.83 40 4.4 0.3 1 23 395 418 395 418 0.95
5 16 2.7 1.3e+02 2.8 1.6 2 14 425 437 424 447 0.76
6 16 2.9e-06 0.00014 21.6 0.2 1 23 477 499 477 499 0.97
7 16 3.6 1.7e+02 2.4 0.1 2 10 506 514 505 521 0.76
8 16 0.072 3.4 7.8 0.4 3 23 536 556 535 556 0.99
9 16 0.0022 0.11 12.5 0.1 1 20 562 581 562 583 0.91
10 16 0.016 0.78 9.8 0.4 2 23 624 645 623 645 0.95
11 16 1.8e-05 0.00085 19.1 5.0 2 23 652 673 651 673 0.97
12 16 9.1e-08 4.4e-06 26.3 0.7 1 23 680 702 680 702 0.98
13 16 0.00021 0.01 15.7 2.1 1 23 708 730 708 730 0.97
14 16 5e-07 2.4e-05 24.0 1.9 1 23 761 783 761 783 0.98
15 16 3.7e-06 0.00018 21.3 0.5 1 23 789 811 789 811 0.98
16 16 3.5 1.7e+02 2.5 1.4 1 20 817 836 817 838 0.89

Sequence Information

Coding Sequence
ATGTTGCTTCGTCATATCATCCCATCGAATAACGATGTAGAAGAGATCTATATTGTTAAAAAAGATGATAATTTACAGGATTTTGACAACAAGCCTATAGATTCTGGAAGTAGCTCAGAATGCCTTTCAGCAGTATTTGTGAACGAAAATGTGGAAATCAAAGTTGATTCTGGAAATGCTCATTACAGCAATAATAGTGGTGCGGAACACAGTGACATCTTGAATCATACTAATGAATCAAAAGAGGAACCTACGGAAAGAGTAGAACAAAACGCACGGAACGTCGAATGGCgtgcaaataataaatattatacTTCAGGAATACTAGGCGATAACACAGCCTCTCTCATAACGTGCGCTTTTCAAGGCAACTCAGagcgtgtaaaaaaatattcgtcGATGGAATATGATAGACAAGATCAAAGTGAAGATCAATCGGAGTATGTAGAATCTAAAACCTATCCGGCCCGAACCGAACATGATAGTACAAATGatcatcaaaaatgtacaTTTGAAACTGATATTAGCGAAGAGTACAATTCGACAGACTTAAAGAAGTTGTTGCAACAAAGTTTAAAACCTAAAAATGTCAGCAGACTACGGAAGGAAAGCTTGGAAATGAACAAAATGTCGAAGATGGCATGTTTAAACCGTAAAAATACAAACGGAAATGAAGAGACAGATGATATGAAAACGAATAATATAACGCAGTGTTATATTTGTAGAAAAAGATTCCGGTTTCGCATGGATTTGCGTCAACACCTCCAAAATGAGCATGCGAAAGACATTCCATTCAACTGTAATATATGTGTATCGGAAACGATTACTAATTTGCATCGTTTAAATatgcatcatcagcagcatgaTCCAGCGTTAAACCGACGCTGCCTTTATTGTCCCGCCCGCTTTTCTTGTGGACGAGCTGTAAGCAGACATATGCGTAATTTACATGAGCAGAAATACGACATCGATGCCGATAAGGGTAGACGGTTTGTGTGTCGATACTGTGCAACAACATTTTCGAATCAAATTGATCTAGataaacacgaaaaaaaacatcacgtacaaaaaattaaaaaaaaagaaaatcgtaAGATGATTTGTTACATATGTAACGACTTCATTGGAAAATCGCATCAAGACCTTAATAATCATCTCGTATTGCATTCCGATTCGCTGCCGTTTCAGTGCGGTAAGTGTGATGACAAAATGATTAGCTCGATAAGAGTGCTTCAAGACCATCTTCGTCAACATGCGGAAGGCTTAGCTATCAAATGCTTTTACTGTGAGAAGCGTTTTGTGGCGCTAGCGGACTGTCAGCACCATGAAGGACAGGTACATTCTCAAGGGAACCAGCAAGACGAACATCAAGAAGCTGAAACACAATCTGAAATACACAATACTAGGGTAATAGAAGGGCACAAACGATTTATATGTCCGATCTGTGATCGATCTTACACAATGCTTAGTACCCTACGGCGTCATCAGGCCATACATGAGCAGGAAAATCAATTAGAATGTAAATATTGTGGTGAAGTGCGCCAAAAATCTACCACACTgataattaatgaaaaaagaaatcaaaaagAGAATAGTGTGCATGGTTGTAATGTTTGTGGAAACCCACTAAAACAAACAGACGAATTTATTGATCACCATCTTACACACAATAGAGGTAAACCGTTTATTTGTGAGGTGTGTGGAAAATCCTTCCGAGCGCAACAGGTATTGCGCGAACATAAACTAAACTGTCTTGGTGCAGAAGCTAGTCAACCATGCTACTGTGTGCTCTGTGCGCAAACTTTCGATAATCTTTCTATTGCACTGGAACACGTAAAGAATTCTCACGAATCGAACATAACGGATAAAAAGTGTCGTTATTGTGATTTGATATTTCGGGAGGCAGAATCGTTGGTTGAACATGAGTTTCGTCATACAATACATGGTATCATTACATGTAAGGTTTGCAATCGTATTTTTAAACATCACAAAAATCTCATTCGCCATATTAAAATGCATGCCGACCAACCTGTACCATATATGTGTGATTTGTGTGGAAAAACATTTACACAAAAAGGATCGCTGACGATACATCGTCGCATACATACTGGTGAACGTCCATTCTCATGCCAGCTATGCCAGAAAGGGTTTGTTGATAAGAAGGAAATGCGTCGACACTACACATCCCACTTTAATCCCCAAAGTAAATTATACATACCGAACGCTCATGCAATAGCAATCCCACCAGAAGCTGGTCCCACTGGTAAGAAGTACAAAACATATAATTGCAAGATATGCAATCGGCAATTTACATCTAGTTCGAATCTTGCAAAGCATCTTACTACTCATACAGgggaaaaaaaatatgtttgcgaATTCTGCGATAAAAGATTTAGTCAGGGTGGCCAATTGACTGTTCATAGGCGTATACACACTGGAGAGCGTCCGTTTACATGTGAAAATTGTGGTGACAGATTTTTGGATGGAAGCAGTTATAAACGCCATAAAACACATTACTTATGCCGAAACATTTCATCCAAATCATCGAGTGTACCTATTGCCACAGAAAATTCTCCAGCATTAACTAAATTTTCAATTACTATGCCTAAAGATGAAGGTACACCGTAA
Protein Sequence
MLLRHIIPSNNDVEEIYIVKKDDNLQDFDNKPIDSGSSSECLSAVFVNENVEIKVDSGNAHYSNNSGAEHSDILNHTNESKEEPTERVEQNARNVEWRANNKYYTSGILGDNTASLITCAFQGNSERVKKYSSMEYDRQDQSEDQSEYVESKTYPARTEHDSTNDHQKCTFETDISEEYNSTDLKKLLQQSLKPKNVSRLRKESLEMNKMSKMACLNRKNTNGNEETDDMKTNNITQCYICRKRFRFRMDLRQHLQNEHAKDIPFNCNICVSETITNLHRLNMHHQQHDPALNRRCLYCPARFSCGRAVSRHMRNLHEQKYDIDADKGRRFVCRYCATTFSNQIDLDKHEKKHHVQKIKKKENRKMICYICNDFIGKSHQDLNNHLVLHSDSLPFQCGKCDDKMISSIRVLQDHLRQHAEGLAIKCFYCEKRFVALADCQHHEGQVHSQGNQQDEHQEAETQSEIHNTRVIEGHKRFICPICDRSYTMLSTLRRHQAIHEQENQLECKYCGEVRQKSTTLIINEKRNQKENSVHGCNVCGNPLKQTDEFIDHHLTHNRGKPFICEVCGKSFRAQQVLREHKLNCLGAEASQPCYCVLCAQTFDNLSIALEHVKNSHESNITDKKCRYCDLIFREAESLVEHEFRHTIHGIITCKVCNRIFKHHKNLIRHIKMHADQPVPYMCDLCGKTFTQKGSLTIHRRIHTGERPFSCQLCQKGFVDKKEMRRHYTSHFNPQSKLYIPNAHAIAIPPEAGPTGKKYKTYNCKICNRQFTSSSNLAKHLTTHTGEKKYVCEFCDKRFSQGGQLTVHRRIHTGERPFTCENCGDRFLDGSSYKRHKTHYLCRNISSKSSSVPIATENSPALTKFSITMPKDEGTP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00102542;
90% Identity
iTF_00102542;
80% Identity
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