Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.0052 0.73 11.7 4.6 1 23 120 143 120 143 0.97

2 6 7.4e-06 0.001 20.7 0.3 2 21 151 170 151 171 0.94

3 6 0.0028 0.4 12.6 2.5 1 23 180 202 180 202 0.97

4 6 0.00026 0.036 15.8 2.5 1 23 208 231 208 231 0.98

5 6 7.1e-05 0.0099 17.6 0.5 1 23 236 260 236 260 0.94

6 6 0.0001 0.014 17.1 1.6 1 23 266 289 266 289 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.0052	0.73	11.7	4.6	1	23	120	143	120	143	0.97
2	6	7.4e-06	0.001	20.7	0.3	2	21	151	170	151	171	0.94
3	6	0.0028	0.4	12.6	2.5	1	23	180	202	180	202	0.97
4	6	0.00026	0.036	15.8	2.5	1	23	208	231	208	231	0.98
5	6	7.1e-05	0.0099	17.6	0.5	1	23	236	260	236	260	0.94
6	6	0.0001	0.014	17.1	1.6	1	23	266	289	266	289	0.97

Coding Sequence: ATGTTTGTTCACAAAACCTACCAACGCGCTAACGAACACTTTGTAACACATATTCTAGACATTCGAAAGGACGAGCGTATTCTCTCAATTAAGCTTGAAGAGGATTCTGCACATTTTCCGGTGGAAGTATCCTACGAAGAATCCTCAGCGCATTGCTCAAAAAATGAGACGTCAAAAAATCCACCCGTACTTATGAATATGGCTCCTCCGTCAGATGCTGATGATATTAATTTGGCGGAATATCTCTTTGAGAATCCCGACTTGTTAACGAAAGCCCAGGCTGCCGACGAACAATTGCATATTTTGTCGAAACCACGAAAACGCGGACGTGCTCCACTTATTCCTGGCGGTCCACCATTTCAGTGCGAATATTGTGATCATAAAAGTCCATCGCGCTCACTCTTGGCATCCCATCGACATCGTAAGCATCGCTTCAATAAGTCACCGAATAGATGTGCTGAATGCGGCAAAGAGTTTGCAACAAAGCAACAACTTGAACGTCATCAACAGCGAGTGACTTGCCAATCATATCCGGTATTCAATTGTGAGTTTTGCGAGAAAACATGCATTGGTCGCGCCAATTACCAGATACATCTGCGCTTCCATAAGAAAGTATATCCATTTGTTTGTCATATATGTGCCAAGCCATTTATGATGGCCCAACATCTGAACAATCATGTGAAAACGAAGCATGAAGGACAGCGATTTATTTGCGAGCAACCAGAGTGTGGAAAAATGTTTCAAACTGCGCATGCGCTCAAGAATCATGCATATACTCACGTCGATCAATTGCCTTATCGTTGCGACTACTGCCAGCATGATTTTCCAACCAAGGGCAGATTGCGTTGGCACATCAGCCGAATACATGGCATTGAGCATACGCTGGACGAGCTCGATTGCATGCTGGTGGCCAAAGAGATTAAGCTAAAAGCACAATTGCGGCCGGTGCTGACACCGGAGCCCGAAGTGATTGCTGCGAACGAACTTGAGGGCTACGCCGACTGA
Protein Sequence: MFVHKTYQRANEHFVTHILDIRKDERILSIKLEEDSAHFPVEVSYEESSAHCSKNETSKNPPVLMNMAPPSDADDINLAEYLFENPDLLTKAQAADEQLHILSKPRKRGRAPLIPGGPPFQCEYCDHKSPSRSLLASHRHRKHRFNKSPNRCAECGKEFATKQQLERHQQRVTCQSYPVFNCEFCEKTCIGRANYQIHLRFHKKVYPFVCHICAKPFMMAQHLNNHVKTKHEGQRFICEQPECGKMFQTAHALKNHAYTHVDQLPYRCDYCQHDFPTKGRLRWHISRIHGIEHTLDELDCMLVAKEIKLKAQLRPVLTPEPEVIAANELEGYAD

Sequence clustering based on sequence similarity using MMseqs2