Basic Information

Gene Symbol
Zfy2
Assembly
GCA_952773225.1
Location
OX731548.1:9468713-9473618[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 2.9e-07 2.9e-05 24.8 2.4 1 23 155 177 155 177 0.98
2 15 0.0003 0.03 15.3 1.0 1 23 183 205 183 205 0.98
3 15 0.037 3.8 8.7 1.5 1 23 212 235 212 235 0.97
4 15 0.00026 0.027 15.5 5.4 1 23 241 263 241 263 0.97
5 15 0.00046 0.047 14.7 0.2 2 19 269 286 269 289 0.93
6 15 6.4e-07 6.5e-05 23.7 2.4 1 23 327 349 327 349 0.99
7 15 1.3 1.3e+02 3.8 0.8 3 23 428 447 427 447 0.85
8 15 0.0061 0.62 11.2 5.1 1 23 453 476 453 476 0.95
9 15 0.00054 0.055 14.5 3.7 1 23 482 505 482 505 0.97
10 15 1.1e-05 0.0011 19.8 0.6 1 23 511 533 511 533 0.98
11 15 2.9 3e+02 2.7 1.4 2 23 539 561 538 561 0.81
12 15 0.00087 0.088 13.8 1.4 1 23 568 590 568 590 0.97
13 15 8.8e-07 8.9e-05 23.3 0.3 1 23 594 616 594 616 0.99
14 15 0.00011 0.012 16.6 1.5 1 23 622 644 622 644 0.98
15 15 2e-05 0.002 19.0 1.3 1 23 650 673 650 673 0.97

