Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00043 0.053 14.8 0.1 1 21 4 24 4 25 0.96

2 6 8.2e-07 0.0001 23.3 0.2 2 21 82 101 81 102 0.93

3 6 4.1e-06 0.00052 21.1 0.4 1 21 160 180 160 181 0.95

4 6 2.4e-06 0.00031 21.8 1.0 1 21 201 221 201 222 0.96

5 6 1.8e-05 0.0023 19.1 0.3 1 22 288 309 288 309 0.96

6 6 7.8e-05 0.0098 17.1 7.6 1 23 318 340 318 341 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00043	0.053	14.8	0.1	1	21	4	24	4	25	0.96
2	6	8.2e-07	0.0001	23.3	0.2	2	21	82	101	81	102	0.93
3	6	4.1e-06	0.00052	21.1	0.4	1	21	160	180	160	181	0.95
4	6	2.4e-06	0.00031	21.8	1.0	1	21	201	221	201	222	0.96
5	6	1.8e-05	0.0023	19.1	0.3	1	22	288	309	288	309	0.96
6	6	7.8e-05	0.0098	17.1	7.6	1	23	318	340	318	341	0.96

Coding Sequence: ATGCAACCCTACATGTGCGGGGAGTGTGGAAAGGGGTACAAGTGGATGGCGAACCTTCGCAGACACCAGAGGCTTGAGTGCGGGAAACTGCCCAAGCATCATTGGAATCAAGGGGATCTCTGCGAGTGGTTCGTGAAGCAAGAGCAGGATTACGAGGGGCCGCAGACCCTGTTCGAGTTCGTGGCCAGCAATTACCAACCGGTGCAGGACACCGAGGAACGGAGGAAGTCATCGAAGACGGTGGTCTGCGAGGAGTGCGGCAAGAGCTTCTCGAGGCTCGACAGTCTTCGTAGACACGAGAAGAATTATTGGGAGAACTCGGAGAGCAGCGCGGAGAAGGACCAAGAGGAGGACGCCGAGGTGTGTGAGATCTCGTTTCACGATCAGTTGCAGATGAACTACTTGCTGTGCGACTCGTCCCTTCTCACCTCCATGGAGACGAGCATCGTCCAGAAGAACACGAAGACCCATCAGCAGTTCCGCTGCGACGGCTGTGGCAGAGCTTACACGCGGATGGACAGCCTGAAGCGTCACCAGACCAAGTGCGACGCCTCCTTGGAGAAGTTACAGGACGAAGCTGAGTGGCTTCACAGGCAGAAGTTCTATTGCAGCCAGTGCGGCAAGGGTTACAAGAGGCTGGACACCCTTAGAAGGCACCAGAGGCTCGTTTGCGGTATCGAGGAGGCGAGAGAGCACGACGCGCTGTGGCTGCTGGAGAGGAGGACAAGGAGCATAGGGGAAGATCAGGACTTGAACTTGTTCGAGAAATCGTACGCGTCAAGAGCGGGGGAATCGATGGACCCGAGGTACGGGGATCAACATTGCGGGCCGGATTCCTACGCGGGCGTTCTTCAAACACAGTACGTCTGCAACGATTGCGGGAGAAGCTATAAGTGGTACGACAGTCTGAAGAGGCACCAGAGGGTCGATTGTGGGAATAAAGAGAAGAAATTTTCCTGCCACATGTGCGAGAGGAAGTTCAAGTATCGATACGAACTGCGTAATCACCTGACCACCCACCATAGGATATGA
Protein Sequence: MQPYMCGECGKGYKWMANLRRHQRLECGKLPKHHWNQGDLCEWFVKQEQDYEGPQTLFEFVASNYQPVQDTEERRKSSKTVVCEECGKSFSRLDSLRRHEKNYWENSESSAEKDQEEDAEVCEISFHDQLQMNYLLCDSSLLTSMETSIVQKNTKTHQQFRCDGCGRAYTRMDSLKRHQTKCDASLEKLQDEAEWLHRQKFYCSQCGKGYKRLDTLRRHQRLVCGIEEAREHDALWLLERRTRSIGEDQDLNLFEKSYASRAGESMDPRYGDQHCGPDSYAGVLQTQYVCNDCGRSYKWYDSLKRHQRVDCGNKEKKFSCHMCERKFKYRYELRNHLTTHHRI

Sequence clustering based on sequence similarity using MMseqs2