Aobl029467.1
Basic Information
- Insect
- Anastrepha obliqua
- Gene Symbol
- Runx1
- Assembly
- GCA_027943255.1
- Location
- JAPTHQ010000087.1:2845985-2853369[-]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 5 4.7e+04 -6.3 5.4 59 76 37 54 27 60 0.53 2 2 4.1e-52 3.9e-48 163.7 0.0 4 94 77 167 74 170 0.97
Sequence Information
- Coding Sequence
- ATGCACATCTCAAGTGAAGTGAGTTCAACCACAAATCATCAGCAGCCACCGCCCGTCAACAGTGGTGCGCCATCGAAACGCAATGCTAGTGCAAATAACACAAACAACAATAACAACAACAATAATAGTAGTGTTAATAACAACAATGCGAGTAGTAATAACAAAAAAGTGGTGGACACAAGTCCATACCTTACACCTGAAAACCTCATTGAACGAACTGTGGATGTGTTGTTGGCCGAGCATCCGGGTGAATTGGTGAAGACCGGCTCTCCACATGTGGTATGCACAACATTACCCACACATTGGCGCTCGAATAAAACGCTACCAATTGCCTTTAAAGTACTCGCTCTGGGCGAGGTGATGGATGGCACAATTGTGACAATACGCGCGGGGAATGACGAGAACTTCTGTGCGGAGTTGCGGAATTGTACGGCCGTAATGAAAAATCAAGTGGCCAAATTCAATGATTTGCGCTTCGTCGGACGCAGTGGACGTGGTAGGTTGAAAGAAAAATGA
- Protein Sequence
- MHISSEVSSTTNHQQPPPVNSGAPSKRNASANNTNNNNNNNNSSVNNNNASSNNKKVVDTSPYLTPENLIERTVDVLLAEHPGELVKTGSPHVVCTTLPTHWRSNKTLPIAFKVLALGEVMDGTIVTIRAGNDENFCAELRNCTAVMKNQVAKFNDLRFVGRSGRGRLKEK
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00189714;
- 90% Identity
- iTF_00080971; iTF_01357705; iTF_01563465; iTF_00992334; iTF_00189714; iTF_00191856; iTF_00090941;
- 80% Identity
- -