Basic Information

Gene Symbol
-
Assembly
GCA_951828415.1
Location
OX639997.1:110859319-110860555[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 7 2 4.2e+02 3.6 0.4 1 11 184 194 184 207 0.73
2 7 0.0034 0.73 12.2 0.2 1 23 215 238 215 238 0.94
3 7 0.00024 0.052 15.9 0.5 1 23 247 270 247 270 0.94
4 7 0.00016 0.034 16.4 1.1 1 23 275 300 275 300 0.96
5 7 0.013 2.8 10.4 1.5 1 23 308 331 308 331 0.91
6 7 0.0016 0.34 13.3 0.1 2 21 337 356 336 357 0.92
7 7 0.00026 0.056 15.7 0.3 2 23 366 388 365 388 0.95

Sequence Information

Coding Sequence
atgactATTAGTTGTCGAGTTTGTTTTAGGGaaaattcagataatttttcGATCCACACGTTTATGAAGAACAAATATATACCCCGAATCATTTTCCGCATTAGTGGAGTGAAAGTATCTAAAGAGGAGGAGTCGGGAGCACAAATATGTCATCGCTGCGCTGCATCAGTATTAGTGGCTGAAAACATAATATTGCGAATTCAAGAATCGgaagaatattttcaatttcaacgtCTCCAGGAGAAGCATAACTTACAAAGACAATCGGTAGCAACGACTACAGAATACTCTAACAGAAATGACaaagaatcaaatttaaatgtttatgaAGATTCACAATCGGCTTCCACTTCCAGTGAAACAGATGAGTTTTCGAATTTTACTGAAAGCAGCagaaatatttcactttatgATGGTCATCCACAACTAACCGCGGAAATTCAACCAATTACATCAAATATAACCGCTATTGCTGGCAGACCACTTTTATCACAAAGGGAACCAACAGCCAAACGCTTCAAAAGCGAAGAGGATACTACTGTACAAATTTTCGAATGCGATCAGTGTGATTATAGCAGCAAGATTGGTAAACGTATAATAGAACATAAACAAACTGTGCATGATATCTATGATCCAAATATCTACGCTTGCAACCTTTGTGATCAACGTTTTTCTTGGAAACCCACACTCTATCGGCATATTGAGCTGGATCATAAAACATTGCCTGCAGATAAAAAGTATCTTTGCAATGAATGTGGACGTGCCTACATGCGTGAAATACATCTAATCGAACATATAAAACAACGACATGGACCACGGAATTTCCAATGTCCAGATCCATTGTGTGAGCAAACTTTTACTCGAACATTTACGCTACGGCGTCATTTCATCACGTCACATACAGAACAAACTAGCACACGTTATCATTGTGTAGATTGTGATAAGTACTTTAAAGTCTACGATCAATGGAAATATCATAATGAAGTGATACACAAAAATGAAACGGTATATTGTCCACAATGTGGGTACCCTTTCCGATTTAAGGAAAAGTTAGATGAGCATCTACTAAAGGATGTTTGCAAGCGCAGCATTGTGCCCTGCGCTTATTGTCAGAGGCGTTTCACCATGAAAACTGGACTTAGAGAGCACGTGCGGAATATACATAACATTTATTAA
Protein Sequence
MTISCRVCFRENSDNFSIHTFMKNKYIPRIIFRISGVKVSKEEESGAQICHRCAASVLVAENIILRIQESEEYFQFQRLQEKHNLQRQSVATTTEYSNRNDKESNLNVYEDSQSASTSSETDEFSNFTESSRNISLYDGHPQLTAEIQPITSNITAIAGRPLLSQREPTAKRFKSEEDTTVQIFECDQCDYSSKIGKRIIEHKQTVHDIYDPNIYACNLCDQRFSWKPTLYRHIELDHKTLPADKKYLCNECGRAYMREIHLIEHIKQRHGPRNFQCPDPLCEQTFTRTFTLRRHFITSHTEQTSTRYHCVDCDKYFKVYDQWKYHNEVIHKNETVYCPQCGYPFRFKEKLDEHLLKDVCKRSIVPCAYCQRRFTMKTGLREHVRNIHNIY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-