Basic Information

Gene Symbol
-
Assembly
GCA_952773225.1
Location
OX731548.1:61759701-61761059[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 8.5e-05 0.0086 17.0 1.0 1 23 39 63 39 63 0.97
2 9 1.2e-06 0.00012 22.9 4.1 1 23 69 93 69 93 0.98
3 9 2.1e-06 0.00021 22.1 1.7 1 23 100 123 100 123 0.98
4 9 1.1e-06 0.00011 23.0 1.0 2 23 130 151 129 151 0.97
5 9 0.0004 0.04 14.9 4.3 1 23 156 178 156 178 0.96
6 9 0.00059 0.059 14.4 0.0 1 23 185 209 185 209 0.97
7 9 0.00015 0.015 16.2 2.7 3 23 213 235 211 235 0.94
8 9 0.00057 0.058 14.4 0.5 3 23 244 267 242 267 0.94
9 9 0.74 75 4.6 0.2 1 23 272 295 272 295 0.93

Sequence Information

Coding Sequence
ATGGGACAAGGGAGAACCACAGAGTCCGATAGCATTTTCTGTGAAACTGAGAATTGCAGTGCGATAGGAAAAACTGATATTGAGTTTACTCGGACAAAGAGGGATATAAAAAGGCATAAATGTACATATGATGGATGCGATGCAATTTTTAATAGGCCATCCCGACTGGCCAGGCATATTAGATTTCATACTGGAGAGAGAAATTATAAATGTAATCATCCTGGCTGCGATAAAGCTTACACAAATTCCTCTCATCTGAAGCGCCATACAGAAACTCATAGTATACAGAAGAAGACATTCCAATGTCCCGAGTGTCCATTATCCATTAGTAATCGACATAACTTGAAGCGTCATTATAACACTATGCACGGGGATCGTAGTAAACTGACTTGCAAAGAATGTAATGAAACCTTCGCTAAAAAGTATCAACTCGCGACGCACATGTCGACCCATACTGGACAGCTGTACAACTGCGATCAGTGTAAGAAAAGCTTTACGAACATGAACAAATTCAAAAGACACAAAGTTAGTCACGAAGAGGGAAAGAAAGTTTATCCCTGCAGTGCGCCGGGATGCACCGAAGTTTTTGGGAGATGGTTGCTTCTTCGTGCTCATGCAAAGACACATGTGCTTAACTGTAAGTTTAAGGATTGCAACAAAGTGTTCACCAACAAATATCGTTTAAGGACTCATTCTAAAGTCCACCTGGAAAACAGATCAGTTGTGCCTTGTCCGTACGACGGATGTAATAgaagttattatttaaaaagtaatctAGACCATCATGTACGAATCAAACATTTAGGGGAAAGATACGAGTGCGACGTGTGCAAAGTATTGCTGTCATCCAAAGCGAGAGTAGCAGATCATATTCATAGAATACACATGTCGGATAGAAGGATAAAAAGGGCCAAAATATTACAGCGCAAGAGGAGAAAGGATGTCGGGACGCGTAAAAGAAGCGCGGTGTCCGCATTGGTCGGAGTTAACTTGCCGCCGAAGATTGAAAGGATGGTATTGAAACGGCAGGAAGACATAACATATATAGAACAATTTAATGGAGCGTTAGATGATAACCAAAATTCATGA
Protein Sequence
MGQGRTTESDSIFCETENCSAIGKTDIEFTRTKRDIKRHKCTYDGCDAIFNRPSRLARHIRFHTGERNYKCNHPGCDKAYTNSSHLKRHTETHSIQKKTFQCPECPLSISNRHNLKRHYNTMHGDRSKLTCKECNETFAKKYQLATHMSTHTGQLYNCDQCKKSFTNMNKFKRHKVSHEEGKKVYPCSAPGCTEVFGRWLLLRAHAKTHVLNCKFKDCNKVFTNKYRLRTHSKVHLENRSVVPCPYDGCNRSYYLKSNLDHHVRIKHLGERYECDVCKVLLSSKARVADHIHRIHMSDRRIKRAKILQRKRRKDVGTRKRSAVSALVGVNLPPKIERMVLKRQEDITYIEQFNGALDDNQNS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00085643;
90% Identity
iTF_00087412;
80% Identity
-