Sequence Information

Coding Sequence
ATGTTCGCTGCCTTTGATTCGTTCAAATGGCTAACgcCAGCGATAAGTGTCCACCCCACGCGAAACTCTAGCGCGACAAGAGACACAAGCAAATATCAGCTGCCTGCCAGTCACAATGCTCACACTATCAAACAAGAGAGAGAAGACCACGCAACGTGCAACGTCAACATTAAAATAGAAATACCTGACCAGTCACCCGAAGACACACCAAACGGGTCGTTTGAGGAGCAATTGCAAAATTTTCCTGCAGAATCGTGCGAAGGGTTTCCACATGAATCTTATCAAGGTGTCCCACATGCATCACCTGACCAAGCTCCTCAAAGCTTGCCTGCCCCATTGGACACAGAATTGCCTAAAAACCTGCCCATGCAGTTACCCATGCACTTCTTGGAGCAGGTAGGGAACTCAACGCCCCCACTTCTGACGATCGCACGAAGAGAGAAGATACAGTACCTAAGGAAGTTCGTGTGCGAGGTCTGCCATAAAGCATTTGGCAACAATTACAACCTGCGGAAGCACTTGAAGACTCACGGCATGGAGCCCACGTACCAGTGCTCCGTGTGCCACCAGCAGCTGGAGAATAAGAAGTCCCTGGAAGTGCACATGGACATTCACAAGGGTGGCCACAATATATTCCAGTGTTCCGAATGCGGCTTCCTGGCGAGGCGAATGTATTACGTGAAGAGACACCAAATTAGGAAGCACACGAAGCTCTTTGCGTTTCACTGTCATCTTTGTCCGAAGATGTTCAACCTGAACGCGGACTTCAGGCGTCATATGACACGGCACGTGATCGCGCCGCGCTATTGCGAGTATTGCGGGCAAACGTTCAAGAACGAATACTACTTCCGGGTACATGGATTGCAGCGCAAATCGATCAGGTTTCGTTGCAAGGGATCATTTTGCGATGGCGTTAAAGTTGTTAAGAAACAACAGGTGAAGGAGGAGGGACTGGAAGTAAAGATAACAGGCAAACAGTACAAGTGCCCCCAGTGCAAGTGGAGCTTCCAGAACTGGAAATCTCTTCGTAAGCACCTGAAACGCCATACACTTAGATACAATTGTGATAAATGCACTGCGGTGTATAAGTTGCtaaagaagaagacgaagaagatgGTGAAGAAAAAGGTTCTCGGCAAGAGAACGTCGCCGAAGACGCGGATTTCGTTATCGAAAAAGTCACAGAGCACATCAGTGAAGAAGGAGAAGTCGGATTCGGAGAATACGCGTGAAGAAATGAGTGAAAATCGTGATGAAACAGTGAAGATGGAGAAAGTATTCTGTGATATCTGTAAAGTTACCATTCTAGAGAAGAATTATACGAAGCATATGCTGAAGCACAGCAATGTCAATGGCTTCCAGTGCGACGTGTGCTCCAGGAAGTACAAGCACAAGAGAACAATGACGAAACATAAGTTGTATGCGCATGGGGATGCACCGACGTACAATTGCCAACATTGTGATTTCACAACGATTCACGCCTCTTACCTGCAGGTGCACATTATGCGCAAGCACACCGTCAATTATCCTTTTCCCTGCAACAAGTGCGACCGAATGTTTCGGGTGAAAGCTGATTACATGAAACACATAGTCACCCACGACGGGGAGCCATGTATCTGCGACGTGTGCGGCACCAAAGTGGCCAACAAGATCTCCCTCTACTTCCACAAGAATTACAATCACACGGTGAAGGACGCCAGGTTCCAGTGCCCCCTCTGCAAGAAGAAGCTGCAGACCCAGAAGAACCTCGACAGCCACGTGCAGCAGCACCAGCGGAAGTACGTGTGCGAAGAATGCGGGATGGAATTGACGCGCAAGACCGCCCTTCGAAAGCACATTAGGACGCACTCAGGCGAGAAATCCTATTCCTGCCATATCTGCCGCAAAGCTTTCGCCAGCGCCACCAGCCGCAAGGTCCACCTTCTGACGCACTCAGGCGTCAGGCCATACGTATGCACAATATGTGGGCAGAACTTCACGCAACGCCCAGCTCTTTGCGTCCACTGGAAGAAGAAGCATCCTGATGCCACGGAGGCACCACCGTCGGTGTCCATCACGAACATCATCAACTCTATAACACAGTCTGCTGTCAAAGCAAACGACGTATAA
Protein Sequence
MFAAFDSFKWLTPAISVHPTRNSSATRDTSKYQLPASHNAHTIKQEREDHATCNVNIKIEIPDQSPEDTPNGSFEEQLQNFPAESCEGFPHESYQGVPHASPDQAPQSLPAPLDTELPKNLPMQLPMHFLEQVGNSTPPLLTIARREKIQYLRKFVCEVCHKAFGNNYNLRKHLKTHGMEPTYQCSVCHQQLENKKSLEVHMDIHKGGHNIFQCSECGFLARRMYYVKRHQIRKHTKLFAFHCHLCPKMFNLNADFRRHMTRHVIAPRYCEYCGQTFKNEYYFRVHGLQRKSIRFRCKGSFCDGVKVVKKQQVKEEGLEVKITGKQYKCPQCKWSFQNWKSLRKHLKRHTLRYNCDKCTAVYKLLKKKTKKMVKKKVLGKRTSPKTRISLSKKSQSTSVKKEKSDSENTREEMSENRDETVKMEKVFCDICKVTILEKNYTKHMLKHSNVNGFQCDVCSRKYKHKRTMTKHKLYAHGDAPTYNCQHCDFTTIHASYLQVHIMRKHTVNYPFPCNKCDRMFRVKADYMKHIVTHDGEPCICDVCGTKVANKISLYFHKNYNHTVKDARFQCPLCKKKLQTQKNLDSHVQQHQRKYVCEECGMELTRKTALRKHIRTHSGEKSYSCHICRKAFASATSRKVHLLTHSGVRPYVCTICGQNFTQRPALCVHWKKKHPDATEAPPSVSITNIINSITQSAVKANDV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00084735;
90% Identity
iTF_00084735;
80% Identity
-