Basic Information

Gene Symbol
-
Assembly
GCA_013758885.1
Location
NC:66227357-66238949[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 8 0.003 0.14 12.0 1.4 3 23 480 501 478 501 0.95
2 8 0.046 2.2 8.3 1.0 2 23 526 547 525 547 0.97
3 8 0.012 0.56 10.1 0.0 2 23 1224 1245 1223 1245 0.96
4 8 0.21 10 6.2 0.0 2 23 1272 1294 1271 1294 0.95
5 8 0.00047 0.022 14.6 2.1 2 23 1335 1356 1334 1356 0.97
6 8 8.6e-07 4.1e-05 23.2 1.4 1 23 1362 1385 1362 1385 0.98
7 8 2.4 1.1e+02 2.9 0.1 3 23 2212 2232 2212 2232 0.93
8 8 0.34 16 5.6 0.2 1 23 2259 2282 2259 2282 0.89

Sequence Information

Coding Sequence
ATGGAGATCAACCCGATgtacaagaagaaaaagaaccgGTGGTCGATGTCGAAGATTGAGCTGCTCATTGACCTGTGGGCCGAGCACTATCGGCAGCTGAAATCGTGCCGCCGGAACGACCACGTcttgatgaagatgaagaacaaGCTGGAGAAAAGTGGCTGCAAGGTGACGGTCGAGGATATCCGAATCCGGATCAATAATCTGTCGGCCAAGTACAGGAAAGAGTCGATGTTAATGCTGGCAGGTGGTTCTCCGTCCAAGTGGCCGCTGTTCGTGAAAATCCACAACATCCTTAGCAACGAGAGTACGCTGGACGAAACCGTCGAAACGCAGGATGAGAGCTTAGAGGCTCCCGAGCCGCCACCCGAACCGCCTCGTTCGAAGGTTTACCAGCTGAAGTGCAACTATCGGCAGGAGAATATTGACAACTTTTTCACCGATTTGTATTTCAATCCCCGTTATGCGGACGTAACCTTGGTTACTTGCTACGAAGGCGAAACGTTCGCCATTCCAGCGCACAAAATGGTCCTGGGAAACTTCAGTATGTATTTTGCGAACATTTTCGAAAAGCTGAATCTGCCGCAAAACTCCAACACCTACATCGTGCTGCCAGCTAACGTCTCGCACCAGACGATGCAGATACTGATGCAATATATGTACACCGGCCAGTCCTCCGTGCCGGAGTACAACGTCGATGAAGTATTACGCTGCGGAGAGCTGCTGAAGATTCGCGGCTTCTGGAGTGAAACCAAGGCCTCCGTATCAGGAGTTGGCTTGTCGCATAAGCGGCGACAGTTGAACGGATCTGACGTATCCGGACGTAAGATGCATCGCAAACCTGGCACTTCTTCGCAGGGCAGTGGCGAACAGCGGGCCGGAACTTCACTCCCAGCCGACCAACAATCGGAGGTAGCCTCTGACTCGGGAACATCGGCACTGGATACGCTCGATGAGCAGAAGCGCCTAGCGATTGCGGCGATCCAGCGTGATCTTCATGCGAGCTCGATGCGCGCGATGGCGCATGGTGCGGCAGCTCTCTTCAGTAGCAACATGTCTACCGAAGTTAAGCATGAATCGAACGAATGGGATGATCTGGATGGTGACAACGATTCAGACGAAGACGTGATGATTCTACCCGATGAGCTGACAGCAAAGCCAACTGATGGTCCTGAGGAGAAGCCAAATCCATCGGCCGAACTCGCTGAACAGATTGcacaattgcagcagcagcaccaccaccagcagcaacatttacTCATGAACAATACctcagagcagcagcagcaccagcagcaacaacagcagcagcagcagccgcagcaacagacaccgccgcagcagcaggcccaaccgcaaccgcagctACACCAGCAATCGCACTCCTCAtcgcagcaacaaccatcggCGACTGTGGGCTCCCAATCTACGATGGCTTGTGAGCTGTGCAGCGCCTGCTTCTCTCATCAGGACGAGCTACTGCAGCATCTCATCAGCTCGCACAGTGACGCGGCCGAGATGCTTCGTAAACGAAGCAGGCTTGCAACGGATGAGGAAAATCCTGTGAACGCGATACGTTGCGAGTTTTGCGGCAAGTACTTCTTCTCGACCGTGGAATGGGCTCAGCACGTGCACACGCATACcgagcgcgcggtcgagctgccGCAACAGATGGCCCAGTTTTCCGGCACCATCCCACACTCGTTAACTTCGAATAAAGGACGACACGCATCGAACAGGACCGCGATGGCCACCGCAAACCCACCGGCGTTTCACTGCATCGTCTGCACACTAACGAAGATCCCGTTCGCTTCACTGAGCAAGGAAAGCCAGCACAAGATCGTCCGAAATGGACGGCCGACGCCGAAGATGCCGAATCTAACGGCTCGCTGCCTGCATGACTGGATGACCGGATGCGACCGCGAAAAGAAGCTTTACTGCTGGCCCTGTCTGCTGTTCAACACGTCCGAGTACGATGTGTGGGGAAAGCGAGGATTCAGCGATTTTCATCGGCTTTCCTCCGCCACGATCGAGCATACCAAGGACGTCTCGCACCAggccaaaagcaaaacgctGAAGCTGTGGATCGAGACAGCCGAAGAGCTGAGTGATAGCGAACCTGAGGAGGATGTAGAGTGCATCCCGGAGTTGGATTTTCTGAATGCTGCCGCATCCGAGATGGACGAAGAGCTGGACGTGAAACCGAACGTAGAAGCGCTAAATGCGGCTCTAGGATTGTCCCAGGACTTTGCCCGTCCCGTTGTGGATCTGTGCGAAACGGCGGAAGATGGTGGCAGCGTCACTGGGTTTCATTTCATGAGCGCGGCCATAGAGGTGGATTGTCTGGAGGATGAAGAGCAAAACTCAGCTcccgcaccaccacaaccgccaccaccgccggaagTGCAGGGGGAAAATAGCCTGGCGAGCAATGCCTCGTCGACAAACCACATCGAgccggccgccgctgccggcgATGGGTTAGCACGTATCTACAAAAACACACCTAGTTGCGAGGAACCTAGTGCAATGATGTCGCAAACGGCGACCCAGAATGGAACGGACAAGTACCAACTCAAGTGGCAGGGACATCATCAGAACGTTAATGTGTCGTTGTCGAGTCTTTACAGAAACGATCGCTACGCCGATGTAATGCTGTTGACGTGTAATGGAGACGAGAACTACGTGATACCTGCCCACAAGCTCATTCTTGGGACTTCCAGTTTGtattttgcaaacattttcgaCAAAAACGCGATACCAATGAATGCGATTAGCTACATTGTGCTTCCACCTGATCTAACCTACCGCTCGATGCAGATACTGATACAGTACATGTACACCGGCGAATCGACTGTCTCGACTGACATACTGAGTGAGGTGTTGCGTGGGGGAGAAATTTTGAAAATCCGTGGTCTGTGGCGAAATGATGGCTGCAAGCCGTCTTCCAACGCTGACAGCAGAGAGGCACAAGCGCCTGGCAGCAGTGAATCGGCAACGCGGCGATTTGCTAGTCCCGTATCTGTAACGCTTCCATCACACAACACATCCGCAATACAGGCGGCCGCAGGCGGTACCCCAGCTGTGGCCATAGGACACATAAACATAAAGCGTGACGTAGCCATTGATCCCGGTGATCGACACAGAACTGGTCACACCGAAGGGCCTCGACGATCTCAAAGAAATCAGGAGCATACGCATCAAGCGTCCGGGGATGCTCCCTGTccagagccgcagcagcagcagcaatcgtcgTCCCAAGTGCTTTCGGACGAACagcaaatttcatttccaattcATGAAAATCAGCGTAGGCTGCGTGGAGGTGCTCAGGAACTGCAGCGTATGGAAACTGCCTCGCCTACCCGGATGGCACTTCCGAATGCAGGAAATGGCGGTACGGAGGAGAATTCGGCATCCACCATGACCGGAGCACCTGGCACTGCGATACCCGAGGAACTGAACTTCCTGAACGTGAAAGCGGAGCCTATCGAGTGGATGGATGTGAGAGCGGGGGAGCTTGCCCTTCCCAGCAGTGGCCAGAAAGCAGCTGGAAACCAAACACCTCCGATTCAGACAGTGAAAGCTGAAGCGCCAGAACCGGGAATAGAACATTCCCGGTCATCCTCTGCGACATCCTCAACGGAGCATCTCACATACTCGCCATTAACCTGTGAGCTTTGTAGCGAAACGTTTACTATACCGGGCGAATGGGTTCGCCATATCGAGAGTCACGGTGATTCATCACACACAAttccaaaacggaaaagaCGGTTGGAGGGATCCGACGACACTGTTGAGACGGCCGCATTGCGATGCGATCTGTGTGCAACGTTCTACGTAACACCGGCCGACTGGGTGCGACACGTACAGAGTGCACACACGGAAACGGAGCTGGCCATTTCAAACAAACGCCAGACGTATCCTCGCCGGACGTCGACAAGCTCATTAGGCACAGGATCATCGCTCACATCGAGCGAGACGGCGGGGCAGCAGGACAAAGTGTGTAAAGTTTGCAACAAATCCTTCCCTTCCCATGCTAGTATGCTCGTCCATAAGCGTACCCATACCGGTGAGAAACCATTCTATTGCGACACGTGTAACAAGGGGTTTAGTGTAAAATCAAATCTACTGAGACACCTGCGAACACTACACAACGTCCAGGGCGACCTGCCAGCCTCGCCGCACACCGATCACGATGGTTCCGAGCCATCGCGCTGGCCTGGCAGAGCGCTGGCCATGGATCGGCGTGGCAACTGGGCGGCCGATGAGGTCGAGGAGATGATCGAGAGCATCAAAGAAAGAGAGATCTTATGTTTACCGGAAGGCAAGAAAGTCCGTTCGCTCGACATCTTCAAGGGCGTAGCGAACGATCTGCGGGCCAAGGGCATGCACCGGACACCAGAGCAAATCCGCACGAAACTGCGCACCTTGCGGAAGGACTACTTCAAGGCGCTCCGTTCCGGATCGAAGAGTGAATATCGGGCATGTGAGTTTTTTACCTCGCTGCACGACCTCTTCACCGATGCGCATCGTAAGATGGAGGCGAAAAAGCGCCGGCTACAGCgtcgccagcaacagcagcagcaacagttgcggGTACTGACTGAGAATCCCTCGAACGGTAACtaccagccatcatcatcccatcgGGTTGAATACCCCGGGGATGTTCAGGAGCAACGACCTCAGAAGCGAACGtcgacaacaacatcatctGTTACGATCAAAAGTAGTCGAAGCAGTAGTGTGATCAGTTCACGAATGCTTAACGAGGAAGCGATATGCGTGGATCAAAGCGCCAGCTTCGCGGTGCCCACCGTCGTTAAcgatagtggtggtggtggaccgggTGGTACGCCGGATGGCAGTGTCAGTGGAAAACAGAGACCGGAACCACTACCGGACAAGTATCACCTCAAGCTGAATGAGTATCTGCCGAACCTGAACAGTTCGTTGGCCAATCTGTGCAAAACCGAGAGATACGCGGATGTCACGTTATTGGTTTGCAACGACGAAGAAAGCCTCTCGATTCCGGCCCATAGGCTTCTGCTGGGAACGTTCAGTTCGTACTTTGCCAACATCTTTGAGCGAACGGCACTACTGGCTCCGCAGGGAATGATGTACATCGTGCTACCGCCGCTCGTGACTAGAGCAGCCATCCAGAGCCTACTGCAATACATGTATTCTGGCGAGACGATCGTACCGGCGGATCTACTCGATGATGTGATGCTCTGTGGTCAACTGCTACGGGTGCATGGATTTTGCACGAGAAAATCGACCGGATTACAAACGCAAAAAGCACAACCTTCCCTCACATCAATTCCGTTGGTCTCGGTGACGAAAAACCTTACGCTGAATCATACTCTCGAGACTCTTGAGGAGATGCAGCAAGTCGCACCTGCCTGCGAAGCACCTGTACCCATGGAGacggatcagcagcaacggccgcAACAACGAACACCAGTCCGCGATTACCGATCTGGTCCGGATCGGCAGATGTTAGTCGCAGCACCAACCGTTCCAACCGCTCCAATCGCTCCAGCCGCGCCAATCGCTCCAGCCGCTCCAATCGCTCCAACAGCTCCAGTCGCTCCAATCGCTCCAACAGCTCCAGCCGCTCCGGCCATCGAGCGACCATCTTCCGCGTTGGCACGTGAACGAGAACAAGCTGAAAAGCAACTAGAACTAGAACGTgcgcgagaacgagagcggGAGGAAGAGCGCAAGCGAGAACGacaactggaactggaaaaagaaaaggagcgCGAAAAGGAACGAGAGCGGGAGGAAATGGAacgagagaggaaggaaaaggagcgCGAAAGGGTGGAAAAGGAGCGTGAGCGGGTGGAAAGGGAGCGTgaacgagaggaaaagaagcgcgagcgcgaggaaAAGGAGCGTGAAAGGGTGGAAAAAGAGCGCGAAGAAAAGGAGCGCGAGAGGGAGCGGCAAAGGCAATGGGAAAAGGATCGTGAAAGGCAGCGTTTACGGGAGCTGGAGCTCGATCGTGCCCGGGAGCTTGAGCGGGATCGTCAGCGGCAGATGGACAGGGAGCGGCTAAGAGCACTAGGGCTCGAGCGTGTCCGTGTGAACAATCTGGATGAATTGGCACGGGCACCTTCTAGGATACTTGCCGAACCGGATGTCGCGGTGCTTGGCGCTAACGGTAGAGCGTcggatgaagatgacgatgaggatgaggaaatCCGGAATatcaaaacggaaaatacTGCAGCcacagaggaggaggaagatgccGAAGATAGCCGTGATTCACGATCGCCTACCCCCCAGCCGATCGTGTTGCGGCCGAAGAACAAACCAAAACTCCCCCTCACCGACGATATGCGCACAATCGACGGTTTAACATCTGATGAGTCAGCGCTAGAAATAGTAACGAATGGCCCGGAATCGTCCCCGTTCAGCAGCCGAGCGCAAAACAGTCCAAAAAGCATTCGAAGCAGTCCGCGACTCGAGTCAATTATTGAGTCTGATAACGAGGATCTGAGTCTACCAAACAGCAGCGAACTGCCGGGGTTGGCCTCCGCTCGACCCGATGATGACCGTCTCGATGAACCCCATTCCGTCAGTGCGCCAGATGATCATCTTGTCTATTCGCCGCTAGGTTGCCAGCTCTGTAGTGACACGTTTACGACACCCGGCGACTGGGTGCAGCACGTGTACGGCCACTGCGGCGAAGATCAGTCCCAGTGGAAAAGGAGACGACTGTCGAGGCACGACGATAAGGGAACGCTCTGCGATTCGCGCTACCGGTGTGACATGTGTTCGTCCTTCTTCAGCACGAGAAACGATTGGCTGGGGCACGTGGTCGTGGATCACGAGGAATGCATCAACGACTGTCTGATTGCGCTGCCGTTCAGCGATTACGATATGAAAAAGCCCAGCTTTCCTAGCCTTTGA
Protein Sequence
MEINPMYKKKKNRWSMSKIELLIDLWAEHYRQLKSCRRNDHVLMKMKNKLEKSGCKVTVEDIRIRINNLSAKYRKESMLMLAGGSPSKWPLFVKIHNILSNESTLDETVETQDESLEAPEPPPEPPRSKVYQLKCNYRQENIDNFFTDLYFNPRYADVTLVTCYEGETFAIPAHKMVLGNFSMYFANIFEKLNLPQNSNTYIVLPANVSHQTMQILMQYMYTGQSSVPEYNVDEVLRCGELLKIRGFWSETKASVSGVGLSHKRRQLNGSDVSGRKMHRKPGTSSQGSGEQRAGTSLPADQQSEVASDSGTSALDTLDEQKRLAIAAIQRDLHASSMRAMAHGAAALFSSNMSTEVKHESNEWDDLDGDNDSDEDVMILPDELTAKPTDGPEEKPNPSAELAEQIAQLQQQHHHQQQHLLMNNTSEQQQHQQQQQQQQQPQQQTPPQQQAQPQPQLHQQSHSSSQQQPSATVGSQSTMACELCSACFSHQDELLQHLISSHSDAAEMLRKRSRLATDEENPVNAIRCEFCGKYFFSTVEWAQHVHTHTERAVELPQQMAQFSGTIPHSLTSNKGRHASNRTAMATANPPAFHCIVCTLTKIPFASLSKESQHKIVRNGRPTPKMPNLTARCLHDWMTGCDREKKLYCWPCLLFNTSEYDVWGKRGFSDFHRLSSATIEHTKDVSHQAKSKTLKLWIETAEELSDSEPEEDVECIPELDFLNAAASEMDEELDVKPNVEALNAALGLSQDFARPVVDLCETAEDGGSVTGFHFMSAAIEVDCLEDEEQNSAPAPPQPPPPPEVQGENSLASNASSTNHIEPAAAAGDGLARIYKNTPSCEEPSAMMSQTATQNGTDKYQLKWQGHHQNVNVSLSSLYRNDRYADVMLLTCNGDENYVIPAHKLILGTSSLYFANIFDKNAIPMNAISYIVLPPDLTYRSMQILIQYMYTGESTVSTDILSEVLRGGEILKIRGLWRNDGCKPSSNADSREAQAPGSSESATRRFASPVSVTLPSHNTSAIQAAAGGTPAVAIGHINIKRDVAIDPGDRHRTGHTEGPRRSQRNQEHTHQASGDAPCPEPQQQQQSSSQVLSDEQQISFPIHENQRRLRGGAQELQRMETASPTRMALPNAGNGGTEENSASTMTGAPGTAIPEELNFLNVKAEPIEWMDVRAGELALPSSGQKAAGNQTPPIQTVKAEAPEPGIEHSRSSSATSSTEHLTYSPLTCELCSETFTIPGEWVRHIESHGDSSHTIPKRKRRLEGSDDTVETAALRCDLCATFYVTPADWVRHVQSAHTETELAISNKRQTYPRRTSTSSLGTGSSLTSSETAGQQDKVCKVCNKSFPSHASMLVHKRTHTGEKPFYCDTCNKGFSVKSNLLRHLRTLHNVQGDLPASPHTDHDGSEPSRWPGRALAMDRRGNWAADEVEEMIESIKEREILCLPEGKKVRSLDIFKGVANDLRAKGMHRTPEQIRTKLRTLRKDYFKALRSGSKSEYRACEFFTSLHDLFTDAHRKMEAKKRRLQRRQQQQQQQLRVLTENPSNGNYQPSSSHRVEYPGDVQEQRPQKRTSTTTSSVTIKSSRSSSVISSRMLNEEAICVDQSASFAVPTVVNDSGGGGPGGTPDGSVSGKQRPEPLPDKYHLKLNEYLPNLNSSLANLCKTERYADVTLLVCNDEESLSIPAHRLLLGTFSSYFANIFERTALLAPQGMMYIVLPPLVTRAAIQSLLQYMYSGETIVPADLLDDVMLCGQLLRVHGFCTRKSTGLQTQKAQPSLTSIPLVSVTKNLTLNHTLETLEEMQQVAPACEAPVPMETDQQQRPQQRTPVRDYRSGPDRQMLVAAPTVPTAPIAPAAPIAPAAPIAPTAPVAPIAPTAPAAPAIERPSSALAREREQAEKQLELERAREREREEERKRERQLELEKEKEREKEREREEMERERKEKERERVEKERERVEREREREEKKREREEKERERVEKEREEKERERERQRQWEKDRERQRLRELELDRARELERDRQRQMDRERLRALGLERVRVNNLDELARAPSRILAEPDVAVLGANGRASDEDDDEDEEIRNIKTENTAATEEEEDAEDSRDSRSPTPQPIVLRPKNKPKLPLTDDMRTIDGLTSDESALEIVTNGPESSPFSSRAQNSPKSIRSSPRLESIIESDNEDLSLPNSSELPGLASARPDDDRLDEPHSVSAPDDHLVYSPLGCQLCSDTFTTPGDWVQHVYGHCGEDQSQWKRRRLSRHDDKGTLCDSRYRCDMCSSFFSTRNDWLGHVVVDHEECINDCLIALPFSDYDMKKPSFPSL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00092226;
90% Identity
iTF_00092226;
80% Identity
iTF_00092226;